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P11942

- CD3G_MOUSE

UniProt

P11942 - CD3G_MOUSE

Protein

T-cell surface glycoprotein CD3 gamma chain

Gene

Cd3g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    The CD3 complex mediates signal transduction.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. protein heterodimerization activity Source: UniProtKB
    3. transmembrane signaling receptor activity Source: UniProtKB

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: UniProtKB
    2. establishment or maintenance of cell polarity Source: UniProtKB
    3. protein transport Source: UniProtKB
    4. regulation of lymphocyte apoptotic process Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_196487. FCGR activation.
    REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
    REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_210240. Role of phospholipids in phagocytosis.
    REACT_215414. Translocation of ZAP-70 to Immunological synapse.
    REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
    REACT_225145. Downstream TCR signaling.
    REACT_225768. Generation of second messenger molecules.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell surface glycoprotein CD3 gamma chain
    Alternative name(s):
    T-cell receptor T3 gamma chain
    CD_antigen: CD3g
    Gene namesi
    Name:Cd3g
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88333. Cd3g.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-beta T cell receptor complex Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Add
    BLAST
    Chaini23 – 182160T-cell surface glycoprotein CD3 gamma chainPRO_0000014617Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 87By similarity
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Modified residuei145 – 1451PhosphoserineBy similarity
    Modified residuei148 – 1481PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP11942.
    PRIDEiP11942.

    PTM databases

    PhosphoSiteiP11942.

    Expressioni

    Gene expression databases

    ArrayExpressiP11942.
    BgeeiP11942.
    CleanExiMM_CD3G.
    GenevestigatoriP11942.

    Interactioni

    Subunit structurei

    The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

    Structurei

    Secondary structure

    1
    182
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi16 – 183
    Beta strandi37 – 393
    Beta strandi41 – 455
    Beta strandi47 – 493
    Beta strandi53 – 575
    Beta strandi73 – 764
    Beta strandi82 – 9110
    Beta strandi93 – 1008

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JBJNMR-A22-103[»]
    ProteinModelPortaliP11942.
    SMRiP11942. Positions 22-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11942.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 11694ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 18245CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 9458Ig-likeAdd
    BLAST
    Domaini149 – 17729ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43749.
    HOGENOMiHOG000015287.
    HOVERGENiHBG005278.
    InParanoidiP11942.
    KOiK06452.
    OMAiDRENDQY.
    OrthoDBiEOG7S4X7Q.
    PhylomeDBiP11942.
    TreeFamiTF335892.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR015484. CD3_esu/gsu/dsu.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view]
    PANTHERiPTHR10570. PTHR10570. 1 hit.
    PfamiPF02189. ITAM. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view]
    PROSITEiPS51055. ITAM_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11942-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQRKGLAGL FLVISLLQGT VAQTNKAKNL VQVDGSRGDG SVLLTCGLTD    50
    KTIKWLKDGS IISPLNATKN TWNLGNNAKD PRGTYQCQGA KETSNPLQVY 100
    YRMCENCIEL NIGTISGFIF AEVISIFFLA LGVYLIAGQD GVRQSRASDK 150
    QTLLQNEQLY QPLKDREYDQ YSHLQGNQLR KK 182
    Length:182
    Mass (Da):20,234
    Last modified:October 1, 1989 - v1
    Checksum:i7F9D8D44A5C360D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00635 mRNA. Translation: CAA68667.1.
    M58149 mRNA. Translation: AAA63289.1. Sequence problems.
    M18227
    , M18222, M18223, M18224, M18225, M18226 Genomic DNA. Translation: AAA37400.1.
    BC027528 mRNA. Translation: AAH27528.1.
    CCDSiCCDS23123.1.
    PIRiA39952. A28508.
    RefSeqiNP_033980.1. NM_009850.2.
    UniGeneiMm.335106.

    Genome annotation databases

    EnsembliENSMUST00000002101; ENSMUSP00000002101; ENSMUSG00000002033.
    GeneIDi12502.
    KEGGimmu:12502.
    UCSCiuc009pex.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00635 mRNA. Translation: CAA68667.1 .
    M58149 mRNA. Translation: AAA63289.1 . Sequence problems.
    M18227
    , M18222 , M18223 , M18224 , M18225 , M18226 Genomic DNA. Translation: AAA37400.1 .
    BC027528 mRNA. Translation: AAH27528.1 .
    CCDSi CCDS23123.1.
    PIRi A39952. A28508.
    RefSeqi NP_033980.1. NM_009850.2.
    UniGenei Mm.335106.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JBJ NMR - A 22-103 [» ]
    ProteinModelPortali P11942.
    SMRi P11942. Positions 22-103.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P11942.

    Proteomic databases

    MaxQBi P11942.
    PRIDEi P11942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002101 ; ENSMUSP00000002101 ; ENSMUSG00000002033 .
    GeneIDi 12502.
    KEGGi mmu:12502.
    UCSCi uc009pex.2. mouse.

    Organism-specific databases

    CTDi 917.
    MGIi MGI:88333. Cd3g.

    Phylogenomic databases

    eggNOGi NOG43749.
    HOGENOMi HOG000015287.
    HOVERGENi HBG005278.
    InParanoidi P11942.
    KOi K06452.
    OMAi DRENDQY.
    OrthoDBi EOG7S4X7Q.
    PhylomeDBi P11942.
    TreeFami TF335892.

    Enzyme and pathway databases

    Reactomei REACT_196487. FCGR activation.
    REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
    REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_210240. Role of phospholipids in phagocytosis.
    REACT_215414. Translocation of ZAP-70 to Immunological synapse.
    REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
    REACT_225145. Downstream TCR signaling.
    REACT_225768. Generation of second messenger molecules.

    Miscellaneous databases

    EvolutionaryTracei P11942.
    NextBioi 281454.
    PROi P11942.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11942.
    Bgeei P11942.
    CleanExi MM_CD3G.
    Genevestigatori P11942.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR015484. CD3_esu/gsu/dsu.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view ]
    PANTHERi PTHR10570. PTHR10570. 1 hit.
    Pfami PF02189. ITAM. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view ]
    PROSITEi PS51055. ITAM_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of murine T3 gamma cDNA from a subtractive cDNA library."
      Haser W.G., Saito H., Koyama T., Tonegawa S.
      J. Exp. Med. 166:1186-1191(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of the cDNA encoding the T3 gamma subunit of the mouse T3/T cell antigen receptor complex."
      Krissansen G.W., Owen M.J., Fink P.J., Crumpton M.J.
      J. Immunol. 138:3513-3518(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements."
      Saito H., Koyama T., Georgopoulos K., Clevers H., Haser W.G., Lebien T., Tonegawa S., Terhorst C.
      Proc. Natl. Acad. Sci. U.S.A. 84:9131-9134(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCD3G_MOUSE
    AccessioniPrimary (citable) accession number: P11942
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3