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Protein

T-cell surface glycoprotein CD3 gamma chain

Gene

Cd3g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The CD3 complex mediates signal transduction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_280649. Downstream TCR signaling.
REACT_292208. Role of phospholipids in phagocytosis.
REACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_309115. PD-1 signaling.
REACT_333749. FCGR activation.
REACT_334692. Generation of second messenger molecules.
REACT_344463. Regulation of actin dynamics for phagocytic cup formation.
REACT_345130. Translocation of ZAP-70 to Immunological synapse.
REACT_345471. Phosphorylation of CD3 and TCR zeta chains.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 gamma chain
Alternative name(s):
T-cell receptor T3 gamma chain
CD_antigen: CD3g
Gene namesi
Name:Cd3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88333. Cd3g.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 11694ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 18245CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • alpha-beta T cell receptor complex Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 182160T-cell surface glycoprotein CD3 gamma chainPRO_0000014617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 87By similarity
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Modified residuei145 – 1451PhosphoserineBy similarity
Modified residuei148 – 1481PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP11942.
PRIDEiP11942.

PTM databases

PhosphoSiteiP11942.

Expressioni

Gene expression databases

BgeeiP11942.
CleanExiMM_CD3G.
ExpressionAtlasiP11942. baseline and differential.
GenevisibleiP11942. MM.

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002101.

Structurei

Secondary structure

1
182
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 183
Beta strandi37 – 393
Beta strandi41 – 455
Beta strandi47 – 493
Beta strandi53 – 575
Beta strandi73 – 764
Beta strandi82 – 9110
Beta strandi93 – 1008

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JBJNMR-A22-103[»]
ProteinModelPortaliP11942.
SMRiP11942. Positions 22-103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11942.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 9458Ig-likeAdd
BLAST
Domaini149 – 17729ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43749.
GeneTreeiENSGT00510000046930.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP11942.
KOiK06452.
OMAiDRENDQY.
OrthoDBiEOG7S4X7Q.
PhylomeDBiP11942.
TreeFamiTF335892.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQRKGLAGL FLVISLLQGT VAQTNKAKNL VQVDGSRGDG SVLLTCGLTD
60 70 80 90 100
KTIKWLKDGS IISPLNATKN TWNLGNNAKD PRGTYQCQGA KETSNPLQVY
110 120 130 140 150
YRMCENCIEL NIGTISGFIF AEVISIFFLA LGVYLIAGQD GVRQSRASDK
160 170 180
QTLLQNEQLY QPLKDREYDQ YSHLQGNQLR KK
Length:182
Mass (Da):20,234
Last modified:October 1, 1989 - v1
Checksum:i7F9D8D44A5C360D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00635 mRNA. Translation: CAA68667.1.
M58149 mRNA. Translation: AAA63289.1. Sequence problems.
M18227
, M18222, M18223, M18224, M18225, M18226 Genomic DNA. Translation: AAA37400.1.
BC027528 mRNA. Translation: AAH27528.1.
CCDSiCCDS23123.1.
PIRiA39952. A28508.
RefSeqiNP_033980.1. NM_009850.2.
UniGeneiMm.335106.

Genome annotation databases

EnsembliENSMUST00000002101; ENSMUSP00000002101; ENSMUSG00000002033.
GeneIDi12502.
KEGGimmu:12502.
UCSCiuc009pex.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00635 mRNA. Translation: CAA68667.1.
M58149 mRNA. Translation: AAA63289.1. Sequence problems.
M18227
, M18222, M18223, M18224, M18225, M18226 Genomic DNA. Translation: AAA37400.1.
BC027528 mRNA. Translation: AAH27528.1.
CCDSiCCDS23123.1.
PIRiA39952. A28508.
RefSeqiNP_033980.1. NM_009850.2.
UniGeneiMm.335106.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JBJNMR-A22-103[»]
ProteinModelPortaliP11942.
SMRiP11942. Positions 22-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002101.

PTM databases

PhosphoSiteiP11942.

Proteomic databases

MaxQBiP11942.
PRIDEiP11942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002101; ENSMUSP00000002101; ENSMUSG00000002033.
GeneIDi12502.
KEGGimmu:12502.
UCSCiuc009pex.2. mouse.

Organism-specific databases

CTDi917.
MGIiMGI:88333. Cd3g.

Phylogenomic databases

eggNOGiNOG43749.
GeneTreeiENSGT00510000046930.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP11942.
KOiK06452.
OMAiDRENDQY.
OrthoDBiEOG7S4X7Q.
PhylomeDBiP11942.
TreeFamiTF335892.

Enzyme and pathway databases

ReactomeiREACT_280649. Downstream TCR signaling.
REACT_292208. Role of phospholipids in phagocytosis.
REACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_309115. PD-1 signaling.
REACT_333749. FCGR activation.
REACT_334692. Generation of second messenger molecules.
REACT_344463. Regulation of actin dynamics for phagocytic cup formation.
REACT_345130. Translocation of ZAP-70 to Immunological synapse.
REACT_345471. Phosphorylation of CD3 and TCR zeta chains.

Miscellaneous databases

EvolutionaryTraceiP11942.
NextBioi281454.
PROiP11942.
SOURCEiSearch...

Gene expression databases

BgeeiP11942.
CleanExiMM_CD3G.
ExpressionAtlasiP11942. baseline and differential.
GenevisibleiP11942. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of murine T3 gamma cDNA from a subtractive cDNA library."
    Haser W.G., Saito H., Koyama T., Tonegawa S.
    J. Exp. Med. 166:1186-1191(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of the cDNA encoding the T3 gamma subunit of the mouse T3/T cell antigen receptor complex."
    Krissansen G.W., Owen M.J., Fink P.J., Crumpton M.J.
    J. Immunol. 138:3513-3518(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements."
    Saito H., Koyama T., Georgopoulos K., Clevers H., Haser W.G., Lebien T., Tonegawa S., Terhorst C.
    Proc. Natl. Acad. Sci. U.S.A. 84:9131-9134(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCD3G_MOUSE
AccessioniPrimary (citable) accession number: P11942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 22, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.