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P11942

- CD3G_MOUSE

UniProt

P11942 - CD3G_MOUSE

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Protein
T-cell surface glycoprotein CD3 gamma chain
Gene
Cd3g
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The CD3 complex mediates signal transduction.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. protein heterodimerization activity Source: UniProtKB
  3. transmembrane signaling receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell surface receptor signaling pathway Source: UniProtKB
  2. establishment or maintenance of cell polarity Source: UniProtKB
  3. protein transport Source: UniProtKB
  4. regulation of lymphocyte apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_196487. FCGR activation.
REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_210240. Role of phospholipids in phagocytosis.
REACT_215414. Translocation of ZAP-70 to Immunological synapse.
REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
REACT_225145. Downstream TCR signaling.
REACT_225768. Generation of second messenger molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 gamma chain
Alternative name(s):
T-cell receptor T3 gamma chain
CD_antigen: CD3g
Gene namesi
Name:Cd3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88333. Cd3g.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 11694Extracellular Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Topological domaini138 – 18245Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. alpha-beta T cell receptor complex Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222
Add
BLAST
Chaini23 – 182160T-cell surface glycoprotein CD3 gamma chain
PRO_0000014617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 87 By similarity
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Modified residuei145 – 1451Phosphoserine By similarity
Modified residuei148 – 1481Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP11942.
PRIDEiP11942.

PTM databases

PhosphoSiteiP11942.

Expressioni

Gene expression databases

ArrayExpressiP11942.
BgeeiP11942.
CleanExiMM_CD3G.
GenevestigatoriP11942.

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 183
Beta strandi37 – 393
Beta strandi41 – 455
Beta strandi47 – 493
Beta strandi53 – 575
Beta strandi73 – 764
Beta strandi82 – 9110
Beta strandi93 – 1008

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JBJNMR-A22-103[»]
ProteinModelPortaliP11942.
SMRiP11942. Positions 22-103.

Miscellaneous databases

EvolutionaryTraceiP11942.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 9458Ig-like
Add
BLAST
Domaini149 – 17729ITAM
Add
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43749.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP11942.
KOiK06452.
OMAiDRENDQY.
OrthoDBiEOG7S4X7Q.
PhylomeDBiP11942.
TreeFamiTF335892.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11942-1 [UniParc]FASTAAdd to Basket

« Hide

MEQRKGLAGL FLVISLLQGT VAQTNKAKNL VQVDGSRGDG SVLLTCGLTD    50
KTIKWLKDGS IISPLNATKN TWNLGNNAKD PRGTYQCQGA KETSNPLQVY 100
YRMCENCIEL NIGTISGFIF AEVISIFFLA LGVYLIAGQD GVRQSRASDK 150
QTLLQNEQLY QPLKDREYDQ YSHLQGNQLR KK 182
Length:182
Mass (Da):20,234
Last modified:October 1, 1989 - v1
Checksum:i7F9D8D44A5C360D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00635 mRNA. Translation: CAA68667.1.
M58149 mRNA. Translation: AAA63289.1. Sequence problems.
M18227
, M18222, M18223, M18224, M18225, M18226 Genomic DNA. Translation: AAA37400.1.
BC027528 mRNA. Translation: AAH27528.1.
CCDSiCCDS23123.1.
PIRiA39952. A28508.
RefSeqiNP_033980.1. NM_009850.2.
UniGeneiMm.335106.

Genome annotation databases

EnsembliENSMUST00000002101; ENSMUSP00000002101; ENSMUSG00000002033.
GeneIDi12502.
KEGGimmu:12502.
UCSCiuc009pex.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00635 mRNA. Translation: CAA68667.1 .
M58149 mRNA. Translation: AAA63289.1 . Sequence problems.
M18227
, M18222 , M18223 , M18224 , M18225 , M18226 Genomic DNA. Translation: AAA37400.1 .
BC027528 mRNA. Translation: AAH27528.1 .
CCDSi CCDS23123.1.
PIRi A39952. A28508.
RefSeqi NP_033980.1. NM_009850.2.
UniGenei Mm.335106.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JBJ NMR - A 22-103 [» ]
ProteinModelPortali P11942.
SMRi P11942. Positions 22-103.
ModBasei Search...

PTM databases

PhosphoSitei P11942.

Proteomic databases

MaxQBi P11942.
PRIDEi P11942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002101 ; ENSMUSP00000002101 ; ENSMUSG00000002033 .
GeneIDi 12502.
KEGGi mmu:12502.
UCSCi uc009pex.2. mouse.

Organism-specific databases

CTDi 917.
MGIi MGI:88333. Cd3g.

Phylogenomic databases

eggNOGi NOG43749.
HOGENOMi HOG000015287.
HOVERGENi HBG005278.
InParanoidi P11942.
KOi K06452.
OMAi DRENDQY.
OrthoDBi EOG7S4X7Q.
PhylomeDBi P11942.
TreeFami TF335892.

Enzyme and pathway databases

Reactomei REACT_196487. FCGR activation.
REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_210240. Role of phospholipids in phagocytosis.
REACT_215414. Translocation of ZAP-70 to Immunological synapse.
REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
REACT_225145. Downstream TCR signaling.
REACT_225768. Generation of second messenger molecules.

Miscellaneous databases

EvolutionaryTracei P11942.
NextBioi 281454.
PROi P11942.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11942.
Bgeei P11942.
CleanExi MM_CD3G.
Genevestigatori P11942.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR015484. CD3_esu/gsu/dsu.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view ]
PANTHERi PTHR10570. PTHR10570. 1 hit.
Pfami PF02189. ITAM. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view ]
PROSITEi PS51055. ITAM_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of murine T3 gamma cDNA from a subtractive cDNA library."
    Haser W.G., Saito H., Koyama T., Tonegawa S.
    J. Exp. Med. 166:1186-1191(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of the cDNA encoding the T3 gamma subunit of the mouse T3/T cell antigen receptor complex."
    Krissansen G.W., Owen M.J., Fink P.J., Crumpton M.J.
    J. Immunol. 138:3513-3518(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements."
    Saito H., Koyama T., Georgopoulos K., Clevers H., Haser W.G., Lebien T., Tonegawa S., Terhorst C.
    Proc. Natl. Acad. Sci. U.S.A. 84:9131-9134(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCD3G_MOUSE
AccessioniPrimary (citable) accession number: P11942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 3, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi