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P11942 (CD3G_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell surface glycoprotein CD3 gamma chain
Alternative name(s):
T-cell receptor T3 gamma chain
CD_antigen=CD3g
Gene names
Name:Cd3g
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The CD3 complex mediates signal transduction.

Subunit structure

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Contains 1 ITAM domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222
Chain23 – 182160T-cell surface glycoprotein CD3 gamma chain
PRO_0000014617

Regions

Topological domain23 – 11694Extracellular Potential
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 18245Cytoplasmic Potential
Domain37 – 9458Ig-like
Domain149 – 17729ITAM

Amino acid modifications

Modified residue1451Phosphoserine By similarity
Modified residue1481Phosphoserine By similarity
Glycosylation661N-linked (GlcNAc...) Potential
Disulfide bond46 ↔ 87 By similarity

Secondary structure

................. 182
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P11942 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 7F9D8D44A5C360D5

FASTA18220,234
        10         20         30         40         50         60 
MEQRKGLAGL FLVISLLQGT VAQTNKAKNL VQVDGSRGDG SVLLTCGLTD KTIKWLKDGS 

        70         80         90        100        110        120 
IISPLNATKN TWNLGNNAKD PRGTYQCQGA KETSNPLQVY YRMCENCIEL NIGTISGFIF 

       130        140        150        160        170        180 
AEVISIFFLA LGVYLIAGQD GVRQSRASDK QTLLQNEQLY QPLKDREYDQ YSHLQGNQLR 


KK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of murine T3 gamma cDNA from a subtractive cDNA library."
Haser W.G., Saito H., Koyama T., Tonegawa S.
J. Exp. Med. 166:1186-1191(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning of the cDNA encoding the T3 gamma subunit of the mouse T3/T cell antigen receptor complex."
Krissansen G.W., Owen M.J., Fink P.J., Crumpton M.J.
J. Immunol. 138:3513-3518(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements."
Saito H., Koyama T., Georgopoulos K., Clevers H., Haser W.G., Lebien T., Tonegawa S., Terhorst C.
Proc. Natl. Acad. Sci. U.S.A. 84:9131-9134(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00635 mRNA. Translation: CAA68667.1.
M58149 mRNA. Translation: AAA63289.1. Sequence problems.
M18227 expand/collapse EMBL AC list , M18222, M18223, M18224, M18225, M18226 Genomic DNA. Translation: AAA37400.1.
BC027528 mRNA. Translation: AAH27528.1.
CCDSCCDS23123.1.
PIRA28508. A39952.
RefSeqNP_033980.1. NM_009850.2.
UniGeneMm.335106.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JBJNMR-A22-103[»]
ProteinModelPortalP11942.
SMRP11942. Positions 22-103.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP11942.

Proteomic databases

MaxQBP11942.
PRIDEP11942.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002101; ENSMUSP00000002101; ENSMUSG00000002033.
GeneID12502.
KEGGmmu:12502.
UCSCuc009pex.2. mouse.

Organism-specific databases

CTD917.
MGIMGI:88333. Cd3g.

Phylogenomic databases

eggNOGNOG43749.
HOGENOMHOG000015287.
HOVERGENHBG005278.
InParanoidP11942.
KOK06452.
OMADRENDQY.
OrthoDBEOG7S4X7Q.
PhylomeDBP11942.
TreeFamTF335892.

Gene expression databases

ArrayExpressP11942.
BgeeP11942.
CleanExMM_CD3G.
GenevestigatorP11942.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR015484. CD3_esu/gsu/dsu.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERPTHR10570. PTHR10570. 1 hit.
PfamPF02189. ITAM. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP11942.
NextBio281454.
PROP11942.
SOURCESearch...

Entry information

Entry nameCD3G_MOUSE
AccessionPrimary (citable) accession number: P11942
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot