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Protein

Proto-oncogene c-Fos

Gene

FOS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene c-Fos
Alternative name(s):
Cellular oncogene fos
Gene namesi
Name:FOS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

  • Nucleus
  • Endoplasmic reticulum By similarity
  • Cytoplasmcytosol By similarity

  • Note: In quiescent cells, may be present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and later to the nucleus (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764711 – 367Proto-oncogene c-FosAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphotyrosine; by SRCBy similarity1
Modified residuei30Phosphotyrosine; by SRCBy similarity1

Post-translational modificationi

May be Tyr-phosphorylated in quiescent cells and dephosphorylated upon cell growth induction.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.

Gene expression databases

ExpressionAtlasiP11939. baseline.

Interactioni

Subunit structurei

Heterodimer. Interacts with MAFB.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP11939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 199bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 158Basic motif; required for the activation of phospholipid synthesisPROSITE-ProRule annotationAdd BLAST21
Regioni164 – 192Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

HOVERGENiHBG005743.
InParanoidiP11939.
KOiK04379.
PhylomeDBiP11939.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029816. c-Fos/v-Fos.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF31. PTHR23351:SF31. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P11939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYQGFAGEY EAPSSRCSSA SPAGDSLTYY PSPADSFSSM GSPVNSQDFC
60 70 80 90 100
TDLAVSSANF VPTVTAISTS PDLQWLVQPT LISSVAPSQN RGHPYGVPAP
110 120 130 140 150
APPAAYSRPA VLKAPGGRGQ SIGRRGKVEQ LSPEEEEKRR IRRERNKMAA
160 170 180 190 200
AKCRNRRREL TDTLQAETDQ LEEEKSALQA EIANLLKEKE KLEFILAAHR
210 220 230 240 250
PACKMPEELR FSEELAAATA LDLGAPSPAA AEEAFALPLM TEAPPAVPPK
260 270 280 290 300
EPSGSGLELK AEPFDELLFS AGPREASRSV PDMDLPGASS FYASDWEPLG
310 320 330 340 350
AGSGGELEPL CTPVVTCTPC PSTYTSTFVF TYPEADAFPS CAAAHRKGSS
360
SNEPSSDSLS SPTLLAL
Length:367
Mass (Da):39,005
Last modified:October 1, 1989 - v1
Checksum:iCB7F2BF658713599
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37000 mRNA. Translation: AAA48670.1.
M18043 Genomic DNA. Translation: AAA76823.1.
PIRiA28368. TVCHFS.
RefSeqiNP_990839.1. NM_205508.1.
UniGeneiGga.8709.

Genome annotation databases

EnsembliENSGALT00000043488; ENSGALP00000041340; ENSGALG00000028037.
GeneIDi396512.
KEGGigga:396512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37000 mRNA. Translation: AAA48670.1.
M18043 Genomic DNA. Translation: AAA76823.1.
PIRiA28368. TVCHFS.
RefSeqiNP_990839.1. NM_205508.1.
UniGeneiGga.8709.

3D structure databases

ProteinModelPortaliP11939.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000043488; ENSGALP00000041340; ENSGALG00000028037.
GeneIDi396512.
KEGGigga:396512.

Organism-specific databases

CTDi2353.

Phylogenomic databases

HOVERGENiHBG005743.
InParanoidiP11939.
KOiK04379.
PhylomeDBiP11939.

Miscellaneous databases

PROiP11939.

Gene expression databases

ExpressionAtlasiP11939. baseline.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029816. c-Fos/v-Fos.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF31. PTHR23351:SF31. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFOS_CHICK
AccessioniPrimary (citable) accession number: P11939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 15, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.