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Protein

Nucleoside diphosphate-linked moiety X motif 19

Gene

Nudt19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates.1 Publication

Cofactori

Mg2+1 Publication, Mn2+1 Publication

Kineticsi

  1. KM=0.6 mM for CoA1 Publication
  2. KM=0.58 mM for oxidized CoA1 Publication
  3. KM=0.08 mM for lauroyl-CoA1 Publication
  4. KM=0.01 mM for palmitoyl-CoA1 Publication
  5. KM=0.1 mM for choloyl-CoA1 Publication
  6. KM=0.1 mM for pristanoyl-CoA1 Publication
  1. Vmax=0.56 µmol/min/mg enzyme with CoA as substrate1 Publication
  2. Vmax=0.012 µmol/min/mg enzyme with oxidized CoA as substrate1 Publication
  3. Vmax=0.2 µmol/min/mg enzyme with lauroyl-CoA as substrate1 Publication
  4. Vmax=0.013 µmol/min/mg enzyme with palmitoyl-CoA as substrate1 Publication
  5. Vmax=0.17 µmol/min/mg enzyme with choloyl-CoA as substrate1 Publication
  6. Vmax=0.009 µmol/min/mg enzyme with pristanoyl-CoA as substrate1 Publication

pH dependencei

Optimum pH is 9.0.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112Magnesium or manganeseBy similarity1
Metal bindingi116Magnesium or manganeseBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-390918 Peroxisomal lipid metabolism
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 19 (EC:3.6.1.-)
Short name:
Nudix motif 19
Alternative name(s):
Androgen-regulated protein RP2
Testosterone-regulated RP2 protein
Short name:
RP2p
Gene namesi
Name:Nudt19
Synonyms:D7Rp2e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:94203 Nudt19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571191 – 357Nucleoside diphosphate-linked moiety X motif 19Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300N6-succinyllysineCombined sources1

Proteomic databases

MaxQBiP11930
PaxDbiP11930
PeptideAtlasiP11930
PRIDEiP11930

PTM databases

iPTMnetiP11930
PhosphoSitePlusiP11930

Expressioni

Inductioni

By testosterone.1 Publication

Gene expression databases

BgeeiENSMUSG00000034875
GenevisibleiP11930 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP11930, 3 interactors
MINTiP11930
STRINGi10090.ENSMUSP00000047778

Structurei

3D structure databases

ProteinModelPortaliP11930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 242Nudix hydrolasePROSITE-ProRule annotationAdd BLAST233

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 118Nudix boxAdd BLAST22
Motifi355 – 357Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG3904 Eukaryota
ENOG4111FKM LUCA
GeneTreeiENSGT00420000029858
HOGENOMiHOG000060163
HOVERGENiHBG017737
InParanoidiP11930
KOiK13355
OMAiCDYNALL
OrthoDBiEOG091G0B8I
TreeFamiTF313185

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
SUPFAMiSSF55811 SSF55811, 3 hits
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

P11930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSSSWRRA ATVMLAAGWT HSSPAGFRLL LLQRAQNQRF LPGAHVFPGG
60 70 80 90 100
VLDAADSSPD WVRLFAPRHT PPRFGLGPEP PRQPPFPGLS HGDADPAALP
110 120 130 140 150
DDVALRICAI REAFEEAGVL LLRPRDAAPA SQEPSQALSP PAGLAEWRSR
160 170 180 190 200
VRSDPRCFLQ LCAHLDCTPD IWALHDWGGW LTPYGRTIRR FDTTFFLCCL
210 220 230 240 250
RDIPRVEPDV AEVVGYQWLS PSEATECFLS KEIWLAPPQF YEMRRLENFA
260 270 280 290 300
SLSALYRFCS DRPSEVPEKW LPIILLTSDG TIHLLPGDEL YVKDSDFLEK
310 320 330 340 350
NMSTDKKTEE IVKEGKVLNR VVIHSPYVYE IYMTLPSENK HVYPRNYIVN

KRCTAHL
Length:357
Mass (Da):40,320
Last modified:July 27, 2011 - v2
Checksum:i6ED30EC4BF2955FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203I → T in CAA27722 (PubMed:3755524).Curated1
Sequence conflicti353C → Y in CAA27722 (PubMed:3755524).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04097 mRNA Translation: CAA27722.1
BC138674 mRNA Translation: AAI38675.1
BC138675 mRNA Translation: AAI38676.1
CCDSiCCDS21152.1
PIRiA23641
RefSeqiNP_149071.2, NM_033080.2
UniGeneiMm.410206
Mm.418631
Mm.474965

Genome annotation databases

EnsembliENSMUST00000040962; ENSMUSP00000047778; ENSMUSG00000034875
GeneIDi110959
KEGGimmu:110959
UCSCiuc009gka.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNUD19_MOUSE
AccessioniPrimary (citable) accession number: P11930
Secondary accession number(s): B2RS21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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