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Protein

Ornithine decarboxylase

Gene

ODC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.1 Publication

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Enzyme regulationi

Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.1 Publication

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase (ODC1)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei360Proton donor; shared with dimeric partner1

GO - Molecular functioni

  • ornithine decarboxylase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS03935-MONOMER.
ZFISH:HS03935-MONOMER.
BRENDAi4.1.1.17. 2681.
ReactomeiR-HSA-350562. Regulation of ornithine decarboxylase (ODC).
R-HSA-351202. Metabolism of polyamines.
SABIO-RKP11926.
UniPathwayiUPA00535; UER00288.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase (EC:4.1.1.17)
Short name:
ODC
Gene namesi
Name:ODC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8109. ODC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi360C → A: 25% decrease of in vitro nitrosylation level. 1 Publication1

Organism-specific databases

DisGeNETi4953.
MalaCardsiODC1.
OpenTargetsiENSG00000115758.
PharmGKBiPA31897.

Chemistry databases

ChEMBLiCHEMBL1869.
DrugBankiDB06243. Eflornithine.
DB00127. Spermine.
GuidetoPHARMACOLOGYi1276.

Polymorphism and mutation databases

BioMutaiODC1.
DMDMi118377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001498911 – 461Ornithine decarboxylaseAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-(pyridoxal phosphate)lysine1
Modified residuei303Phosphoserine; by CK2By similarity1
Modified residuei360S-nitrosocysteine; in inhibited form1 Publication1

Post-translational modificationi

S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.2 Publications

Keywords - PTMi

Phosphoprotein, S-nitrosylation

Proteomic databases

EPDiP11926.
PaxDbiP11926.
PeptideAtlasiP11926.
PRIDEiP11926.

PTM databases

iPTMnetiP11926.
PhosphoSitePlusiP11926.

Expressioni

Inductioni

Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000115758.
CleanExiHS_ODC1.
ExpressionAtlasiP11926. baseline and differential.
GenevisibleiP11926. HS.

Organism-specific databases

HPAiCAB035996.
HPA001536.

Interactioni

Subunit structurei

Monomer. Does not form a heterodimer with AZIN2 (By similarity). Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GORASP2Q9H8Y89EBI-1044287,EBI-739467
KAT5Q929933EBI-1044287,EBI-399080
OAZ3Q9UMX23EBI-1044287,EBI-10281601
OAZ3Q9UMX2-24EBI-1044287,EBI-12049527

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111007. 9 interactors.
IntActiP11926. 16 interactors.
MINTiMINT-1208473.
STRINGi9606.ENSP00000234111.

Chemistry databases

BindingDBiP11926.

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 5Combined sources5
Turni6 – 8Combined sources3
Beta strandi11 – 14Combined sources4
Helixi20 – 30Combined sources11
Turni31 – 33Combined sources3
Beta strandi40 – 44Combined sources5
Helixi45 – 58Combined sources14
Beta strandi62 – 67Combined sources6
Helixi68 – 70Combined sources3
Helixi74 – 83Combined sources10
Beta strandi86 – 89Combined sources4
Helixi92 – 100Combined sources9
Helixi105 – 107Combined sources3
Beta strandi108 – 110Combined sources3
Helixi117 – 125Combined sources9
Beta strandi130 – 133Combined sources4
Helixi136 – 145Combined sources10
Beta strandi150 – 155Combined sources6
Beta strandi162 – 164Combined sources3
Turni167 – 169Combined sources3
Helixi174 – 186Combined sources13
Beta strandi190 – 195Combined sources6
Helixi206 – 225Combined sources20
Beta strandi231 – 233Combined sources3
Beta strandi240 – 246Combined sources7
Helixi248 – 262Combined sources15
Helixi265 – 267Combined sources3
Beta strandi270 – 273Combined sources4
Helixi277 – 280Combined sources4
Helixi281 – 283Combined sources3
Beta strandi284 – 296Combined sources13
Beta strandi313 – 319Combined sources7
Turni322 – 324Combined sources3
Helixi325 – 327Combined sources3
Helixi328 – 331Combined sources4
Beta strandi339 – 342Combined sources4
Beta strandi350 – 356Combined sources7
Beta strandi358 – 360Combined sources3
Beta strandi365 – 373Combined sources9
Beta strandi380 – 383Combined sources4
Beta strandi388 – 390Combined sources3
Helixi391 – 393Combined sources3
Helixi397 – 399Combined sources3
Beta strandi404 – 410Combined sources7
Helixi411 – 420Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D7KX-ray2.10A/B7-427[»]
2ON3X-ray3.00A/B1-461[»]
2OO0X-ray1.90A/B1-461[»]
4ZGYX-ray2.63A2-421[»]
5BWAX-ray3.20A1-461[»]
ProteinModelPortaliP11926.
SMRiP11926.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11926.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiP11926.
KOiK01581.
OMAiPACCGRE.
OrthoDBiEOG091G0AJV.
PhylomeDBiP11926.
TreeFamiTF300760.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFGNEEFD CHFLDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK
60 70 80 90 100
KHLRWLKALP RVTPFYAVKC NDSKAIVKTL AATGTGFDCA SKTEIQLVQS
110 120 130 140 150
LGVPPERIIY ANPCKQVSQI KYAANNGVQM MTFDSEVELM KVARAHPKAK
160 170 180 190 200
LVLRIATDDS KAVCRLSVKF GATLRTSRLL LERAKELNID VVGVSFHVGS
210 220 230 240 250
GCTDPETFVQ AISDARCVFD MGAEVGFSMY LLDIGGGFPG SEDVKLKFEE
260 270 280 290 300
ITGVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKIVLKEQ
310 320 330 340 350
TGSDDEDESS EQTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY
360 370 380 390 400
YSSSIWGPTC DGLDRIVERC DLPEMHVGDW MLFENMGAYT VAAASTFNGF
410 420 430 440 450
QRPTIYYVMS GPAWQLMQQF QNPDFPPEVE EQDASTLPVS CAWESGMKRH
460
RAACASASIN V
Length:461
Mass (Da):51,148
Last modified:April 1, 1990 - v2
Checksum:i8CCB88CE80E823C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16650 mRNA. Translation: AAA59966.2.
M31061 Genomic DNA. Translation: AAA60563.1.
X16277 Genomic DNA. Translation: CAA34353.1.
M33764 Genomic DNA. Translation: AAA60564.1.
M34158 Genomic DNA. Translation: AAA59969.1.
M81740 Genomic DNA. Translation: AAA59967.1.
X55362 mRNA. Translation: CAA39047.1.
AK292352 mRNA. Translation: BAF85041.1.
AK312766 mRNA. Translation: BAG35632.1.
AY841870 Genomic DNA. Translation: AAV88093.1.
AC007249 Genomic DNA. Translation: AAY15034.1.
CH471053 Genomic DNA. Translation: EAX00958.1.
CH471053 Genomic DNA. Translation: EAX00959.1.
BC025296 mRNA. Translation: AAH25296.1.
X53271 mRNA. Translation: CAA37369.1.
M20372 mRNA. Translation: AAA59968.1.
CCDSiCCDS1672.1.
PIRiS06900. DCHUO.
RefSeqiNP_001274118.1. NM_001287189.1.
NP_001274119.1. NM_001287190.1.
NP_002530.1. NM_002539.2.
UniGeneiHs.467701.

Genome annotation databases

EnsembliENST00000234111; ENSP00000234111; ENSG00000115758.
ENST00000405333; ENSP00000385333; ENSG00000115758.
GeneIDi4953.
KEGGihsa:4953.
UCSCiuc002rao.3. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Ornithine decarboxylase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16650 mRNA. Translation: AAA59966.2.
M31061 Genomic DNA. Translation: AAA60563.1.
X16277 Genomic DNA. Translation: CAA34353.1.
M33764 Genomic DNA. Translation: AAA60564.1.
M34158 Genomic DNA. Translation: AAA59969.1.
M81740 Genomic DNA. Translation: AAA59967.1.
X55362 mRNA. Translation: CAA39047.1.
AK292352 mRNA. Translation: BAF85041.1.
AK312766 mRNA. Translation: BAG35632.1.
AY841870 Genomic DNA. Translation: AAV88093.1.
AC007249 Genomic DNA. Translation: AAY15034.1.
CH471053 Genomic DNA. Translation: EAX00958.1.
CH471053 Genomic DNA. Translation: EAX00959.1.
BC025296 mRNA. Translation: AAH25296.1.
X53271 mRNA. Translation: CAA37369.1.
M20372 mRNA. Translation: AAA59968.1.
CCDSiCCDS1672.1.
PIRiS06900. DCHUO.
RefSeqiNP_001274118.1. NM_001287189.1.
NP_001274119.1. NM_001287190.1.
NP_002530.1. NM_002539.2.
UniGeneiHs.467701.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D7KX-ray2.10A/B7-427[»]
2ON3X-ray3.00A/B1-461[»]
2OO0X-ray1.90A/B1-461[»]
4ZGYX-ray2.63A2-421[»]
5BWAX-ray3.20A1-461[»]
ProteinModelPortaliP11926.
SMRiP11926.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111007. 9 interactors.
IntActiP11926. 16 interactors.
MINTiMINT-1208473.
STRINGi9606.ENSP00000234111.

Chemistry databases

BindingDBiP11926.
ChEMBLiCHEMBL1869.
DrugBankiDB06243. Eflornithine.
DB00127. Spermine.
GuidetoPHARMACOLOGYi1276.

PTM databases

iPTMnetiP11926.
PhosphoSitePlusiP11926.

Polymorphism and mutation databases

BioMutaiODC1.
DMDMi118377.

Proteomic databases

EPDiP11926.
PaxDbiP11926.
PeptideAtlasiP11926.
PRIDEiP11926.

Protocols and materials databases

DNASUi4953.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234111; ENSP00000234111; ENSG00000115758.
ENST00000405333; ENSP00000385333; ENSG00000115758.
GeneIDi4953.
KEGGihsa:4953.
UCSCiuc002rao.3. human.

Organism-specific databases

CTDi4953.
DisGeNETi4953.
GeneCardsiODC1.
HGNCiHGNC:8109. ODC1.
HPAiCAB035996.
HPA001536.
MalaCardsiODC1.
MIMi165640. gene.
neXtProtiNX_P11926.
OpenTargetsiENSG00000115758.
PharmGKBiPA31897.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiP11926.
KOiK01581.
OMAiPACCGRE.
OrthoDBiEOG091G0AJV.
PhylomeDBiP11926.
TreeFamiTF300760.

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.
BioCyciMetaCyc:HS03935-MONOMER.
ZFISH:HS03935-MONOMER.
BRENDAi4.1.1.17. 2681.
ReactomeiR-HSA-350562. Regulation of ornithine decarboxylase (ODC).
R-HSA-351202. Metabolism of polyamines.
SABIO-RKP11926.

Miscellaneous databases

ChiTaRSiODC1. human.
EvolutionaryTraceiP11926.
GeneWikiiODC1.
GenomeRNAii4953.
PROiP11926.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115758.
CleanExiHS_ODC1.
ExpressionAtlasiP11926. baseline and differential.
GenevisibleiP11926. HS.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCOR_HUMAN
AccessioniPrimary (citable) accession number: P11926
Secondary accession number(s): Q53TU3, Q6LDS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 185 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.