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P11926

- DCOR_HUMAN

UniProt

P11926 - DCOR_HUMAN

Protein

Ornithine decarboxylase

Gene

ODC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 160 (01 Oct 2014)
      Sequence version 2 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.1 Publication

    Catalytic activityi

    L-ornithine = putrescine + CO2.

    Cofactori

    Pyridoxal phosphate.

    Enzyme regulationi

    Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei360 – 3601Proton donor; shared with dimeric partner

    GO - Molecular functioni

    1. ornithine decarboxylase activity Source: UniProtKB
    2. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. cellular nitrogen compound metabolic process Source: Reactome
    2. kidney development Source: Ensembl
    3. polyamine metabolic process Source: Reactome
    4. positive regulation of cell proliferation Source: Ensembl
    5. putrescine biosynthetic process from ornithine Source: UniProtKB
    6. regulation of cellular amino acid metabolic process Source: Reactome
    7. regulation of protein catabolic process Source: UniProtKB
    8. response to virus Source: UniProtKB
    9. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:HS03935-MONOMER.
    ReactomeiREACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_14820. Metabolism of polyamines.
    SABIO-RKP11926.
    UniPathwayiUPA00535; UER00288.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine decarboxylase (EC:4.1.1.17)
    Short name:
    ODC
    Gene namesi
    Name:ODC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:8109. ODC1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi360 – 3601C → A: 25% decrease of in vitro nitrosylation level. 1 Publication

    Organism-specific databases

    PharmGKBiPA31897.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Ornithine decarboxylasePRO_0000149891Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei69 – 691N6-(pyridoxal phosphate)lysine
    Modified residuei303 – 3031Phosphoserine; by CK2By similarity
    Modified residuei360 – 3601S-nitrosocysteine; in inhibited form2 Publications

    Post-translational modificationi

    S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.2 Publications

    Keywords - PTMi

    Phosphoprotein, S-nitrosylation

    Proteomic databases

    MaxQBiP11926.
    PaxDbiP11926.
    PRIDEiP11926.

    PTM databases

    PhosphoSiteiP11926.

    Expressioni

    Inductioni

    Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP11926.
    BgeeiP11926.
    CleanExiHS_ODC1.
    GenevestigatoriP11926.

    Organism-specific databases

    HPAiCAB035996.
    HPA001536.

    Interactioni

    Subunit structurei

    Monomer. Does not form an heterodimer with AZIN2 By similarity. Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi111007. 9 interactions.
    IntActiP11926. 3 interactions.
    MINTiMINT-1208473.
    STRINGi9606.ENSP00000234111.

    Structurei

    Secondary structure

    461
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1 – 55
    Turni6 – 83
    Beta strandi11 – 144
    Helixi20 – 3011
    Turni31 – 333
    Beta strandi40 – 445
    Helixi45 – 5814
    Beta strandi62 – 676
    Helixi68 – 703
    Helixi74 – 8310
    Beta strandi86 – 894
    Helixi92 – 1009
    Helixi105 – 1073
    Beta strandi108 – 1103
    Helixi117 – 1259
    Beta strandi130 – 1334
    Helixi136 – 14510
    Beta strandi150 – 1556
    Beta strandi162 – 1643
    Turni167 – 1693
    Helixi174 – 18613
    Beta strandi190 – 1956
    Helixi206 – 22520
    Beta strandi231 – 2333
    Beta strandi240 – 2467
    Helixi248 – 26215
    Helixi265 – 2673
    Beta strandi270 – 2734
    Helixi277 – 2804
    Helixi281 – 2833
    Beta strandi284 – 29613
    Beta strandi313 – 3197
    Turni322 – 3243
    Helixi325 – 3273
    Helixi328 – 3314
    Beta strandi339 – 3424
    Beta strandi350 – 3567
    Beta strandi358 – 3603
    Beta strandi365 – 3739
    Beta strandi380 – 3834
    Beta strandi388 – 3903
    Helixi391 – 3933
    Helixi397 – 3993
    Beta strandi404 – 4107
    Helixi411 – 42010

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D7KX-ray2.10A/B7-427[»]
    2ON3X-ray3.00A/B1-461[»]
    2OO0X-ray1.90A/B1-461[»]
    ProteinModelPortaliP11926.
    SMRiP11926. Positions 7-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11926.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0019.
    HOGENOMiHOG000274133.
    HOVERGENiHBG005456.
    InParanoidiP11926.
    KOiK01581.
    OMAiTIHYVMS.
    OrthoDBiEOG73Z2T6.
    PhylomeDBiP11926.
    TreeFamiTF300760.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR002433. Orn_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PRINTSiPR01179. ODADCRBXLASE.
    PR01182. ORNDCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11926-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNFGNEEFD CHFLDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK    50
    KHLRWLKALP RVTPFYAVKC NDSKAIVKTL AATGTGFDCA SKTEIQLVQS 100
    LGVPPERIIY ANPCKQVSQI KYAANNGVQM MTFDSEVELM KVARAHPKAK 150
    LVLRIATDDS KAVCRLSVKF GATLRTSRLL LERAKELNID VVGVSFHVGS 200
    GCTDPETFVQ AISDARCVFD MGAEVGFSMY LLDIGGGFPG SEDVKLKFEE 250
    ITGVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKIVLKEQ 300
    TGSDDEDESS EQTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY 350
    YSSSIWGPTC DGLDRIVERC DLPEMHVGDW MLFENMGAYT VAAASTFNGF 400
    QRPTIYYVMS GPAWQLMQQF QNPDFPPEVE EQDASTLPVS CAWESGMKRH 450
    RAACASASIN V 461
    Length:461
    Mass (Da):51,148
    Last modified:April 1, 1990 - v2
    Checksum:i8CCB88CE80E823C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16650 mRNA. Translation: AAA59966.2.
    M31061 Genomic DNA. Translation: AAA60563.1.
    X16277 Genomic DNA. Translation: CAA34353.1.
    M33764 Genomic DNA. Translation: AAA60564.1.
    M34158 Genomic DNA. Translation: AAA59969.1.
    M81740 Genomic DNA. Translation: AAA59967.1.
    X55362 mRNA. Translation: CAA39047.1.
    AK292352 mRNA. Translation: BAF85041.1.
    AK312766 mRNA. Translation: BAG35632.1.
    AY841870 Genomic DNA. Translation: AAV88093.1.
    AC007249 Genomic DNA. Translation: AAY15034.1.
    CH471053 Genomic DNA. Translation: EAX00958.1.
    CH471053 Genomic DNA. Translation: EAX00959.1.
    BC025296 mRNA. Translation: AAH25296.1.
    X53271 mRNA. Translation: CAA37369.1.
    M20372 mRNA. Translation: AAA59968.1.
    CCDSiCCDS1672.1.
    PIRiS06900. DCHUO.
    RefSeqiNP_001274118.1. NM_001287189.1.
    NP_001274119.1. NM_001287190.1.
    NP_002530.1. NM_002539.2.
    UniGeneiHs.467701.

    Genome annotation databases

    EnsembliENST00000234111; ENSP00000234111; ENSG00000115758.
    ENST00000405333; ENSP00000385333; ENSG00000115758.
    GeneIDi4953.
    KEGGihsa:4953.
    UCSCiuc002rao.1. human.

    Polymorphism databases

    DMDMi118377.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    Wikipedia

    Ornithine decarboxylase entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16650 mRNA. Translation: AAA59966.2 .
    M31061 Genomic DNA. Translation: AAA60563.1 .
    X16277 Genomic DNA. Translation: CAA34353.1 .
    M33764 Genomic DNA. Translation: AAA60564.1 .
    M34158 Genomic DNA. Translation: AAA59969.1 .
    M81740 Genomic DNA. Translation: AAA59967.1 .
    X55362 mRNA. Translation: CAA39047.1 .
    AK292352 mRNA. Translation: BAF85041.1 .
    AK312766 mRNA. Translation: BAG35632.1 .
    AY841870 Genomic DNA. Translation: AAV88093.1 .
    AC007249 Genomic DNA. Translation: AAY15034.1 .
    CH471053 Genomic DNA. Translation: EAX00958.1 .
    CH471053 Genomic DNA. Translation: EAX00959.1 .
    BC025296 mRNA. Translation: AAH25296.1 .
    X53271 mRNA. Translation: CAA37369.1 .
    M20372 mRNA. Translation: AAA59968.1 .
    CCDSi CCDS1672.1.
    PIRi S06900. DCHUO.
    RefSeqi NP_001274118.1. NM_001287189.1.
    NP_001274119.1. NM_001287190.1.
    NP_002530.1. NM_002539.2.
    UniGenei Hs.467701.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D7K X-ray 2.10 A/B 7-427 [» ]
    2ON3 X-ray 3.00 A/B 1-461 [» ]
    2OO0 X-ray 1.90 A/B 1-461 [» ]
    ProteinModelPortali P11926.
    SMRi P11926. Positions 7-427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111007. 9 interactions.
    IntActi P11926. 3 interactions.
    MINTi MINT-1208473.
    STRINGi 9606.ENSP00000234111.

    Chemistry

    BindingDBi P11926.
    ChEMBLi CHEMBL1869.
    DrugBanki DB00114. Pyridoxal Phosphate.
    DB00127. Spermine.
    GuidetoPHARMACOLOGYi 1276.

    PTM databases

    PhosphoSitei P11926.

    Polymorphism databases

    DMDMi 118377.

    Proteomic databases

    MaxQBi P11926.
    PaxDbi P11926.
    PRIDEi P11926.

    Protocols and materials databases

    DNASUi 4953.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000234111 ; ENSP00000234111 ; ENSG00000115758 .
    ENST00000405333 ; ENSP00000385333 ; ENSG00000115758 .
    GeneIDi 4953.
    KEGGi hsa:4953.
    UCSCi uc002rao.1. human.

    Organism-specific databases

    CTDi 4953.
    GeneCardsi GC02M010580.
    HGNCi HGNC:8109. ODC1.
    HPAi CAB035996.
    HPA001536.
    MIMi 165640. gene.
    neXtProti NX_P11926.
    PharmGKBi PA31897.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0019.
    HOGENOMi HOG000274133.
    HOVERGENi HBG005456.
    InParanoidi P11926.
    KOi K01581.
    OMAi TIHYVMS.
    OrthoDBi EOG73Z2T6.
    PhylomeDBi P11926.
    TreeFami TF300760.

    Enzyme and pathway databases

    UniPathwayi UPA00535 ; UER00288 .
    BioCyci MetaCyc:HS03935-MONOMER.
    Reactomei REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_14820. Metabolism of polyamines.
    SABIO-RK P11926.

    Miscellaneous databases

    ChiTaRSi ODC1. human.
    EvolutionaryTracei P11926.
    GeneWikii ODC1.
    GenomeRNAii 4953.
    NextBioi 19080.
    PROi P11926.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11926.
    Bgeei P11926.
    CleanExi HS_ODC1.
    Genevestigatori P11926.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR002433. Orn_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR01179. ODADCRBXLASE.
    PR01182. ORNDCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA."
      Hickok N.J., Seppaenen P.J., Gunsalus G.L., Jaenne O.A.
      DNA 6:179-187(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Jaenne O.A.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 415.
    3. "Characterization and sequence analysis of the human ornithine decarboxylase gene."
      Fitzgerald M.C., Flanagan M.A.
      DNA 8:623-634(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene."
      Hickok N.J., Wahlfors J., Crozat A., Halmekytoe M., Alhonen L., Jaenne J., Jaenne O.A.
      Gene 93:257-263(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Isolation and expression of a human ornithine decarboxylase gene."
      Moshier J.A., Gilbert J.D., Skunca M., Dosescu J., Almodovar K.M., Luk G.D.
      J. Biol. Chem. 265:4884-4892(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells."
      Moshier J.A., Osborne D.L., Skunca M., Dosescu J., Gilbert J.D., Fitzgerald M.C., Polidori G., Wagner R.L., Friezner Degen S.J., Luk G.D., Flanagan M.A.
      Nucleic Acids Res. 20:2581-2590(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element."
      Wright P.S., Cooper J.R., Cross-Doersen D.E., Miller J.A., Chmielewski P.A., Wagner R.L., Streng K.A., Flanagan M.A.
      Cell Growth Differ. 6:1097-1102(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Esophagus and Testis.
    10. NIEHS SNPs program
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    11. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    14. "Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells."
      Hsieh J.T., Denning M.F., Heidel S.M., Verma A.K.
      Cancer Res. 50:2239-2244(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-22.
    15. "Cell-cycle-dependent expression of human ornithine decarboxylase."
      Kaczmarek L., Calabretta B., Ferrari S., de Riel J.K.
      J. Cell. Physiol. 132:545-551(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-461.
    16. "Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation."
      Bauer P.M., Fukuto J.M., Buga G.M., Pegg A.E., Ignarro L.J.
      Biochem. Biophys. Res. Commun. 262:355-358(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: S-NITROSYLATION.
    17. "Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme."
      Bauer P.M., Buga G.M., Fukuto J.M., Pegg A.E., Ignarro L.J.
      J. Biol. Chem. 276:34458-34464(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: S-NITROSYLATION AT CYS-360, MUTAGENESIS OF CYS-360.
    18. "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
      Leong W.F., Chow V.T.
      Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
    19. "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."
      Kanerva K., Makitie L.T., Pelander A., Heiskala M., Andersson L.C.
      Biochem. J. 409:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION.
    20. "Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding."
      Almrud J.J., Oliveira M.A., Kern A.D., Grishin N.V., Phillips M.A., Hackert M.L.
      J. Mol. Biol. 295:7-16(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

    Entry informationi

    Entry nameiDCOR_HUMAN
    AccessioniPrimary (citable) accession number: P11926
    Secondary accession number(s): Q53TU3, Q6LDS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 160 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3