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Protein

Invasin

Gene

YPTB1668

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-1724-MONOMER.

Protein family/group databases

TCDBi1.B.54.1.2. the intimin/invasin (int/inv) or autotransporter-3 (at-3) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Invasin
Gene namesi
Ordered Locus Names:YPTB1668
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000001011 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini494 – 985ExtracellularAdd BLAST492

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002118311 – 985InvasinAdd BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi906 ↔ 981

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1985
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi151 – 158Combined sources8
Beta strandi164 – 177Combined sources14
Beta strandi179 – 192Combined sources14
Beta strandi195 – 208Combined sources14
Beta strandi211 – 222Combined sources12
Turni223 – 226Combined sources4
Beta strandi227 – 238Combined sources12
Beta strandi241 – 250Combined sources10
Beta strandi264 – 267Combined sources4
Beta strandi270 – 279Combined sources10
Beta strandi282 – 294Combined sources13
Beta strandi296 – 299Combined sources4
Beta strandi308 – 310Combined sources3
Beta strandi312 – 323Combined sources12
Beta strandi326 – 334Combined sources9
Helixi336 – 338Combined sources3
Beta strandi340 – 351Combined sources12
Helixi356 – 359Combined sources4
Helixi362 – 364Combined sources3
Helixi365 – 368Combined sources4
Helixi371 – 374Combined sources4
Beta strandi387 – 390Combined sources4
Beta strandi503 – 510Combined sources8
Beta strandi512 – 519Combined sources8
Beta strandi521 – 528Combined sources8
Beta strandi539 – 543Combined sources5
Beta strandi552 – 556Combined sources5
Beta strandi561 – 568Combined sources8
Beta strandi573 – 581Combined sources9
Beta strandi584 – 593Combined sources10
Helixi599 – 601Combined sources3
Beta strandi603 – 613Combined sources11
Beta strandi619 – 624Combined sources6
Beta strandi638 – 647Combined sources10
Beta strandi654 – 663Combined sources10
Beta strandi668 – 676Combined sources9
Beta strandi679 – 691Combined sources13
Turni698 – 700Combined sources3
Beta strandi702 – 706Combined sources5
Beta strandi708 – 711Combined sources4
Beta strandi718 – 723Combined sources6
Beta strandi737 – 745Combined sources9
Beta strandi759 – 764Combined sources6
Beta strandi769 – 777Combined sources9
Helixi783 – 785Combined sources3
Beta strandi787 – 792Combined sources6
Beta strandi797 – 802Combined sources6
Beta strandi805 – 807Combined sources3
Beta strandi815 – 818Combined sources4
Beta strandi822 – 827Combined sources6
Helixi831 – 836Combined sources6
Beta strandi837 – 843Combined sources7
Turni844 – 846Combined sources3
Beta strandi847 – 849Combined sources3
Beta strandi854 – 857Combined sources4
Beta strandi865 – 874Combined sources10
Beta strandi878 – 883Combined sources6
Beta strandi887 – 892Combined sources6
Helixi899 – 905Combined sources7
Beta strandi912 – 914Combined sources3
Helixi917 – 920Combined sources4
Beta strandi926 – 929Combined sources4
Helixi931 – 935Combined sources5
Helixi938 – 940Combined sources3
Beta strandi947 – 957Combined sources11
Beta strandi959 – 963Combined sources5
Turni964 – 966Combined sources3
Beta strandi977 – 983Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CWVX-ray2.30A494-983[»]
4E1TX-ray2.26A147-390[»]
ProteinModelPortaliP11922.
SMRiP11922.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11922.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini503 – 594Big-1 1PROSITE-ProRule annotationAdd BLAST92
Domaini601 – 691Big-1 2PROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni494 – 594D1Add BLAST101
Regioni595 – 694D2Add BLAST100
Regioni695 – 794D3Add BLAST100
Regioni795 – 985Integrin-bindingAdd BLAST191
Regioni795 – 886D4Add BLAST92
Regioni887 – 985D5Add BLAST99

Sequence similaritiesi

Belongs to the intimin/invasin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000219559.
OMAiFETMNMD.

Family and domain databases

Gene3Di2.60.40.920. 3 hits.
3.10.100.10. 1 hit.
InterProiIPR003344. Big_1_dom.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR024519. IAT_beta.
IPR003535. Intimin/invasin_bac.
IPR013117. Intimin_C.
IPR008964. Invasin/intimin_cell_adhesion.
IPR015217. Invasin_dom_3.
[Graphical view]
PfamiPF02369. Big_1. 1 hit.
PF11924. IAT_beta. 1 hit.
PF07979. Intimin_C. 1 hit.
PF09134. Invasin_D3. 2 hits.
[Graphical view]
PRINTSiPR01369. INTIMIN.
SMARTiSM00634. BID_1. 3 hits.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 4 hits.
SSF56436. SSF56436. 1 hit.
PROSITEiPS51127. BIG1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFQPISEFL LIRNAGMSMY FNKIISFNII SRIVICIFLI CGMFMAGASE
60 70 80 90 100
KYDANAPQQV QPYSVSSSAF ENLHPNNEME SSINPFSASD TERNAAIIDR
110 120 130 140 150
ANKEQETEAV NKMISTGARL AASGRASDVA HSMVGDAVNQ EIKQWLNRFG
160 170 180 190 200
TAQVNLNFDK NFSLKESSLD WLAPWYDSAS FLFFSQLGIR NKDSRNTLNL
210 220 230 240 250
GVGIRTLENG WLYGLNTFYD NDLTGHNHRI GLGAEAWTDY LQLAANGYFR
260 270 280 290 300
LNGWHSSRDF SDYKERPATG GDLRANAYLP ALPQLGGKLM YEQYTGERVA
310 320 330 340 350
LFGKDNLQRN PYAVTAGINY TPVPLLTVGV DQRMGKSSKH ETQWNLQMNY
360 370 380 390 400
RLGESFQSQL SPSAVAGTRL LAESRYNLVD RNNNIVLEYQ KQQVVKLTLS
410 420 430 440 450
PATISGLPGQ VYQVNAQVQG ASAVREIVWS DAELIAAGGT LTPLSTTQFN
460 470 480 490 500
LVLPPYKRTA QVSRVTDDLT ANFYSLSALA VDHQGNRSNS FTLSVTVQQP
510 520 530 540 550
QLTLTAAVIG DGAPANGKTA ITVEFTVADF EGKPLAGQEV VITTNNGALP
560 570 580 590 600
NKITEKTDAN GVARIALTNT TDGVTVVTAE VEGQRQSVDT HFVKGTIAAD
610 620 630 640 650
KSTLAAVPTS IIADGLMAST ITLELKDTYG DPQAGANVAF DTTLGNMGVI
660 670 680 690 700
TDHNDGTYSA PLTSTTLGVA TVTVKVDGAA FSVPSVTVNF TADPIPDAGR
710 720 730 740 750
SSFTVSTPDI LADGTMSSTL SFVPVDKNGH FISGMQGLSF TQNGVPVSIS
760 770 780 790 800
PITEQPDSYT ATVVGNTAGD VTITPQVDTL ILSTLQKKIS LFPVPTLTGI
810 820 830 840 850
LVNGQNFATD KGFPKTIFKN ATFQLQMDND VANNTQYEWS SSFTPNVSVN
860 870 880 890 900
DQGQVTITYQ TYSEVAVTAK SKKFPSYSVS YRFYPNRWIY DGGTSLVSSL
910 920 930 940 950
EASRQCQGSD MSAVLESSRA TNGTRAPDGT LWGEWGSLTA YSSDWQSGEY
960 970 980
WVKKTSTDFE TMNMDTGALV QGPAYLAFPL CALAI
Length:985
Mass (Da):106,544
Last modified:November 23, 2004 - v2
Checksum:i42007F9EEB984D50
GO

Sequence cautioni

The sequence AAA27632 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA27634 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA27635 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti767 – 768TA → SV in AAA27633 (PubMed:3304658).Curated2
Sequence conflicti767 – 768TA → SV in AAA27632 (PubMed:3304658).Curated2
Sequence conflicti894T → R in AAA27633 (PubMed:3304658).Curated1
Sequence conflicti894T → R in AAA27632 (PubMed:3304658).Curated1
Sequence conflicti970 – 971VQ → QP in AAA27633 (PubMed:3304658).Curated2
Sequence conflicti970 – 971VQ → QP in AAA27632 (PubMed:3304658).Curated2
Sequence conflicti984A → S in AAA27633 (PubMed:3304658).Curated1
Sequence conflicti984A → S in AAA27632 (PubMed:3304658).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17448 Genomic DNA. Translation: AAA27633.1.
M17448 Genomic DNA. Translation: AAA27632.1. Different initiation.
M17448 Genomic DNA. Translation: AAA27634.1. Different initiation.
M17448 Genomic DNA. Translation: AAA27635.1. Different initiation.
BX936398 Genomic DNA. Translation: CAH20907.1.
PIRiA29646.

Genome annotation databases

EnsemblBacteriaiCAH20907; CAH20907; YPTB1668.
KEGGiyps:YPTB1668.
PATRICi18642013. VBIYerPse22266_2071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17448 Genomic DNA. Translation: AAA27633.1.
M17448 Genomic DNA. Translation: AAA27632.1. Different initiation.
M17448 Genomic DNA. Translation: AAA27634.1. Different initiation.
M17448 Genomic DNA. Translation: AAA27635.1. Different initiation.
BX936398 Genomic DNA. Translation: CAH20907.1.
PIRiA29646.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CWVX-ray2.30A494-983[»]
4E1TX-ray2.26A147-390[»]
ProteinModelPortaliP11922.
SMRiP11922.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.B.54.1.2. the intimin/invasin (int/inv) or autotransporter-3 (at-3) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH20907; CAH20907; YPTB1668.
KEGGiyps:YPTB1668.
PATRICi18642013. VBIYerPse22266_2071.

Phylogenomic databases

HOGENOMiHOG000219559.
OMAiFETMNMD.

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-1724-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP11922.

Family and domain databases

Gene3Di2.60.40.920. 3 hits.
3.10.100.10. 1 hit.
InterProiIPR003344. Big_1_dom.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR024519. IAT_beta.
IPR003535. Intimin/invasin_bac.
IPR013117. Intimin_C.
IPR008964. Invasin/intimin_cell_adhesion.
IPR015217. Invasin_dom_3.
[Graphical view]
PfamiPF02369. Big_1. 1 hit.
PF11924. IAT_beta. 1 hit.
PF07979. Intimin_C. 1 hit.
PF09134. Invasin_D3. 2 hits.
[Graphical view]
PRINTSiPR01369. INTIMIN.
SMARTiSM00634. BID_1. 3 hits.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 4 hits.
SSF56436. SSF56436. 1 hit.
PROSITEiPS51127. BIG1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINVA_YERPS
AccessioniPrimary (citable) accession number: P11922
Secondary accession number(s): Q66BU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-17 or Met-19 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.