Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Non-specific lipid-transfer protein

Gene

Scp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.

Catalytic activityi

3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA.

GO - Molecular functioni

  • acetyl-CoA C-acyltransferase activity Source: RGD
  • cholesterol transporter activity Source: RGD
  • phosphatidylcholine transporter activity Source: RGD
  • phosphatidylethanolamine transporter activity Source: RGD
  • propanoyl-CoA C-acyltransferase activity Source: UniProtKB-EC
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • sterol binding Source: GO_Central

GO - Biological processi

  • aging Source: RGD
  • cellular response to cholesterol Source: RGD
  • metabolic process Source: InterPro
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of cholesterol biosynthetic process Source: RGD
  • positive regulation of cholesterol import Source: RGD
  • positive regulation of steroid biosynthetic process Source: UniProtKB
  • response to estradiol Source: RGD
  • response to luteinizing hormone Source: RGD

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14332
SABIO-RKiP11915

Chemistry databases

SwissLipidsiSLP:000001233 [P11915-1]

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific lipid-transfer protein (EC:2.3.1.176)
Short name:
NSL-TP
Alternative name(s):
Propanoyl-CoA C-acyltransferase
SCP-chi
SCPX
Sterol carrier protein 2
Short name:
SCP-2
Sterol carrier protein X
Short name:
SCP-X
Gene namesi
Name:Scp2
Synonyms:Scp-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3642 Scp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000340971 – 547Non-specific lipid-transfer proteinAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei40N6-succinyllysineBy similarity1
Modified residuei132N6-acetyllysine; alternateBy similarity1
Modified residuei132N6-succinyllysine; alternateBy similarity1
Modified residuei168N6-succinyllysineBy similarity1
Modified residuei177N6-acetyllysineBy similarity1
Modified residuei183N6-acetyllysine; alternateBy similarity1
Modified residuei183N6-succinyllysine; alternateBy similarity1
Modified residuei211N6-succinyllysineBy similarity1
Modified residuei282N6-succinyllysineBy similarity1
Modified residuei341N6-acetyllysine; alternateBy similarity1
Modified residuei341N6-succinyllysine; alternateBy similarity1
Modified residuei432N6-acetyllysine; alternateBy similarity1
Modified residuei432N6-succinyllysine; alternateBy similarity1
Modified residuei438N6-acetyllysine; alternateBy similarity1
Modified residuei438N6-succinyllysine; alternateBy similarity1
Modified residuei443N6-acetyllysine; alternateBy similarity1
Modified residuei443N6-succinyllysine; alternateBy similarity1
Modified residuei453N6-acetyllysine; alternateBy similarity1
Modified residuei453N6-succinyllysine; alternateBy similarity1
Modified residuei464N6-succinyllysineBy similarity1
Modified residuei470N6-acetyllysine; alternateBy similarity1
Modified residuei470N6-succinyllysine; alternateBy similarity1
Modified residuei479N6-succinyllysineBy similarity1
Modified residuei491N6-acetyllysineBy similarity1
Modified residuei492N6-succinyllysineBy similarity1
Modified residuei511N6-succinyllysineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei522N6-succinyllysineBy similarity1
Modified residuei534N6-succinyllysineBy similarity1
Modified residuei537PhosphoserineCombined sources1
Modified residuei544N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11915
PRIDEiP11915

PTM databases

iPTMnetiP11915
PhosphoSitePlusiP11915

Expressioni

Tissue specificityi

Liver > intestine > brain > lung, colon, stomach, spleen, kidney, heart and ovary.

Interactioni

Subunit structurei

Interacts with PEX5.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

IntActiP11915, 1 interactor
STRINGi10116.ENSRNOP00000015420

Structurei

3D structure databases

ProteinModelPortaliP11915
SMRiP11915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 543SCP2Add BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi545 – 547Microbody targeting signalSequence analysis3

Sequence similaritiesi

In the N-terminal section; belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiKOG1406 Eukaryota
KOG4170 Eukaryota
ENOG410XPRW LUCA
HOGENOMiHOG000221741
HOVERGENiHBG006506
InParanoidiP11915
KOiK08764

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02036 SCP2, 1 hit
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
SSF55718 SSF55718, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform SCPx (identifier: P11915-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSVALNSPR LPRVFVVGVG MTKFMKPGGE NSRDYPDLAK EAGQKALADR
60 70 80 90 100
QIPYSAVEQA CVGYVYGEST CGQRAIYHSL GLTGIPIINV NNNCSTGSTA
110 120 130 140 150
LFMAQQLVQG GLANCVLALG FEKMEKGSLG TKYSDRSNPL EKHIDVLINK
160 170 180 190 200
YGMSACPFAP QLFGSAGKEH METYGTKVEH FAKIGWKNHK HSVNNPYSQF
210 220 230 240 250
QDEYSLDEIM KSRPVFDFLT VLQCCPTSDG AAAAIVSSEE FVQKHGLQSK
260 270 280 290 300
AVEIVAQEMV TDMPSTFEEK SVIKMVGYDM SKEAARKCYE KSGLGPSDVD
310 320 330 340 350
VIELHDCFST NELLTYEALG LCPEGQGGAL VDRGDNTYGG KWVINPSGGL
360 370 380 390 400
ISKGHPLGAT GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGLGGAAVV
410 420 430 440 450
TLYRMGFPEA ASSFRTHQIS AAPTSSAGDG FKANLIFKEI EKKLEEEGEE
460 470 480 490 500
FVKKIGGIFA FKVKDGPGGK EATWVVDVKN GKGSVLPDSD KKADCTITMA
510 520 530 540
DSDLLALMTG KMNPQSAFFQ GKLKIAGNMG LAMKLQSLQL QPDKAKL
Length:547
Mass (Da):58,813
Last modified:August 1, 1991 - v3
Checksum:iD0D1B435D2DC6AFB
GO
Isoform SCP2 (identifier: P11915-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.

Note: Mitochondrial precursor. Contains a mitochondrial transit peptide at positions 405-424 (Potential).Curated
Show »
Length:143
Mass (Da):15,298
Checksum:iF80FB9B958462F52
GO

Sequence cautioni

The sequence AAA40623 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA43060 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → R in AAA40622 (PubMed:2034675).Curated1
Sequence conflicti12P → R in CAA43061 (PubMed:2034675).Curated1
Sequence conflicti12P → R in AAH81713 (PubMed:15489334).Curated1
Sequence conflicti50R → A in AAA40622 (PubMed:2034675).Curated1
Sequence conflicti50R → A in AAH81713 (PubMed:15489334).Curated1
Sequence conflicti265S → T in AAA42122 (PubMed:1985920).Curated1
Sequence conflicti427 – 428AG → SV AA sequence (PubMed:3395344).Curated2
Sequence conflicti436I → V AA sequence (PubMed:3395344).Curated1
Sequence conflicti446E → D AA sequence (PubMed:3395344).Curated1
Sequence conflicti450E → Q AA sequence (PubMed:3395344).Curated1
Sequence conflicti488D → N AA sequence (PubMed:3395344).Curated1
Sequence conflicti516S → T AA sequence (PubMed:3395344).Curated1
Sequence conflicti526A → N AA sequence (PubMed:3395344).Curated1
Sequence conflicti537S → N AA sequence (PubMed:3395344).Curated1
Sequence conflicti543D → G AA sequence (PubMed:3395344).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188971 – 404Missing in isoform SCP2. CuratedAdd BLAST404

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62763 mRNA Translation: AAA40622.1
M62763 mRNA Translation: AAA40623.1 Different initiation.
M57454 mRNA Translation: AAA42121.1
M57453 mRNA Translation: AAA42122.1
M58287 mRNA Translation: AAA41726.1
BC081713 mRNA Translation: AAH81713.1
M34728 mRNA Translation: AAA42120.1
X60654 mRNA Translation: CAA43060.1 Different initiation.
X60654 mRNA Translation: CAA43061.1
PIRiA39368
RefSeqiNP_612517.2, NM_138508.4
UniGeneiRn.31887

Genome annotation databases

GeneIDi25541
KEGGirno:25541
UCSCiRGD:3642 rat [P11915-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiNLTP_RAT
AccessioniPrimary (citable) accession number: P11915
Secondary accession number(s): Q63383, Q642G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1991
Last modified: May 23, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health