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Protein

Mitochondrial-processing peptidase subunit beta

Gene

pep

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84ZincPROSITE-ProRule annotation1
Active sitei87Proton acceptorPROSITE-ProRule annotation1
Metal bindingi88ZincPROSITE-ProRule annotation1
Metal bindingi164ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processElectron transport, Respiratory chain, Transport
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM16.003

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
Alternative name(s):
Beta-MPP
Ubiquinol-cytochrome-c reductase complex core protein I
Gene namesi
Name:pep
ORF Names:NCU02549
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU02549

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28Mitochondrion1 PublicationAdd BLAST28
ChainiPRO_000002678229 – 476Mitochondrial-processing peptidase subunit betaAdd BLAST448

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.

Structurei

3D structure databases

ProteinModelPortaliP11913
SMRiP11913
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 178Asp/Glu-rich (acidic)Add BLAST29

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000242450
InParanoidiP11913
KOiK17732
OrthoDBiEOG092C25X9

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR037718 MPP_beat
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PANTHERiPTHR11851:SF103 PTHR11851:SF103, 1 hit
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRRLALNL AQGVKARAGG VINPFRRGLA TPHSGTGIKT QTTTLKNGLT
60 70 80 90 100
VASQYSPYAQ TSTVGMWIDA GSRAETDETN GTAHFLEHLA FKGTTKRTQQ
110 120 130 140 150
QLELEIENMG AHLNAYTSRE NTVYFAKALN EDVPKCVDIL QDILQNSKLE
160 170 180 190 200
ESAIERERDV ILRESEEVEK QLEEVVFDHL HATAYQHQPL GRTILGPREN
210 220 230 240 250
IRDITRTELV NYIKNNYTAD RMVLVGAGGV PHEQLVEMAD KYFSKLPATA
260 270 280 290 300
PVSSASILSK KKPDFIGSDI RIRDDTIPTA NIAIAVEGVS WSDDDYFTGL
310 320 330 340 350
VTQAIVGNYD KALGNAPHQG SKLSGFVHKH DLATSFMSFS TSYSDTGLWG
360 370 380 390 400
IYLVTDKLDR VDDLVHFSLR EWTRLCSNVS EAEVERAKAQ LKASILLSLD
410 420 430 440 450
GTTAVAEDIG RQIVTTGRRM SPAEIERIID AVSAKDVMDF ANKKIWDQDI
460 470
AISAVGSIEG LFDYARIRGD MSRNAF
Length:476
Mass (Da):52,556
Last modified:October 1, 1989 - v1
Checksum:iBF3905A20D3945E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20928 mRNA Translation: AAA33606.1
CM002236 Genomic DNA Translation: EAA36444.1
PIRiA29881
RefSeqiXP_965680.1, XM_960587.3

Genome annotation databases

EnsemblFungiiEAA36444; EAA36444; NCU02549
GeneIDi3881830
KEGGincr:NCU02549

Similar proteinsi

Entry informationi

Entry nameiMPPB_NEUCR
AccessioniPrimary (citable) accession number: P11913
Secondary accession number(s): Q7RVM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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