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Protein

Glutathione peroxidase 1

Gene

GPX1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protects the hemoglobin in erythrocytes from oxidative breakdown.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461
Sitei46 – 461Subject to oxidation and hydroselenide loss to dehydroalanineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3729. OcuGPx01.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 1 (EC:1.11.1.9)
Short name:
GPx-1
Short name:
GSHPx-1
Alternative name(s):
Cellular glutathione peroxidase
Gene namesi
Name:GPX1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Glutathione peroxidase 1PRO_0000066616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei85 – 851N6-acetyllysine; alternateBy similarity
Modified residuei85 – 851N6-succinyllysine; alternateBy similarity
Modified residuei111 – 1111N6-acetyllysine; alternateBy similarity
Modified residuei111 – 1111N6-succinyllysine; alternateBy similarity
Modified residuei118 – 1181N6-acetyllysineBy similarity
Modified residuei145 – 1451N6-acetyllysine; alternateBy similarity
Modified residuei145 – 1451N6-succinyllysine; alternateBy similarity
Modified residuei194 – 1941PhosphoserineBy similarity

Post-translational modificationi

During periods of oxidative stress, Sec-46 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Homotetramer. Interacts with MIEN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005141.

Structurei

3D structure databases

ProteinModelPortaliP11909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
HOVERGENiHBG004333.
InParanoidiP11909.
KOiK00432.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAARMAAAA QSVYSFSAHP LAGGEPVNLG SLRGKVLLIE NVASLUGTTV
60 70 80 90 100
RDYTQMNELQ ERLGPRALVV LGFPCNQFGH QENAKNEEIL NSLKYVRPGG
110 120 130 140 150
GFEPNFMLFQ KCEVNGAKAS PLFAFLREAL PPPSDDPTAL MTDPKFITWC
160 170 180 190 200
PVCRNDVSWS FEKFLVGPDG VPVRRYSRRF PTIDIEPDIQ ALLSKGSGGA
Length:200
Mass (Da):21,883
Last modified:February 26, 2008 - v2
Checksum:iD61951FEC2805814
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei46 – 461Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13837 mRNA. Translation: CAB43546.1.
PIRiS03723.
RefSeqiNP_001078913.1. NM_001085444.1.
UniGeneiOcu.6208.

Genome annotation databases

GeneIDi100009258.
KEGGiocu:100009258.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13837 mRNA. Translation: CAB43546.1.
PIRiS03723.
RefSeqiNP_001078913.1. NM_001085444.1.
UniGeneiOcu.6208.

3D structure databases

ProteinModelPortaliP11909.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005141.

Protein family/group databases

PeroxiBasei3729. OcuGPx01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009258.
KEGGiocu:100009258.

Organism-specific databases

CTDi2876.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
HOVERGENiHBG004333.
InParanoidiP11909.
KOiK00432.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of cDNA for rabbit glutathione peroxidase."
    Akasaka M., Mizoguchi J., Yoshimura S., Watanabe K.
    Nucleic Acids Res. 17:2136-2136(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiGPX1_RABIT
AccessioniPrimary (citable) accession number: P11909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 26, 2008
Last modified: February 17, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.