P11909 (GPX1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione peroxidase 1
Short name=GPx-1
Short name=GSHPx-1
EC=1.11.1.9

Alternative name(s):
Cellular glutathione peroxidase

Gene names

Name:

GPX1

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protects the hemoglobin in erythrocytes from oxidative breakdown.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subunit structure	Homotetramer. Interacts with MIEN1 By similarity.
Subcellular location	Cytoplasm.
Post-translational modification	During periods of oxidative stress, Sec-46 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine By similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Selenocysteine
Molecular function	Oxidoreductase Peroxidase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Glutathione peroxidase 1		PRO_0000066616
Sites
	Active site	46	1
	Site	46	1	Subject to oxidation and hydroselenide loss to dehydroalanine By similarity
Amino acid modifications
	Non-standard residue	46	1	Selenocysteine
	Modified residue	145	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P11909 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: D61951FEC2805814	FASTA	200	21,883
	10 20 30 40 50 60 MCAARMAAAA QSVYSFSAHP LAGGEPVNLG SLRGKVLLIE NVASLUGTTV RDYTQMNELQ 70 80 90 100 110 120 ERLGPRALVV LGFPCNQFGH QENAKNEEIL NSLKYVRPGG GFEPNFMLFQ KCEVNGAKAS 130 140 150 160 170 180 PLFAFLREAL PPPSDDPTAL MTDPKFITWC PVCRNDVSWS FEKFLVGPDG VPVRRYSRRF 190 200 PTIDIEPDIQ ALLSKGSGGA

References

[1]	"Nucleotide sequence of cDNA for rabbit glutathione peroxidase." Akasaka M., Mizoguchi J., Yoshimura S., Watanabe K. Nucleic Acids Res. 17:2136-2136(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13837 mRNA. Translation: CAB43546.1.
PIR	S03723.
RefSeq	NP_001078913.1. NM_001085444.1.
UniGene	Ocu.6208.
3D structure databases
ProteinModelPortal	P11909.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000005141.
Protein family/group databases
PeroxiBase	3729. OcuGPx01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100009258.
Organism-specific databases
CTD	2876.
Phylogenomic databases
eggNOG	COG0386.
HOVERGEN	HBG004333.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR11592. PTHR11592. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX1_RABIT

Accession

Primary (citable) accession number: P11909

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program