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Protein

Glutathione peroxidase 1

Gene

GPX1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protects the hemoglobin in erythrocytes from oxidative breakdown.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei461
Sitei46Subject to oxidation and hydroselenide loss to dehydroalanineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3729 OcuGPx01

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 1 (EC:1.11.1.9)
Short name:
GPx-1
Short name:
GSHPx-1
Alternative name(s):
Cellular glutathione peroxidase
Gene namesi
Name:GPX1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666161 – 200Glutathione peroxidase 1Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei85N6-acetyllysine; alternateBy similarity1
Modified residuei85N6-succinyllysine; alternateBy similarity1
Modified residuei111N6-acetyllysine; alternateBy similarity1
Modified residuei111N6-succinyllysine; alternateBy similarity1
Modified residuei118N6-acetyllysineBy similarity1
Modified residuei145N6-acetyllysine; alternateBy similarity1
Modified residuei145N6-succinyllysine; alternateBy similarity1
Modified residuei194PhosphoserineBy similarity1

Post-translational modificationi

During periods of oxidative stress, Sec-46 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP11909

Interactioni

Subunit structurei

Homotetramer. Interacts with MIEN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005141

Structurei

3D structure databases

ProteinModelPortaliP11909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
HOVERGENiHBG004333
InParanoidiP11909
KOiK00432

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

P11909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAARMAAAA QSVYSFSAHP LAGGEPVNLG SLRGKVLLIE NVASLUGTTV
60 70 80 90 100
RDYTQMNELQ ERLGPRALVV LGFPCNQFGH QENAKNEEIL NSLKYVRPGG
110 120 130 140 150
GFEPNFMLFQ KCEVNGAKAS PLFAFLREAL PPPSDDPTAL MTDPKFITWC
160 170 180 190 200
PVCRNDVSWS FEKFLVGPDG VPVRRYSRRF PTIDIEPDIQ ALLSKGSGGA
Length:200
Mass (Da):21,883
Last modified:February 26, 2008 - v2
Checksum:iD61951FEC2805814
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei46Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13837 mRNA Translation: CAB43546.1
PIRiS03723
RefSeqiNP_001078913.1, NM_001085444.1
UniGeneiOcu.6208

Genome annotation databases

GeneIDi100009258
KEGGiocu:100009258

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiGPX1_RABIT
AccessioniPrimary (citable) accession number: P11909
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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