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P11909 (GPX1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione peroxidase 1

Short name=GPx-1
Short name=GSHPx-1
EC=1.11.1.9
Alternative name(s):
Cellular glutathione peroxidase
Gene names
Name:GPX1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protects the hemoglobin in erythrocytes from oxidative breakdown.

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subunit structure

Homotetramer. Interacts with MIEN1 By similarity.

Subcellular location

Cytoplasm.

Post-translational modification

During periods of oxidative stress, Sec-46 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine By similarity.

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversitySelenocysteine
   Molecular functionOxidoreductase
Peroxidase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione peroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Glutathione peroxidase 1
PRO_0000066616

Sites

Active site461
Site461Subject to oxidation and hydroselenide loss to dehydroalanine By similarity

Amino acid modifications

Non-standard residue461Selenocysteine
Modified residue1451N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P11909 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: D61951FEC2805814

FASTA20021,883
        10         20         30         40         50         60 
MCAARMAAAA QSVYSFSAHP LAGGEPVNLG SLRGKVLLIE NVASLUGTTV RDYTQMNELQ 

        70         80         90        100        110        120 
ERLGPRALVV LGFPCNQFGH QENAKNEEIL NSLKYVRPGG GFEPNFMLFQ KCEVNGAKAS 

       130        140        150        160        170        180 
PLFAFLREAL PPPSDDPTAL MTDPKFITWC PVCRNDVSWS FEKFLVGPDG VPVRRYSRRF 

       190        200 
PTIDIEPDIQ ALLSKGSGGA 

« Hide

References

[1]"Nucleotide sequence of cDNA for rabbit glutathione peroxidase."
Akasaka M., Mizoguchi J., Yoshimura S., Watanabe K.
Nucleic Acids Res. 17:2136-2136(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13837 mRNA. Translation: CAB43546.1.
PIRS03723.
RefSeqNP_001078913.1. NM_001085444.1.
UniGeneOcu.6208.

3D structure databases

ProteinModelPortalP11909.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000005141.

Protein family/group databases

PeroxiBase3729. OcuGPx01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009258.

Organism-specific databases

CTD2876.

Phylogenomic databases

eggNOGCOG0386.
HOVERGENHBG004333.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11592. PTHR11592. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPX1_RABIT
AccessionPrimary (citable) accession number: P11909
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 26, 2008
Last modified: April 3, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families