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Protein

Aldehyde dehydrogenase, dimeric NADP-preferring

Gene

Aldh3a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:2831537). Preferentially oxidizes aromatic aldehyde substrates (PubMed:2831537). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).By similarityCurated1 Publication

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210By similarity1
Active sitei244By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NAD or NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cellular aldehyde metabolic process Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
  • positive regulation of cell proliferation Source: RGD
  • response to cAMP Source: RGD
  • response to drug Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hypoxia Source: RGD
  • response to nutrient Source: RGD
  • response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

ReactomeiR-RNO-211945. Phase 1 - Functionalization of compounds.
SABIO-RKP11883.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, dimeric NADP-preferring (EC:1.2.1.51 Publication)
Alternative name(s):
Aldehyde dehydrogenase family 3 member A1
HTC-ALDH
Tumor-associated aldehyde dehydrogenase
Gene namesi
Name:Aldh3a1
Synonyms:Aldd, Aldh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2088. Aldh3a1.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: RGD
  • cytosol Source: UniProtKB
  • endoplasmic reticulum Source: Ensembl
  • extracellular space Source: Ensembl
  • integral component of membrane Source: Ensembl
  • nucleoplasm Source: Ensembl
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000564722 – 453Aldehyde dehydrogenase, dimeric NADP-preferringAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei178N6-acetyllysineBy similarity1
Modified residuei194N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP11883.
PRIDEiP11883.

Expressioni

Inductioni

This protein can be induced by a number of chemical carcinogens during rat hepatocarcinogenesis.

Gene expression databases

BgeeiENSRNOG00000002331.
GenevisibleiP11883. RN.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP11883. 1 interactor.
STRINGi10116.ENSRNOP00000003182.

Structurei

Secondary structure

1453
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Helixi19 – 21Combined sources3
Helixi23 – 52Combined sources30
Helixi56 – 62Combined sources7
Helixi64 – 82Combined sources19
Turni92 – 95Combined sources4
Beta strandi96 – 104Combined sources9
Beta strandi106 – 111Combined sources6
Beta strandi114 – 116Combined sources3
Helixi119 – 130Combined sources12
Beta strandi134 – 138Combined sources5
Helixi144 – 157Combined sources14
Turni160 – 162Combined sources3
Beta strandi163 – 165Combined sources3
Helixi170 – 176Combined sources7
Beta strandi182 – 188Combined sources7
Helixi190 – 201Combined sources12
Turni202 – 204Combined sources3
Beta strandi207 – 210Combined sources4
Beta strandi216 – 219Combined sources4
Beta strandi221 – 223Combined sources3
Helixi225 – 237Combined sources13
Turni238 – 241Combined sources4
Beta strandi249 – 252Combined sources4
Helixi254 – 256Combined sources3
Helixi257 – 272Combined sources16
Helixi276 – 278Combined sources3
Helixi288 – 296Combined sources9
Turni297 – 300Combined sources4
Beta strandi303 – 305Combined sources3
Turni311 – 314Combined sources4
Beta strandi319 – 321Combined sources3
Helixi329 – 331Combined sources3
Beta strandi337 – 340Combined sources4
Beta strandi342 – 344Combined sources3
Helixi348 – 356Combined sources9
Beta strandi362 – 367Combined sources6
Helixi371 – 378Combined sources8
Beta strandi384 – 392Combined sources9
Helixi393 – 396Combined sources4
Helixi406 – 408Combined sources3
Helixi416 – 421Combined sources6
Beta strandi423 – 430Combined sources8
Helixi440 – 442Combined sources3
Beta strandi443 – 445Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AD3X-ray2.60A/B3-453[»]
ProteinModelPortaliP11883.
SMRiP11883.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11883.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP11883.
KOiK00129.
OMAiRIINSQH.
OrthoDBiEOG091G05HC.
PhylomeDBiP11883.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSISDTVKR AREAFNSGKT RSLQFRIQQL EALQRMINEN LKSISGALAS
60 70 80 90 100
DLGKNEWTSY YEEVAHVLEE LDTTIKELPD WAEDEPVAKT RQTQQDDLYI
110 120 130 140 150
HSEPLGVVLV IGAWNYPFNL TIQPMVGAVA AGNAVILKPS EVSGHMADLL
160 170 180 190 200
ATLIPQYMDQ NLYLVVKGGV PETTELLKER FDHIMYTGST AVGKIVMAAA
210 220 230 240 250
AKHLTPVTLE LGGKSPCYVD KDCDLDVACR RIAWGKFMNS GQTCVAPDYI
260 270 280 290 300
LCDPSIQNQI VEKLKKSLKD FYGEDAKQSR DYGRIINDRH FQRVKGLIDN
310 320 330 340 350
QKVAHGGTWD QSSRYIAPTI LVDVDPQSPV MQEEIFGPVM PIVCVRSLEE
360 370 380 390 400
AIQFINQREK PLALYVFSNN EKVIKKMIAE TSSGGVTAND VIVHITVPTL
410 420 430 440 450
PFGGVGNSGM GAYHGKKSFE TFSHRRSCLV KSLLNEEAHK ARYPPSPAKM

PRH
Length:453
Mass (Da):50,339
Last modified:January 23, 2007 - v3
Checksum:i15C501BAB4F9845A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03637 mRNA. Translation: AAA40713.1.
BC070924 mRNA. Translation: AAH70924.1.
PIRiA30149.
RefSeqiNP_114178.1. NM_031972.1.
UniGeneiRn.105627.

Genome annotation databases

EnsembliENSRNOT00000003182; ENSRNOP00000003182; ENSRNOG00000002331.
GeneIDi25375.
KEGGirno:25375.
UCSCiRGD:2088. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03637 mRNA. Translation: AAA40713.1.
BC070924 mRNA. Translation: AAH70924.1.
PIRiA30149.
RefSeqiNP_114178.1. NM_031972.1.
UniGeneiRn.105627.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AD3X-ray2.60A/B3-453[»]
ProteinModelPortaliP11883.
SMRiP11883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11883. 1 interactor.
STRINGi10116.ENSRNOP00000003182.

Proteomic databases

PaxDbiP11883.
PRIDEiP11883.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003182; ENSRNOP00000003182; ENSRNOG00000002331.
GeneIDi25375.
KEGGirno:25375.
UCSCiRGD:2088. rat.

Organism-specific databases

CTDi218.
RGDi2088. Aldh3a1.

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP11883.
KOiK00129.
OMAiRIINSQH.
OrthoDBiEOG091G05HC.
PhylomeDBiP11883.
TreeFamiTF314264.

Enzyme and pathway databases

ReactomeiR-RNO-211945. Phase 1 - Functionalization of compounds.
SABIO-RKP11883.

Miscellaneous databases

EvolutionaryTraceiP11883.
PROiP11883.

Gene expression databases

BgeeiENSRNOG00000002331.
GenevisibleiP11883. RN.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL3A1_RAT
AccessioniPrimary (citable) accession number: P11883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.