##gff-version 3 P11881 UniProtKB Chain 1 2749 . . . ID=PRO_0000153921;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 1 P11881 UniProtKB Topological domain 1 2273 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Transmembrane 2274 2294 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Topological domain 2295 2305 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Transmembrane 2306 2326 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Topological domain 2327 2352 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Transmembrane 2353 2373 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Topological domain 2374 2396 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Transmembrane 2397 2417 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Topological domain 2418 2439 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Transmembrane 2440 2460 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Topological domain 2461 2569 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Transmembrane 2570 2590 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Topological domain 2591 2749 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Domain 112 166 . . . Note=MIR 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 P11881 UniProtKB Domain 173 223 . . . Note=MIR 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 P11881 UniProtKB Domain 231 287 . . . Note=MIR 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 P11881 UniProtKB Domain 294 373 . . . Note=MIR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 P11881 UniProtKB Domain 379 435 . . . Note=MIR 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 P11881 UniProtKB Region 1005 1026 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Region 1136 1167 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Region 1695 1730 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Region 1751 1788 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Region 1881 1906 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Region 1932 1952 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Region 2463 2528 . . . Note=Interaction with ERP44;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15652484;Dbxref=PMID:15652484 P11881 UniProtKB Region 2721 2749 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Compositional bias 1006 1023 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Compositional bias 1145 1163 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Compositional bias 1705 1719 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11881 UniProtKB Binding site 265 269 . . . . P11881 UniProtKB Binding site 508 511 . . . . P11881 UniProtKB Binding site 567 569 . . . . P11881 UniProtKB Modified residue 482 482 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Modified residue 1588 1588 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17208939,ECO:0007744|PubMed:18630941,ECO:0007744|PubMed:21183079;Dbxref=PMID:17208939,PMID:18630941,PMID:21183079 P11881 UniProtKB Modified residue 1755 1755 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q14643,ECO:0000255 P11881 UniProtKB Modified residue 2655 2655 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11881 UniProtKB Lipidation 56 56 . . . Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25368151;Dbxref=PMID:25368151 P11881 UniProtKB Lipidation 849 849 . . . Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25368151;Dbxref=PMID:25368151 P11881 UniProtKB Cross-link 916 916 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 962 962 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 1571 1571 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 1771 1771 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 1884 1884 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 1885 1885 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 1886 1886 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 1901 1901 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 1924 1924 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 2118 2118 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Cross-link 2257 2257 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29994 P11881 UniProtKB Alternative sequence 318 332 . . . ID=VSP_002691;Note=In isoform 2%2C isoform 4%2C isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11881 UniProtKB Alternative sequence 1692 1714 . . . ID=VSP_002692;Note=In isoform 7 and isoform 8. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11881 UniProtKB Alternative sequence 1715 1715 . . . ID=VSP_002693;Note=In isoform 3%2C isoform 4%2C isoform 5%2C isoform 6%2C isoform 7 and isoform 8. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11881 UniProtKB Alternative sequence 1716 1731 . . . ID=VSP_002694;Note=In isoform 5%2C isoform 6%2C isoform 7 and isoform 8. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11881 UniProtKB Mutagenesis 56 56 . . . Note=Strongly reduced palmitoylation%3B when associated with A-849 and A-2215. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25368151;Dbxref=PMID:25368151 P11881 UniProtKB Mutagenesis 167 167 . . . Note=Nearly abolishes calcium flux. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20813840;Dbxref=PMID:20813840 P11881 UniProtKB Mutagenesis 168 168 . . . Note=Reduces calcium flux by about 50%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20813840;Dbxref=PMID:20813840 P11881 UniProtKB Mutagenesis 169 169 . . . Note=Reduces calcium flux by about 50%25. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20813840;Dbxref=PMID:20813840 P11881 UniProtKB Mutagenesis 267 267 . . . Note=Abolishes inositol 1%2C4%2C5-triphosphate binding. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12442173;Dbxref=PMID:12442173 P11881 UniProtKB Mutagenesis 567 567 . . . Note=Abolishes inositol 1%2C4%2C5-triphosphate binding. Y->A%2CF;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12442173;Dbxref=PMID:12442173 P11881 UniProtKB Mutagenesis 849 849 . . . Note=Strongly reduced palmitoylation%3B when associated with A-56 and A-2215. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25368151;Dbxref=PMID:25368151 P11881 UniProtKB Mutagenesis 1588 1588 . . . Note=Increases interaction with AHCYL1%3B when associated with A-1755. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23542070;Dbxref=PMID:23542070 P11881 UniProtKB Mutagenesis 1588 1588 . . . Note=Decreases interaction with AHCYL1%3B when associated with A-1755. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23542070;Dbxref=PMID:23542070 P11881 UniProtKB Mutagenesis 1755 1755 . . . Note=Increases interaction with AHCYL1%3B when associated with A-1588. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23542070;Dbxref=PMID:23542070 P11881 UniProtKB Mutagenesis 1755 1755 . . . Note=Decreases interaction with AHCYL1%3B when associated with A-1588. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23542070;Dbxref=PMID:23542070 P11881 UniProtKB Mutagenesis 2215 2215 . . . Note=Strongly reduced palmitoylation%3B when associated with A-56 and A-849. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25368151;Dbxref=PMID:25368151 P11881 UniProtKB Mutagenesis 2496 2496 . . . Note=No effect on channel activity. Significant decrease of interaction with ERP44. Complete loss of channel inhibition by ERP44. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15652484;Dbxref=PMID:15652484 P11881 UniProtKB Mutagenesis 2504 2504 . . . Note=No effect on channel activity. Significant decrease of interaction with ERP44. Complete loss of channel inhibition by ERP44. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15652484;Dbxref=PMID:15652484 P11881 UniProtKB Mutagenesis 2527 2527 . . . Note=Complete loss of channel activity. Significant decrease of interaction with ERP44. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15652484;Dbxref=PMID:15652484 P11881 UniProtKB Sequence conflict 1264 1264 . . . Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11881 UniProtKB Sequence conflict 2675 2675 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11881 UniProtKB Beta strand 14 23 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 25 30 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 36 39 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Helix 41 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 46 48 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Helix 53 56 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 58 61 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Helix 67 74 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Helix 86 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Turn 110 112 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 120 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Turn 126 129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 130 139 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 141 143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 146 154 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Helix 157 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 161 167 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 181 189 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 193 199 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 201 205 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 207 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 217 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XZZ P11881 UniProtKB Beta strand 239 244 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Turn 245 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 249 255 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 257 265 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 269 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 272 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 278 280 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 282 286 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 303 307 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Turn 308 310 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 313 318 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 353 359 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 364 366 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 368 371 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 388 392 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Turn 393 396 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 397 406 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 409 412 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 415 423 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Beta strand 430 434 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 437 461 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 467 484 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Turn 485 487 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 495 499 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 504 512 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 515 524 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 525 527 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 547 564 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 568 585 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K P11881 UniProtKB Helix 589 599 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N4K