Gas2

Functionⁱ

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process.1 Publication

GO - Molecular functionⁱ

microtubule binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cell cycle arrest Source: UniProtKB-KW
regulation of cell shape Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Biological process	Apoptosis, Cell cycle, Cell shape, Growth arrest

Biological process

Apoptosis, Cell cycle, Cell shape, Growth arrest

Enzyme and pathway databases

Reactomeⁱ	R-MMU-264870. Caspase-mediated cleavage of cytoskeletal proteins.

Reactomeⁱ

R-MMU-264870. Caspase-mediated cleavage of cytoskeletal proteins.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Growth arrest-specific protein 2 Short name: GAS-2
Gene namesⁱ	Name:Gas2 Synonyms:Gas-2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:95657. Gas2.

Subcellular locationⁱ

Note:

Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-KW
cytoskeleton Source: UniProtKB-SubCell
membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	279	D → A: Abolishes proteolytic processing.		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000190441	1 – 314	Growth arrest-specific protein 2Add BLAST		314

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	184	PhosphoserineCombined sources		1
Modified residueⁱ	188	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Cleaved, during apoptosis, on a specific aspartic residue by caspases.By similarity

Phosphorylated on serine residues during the G0-G1 transition phase.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	279 – 280	Cleavage; by a caspase during apoptosis		2

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11862.
PaxDbⁱ	P11862.
PeptideAtlas More...PeptideAtlasⁱ	P11862.
PRIDEⁱ	P11862.

PTM databases

iPTMnetⁱ	P11862.
PhosphoSitePlusⁱ	P11862.

Expressionⁱ

Tissue specificityⁱ

Expressed in most tissues. Highest levels in liver, lung and kidney. In the embryo strongly expressed in regions that undergo extensive apoptosis, such as the intervertebral tissues, the cranofacial mesenchyme and the cartilage of the limbs.

Developmental stageⁱ

At embryonic days E11.5 and E13.5 strongly expressed in the soft connective tissue of the face and trunk, and in the invertebral tissues. Low levels are found in brain and neural tube. Low levels are found in day E13.5 lung, kidney, eye lens and in vertebral cartilage located cranially. In day E11.5 hindlimbs weakly expressed by the mesenchymal cells surrounding the perspective cartilage-forming regions. In day E12.5 hindlimbs strongly expressed by cells enveloping the chondrogenic primordia of the digits, metatarsals, tibia, and femur, and the soft connective tissue in the interdigital tissues. In day E13.5 hindlimbs expression is maintained in the intergigital tissues located proximally and is found in some chondrocytes in te stylopod and in mesenchymal cells surrounding the cartilage in the autopod and zygopod. In day E13.5 forelimb strongly expressed in the pre-hypertrophic and hypertrophic regions of the humerus, radius, and ulna. Expression in hypertrophic chondrocytes is maintained at day E14.5 and is not detectable at day E15.5. At day E14.5 also expressed by chondrocytes in the cartilage forming the carpals and tarsals and by mesenchymal cells in the process of condensing to form tendons. In day E13.5 hindlimbs expressed in some myoblasts in the proximal myogenic region. In older limbs expression is maintained in the myotubules.1 Publication

Inductionⁱ

Down-regulated by mitogens.

Gene expression databases

Bgeeⁱ	ENSMUSG00000030498.
CleanExⁱ	MM_GAS2.
ExpressionAtlasⁱ	P11862. baseline and differential.
Genevisibleⁱ	P11862. MM.

Interactionⁱ

GO - Molecular functionⁱ

microtubule binding Source: InterPro

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000053514.

STRINGⁱ

10090.ENSMUSP00000053514.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	202 – 211	Combined sources	10
Beta strandⁱ	218 – 220	Combined sources	3
Beta strandⁱ	224 – 228	Combined sources	5
Beta strandⁱ	231 – 234	Combined sources	4
Beta strandⁱ	237 – 244	Combined sources	8
Turnⁱ	245 – 247	Combined sources	3
Beta strandⁱ	248 – 253	Combined sources	6
Beta strandⁱ	256 – 259	Combined sources	4
Helixⁱ	260 – 267	Combined sources	8
Helixⁱ	269 – 272	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1V5R	NMR	-	A	201-284	[»]
ProteinModelPortalⁱ	P11862.
SMRⁱ	P11862.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P11862.

EvolutionaryTraceⁱ

P11862.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 157	Calponin-homologyPROSITE-ProRule annotationAdd BLAST		123
Domainⁱ	198 – 271	GARPROSITE-ProRule annotationAdd BLAST		74

Sequence similaritiesⁱ

Belongs to the GAS2 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410KD4B. Eukaryota. ENOG4111BF1. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002205.
HOGENOMⁱ	HOG000007404.
HOVERGENⁱ	HBG005805.
InParanoidⁱ	P11862.
OMAⁱ	WETFESY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PJ6.
PhylomeDBⁱ	P11862.
TreeFamⁱ	TF323754.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00014. CH. 1 hit.
Gene3Dⁱ	1.10.418.10. 1 hit. 3.30.920.20. 1 hit.
InterProⁱ	View protein in InterPro IPR001715. CH-domain. IPR029929. GAS2. IPR003108. GAS_dom.
PANTHERⁱ	PTHR11915:SF396. PTHR11915:SF396. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00307. CH. 1 hit. PF02187. GAS2. 1 hit.
SMARTⁱ	View protein in SMART SM00033. CH. 1 hit. SM00243. GAS2. 1 hit.
SUPFAMⁱ	SSF143575. SSF143575. 1 hit. SSF47576. SSF47576. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS51460. GAR. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P11862-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMCTALSPKV RSGPGLSDMH QYSQWLASRH EANLLPMKED LALWLTNLLG 
        60         70         80         90        100
KEITAETFME KLDNGALLCQ LAATVQEKFK ESMDANKPAK TLPLKKIPCK 
       110        120        130        140        150
ASAPSGSFFA RDNTANFLSW CRDLGVDETC LFESEGLVLH KQPREVCLCL 
       160        170        180        190        200
LELGRIAARY GVEPPGLIKL EKEIEQEETL SAPSPSPSPS SKSSGKKSTG 
       210        220        230        240        250
NLLDDAVKRI SEDPPCKCPT KFCVERLSQG RYRVGEKILF IRMLHNKHVM 
       260        270        280        290        300
VRVGGGWETF AGYLLKHDPC RMLQISRVDG KTSPVQSKSP TLKDMNPDNY 
       310 
LVVSATYKAK KEIK

Length:314

Mass (Da):34,901

Last modified:October 1, 1989 - v1

Checksum:ⁱ7F2CC704B4057FAC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M21828 mRNA. Translation: AAA37660.1. BC013456 mRNA. Translation: AAH13456.1. BC053446 mRNA. Translation: AAH53446.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21310.1.
PIRⁱ	A31590.
NCBI Reference Sequences More...RefSeqⁱ	NP_001317536.1. NM_001330607.1. NP_032113.1. NM_008087.3. XP_006540687.1. XM_006540624.3. XP_006540688.1. XM_006540625.3. XP_006540689.1. XM_006540626.3.
UniGeneⁱ	Mm.207360. Mm.471773.

Genome annotation databases

Ensemblⁱ	ENSMUST00000051912; ENSMUSP00000053514; ENSMUSG00000030498. ENSMUST00000107591; ENSMUSP00000103217; ENSMUSG00000030498. ENSMUST00000208711; ENSMUSP00000146537; ENSMUSG00000030498.
GeneIDⁱ	14453.
KEGGⁱ	mmu:14453.
UCSC genome browser More...UCSCⁱ	uc009hch.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M21828 mRNA. Translation: AAA37660.1. BC013456 mRNA. Translation: AAH13456.1. BC053446 mRNA. Translation: AAH53446.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21310.1.
PIRⁱ	A31590.
NCBI Reference Sequences More...RefSeqⁱ	NP_001317536.1. NM_001330607.1. NP_032113.1. NM_008087.3. XP_006540687.1. XM_006540624.3. XP_006540688.1. XM_006540625.3. XP_006540689.1. XM_006540626.3.
UniGeneⁱ	Mm.207360. Mm.471773.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1V5R	NMR	-	A	201-284	[»]
ProteinModelPortalⁱ	P11862.
SMRⁱ	P11862.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000053514.

STRINGⁱ

10090.ENSMUSP00000053514.

PTM databases

iPTMnetⁱ	P11862.
PhosphoSitePlusⁱ	P11862.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11862.
PaxDbⁱ	P11862.
PeptideAtlas More...PeptideAtlasⁱ	P11862.
PRIDEⁱ	P11862.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000051912; ENSMUSP00000053514; ENSMUSG00000030498. ENSMUST00000107591; ENSMUSP00000103217; ENSMUSG00000030498. ENSMUST00000208711; ENSMUSP00000146537; ENSMUSG00000030498.
GeneIDⁱ	14453.
KEGGⁱ	mmu:14453.
UCSC genome browser More...UCSCⁱ	uc009hch.1. mouse.

Organism-specific databases

CTDⁱ	2620.
MGIⁱ	MGI:95657. Gas2.

Phylogenomic databases

eggNOGⁱ	ENOG410KD4B. Eukaryota. ENOG4111BF1. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002205.
HOGENOMⁱ	HOG000007404.
HOVERGENⁱ	HBG005805.
InParanoidⁱ	P11862.
OMAⁱ	WETFESY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PJ6.
PhylomeDBⁱ	P11862.
TreeFamⁱ	TF323754.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-264870. Caspase-mediated cleavage of cytoskeletal proteins.

Reactomeⁱ

R-MMU-264870. Caspase-mediated cleavage of cytoskeletal proteins.

Miscellaneous databases

ChiTaRSⁱ	Gas2. mouse.
EvolutionaryTraceⁱ	P11862.
Protein Ontology More...PROⁱ	PR:P11862.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030498.
CleanExⁱ	MM_GAS2.
ExpressionAtlasⁱ	P11862. baseline and differential.
Genevisibleⁱ	P11862. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00014. CH. 1 hit.
Gene3Dⁱ	1.10.418.10. 1 hit. 3.30.920.20. 1 hit.
InterProⁱ	View protein in InterPro IPR001715. CH-domain. IPR029929. GAS2. IPR003108. GAS_dom.
PANTHERⁱ	PTHR11915:SF396. PTHR11915:SF396. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00307. CH. 1 hit. PF02187. GAS2. 1 hit.
SMARTⁱ	View protein in SMART SM00033. CH. 1 hit. SM00243. GAS2. 1 hit.
SUPFAMⁱ	SSF143575. SSF143575. 1 hit. SSF47576. SSF47576. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS51460. GAR. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GAS2_MOUSE
Accessionⁱ	P11862Primary (citable) accession number: P11862
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	October 1, 1989
	Last modified:	July 5, 2017
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P11862 (GAS2_MOUSE)

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Growth arrest-specific protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ