UniProtKB - P11862 (GAS2_MOUSE)
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Protein
Growth arrest-specific protein 2
Gene
Gas2
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process.1 Publication
GO - Molecular functioni
- microtubule binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle arrest Source: UniProtKB-KW
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis, Cell cycle, Cell shape, Growth arrest |
Enzyme and pathway databases
Reactomei | R-MMU-264870. Caspase-mediated cleavage of cytoskeletal proteins. |
Names & Taxonomyi
Protein namesi | Recommended name: Growth arrest-specific protein 2Short name: GAS-2 |
Gene namesi | Name:Gas2 Synonyms:Gas-2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95657. Gas2. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 279 | D → A: Abolishes proteolytic processing. | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190441 | 1 – 314 | Growth arrest-specific protein 2Add BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 184 | PhosphoserineCombined sources | 1 | |
Modified residuei | 188 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Cleaved, during apoptosis, on a specific aspartic residue by caspases.By similarity
Phosphorylated on serine residues during the G0-G1 transition phase.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 279 – 280 | Cleavage; by a caspase during apoptosis | 2 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P11862. |
PaxDbi | P11862. |
PeptideAtlasi | P11862. |
PRIDEi | P11862. |
PTM databases
iPTMneti | P11862. |
PhosphoSitePlusi | P11862. |
Expressioni
Tissue specificityi
Expressed in most tissues. Highest levels in liver, lung and kidney. In the embryo strongly expressed in regions that undergo extensive apoptosis, such as the intervertebral tissues, the cranofacial mesenchyme and the cartilage of the limbs.
Developmental stagei
At embryonic days E11.5 and E13.5 strongly expressed in the soft connective tissue of the face and trunk, and in the invertebral tissues. Low levels are found in brain and neural tube. Low levels are found in day E13.5 lung, kidney, eye lens and in vertebral cartilage located cranially. In day E11.5 hindlimbs weakly expressed by the mesenchymal cells surrounding the perspective cartilage-forming regions. In day E12.5 hindlimbs strongly expressed by cells enveloping the chondrogenic primordia of the digits, metatarsals, tibia, and femur, and the soft connective tissue in the interdigital tissues. In day E13.5 hindlimbs expression is maintained in the intergigital tissues located proximally and is found in some chondrocytes in te stylopod and in mesenchymal cells surrounding the cartilage in the autopod and zygopod. In day E13.5 forelimb strongly expressed in the pre-hypertrophic and hypertrophic regions of the humerus, radius, and ulna. Expression in hypertrophic chondrocytes is maintained at day E14.5 and is not detectable at day E15.5. At day E14.5 also expressed by chondrocytes in the cartilage forming the carpals and tarsals and by mesenchymal cells in the process of condensing to form tendons. In day E13.5 hindlimbs expressed in some myoblasts in the proximal myogenic region. In older limbs expression is maintained in the myotubules.1 Publication
Inductioni
Down-regulated by mitogens.
Gene expression databases
Bgeei | ENSMUSG00000030498. |
CleanExi | MM_GAS2. |
ExpressionAtlasi | P11862. baseline and differential. |
Genevisiblei | P11862. MM. |
Interactioni
GO - Molecular functioni
- microtubule binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000053514. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 202 – 211 | Combined sources | 10 | |
Beta strandi | 218 – 220 | Combined sources | 3 | |
Beta strandi | 224 – 228 | Combined sources | 5 | |
Beta strandi | 231 – 234 | Combined sources | 4 | |
Beta strandi | 237 – 244 | Combined sources | 8 | |
Turni | 245 – 247 | Combined sources | 3 | |
Beta strandi | 248 – 253 | Combined sources | 6 | |
Beta strandi | 256 – 259 | Combined sources | 4 | |
Helixi | 260 – 267 | Combined sources | 8 | |
Helixi | 269 – 272 | Combined sources | 4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1V5R | NMR | - | A | 201-284 | [»] | |
ProteinModelPortali | P11862. | |||||
SMRi | P11862. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11862. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 157 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 123 | |
Domaini | 198 – 271 | GARPROSITE-ProRule annotationAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the GAS2 family.Curated
Phylogenomic databases
eggNOGi | ENOG410KD4B. Eukaryota. ENOG4111BF1. LUCA. |
GeneTreei | ENSGT00390000002205. |
HOGENOMi | HOG000007404. |
HOVERGENi | HBG005805. |
InParanoidi | P11862. |
OMAi | WETFESY. |
OrthoDBi | EOG091G0PJ6. |
PhylomeDBi | P11862. |
TreeFami | TF323754. |
Family and domain databases
CDDi | cd00014. CH. 1 hit. |
Gene3Di | 1.10.418.10. 1 hit. 3.30.920.20. 1 hit. |
InterProi | View protein in InterPro IPR001715. CH-domain. IPR036872. CH_dom_sf. IPR003108. GAR_dom. IPR036534. GAR_dom_sf. IPR029929. GAS2. |
PANTHERi | PTHR44350:SF2. PTHR44350:SF2. 2 hits. |
Pfami | View protein in Pfam PF00307. CH. 1 hit. PF02187. GAS2. 1 hit. |
SMARTi | View protein in SMART SM00033. CH. 1 hit. SM00243. GAS2. 1 hit. |
SUPFAMi | SSF143575. SSF143575. 1 hit. SSF47576. SSF47576. 1 hit. |
PROSITEi | View protein in PROSITE PS50021. CH. 1 hit. PS51460. GAR. 1 hit. |
i Sequence
Sequence statusi: Complete.
P11862-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMCTALSPKV RSGPGLSDMH QYSQWLASRH EANLLPMKED LALWLTNLLG
60 70 80 90 100
KEITAETFME KLDNGALLCQ LAATVQEKFK ESMDANKPAK TLPLKKIPCK
110 120 130 140 150
ASAPSGSFFA RDNTANFLSW CRDLGVDETC LFESEGLVLH KQPREVCLCL
160 170 180 190 200
LELGRIAARY GVEPPGLIKL EKEIEQEETL SAPSPSPSPS SKSSGKKSTG
210 220 230 240 250
NLLDDAVKRI SEDPPCKCPT KFCVERLSQG RYRVGEKILF IRMLHNKHVM
260 270 280 290 300
VRVGGGWETF AGYLLKHDPC RMLQISRVDG KTSPVQSKSP TLKDMNPDNY
310
LVVSATYKAK KEIK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21828 mRNA. Translation: AAA37660.1. BC013456 mRNA. Translation: AAH13456.1. BC053446 mRNA. Translation: AAH53446.1. |
CCDSi | CCDS21310.1. |
PIRi | A31590. |
RefSeqi | NP_001317536.1. NM_001330607.1. NP_032113.1. NM_008087.3. XP_006540687.1. XM_006540624.3. XP_006540688.1. XM_006540625.3. XP_006540689.1. XM_006540626.3. |
UniGenei | Mm.207360. Mm.471773. |
Genome annotation databases
Ensembli | ENSMUST00000051912; ENSMUSP00000053514; ENSMUSG00000030498. ENSMUST00000107591; ENSMUSP00000103217; ENSMUSG00000030498. ENSMUST00000208711; ENSMUSP00000146537; ENSMUSG00000030498. |
GeneIDi | 14453. |
KEGGi | mmu:14453. |
UCSCi | uc009hch.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | GAS2_MOUSE | |
Accessioni | P11862Primary (citable) accession number: P11862 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | February 28, 2018 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Caution
It is uncertain whether Met-1 or Met-2 is the initiator.Curated