Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase inhibitor 2

Gene

PPP1R2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2
Short name:
IPP-2
Gene namesi
Name:PPP1R2
Synonyms:IPP2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000714832 – 205Protein phosphatase inhibitor 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine2 Publications1
Modified residuei44Phosphoserine; by ATMBy similarity1
Modified residuei73Phosphothreonine; by GSK31 Publication1
Modified residuei87Phosphoserine1 Publication1
Modified residuei89PhosphothreonineBy similarity1
Modified residuei92PhosphothreonineBy similarity1
Modified residuei96PhosphothreonineBy similarity1
Modified residuei121Phosphoserine1 Publication1
Modified residuei122Phosphoserine1 Publication1
Modified residuei127PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

PTM databases

iPTMnetiP11845.

Interactioni

Subunit structurei

Heterodimer with PP1.1 Publication

Protein-protein interaction databases

DIPiDIP-439N.
STRINGi9986.ENSOCUP00000012136.

Structurei

3D structure databases

DisProtiDP00232.
ProteinModelPortaliP11845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Required for binding PPP1CCBy similarity6
Regioni43 – 55Required for binding PPP1CCBy similarityAdd BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activityBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiP11845.
KOiK16833.
TreeFamiTF105536.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS STSSRVASAE QPRGSVDEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PSTPYHSMIG DDDDAYSDTE TTEAMTPDTL
110 120 130 140 150
AKKLAAAEGS EPKYRIREQE SSGEEDSDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDEE DEEMSETADG ESMNTEESNQ GSTPSDQRQN

KSQSS
Length:205
Mass (Da):23,011
Last modified:January 23, 2007 - v3
Checksum:iB82E80AAD2A0A7D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20858 mRNA. Translation: AAA17541.1.
M95581 mRNA. Translation: AAA31405.1.
PIRiI46876.
RefSeqiNP_001076213.1. NM_001082744.2.
UniGeneiOcu.1811.

Genome annotation databases

GeneIDi100009520.
KEGGiocu:100009520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20858 mRNA. Translation: AAA17541.1.
M95581 mRNA. Translation: AAA31405.1.
PIRiI46876.
RefSeqiNP_001076213.1. NM_001082744.2.
UniGeneiOcu.1811.

3D structure databases

DisProtiDP00232.
ProteinModelPortaliP11845.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-439N.
STRINGi9986.ENSOCUP00000012136.

PTM databases

iPTMnetiP11845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009520.
KEGGiocu:100009520.

Organism-specific databases

CTDi5504.

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiP11845.
KOiK16833.
TreeFamiTF105536.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPP2_RABIT
AccessioniPrimary (citable) accession number: P11845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.