ID   CRGA_HUMAN              Reviewed;         174 AA.
AC   P11844; Q53ST5;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 3.
DT   11-NOV-2015, entry version 138.
DE   RecName: Full=Gamma-crystallin A;
DE   AltName: Full=Gamma-A-crystallin;
DE   AltName: Full=Gamma-crystallin 5;
GN   Name=CRYGA; Synonyms=CRYG1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-148.
RX   PubMed=3670288;
RA   Meakin S.O., Du R.P., Tsui L.-C., Breitman M.L.;
RT   "Gamma-crystallins of the human eye lens: expression analysis of five
RT   members of the gene family.";
RL   Mol. Cell. Biol. 7:2671-2679(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RT   "Human gammaA-crystallin.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [4]
RP   3D-STRUCTURE MODELING.
RX   PubMed=12507494; DOI=10.1016/S0006-291X(02)02895-4;
RA   Salim A., Zaidi Z.H.;
RT   "Homology models of human gamma-crystallins: structural study of the
RT   extensive charge network in gamma-crystallins.";
RL   Biochem. Biophys. Res. Commun. 300:624-630(2003).
RN   [5]
RP   VARIANT LEU-148.
RX   PubMed=12011157; DOI=10.1136/jmg.39.5.352;
RA   Santhiya S.T., Shyam Manohar M., Rawlley D., Vijayalakshmi P.,
RA   Namperumalsamy P., Gopinath P.M., Loester J., Graw J.;
RT   "Novel mutations in the gamma-crystallin genes cause autosomal
RT   dominant congenital cataracts.";
RL   J. Med. Genet. 39:352-358(2002).
CC   -!- FUNCTION: Crystallins are the dominant structural components of
CC       the vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very
CC       similar Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Contains 4 beta/gamma crystallin 'Greek key' domains.
CC       {ECO:0000255|PROSITE-ProRule:PRU00028}.
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DR   EMBL; M17316; AAA52108.1; -; Genomic_DNA.
DR   EMBL; M17315; AAA52108.1; JOINED; Genomic_DNA.
DR   EMBL; EF426311; ABO14696.1; -; mRNA.
DR   EMBL; AC016697; AAX93220.1; -; Genomic_DNA.
DR   CCDS; CCDS33367.1; -.
DR   PIR; A26912; A26912.
DR   RefSeq; NP_055432.2; NM_014617.3.
DR   UniGene; Hs.122566; -.
DR   PDB; 1LER; Model; -; A=1-174.
DR   PDBsum; 1LER; -.
DR   ProteinModelPortal; P11844; -.
DR   SMR; P11844; 2-174.
DR   BioGrid; 107808; 1.
DR   STRING; 9606.ENSP00000302105; -.
DR   PhosphoSite; P11844; -.
DR   BioMuta; CRYGA; -.
DR   DMDM; 148887193; -.
DR   PaxDb; P11844; -.
DR   PRIDE; P11844; -.
DR   Ensembl; ENST00000304502; ENSP00000302105; ENSG00000168582.
DR   GeneID; 1418; -.
DR   KEGG; hsa:1418; -.
DR   UCSC; uc002vcq.4; human.
DR   CTD; 1418; -.
DR   GeneCards; CRYGA; -.
DR   HGNC; HGNC:2408; CRYGA.
DR   MIM; 123660; gene.
DR   neXtProt; NX_P11844; -.
DR   PharmGKB; PA26915; -.
DR   eggNOG; ENOG410IWCR; Eukaryota.
DR   eggNOG; ENOG411298R; LUCA.
DR   GeneTree; ENSGT00760000118812; -.
DR   HOGENOM; HOG000234389; -.
DR   HOVERGEN; HBG003364; -.
DR   InParanoid; P11844; -.
DR   OMA; SCRAIPY; -.
DR   OrthoDB; EOG70CR7Z; -.
DR   PhylomeDB; P11844; -.
DR   GeneWiki; CRYGA; -.
DR   GenomeRNAi; 1418; -.
DR   NextBio; 5799; -.
DR   PRO; PR:P11844; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; P11844; -.
DR   CleanEx; HS_CRYGA; -.
DR   Genevisible; P11844; HS.
DR   GO; GO:0005212; F:structural constituent of eye lens; NAS:UniProtKB.
DR   GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0007601; P:visual perception; NAS:UniProtKB.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-rel.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   3D-structure; Complete proteome; Eye lens protein; Polymorphism;
KW   Reference proteome; Repeat.
FT   INIT_MET      1      1       Removed. {ECO:0000250|UniProtKB:P02527}.
FT   CHAIN         2    174       Gamma-crystallin A.
FT                                /FTId=PRO_0000057585.
FT   DOMAIN        2     40       Beta/gamma crystallin 'Greek key' 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00028}.
FT   DOMAIN       41     83       Beta/gamma crystallin 'Greek key' 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00028}.
FT   DOMAIN       88    128       Beta/gamma crystallin 'Greek key' 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00028}.
FT   DOMAIN      129    171       Beta/gamma crystallin 'Greek key' 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00028}.
FT   REGION       84     87       Connecting peptide.
FT   VARIANT     148    148       P -> L. {ECO:0000269|PubMed:12011157,
FT                                ECO:0000269|PubMed:3670288}.
FT                                /FTId=VAR_021139.
SQ   SEQUENCE   174 AA;  20877 MW;  99889A7641728090 CRC64;
     MGKITFYEDR DFQGRCYNCI SDCPNLRVYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR
     GKYPDYQHWM GLSDSVQSCR IIPHTSSHKL RLYERDDYRG LMSELTDDCA CVPELFRLPE
     IYSLHVLEGC WVLYEMPNYR GRQYLLRPGD YRRYHDWGGA DAKVGSLRRV TDLY
//