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P11844

- CRGA_HUMAN

UniProt

P11844 - CRGA_HUMAN

Protein

Gamma-crystallin A

Gene

CRYGA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Crystallins are the dominant structural components of the vertebrate eye lens.

    GO - Molecular functioni

    1. structural constituent of eye lens Source: UniProtKB

    GO - Biological processi

    1. lens development in camera-type eye Source: Ensembl
    2. visual perception Source: UniProtKB

    Keywords - Molecular functioni

    Eye lens protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-crystallin A
    Alternative name(s):
    Gamma-A-crystallin
    Gamma-crystallin 5
    Gene namesi
    Name:CRYGA
    Synonyms:CRYG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:2408. CRYGA.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26915.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 174173Gamma-crystallin APRO_0000057585Add
    BLAST

    Proteomic databases

    PaxDbiP11844.
    PRIDEiP11844.

    PTM databases

    PhosphoSiteiP11844.

    Expressioni

    Gene expression databases

    BgeeiP11844.
    CleanExiHS_CRYGA.
    GenevestigatoriP11844.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000302105.

    Structurei

    Secondary structure

    1
    174
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 87
    Helixi9 – 113
    Beta strandi12 – 187
    Turni26 – 283
    Beta strandi33 – 4715
    Turni48 – 503
    Beta strandi51 – 577
    Beta strandi59 – 646
    Helixi65 – 684
    Beta strandi71 – 733
    Beta strandi77 – 815
    Beta strandi88 – 947
    Turni95 – 973
    Beta strandi98 – 1047
    Helixi111 – 1144
    Beta strandi122 – 1287
    Beta strandi130 – 1356
    Turni136 – 1383
    Beta strandi139 – 1457
    Beta strandi147 – 1504
    Helixi153 – 1564
    Beta strandi165 – 1684

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LERmodel-A1-174[»]
    ProteinModelPortaliP11844.
    SMRiP11844. Positions 2-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 4039Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini41 – 8343Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini88 – 12841Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini129 – 17143Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 874Connecting peptide

    Domaini

    Has a two-domain beta-structure, folded into four very similar Greek key motifs.

    Sequence similaritiesi

    Belongs to the beta/gamma-crystallin family.Curated
    Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG321245.
    HOGENOMiHOG000234389.
    HOVERGENiHBG003364.
    InParanoidiP11844.
    OMAiSCRAIPY.
    OrthoDBiEOG70CR7Z.
    PhylomeDBiP11844.

    Family and domain databases

    InterProiIPR001064. Beta/gamma_crystallin.
    IPR011024. G_crystallin-rel.
    [Graphical view]
    PfamiPF00030. Crystall. 2 hits.
    [Graphical view]
    PRINTSiPR01367. BGCRYSTALLIN.
    SMARTiSM00247. XTALbg. 2 hits.
    [Graphical view]
    SUPFAMiSSF49695. SSF49695. 1 hit.
    PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11844-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKITFYEDR DFQGRCYNCI SDCPNLRVYF SRCNSIRVDS GCWMLYERPN    50
    YQGHQYFLRR GKYPDYQHWM GLSDSVQSCR IIPHTSSHKL RLYERDDYRG 100
    LMSELTDDCA CVPELFRLPE IYSLHVLEGC WVLYEMPNYR GRQYLLRPGD 150
    YRRYHDWGGA DAKVGSLRRV TDLY 174
    Length:174
    Mass (Da):20,877
    Last modified:May 29, 2007 - v3
    Checksum:i99889A7641728090
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti148 – 1481P → L.2 Publications
    VAR_021139

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17316, M17315 Genomic DNA. Translation: AAA52108.1.
    EF426311 mRNA. Translation: ABO14696.1.
    AC016697 Genomic DNA. Translation: AAX93220.1.
    CCDSiCCDS33367.1.
    PIRiA26912.
    RefSeqiNP_055432.2. NM_014617.3.
    UniGeneiHs.122566.

    Genome annotation databases

    EnsembliENST00000304502; ENSP00000302105; ENSG00000168582.
    GeneIDi1418.
    KEGGihsa:1418.
    UCSCiuc002vcq.4. human.

    Polymorphism databases

    DMDMi148887193.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17316 , M17315 Genomic DNA. Translation: AAA52108.1 .
    EF426311 mRNA. Translation: ABO14696.1 .
    AC016697 Genomic DNA. Translation: AAX93220.1 .
    CCDSi CCDS33367.1.
    PIRi A26912.
    RefSeqi NP_055432.2. NM_014617.3.
    UniGenei Hs.122566.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LER model - A 1-174 [» ]
    ProteinModelPortali P11844.
    SMRi P11844. Positions 2-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000302105.

    PTM databases

    PhosphoSitei P11844.

    Polymorphism databases

    DMDMi 148887193.

    Proteomic databases

    PaxDbi P11844.
    PRIDEi P11844.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304502 ; ENSP00000302105 ; ENSG00000168582 .
    GeneIDi 1418.
    KEGGi hsa:1418.
    UCSCi uc002vcq.4. human.

    Organism-specific databases

    CTDi 1418.
    GeneCardsi GC02M209025.
    HGNCi HGNC:2408. CRYGA.
    MIMi 123660. gene.
    neXtProti NX_P11844.
    PharmGKBi PA26915.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321245.
    HOGENOMi HOG000234389.
    HOVERGENi HBG003364.
    InParanoidi P11844.
    OMAi SCRAIPY.
    OrthoDBi EOG70CR7Z.
    PhylomeDBi P11844.

    Miscellaneous databases

    GeneWikii CRYGA.
    GenomeRNAii 1418.
    NextBioi 5799.
    PROi P11844.
    SOURCEi Search...

    Gene expression databases

    Bgeei P11844.
    CleanExi HS_CRYGA.
    Genevestigatori P11844.

    Family and domain databases

    InterProi IPR001064. Beta/gamma_crystallin.
    IPR011024. G_crystallin-rel.
    [Graphical view ]
    Pfami PF00030. Crystall. 2 hits.
    [Graphical view ]
    PRINTSi PR01367. BGCRYSTALLIN.
    SMARTi SM00247. XTALbg. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49695. SSF49695. 1 hit.
    PROSITEi PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family."
      Meakin S.O., Du R.P., Tsui L.-C., Breitman M.L.
      Mol. Cell. Biol. 7:2671-2679(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-148.
    2. "Human gammaA-crystallin."
      Wistow G.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lens.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins."
      Salim A., Zaidi Z.H.
      Biochem. Biophys. Res. Commun. 300:624-630(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.
    5. "Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts."
      Santhiya S.T., Shyam Manohar M., Rawlley D., Vijayalakshmi P., Namperumalsamy P., Gopinath P.M., Loester J., Graw J.
      J. Med. Genet. 39:352-358(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-148.

    Entry informationi

    Entry nameiCRGA_HUMAN
    AccessioniPrimary (citable) accession number: P11844
    Secondary accession number(s): Q53ST5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3