P11844 (CRGA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-crystallin A

Alternative name(s):
Gamma-A-crystallin
Gamma-crystallin 5

Gene names

Name:	CRYGA
Synonyms:	CRYG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Crystallins are the dominant structural components of the vertebrate eye lens.
Subunit structure	Monomer By similarity.
Domain	Has a two-domain beta-structure, folded into four very similar Greek key motifs.
Sequence similarities	Belongs to the beta/gamma-crystallin family. Contains 4 beta/gamma crystallin 'Greek key' domains.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Molecular function	Eye lens protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lens development in camera-type eye Inferred from electronic annotation. Source: Compara visual perception Non-traceable author statement Ref.4Ref.1. Source: UniProtKB
Molecular_function	structural constituent of eye lens Non-traceable author statement Ref.4Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 174

173

Gamma-crystallin A

PRO_0000057585

Regions

Domain

2 – 40

39

Beta/gamma crystallin 'Greek key' 1

Domain

41 – 83

43

Beta/gamma crystallin 'Greek key' 2

Domain

88 – 128

41

Beta/gamma crystallin 'Greek key' 3

Domain

129 – 171

43

Beta/gamma crystallin 'Greek key' 4

Region

84 – 87

4

Connecting peptide

Natural variations

Natural variant

148

1

P → L. Ref.1 Ref.5

VAR_021139

Secondary structure

1

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174

Helix Strand Turn

Details...

Beta strand

2 – 8

7

Helix

9 – 11

3

Beta strand

12 – 18

7

Turn

26 – 28

3

Beta strand

33 – 47

15

Turn

48 – 50

3

Beta strand

51 – 57

7

Beta strand

59 – 64

6

Helix

65 – 68

4

Beta strand

71 – 73

3

Beta strand

77 – 81

5

Beta strand

88 – 94

7

Turn

95 – 97

3

Beta strand

98 – 104

7

Helix

111 – 114

4

Beta strand

122 – 128

7

Beta strand

130 – 135

6

Turn

136 – 138

3

Beta strand

139 – 145

7

Beta strand

147 – 150

4

Helix

153 – 156

4

Beta strand

165 – 168

4

Sequences

	Sequence		Length	Mass (Da)
	P11844 [UniParc]. Last modified May 29, 2007. Version 3. Checksum: 99889A7641728090	FASTA	174	20,877
	10 20 30 40 50 60 MGKITFYEDR DFQGRCYNCI SDCPNLRVYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR 70 80 90 100 110 120 GKYPDYQHWM GLSDSVQSCR IIPHTSSHKL RLYERDDYRG LMSELTDDCA CVPELFRLPE 130 140 150 160 170 IYSLHVLEGC WVLYEMPNYR GRQYLLRPGD YRRYHDWGGA DAKVGSLRRV TDLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family." Meakin S.O., Du R.P., Tsui L.-C., Breitman M.L. Mol. Cell. Biol. 7:2671-2679(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-148.
[2]	"Human gammaA-crystallin." Wistow G. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lens.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins." Salim A., Zaidi Z.H. Biochem. Biophys. Res. Commun. 300:624-630(2003) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING.
[5]	"Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts." Santhiya S.T., Shyam Manohar M., Rawlley D., Vijayalakshmi P., Namperumalsamy P., Gopinath P.M., Loester J., Graw J. J. Med. Genet. 39:352-358(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LEU-148.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M17316, M17315 Genomic DNA. Translation: AAA52108.1.
EF426311 mRNA. Translation: ABO14696.1.
AC016697 Genomic DNA. Translation: AAX93220.1.

IPI

IPI00221079.

PIR

A26912.

RefSeq

NP_055432.2. NM_014617.3.

UniGene

Hs.122566.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1LER	model	-	A	1-174	[»]

ProteinModelPortal

P11844.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000302105.

PTM databases

PhosphoSite

P11844.

Polymorphism databases

DMDM

148887193.

Proteomic databases

PaxDb

P11844.

PRIDE

P11844.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000304502; ENSP00000302105; ENSG00000168582.

GeneID

1418.

KEGG

hsa:1418.

UCSC

uc002vcq.4. human.

Organism-specific databases

CTD

1418.

GeneCards

GC02M209025.

HGNC

HGNC:2408. CRYGA.

MIM

123660. gene.

neXtProt

NX_P11844.

PharmGKB

PA26915.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG321245.

HOGENOM

HOG000234389.

HOVERGEN

HBG003364.

InParanoid

P11844.

OMA

SCRAIPY.

OrthoDB

EOG4K9BD7.

PhylomeDB

P11844.

Gene expression databases

Bgee

P11844.

CleanEx

HS_CRYGA.

Genevestigator

P11844.

GermOnline

ENSG00000168582. Homo sapiens.

Family and domain databases

InterPro

IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]

Pfam

PF00030. Crystall. 2 hits.
[Graphical view]

PRINTS

PR01367. BGCRYSTALLIN.

SMART

SM00247. XTALbg. 2 hits.
[Graphical view]

SUPFAM

SSF49695. G_crystallin_SF. 1 hit.

PROSITE

PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

1418.

NextBio

5799.

SOURCE

Search...

Entry information

Entry name

CRGA_HUMAN

Accession

Primary (citable) accession number: P11844
Secondary accession number(s): Q53ST5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.