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Protein

Kappa-casein

Gene

CSN3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Enzyme and pathway databases

ReactomeiR-SSC-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:CSN3
Synonyms:CSN10, CSNK
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 188167Kappa-caseinPRO_0000004502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431O-linked (GalNAc...)By similarity
Glycosylationi148 – 1481O-linked (GalNAc...)By similarity
Modified residuei163 – 1631PhosphothreonineBy similarity
Modified residuei167 – 1671Phosphoserine; alternateBy similarity
Glycosylationi167 – 1671O-linked (GalNAc...); alternateBy similarity
Glycosylationi184 – 1841O-linked (GalNAc...)By similarity
Modified residuei185 – 1851PhosphoserineBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei117 – 1182Cleavage; by chymosin/renninBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP11841.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

GenevisibleiP11841. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009882.

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP11841.
KOiK17282.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSSFLIVP ILALTLPFLG AEEQNQEKLT RCESDKRLFN EEKVKYIPIY
60 70 80 90 100
YMLNRFPSYG FFYQHRSAVS PNRQFIPYPY YARPVVAGPH AQKPQWQDQP
110 120 130 140 150
NVYPPTVARR PRPHASFIAI PPKKNQDKTA IPAINSIATV EPTIVPATEP
160 170 180
IVNAEPIVNA VVTPEASSEF LITSAPETTT VQVTSPVV
Length:188
Mass (Da):21,122
Last modified:February 1, 1995 - v2
Checksum:i9B41E4BE19B5D36A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51977 mRNA. Translation: CAA36239.1.
PIRiA48382.
RefSeqiNP_001004026.1. NM_001004026.1.
UniGeneiSsc.81865.

Genome annotation databases

GeneIDi445511.
KEGGissc:445511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51977 mRNA. Translation: CAA36239.1.
PIRiA48382.
RefSeqiNP_001004026.1. NM_001004026.1.
UniGeneiSsc.81865.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009882.

Proteomic databases

PaxDbiP11841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445511.
KEGGissc:445511.

Organism-specific databases

CTDi1448.

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP11841.
KOiK17282.

Enzyme and pathway databases

ReactomeiR-SSC-5223345. Miscellaneous transport and binding events.

Gene expression databases

GenevisibleiP11841. SS.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of the porcine kappa-casein cDNA."
    Levine W.B., Alexander L.J., Hoganson G.E., Beattie C.W.
    Anim. Genet. 23:361-363(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary gland.
  2. "Primary structure of the casein macropeptide of porcine and human kappa caseins."
    Chobert J.-M., Mercier J.-C., Bahy C., Haze G.
    FEBS Lett. 72:173-178(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 118-188.

Entry informationi

Entry nameiCASK_PIG
AccessioniPrimary (citable) accession number: P11841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1995
Last modified: February 17, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.