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P11835

- ITB2_MOUSE

UniProt

P11835 - ITB2_MOUSE

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Protein
Integrin beta-2
Gene
Itgb2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi139 – 1391Calcium; via carbonyl oxygen By similarity
Metal bindingi142 – 1421Calcium By similarity
Metal bindingi143 – 1431Calcium By similarity
Metal bindingi348 – 3481Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. receptor activity Source: InterPro

GO - Biological processi

  1. activated T cell proliferation Source: MGI
  2. cell adhesion Source: MGI
  3. cell-matrix adhesion Source: InterPro
  4. cellular extravasation Source: MGI
  5. integrin-mediated signaling pathway Source: MGI
  6. multicellular organismal development Source: InterPro
  7. neutrophil chemotaxis Source: MGI
  8. single organismal cell-cell adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-2
Alternative name(s):
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
Complement receptor C3 subunit beta
CD_antigen: CD18
Gene namesi
Name:Itgb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96611. Itgb2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 702679Extracellular Reviewed prediction
Add
BLAST
Transmembranei703 – 72523Helical; Reviewed prediction
Add
BLAST
Topological domaini726 – 77146Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integrin complex Source: InterPro
  3. membrane Source: MGI
  4. membrane raft Source: MGI
  5. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323
Add
BLAST
Chaini24 – 771748Integrin beta-2
PRO_0000016342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid By similarity
Disulfide bondi26 ↔ 44 By similarity
Disulfide bondi34 ↔ 448 By similarity
Disulfide bondi37 ↔ 63 By similarity
Disulfide bondi47 ↔ 74 By similarity
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi192 ↔ 199 By similarity
Disulfide bondi247 ↔ 287 By similarity
Glycosylationi255 – 2551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi387 ↔ 401 By similarity
Disulfide bondi421 ↔ 446 By similarity
Disulfide bondi450 ↔ 468 By similarity
Disulfide bondi460 ↔ 471 By similarity
Disulfide bondi473 ↔ 482 By similarity
Disulfide bondi484 ↔ 515 By similarity
Disulfide bondi498 ↔ 513 By similarity
Glycosylationi502 – 5021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi507 ↔ 518 By similarity
Disulfide bondi520 ↔ 535 By similarity
Disulfide bondi537 ↔ 560 By similarity
Disulfide bondi542 ↔ 558 By similarity
Disulfide bondi550 ↔ 563 By similarity
Disulfide bondi565 ↔ 574 By similarity
Disulfide bondi576 ↔ 599 By similarity
Disulfide bondi583 ↔ 597 By similarity
Disulfide bondi591 ↔ 602 By similarity
Disulfide bondi604 ↔ 613 By similarity
Disulfide bondi616 ↔ 619 By similarity
Disulfide bondi623 ↔ 664 By similarity
Glycosylationi626 – 6261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi630 ↔ 649 By similarity
Disulfide bondi633 ↔ 645 By similarity
Glycosylationi644 – 6441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi672 ↔ 697 By similarity
Modified residuei747 – 7471Phosphoserine By similarity
Modified residuei758 – 7581Phosphoserine By similarity
Modified residuei760 – 7601Phosphothreonine By similarity
Modified residuei762 – 7621Phosphothreonine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP11835.
PaxDbiP11835.
PRIDEiP11835.

PTM databases

PhosphoSiteiP11835.

Expressioni

Gene expression databases

CleanExiMM_ITGB2.
GenevestigatoriP11835.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9 By similarity. Interacts with FGR.1 Publication

Protein-protein interaction databases

BioGridi200828. 1 interaction.
DIPiDIP-37428N.
IntActiP11835. 6 interactions.
MINTiMINT-1662243.

Structurei

3D structure databases

ProteinModelPortaliP11835.
SMRiP11835. Positions 24-698.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 364240VWFA
Add
BLAST
Repeati450 – 49748I
Add
BLAST
Repeati498 – 54144II
Add
BLAST
Repeati542 – 58241III
Add
BLAST
Repeati583 – 61836IV
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni450 – 618169Cysteine-rich tandem repeats
Add
BLAST

Sequence similaritiesi

Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP11835.
KOiK06464.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 3 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11835-1 [UniParc]FASTAAdd to Basket

« Hide

MLGLRPSLLL ALAGLFFLGS AVSQECTKYK VSSCRDCIQS GPGCSWCQKL    50
NFTGPGEPDS LRCDTRAQLL LKGCPADDIM DPRSIANPEF DQRGQRKQLS 100
PQKVTLYLRP GQAAAFNVTF RRAKGYPIDL YYLMDLSYSM LDDLNNVKKL 150
GGDLLQALNE ITESGRIGFG SFVDKTVLPF VNTHPEKLRN PCPNKEKACQ 200
PPFAFRHVLK LTDNSNQFQT EVGKQLISGN LDAPEGGLDA IMQVAACPEE 250
IGWRNVTRLL VFATDDGFHF AGDGKLGAIL TPNDGRCHLE DNMYKRSNEF 300
DYPSVGQLAH KLSESNIQPI FAVTKKMVKT YEKLTEIIPK SAVGELSDDS 350
SNVVQLIKNA YYKLSSRVFL DHSTLPDTLK VTYDSFCSNG ASSIGKSRGD 400
CDGVQINNPV TFQVKVMASE CIQEQSFVIR ALGFTDTVTV QVRPQCECQC 450
RDQSREQSLC GGKGVMECGI CRCESGYIGK NCECQTQGRS SQELERNCRK 500
DNSSIVCSGL GDCICGQCVC HTSDVPNKEI FGQYCECDNV NCERYNSQVC 550
GGSDRGSCNC GKCSCKPGYE GSACQCQRST TGCLNARLVE CSGRGHCQCN 600
RCICDEGYQP PMCEDCPSCG SHCRDNHTSC AECLKFDKGP FEKNCSVQCA 650
GMTLQTIPLK KKPCKERDSE GCWITYTLQQ KDGRNIYNIH VEDSLECVKG 700
PNVAAIVGGT VVGVVLIGVL LLVIWKALTH LTDLREYRRF EKEKLKSQWN 750
NDNPLFKSAT TTVMNPKFAE S 771
Length:771
Mass (Da):85,026
Last modified:July 15, 1998 - v2
Checksum:i6FA51DA93AB40D8A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 63LRP → PH in CAA33077. 1 Publication
Sequence conflicti449 – 4491Q → H in AAA39325. 1 Publication
Sequence conflicti667 – 6671R → K in AAA39325. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14951 mRNA. Translation: CAA33077.1.
M31039 mRNA. Translation: AAA39325.1.
PIRiA45839.
S04847.
RefSeqiNP_032430.2. NM_008404.4.
UniGeneiMm.1137.

Genome annotation databases

GeneIDi16414.
KEGGimmu:16414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14951 mRNA. Translation: CAA33077.1 .
M31039 mRNA. Translation: AAA39325.1 .
PIRi A45839.
S04847.
RefSeqi NP_032430.2. NM_008404.4.
UniGenei Mm.1137.

3D structure databases

ProteinModelPortali P11835.
SMRi P11835. Positions 24-698.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200828. 1 interaction.
DIPi DIP-37428N.
IntActi P11835. 6 interactions.
MINTi MINT-1662243.

Chemistry

BindingDBi P11835.

PTM databases

PhosphoSitei P11835.

Proteomic databases

MaxQBi P11835.
PaxDbi P11835.
PRIDEi P11835.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 16414.
KEGGi mmu:16414.

Organism-specific databases

CTDi 3689.
MGIi MGI:96611. Itgb2.

Phylogenomic databases

eggNOGi NOG287997.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P11835.
KOi K06464.

Miscellaneous databases

NextBioi 289605.
PROi P11835.
SOURCEi Search...

Gene expression databases

CleanExi MM_ITGB2.
Genevestigatori P11835.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
Pfami PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 3 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the cDNA from the mouse leukocyte adhesion protein CD18."
    Wilson R.W., O'Brien W.E., Beaudet A.L.
    Nucleic Acids Res. 17:5397-5397(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Thymus.
  2. "Mouse macrophage beta subunit (CD11b) cDNA for the CR3 complement receptor/Mac-1 antigen."
    Zeger D.L., Osman N., Hennings M., McKenzie I.F., Sears D.W., Hogarth P.M.
    Immunogenetics 31:191-197(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Mouse macrophage beta subunit (CD11b) cDNA for the CR3 complement receptor/Mac-1 antigen."
    Kofler R.
    Immunogenetics 33:77-77(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO N-TERMINUS.
  4. "Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins."
    Xu J., Gao X.-P., Ramchandran R., Zhao Y.-Y., Vogel S.M., Malik A.B.
    Nat. Immunol. 9:880-886(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION DURING LUNG INJURY.
  5. "c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration."
    Baruzzi A., Iacobucci I., Soverini S., Lowell C.A., Martinelli G., Berton G.
    FEBS Lett. 584:15-21(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FGR.

Entry informationi

Entry nameiITB2_MOUSE
AccessioniPrimary (citable) accession number: P11835
Secondary accession number(s): Q64482
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi