P11830 (ACP_SACEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl carrier protein
Short name=ACP

Gene names

Name:

acpP

Organism

Saccharopolyspora erythraea (strain NRRL 23338)

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis. HAMAP MF_01217
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01217
Subcellular location	Cytoplasm By similarity HAMAP MF_01217.
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group. HAMAP MF_01217
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Phosphopantetheine
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 95	95	Acyl carrier protein HAMAP MF_01217		PRO_0000180181
Amino acid modifications
	Modified residue	39	1	O-(pantetheine 4'-phosphoryl)serine HAMAP MF_01217

Sequences

	Sequence		Length	Mass (Da)
	P11830 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: A2D1C4ADC2D94898	FASTA	95	10,423
	10 20 30 40 50 60 MDRKEIFERI EQVLAEQLGI PAEQITEEAD LREDLGMDSL DLVELVSALE DEVGMRVEQS 70 80 90 QLEGIETVGH VMELTLDLVA RLATASAADK PEAAS

References

[1]	"Cloning, characterization, and high-level expression in Escherichia coli of the Saccharopolyspora erythraea gene encoding an acyl carrier protein potentially involved in fatty acid biosynthesis." Revill W.P., Leadlay P.F. J. Bacteriol. 173:4379-4385(1991) [PubMed: 2066335] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"A small, discrete acyl carrier protein is involved in de novo fatty acid biosynthesis in Streptomyces erythraeus." Hale R.S., Jordan K.N., Leadlay P.F. FEBS Lett. 224:133-136(1987) [PubMed: 3315744] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-46.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64477 Genomic DNA. Translation: AAA26476.1.
PIR	A47030.
RefSeq	YP_001106326.1. NC_009142.1.
3D structure databases
ProteinModelPortal	P11830.
ModBase	Search...
Protein-protein interaction databases
STRING	P11830.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4943951.
PATRIC	23415708. VBISacEry28377_4148.
Phylogenomic databases
OMA	TINCSED.
Family and domain databases
HAMAP	MF_01217. Acyl_carrier. [Tree]
InterPro	IPR003231. Acyl_carrier. IPR009081. Acyl_carrier_prot-like. IPR006163. Phsphopanteth-bd. IPR006162. PPantetheine_attach_site. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 1 hit.
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
ProDom	PD000887. PD000887. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47336. ACP_like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACP_SACEN

Accession

Primary (citable) accession number: P11830

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program