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Protein

Ornithine carbamoyltransferase, mitochondrial

Gene

argB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase, mitochondrial (argB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381Carbamoyl phosphateBy similarity
Binding sitei138 – 1381OrnithineBy similarity
Binding sitei165 – 1651Carbamoyl phosphateBy similarity
Binding sitei205 – 2051OrnithineBy similarity
Active sitei313 – 3131By similarity
Binding sitei340 – 3401Carbamoyl phosphateBy similarity
Binding sitei340 – 3401OrnithineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase, mitochondrial (EC:2.1.3.3)
Alternative name(s):
Ornithine transcarbamylase
Short name:
OTCase
Gene namesi
Name:argB
ORF Names:AN4409
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome III
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionSequence analysisAdd
BLAST
Chaini25 – 359335Ornithine carbamoyltransferase, mitochondrialPRO_0000042694Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Structurei

3D structure databases

ProteinModelPortaliP11803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni87 – 915Ornithine and carbamoyl phosphate bindingBy similarity
Regioni165 – 1684Ornithine and carbamoyl phosphate bindingBy similarity
Regioni271 – 2755Ornithine bindingBy similarity
Regioni312 – 3154Ornithine bindingBy similarity

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000022686.
InParanoidiP11803.
KOiK00611.
OrthoDBiEOG092C3SF9.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLRSVLKS QSLRHTVRSY SSQTMPPASP FAPRHFLSIA DLSPSEFATL
60 70 80 90 100
VRNASSHKRA IKSGSMPQNL QGSLLGKTVA MIFSKRSTRT RVSTEGAVVQ
110 120 130 140 150
MGGHPMFLGK DDIQLGVNES LYDTSVVISS MVSCIVARVG KHAEVADLAK
160 170 180 190 200
HSSVPVINAL CDSFHPLQAV ADFQTIYEAF TPKAHHLSSL GLEGLKIAWV
210 220 230 240 250
GDANNVLFDM AIAATKMGVD IAVATPKGYE IPPHMLELIK SAGEGVSKPG
260 270 280 290 300
KLLQTNIPEE AVKDADILVT DTWVSMGQEE EKAQRLKEFD GFQITAELAK
310 320 330 340 350
RGGAKEGWKF MHCLPRHPEE VSDEVFYSNR SLVFPEAENR LWAAISALEG

FVVNKGKIE
Length:359
Mass (Da):39,058
Last modified:October 1, 1989 - v1
Checksum:i6B2CBD7BC276F2C4
GO

Sequence cautioni

The sequence CBF77586 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29819 mRNA. Translation: AAA50816.1.
AACD01000076 Genomic DNA. Translation: EAA60326.1.
BN001303 Genomic DNA. Translation: CBF77586.1. Different initiation.
PIRiS07317. OWASN.
RefSeqiXP_662013.1. XM_656921.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006048; CADANIAP00006048; CADANIAG00006048.
EAA60326; EAA60326; AN4409.2.
GeneIDi2872211.
KEGGiani:AN4409.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29819 mRNA. Translation: AAA50816.1.
AACD01000076 Genomic DNA. Translation: EAA60326.1.
BN001303 Genomic DNA. Translation: CBF77586.1. Different initiation.
PIRiS07317. OWASN.
RefSeqiXP_662013.1. XM_656921.1.

3D structure databases

ProteinModelPortaliP11803.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00006048; CADANIAP00006048; CADANIAG00006048.
EAA60326; EAA60326; AN4409.2.
GeneIDi2872211.
KEGGiani:AN4409.2.

Phylogenomic databases

HOGENOMiHOG000022686.
InParanoidiP11803.
KOiK00611.
OrthoDBiEOG092C3SF9.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTC_EMENI
AccessioniPrimary (citable) accession number: P11803
Secondary accession number(s): C8V8T3, Q5B4X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.