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P11799

- MYLK_CHICK

UniProt

P11799 - MYLK_CHICK

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Protein

Myosin light chain kinase, smooth muscle

Gene
Mylk
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals.

Catalytic activityi

ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.

Cofactori

Magnesium By similarity.
Calcium By similarity.

Enzyme regulationi

Activated by phosphorylation on Tyr-478. Isoforms which lack this tyrosine residue are not regulated in this way. All catalytically active isoforms require binding to calcium and calmodulin for activation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1482 – 14821ATP By similarity
Active sitei1574 – 15741Proton acceptor

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1459 – 14679ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. myosin light chain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.18. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain kinase, smooth muscle (EC:2.7.11.18)
Short name:
MLCK
Alternative name(s):
Telokin
Cleaved into the following chain:
Gene namesi
Name:Mylk
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasmcytosol. Membrane
Note: Telokin is cytosolic and can translocate to the membrane upon stimulation.1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1762 – 17621S → A: Decreases membrane translocation. 1 Publication
Mutagenesisi1768 – 17681S → A: Decreases membrane translocation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19061906Myosin light chain kinase, smooth musclePRO_0000024361Add
BLAST
Chaini1 – 19011901Myosin light chain kinase, smooth muscle, deglutamylated formPRO_0000424867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei478 – 4781Phosphotyrosine
Modified residuei1748 – 17481Phosphoserine
Modified residuei1762 – 17621Phosphoserine; by PKG1 Publication
Modified residuei1768 – 17681Phosphoserine; by MAPK Inferred

Post-translational modificationi

The C-terminus is deglutamylated, leading to the formation of Myosin light chain kinase, smooth muscle, deglutamylated form. The C-terminus is variable, with one to five C-terminal glutamyl residues being removed producing five forms differring in their number of C-terminal glutamyl residues.
Acetylated.1 Publication
Phosphorylation of telokin by PKG has no significant effect on its myosin binding activity, but promotes translocation to the membrane.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11799.
PRIDEiP11799.

Expressioni

Tissue specificityi

Isoform telokin is expressed in gizzard, heart, lung, intestine, and skeletal muscle although the levels of the expression in the latter were much less than that in the gizzard.

Interactioni

Subunit structurei

All isoforms including Telokin bind calmodulin.

Protein-protein interaction databases

BioGridi676694. 1 interaction.
IntActiP11799. 3 interactions.

Structurei

Secondary structure

1
1906
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1731 – 174717

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CDLX-ray2.00E/F/G/H1730-1749[»]
1QS7X-ray1.80B/D1731-1749[»]
1QTXX-ray1.65B1731-1749[»]
1VRKX-ray1.90B1731-1749[»]
2O5GX-ray1.08B1730-1748[»]
3EVUX-ray1.75A1731-1749[»]
3EVVX-ray2.60A1731-1749[»]
3O77X-ray2.35A1730-1749[»]
3O78X-ray2.60A/B1730-1749[»]
ProteinModelPortaliP11799.
SMRiP11799. Positions 525-614, 1221-1325, 1448-1716, 1785-1887.

Miscellaneous databases

EvolutionaryTraceiP11799.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 11790Ig-like C2-type 1Add
BLAST
Domaini156 – 24489Ig-like C2-type 2Add
BLAST
Domaini429 – 51789Ig-like C2-type 3Add
BLAST
Domaini521 – 61393Ig-like C2-type 4Add
BLAST
Domaini637 – 72589Ig-like C2-type 5Add
BLAST
Repeati660 – 67617IIA-1Add
BLAST
Repeati693 – 70816IIB-1Add
BLAST
Domaini735 – 83096Ig-like C2-type 6Add
BLAST
Repeati758 – 77417IIA-2Add
BLAST
Repeati791 – 80717IIB-2Add
BLAST
Repeati970 – 98718III-1Add
BLAST
Repeati999 – 101618III-2Add
BLAST
Repeati1061 – 107818III-3Add
BLAST
Domaini1084 – 117289Ig-like C2-type 7Add
BLAST
Repeati1107 – 112317IIA-3Add
BLAST
Repeati1140 – 115617IIB-3Add
BLAST
Repeati1209 – 122618III-4Add
BLAST
Domaini1225 – 131389Ig-like C2-type 8Add
BLAST
Repeati1281 – 129717IIB-4Add
BLAST
Domaini1321 – 141494Fibronectin type-IIIAdd
BLAST
Domaini1453 – 1708256Protein kinaseAdd
BLAST
Domaini1794 – 188592Ig-like C2-type 9Add
BLAST
Repeati1817 – 183317IIA-4Add
BLAST
Repeati1851 – 186616IIB-5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni660 – 183311744 X repeats, motif IIAAdd
BLAST
Regioni693 – 186611745 X repeats, motif IIBAdd
BLAST
Regioni970 – 12262574 X repeats, motif IIIAdd
BLAST
Regioni1317 – 136448Motif IAAdd
BLAST
Regioni1385 – 140218Motif IBAdd
BLAST
Regioni1700 – 176364Calmodulin-bindingAdd
BLAST
Regioni1716 – 172813Calmodulin autoinhibition (AM13) region Reviewed predictionAdd
BLAST
Regioni1730 – 174920Calmodulin recognition (RS20) region Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1896 – 190611Poly-GluAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000049287.
HOVERGENiHBG052551.
InParanoidiP11799.
KOiK00907.
PhylomeDBiP11799.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR020675. Myosin_light_ch_kinase-rel.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015725. Telokin/Myosin_light_ch_kin.
[Graphical view]
PANTHERiPTHR22964. PTHR22964. 1 hit.
PTHR22964:SF44. PTHR22964:SF44. 1 hit.
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 9 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative initiation. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P11799-1) [UniParc]FASTAAdd to Basket

Also known as: MLCK-108, Smooth-muscle

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGDVKLVTST RVSKTSLTLS PSVPAEAPAF TLPPRNIRVQ LGATARFEGK     50
VRGYPEPQIT WYRNGHPLPE GDHYVVDHSI RGIFSLVIKG VQEGDSGKYT 100
CEAANDGGVR QVTVELTVEG NSLKKYSLPS SAKTPGGRLS VPPVEHRPSI 150
WGESPPKFAT KPNRVVVREG QTGRFSCKIT GRPQPQVTWT KGDIHLQQNE 200
RFNMFEKTGI QYLEIQNVQL ADAGIYTCTV VNSAGKASVS AELTVQGPDK 250
TDTHAQPLCM PPKPTTLATK AIENSDFKQA TSNGIAKELK STSTELMVET 300
KDRLSAKKET FYTSREAKDG KQGQNQEANA VPLQESRGTK GPQVLQKTSS 350
TITLQAVKAQ PEPKAEPQTT FIRQAEDRKR TVQPLMTTTT QENPSLTGQV 400
SPRSRETENR AGVRKSVKEE KREPLGIPPQ FESRPQSLEA SEGQEIKFKS 450
KVSGKPKPDV EWFKEGVPIK TGEGIQIYEE DGTHCLWLKK ACLGDSGSYS 500
CAAFNPRGQT STSWLLTVKR PKVEEVAPCF SSVLKGCTVS EGQDFVLQCY 550
VGGVPVPEIT WLLNEQPIQY AHSTFEAGVA KLTVQDALPE DDGIYTCLAE 600
NNAGRASCSA QVTVKEKKSS KKAEGTQAAK LNKTFAPIFL KGLTDLKVMD 650
GSQVIMTVEV SANPCPEIIW LHNGKEIQET EDFHFEKKGN EYSLYIQEVF 700
PEDTGKYTCE AWNELGETQT QATLTVQEPQ DGIQPWFISK PRSVTAAAGQ 750
NVLISCAIAG DPFPTVHWFK DGQEITPGTG CEILQNEDIF TLILRNVQSR 800
HAGQYEIQLR NQVGECSCQV SLMLRESSAS RAEMLRDGRE SASSGERRDG 850
GNYGALTFGR TSGFKKSSSE TRAAEEEQED VRGVLKRRVE TREHTEESLR 900
QQEAEQLDFR DILGKKVSTK SFSEEDLKEI PAEQMDFRAN LQRQVKPKTL 950
SEEERKVHAP QQVDFRSVLA KKGTPKTPLP EKVPPPKPAV TDFRSVLGAK 1000
KKPPAENGSA STPAPNARAG SEAQNATPNS EAPAPKPVVK KEEKNDRKCE 1050
HGCAVVDGGI IGKKAENKPA ASKPTPPPSK GTAPSFTEKL QDAKVADGEK 1100
LVLQCRISSD PPASVSWTLD SKAIKSSKSI VISQEGTLCS LTIEKVMPED 1150
GGEYKCIAEN AAGKAECACK VLVEDTSSTK AAKPAEKKTK KPKTTLPPVL 1200
STESSEATVK KKPAPKTPPK AATPPQITQF PEDRKVRAGE SVELFAKVVG 1250
TAPITCTWMK FRKQIQENEY IKIENAENSS KLTISSTKQE HCGCYTLVVE 1300
NKLGSRQAQV NLTVVDKPDP PAGTPCASDI RSSSLTLSWY GSSYDGGSAV 1350
QSYTVEIWNS VDNKWTDLTT CRSTSFNVQD LQADREYKFR VRAANVYGIS 1400
EPSQESEVVK VGEKQEEELK EEEAELSDDE GKETEVNYRT VTINTEQKVS 1450
DVYNIEERLG SGKFGQVFRL VEKKTGKVWA GKFFKAYSAK EKENIRDEIS 1500
IMNCLHHPKL VQCVDAFEEK ANIVMVLEMV SGGELFERII DEDFELTERE 1550
CIKYMRQISE GVEYIHKQGI VHLDLKPENI MCVNKTGTSI KLIDFGLARR 1600
LESAGSLKVL FGTPEFVAPE VINYEPIGYE TDMWSIGVIC YILVSGLSPF 1650
MGDNDNETLA NVTSATWDFD DEAFDEISDD AKDFISNLLK KDMKSRLNCT 1700
QCLQHPWLQK DTKNMEAKKL SKDRMKKYMA RRKWQKTGHA VRAIGRLSSM 1750
AMISGMSGRK ASGSSPTSPI NADKVENEDA FLEEVAEEKP HVKPYFTKTI 1800
LDMEVVEGSA ARFDCKIEGY PDPEVMWYKD DQPVKESRHF QIDYDEEGNC 1850
SLTISEVCGD DDAKYTCKAV NSLGEATCTA ELLVETMGKE GEGEGEGEED 1900
EEEEEE 1906
Length:1,906
Mass (Da):210,446
Last modified:July 15, 1998 - v2
Checksum:iAD7D8A3B69EE3363
GO
Isoform 2 (identifier: P11799-2) [UniParc]FASTAAdd to Basket

Also known as: MLCK-210, Non-muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-934: Missing.

Show »
Length:972
Mass (Da):107,547
Checksum:i375ED3627731EFFE
GO
Isoform 3 (identifier: P11799-3) [UniParc]FASTAAdd to Basket

Also known as: Telokin

The sequence of this isoform differs from the canonical sequence as follows:
     1-1749: Missing.

Show »
Length:157
Mass (Da):17,337
Checksum:i557E7CD96C672E7D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 17491749Missing in isoform 3. VSP_018852Add
BLAST
Alternative sequencei1 – 934934Missing in isoform 2. VSP_018851Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1439 – 14391R → Q in AAA49069. 1 Publication
Sequence conflicti1439 – 14391R → Q in AAA69964. 1 Publication
Sequence conflicti1776 – 17761E → D AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52876 mRNA. Translation: CAA37056.1.
X52876 mRNA. Translation: CAA37057.1.
X52876 mRNA. Translation: CAA37058.1.
M31048 mRNA. Translation: AAA49069.1.
M14953 mRNA. Translation: AAA69964.1.
AF045285
, AF045255, AF045256, AF045257, AF045260, AF045259, AF045258, AF045261, AF045263, AF045265, AF045274, AF045273, AF045272, AF045271, AF045270, AF045269, AF045268, AF045267, AF045266, AF045283, AF045282, AF045281, AF045280, AF045279, AF045278, AF045277, AF045276, AF045275, AF045284, AF045264, AF045262 Genomic DNA. Translation: AAC29031.1.
M96655 mRNA. Translation: AAA49083.1.
M88283 mRNA. Translation: AAA48647.1.
M88284 Genomic DNA. Translation: AAB53768.1.
PIRiS68235.
RefSeqiNP_990790.1. NM_205459.2. [P11799-1]
UniGeneiGga.4091.

Genome annotation databases

GeneIDi396445.
KEGGigga:396445.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52876 mRNA. Translation: CAA37056.1 .
X52876 mRNA. Translation: CAA37057.1 .
X52876 mRNA. Translation: CAA37058.1 .
M31048 mRNA. Translation: AAA49069.1 .
M14953 mRNA. Translation: AAA69964.1 .
AF045285
, AF045255 , AF045256 , AF045257 , AF045260 , AF045259 , AF045258 , AF045261 , AF045263 , AF045265 , AF045274 , AF045273 , AF045272 , AF045271 , AF045270 , AF045269 , AF045268 , AF045267 , AF045266 , AF045283 , AF045282 , AF045281 , AF045280 , AF045279 , AF045278 , AF045277 , AF045276 , AF045275 , AF045284 , AF045264 , AF045262 Genomic DNA. Translation: AAC29031.1 .
M96655 mRNA. Translation: AAA49083.1 .
M88283 mRNA. Translation: AAA48647.1 .
M88284 Genomic DNA. Translation: AAB53768.1 .
PIRi S68235.
RefSeqi NP_990790.1. NM_205459.2. [P11799-1 ]
UniGenei Gga.4091.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CDL X-ray 2.00 E/F/G/H 1730-1749 [» ]
1QS7 X-ray 1.80 B/D 1731-1749 [» ]
1QTX X-ray 1.65 B 1731-1749 [» ]
1VRK X-ray 1.90 B 1731-1749 [» ]
2O5G X-ray 1.08 B 1730-1748 [» ]
3EVU X-ray 1.75 A 1731-1749 [» ]
3EVV X-ray 2.60 A 1731-1749 [» ]
3O77 X-ray 2.35 A 1730-1749 [» ]
3O78 X-ray 2.60 A/B 1730-1749 [» ]
ProteinModelPortali P11799.
SMRi P11799. Positions 525-614, 1221-1325, 1448-1716, 1785-1887.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676694. 1 interaction.
IntActi P11799. 3 interactions.

Chemistry

BindingDBi P11799.
ChEMBLi CHEMBL3062.

Proteomic databases

PaxDbi P11799.
PRIDEi P11799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396445.
KEGGi gga:396445.

Organism-specific databases

CTDi 4638.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000049287.
HOVERGENi HBG052551.
InParanoidi P11799.
KOi K00907.
PhylomeDBi P11799.

Enzyme and pathway databases

BRENDAi 2.7.11.18. 1306.

Miscellaneous databases

EvolutionaryTracei P11799.
NextBioi 20816486.
PROi P11799.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR020675. Myosin_light_ch_kinase-rel.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015725. Telokin/Myosin_light_ch_kin.
[Graphical view ]
PANTHERi PTHR22964. PTHR22964. 1 hit.
PTHR22964:SF44. PTHR22964:SF44. 1 hit.
Pfami PF00041. fn3. 1 hit.
PF07679. I-set. 9 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple gene products are produced from a novel protein kinase transcription region."
    Watterson D.M., Collinge M., Lukas T.J., van Eldik L.J., Birukov K.G., Stepanova O.V., Shirinsky V.P.
    FEBS Lett. 373:217-220(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Regulatory and structural motifs of chicken gizzard myosin light chain kinase."
    Olson N.J., Pearson R.B., Needleman D.S., Hurwitz M.J., Kemp B.E., Means A.R.
    Proc. Natl. Acad. Sci. U.S.A. 87:2284-2288(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The organization of the genetic locus for chicken myosin light chain kinase is complex: multiple proteins are encoded and exhibit differential expression and localization."
    Birukov K.G., Schavocky J.P., Shirinsky V.P., Van Eldik L.J., Watterson D.M.
    J. Cell. Biochem. 70:402-413(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  4. "Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity."
    Shoemaker M.O., Lau W., Shattuck R.L., Kwiatkowski A.P., Matrisian P.E., Guerra-Santos L., Wilson E., Lukas T.J., van Eldik L.J., Watterson D.M.
    J. Cell Biol. 111:1107-1125(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 649-1906, PARTIAL PROTEIN SEQUENCE.
    Tissue: Fibroblast.
  5. "Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA."
    Guerriero V. Jr., Russo M.A., Olson N.J., Putkey J.A., Means A.R.
    Biochemistry 25:8372-8381(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1259-1906.
    Tissue: Gizzard.
  6. "Molecular cloning of the chicken gizzard telokin gene and cDNA."
    Yoshikai S., Ikebe M.
    Arch. Biochem. Biophys. 299:242-247(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1750-1906 (ISOFORM 3).
    Tissue: Gizzard.
  7. "Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene."
    Collinge M., Matrisian P.E., Zimmer W.E., Shattuck R.L., Lukas T.J., van Eldik L.J., Watterson D.M.
    Mol. Cell. Biol. 12:2359-2371(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1750-1906 (ISOFORM 3).
  8. "Characterization of the chicken telokin heterogeneity by time-of-flight mass spectrometry."
    Rusconi F., Potier M.C., Le Caer J.P., Schmitter J.M., Rossier J.
    Biochemistry 36:11021-11026(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1775-1789, ACETYLATION, DEGLUTAMYLATION, PHOSPHORYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Translocation of telokin by cGMP signaling in smooth muscle cells."
    Komatsu S., Miyazaki K., Tuft R.A., Ikebe M.
    Am. J. Physiol. 283:C752-C761(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-1762 AND SER-1768, MUTAGENESIS OF SER-1762 AND SER-1768.
  10. "Analysis of the functional coupling between calmodulin's calcium binding and peptide recognition properties."
    Mirzoeva S., Weigand S., Lukas T.J., Shuvalova L., Anderson W.F., Watterson D.M.
    Biochemistry 38:3936-3947(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1731-1749 IN COMPLEX WITH CALM1 AND CALCIUM.

Entry informationi

Entry nameiMYLK_CHICK
AccessioniPrimary (citable) accession number: P11799
Secondary accession number(s): P19038, Q549S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi