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Protein

Chitinase B

Gene

chiB

Organism
Serratia marcescens
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei144Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17689.
BRENDAi3.2.1.14. 5690.
SABIO-RKP11797.

Protein family/group databases

CAZyiCBM5. Carbohydrate-Binding Module Family 5.
GH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase B (EC:3.2.1.14)
Gene namesi
Name:chiB
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Add BLAST41
ChainiPRO_000001190942 – 499Chitinase BAdd BLAST458

Interactioni

Chemistry databases

BindingDBiP11797.

Structurei

Secondary structure

1499
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Helixi15 – 19Combined sources5
Turni26 – 28Combined sources3
Helixi33 – 35Combined sources3
Helixi38 – 43Combined sources6
Beta strandi45 – 54Combined sources10
Beta strandi58 – 61Combined sources4
Helixi68 – 80Combined sources13
Helixi81 – 84Combined sources4
Beta strandi89 – 95Combined sources7
Helixi97 – 100Combined sources4
Beta strandi104 – 106Combined sources3
Helixi107 – 113Combined sources7
Helixi117 – 134Combined sources18
Beta strandi137 – 142Combined sources6
Helixi148 – 171Combined sources24
Beta strandi180 – 188Combined sources9
Helixi189 – 192Combined sources4
Turni193 – 195Combined sources3
Helixi196 – 198Combined sources3
Helixi199 – 203Combined sources5
Beta strandi207 – 212Combined sources6
Beta strandi221 – 223Combined sources3
Beta strandi230 – 232Combined sources3
Helixi242 – 245Combined sources4
Helixi252 – 258Combined sources7
Beta strandi261 – 263Combined sources3
Helixi267 – 275Combined sources9
Helixi282 – 284Combined sources3
Beta strandi285 – 298Combined sources14
Beta strandi301 – 303Combined sources3
Turni304 – 307Combined sources4
Beta strandi315 – 317Combined sources3
Beta strandi319 – 321Combined sources3
Helixi329 – 334Combined sources6
Beta strandi339 – 341Combined sources3
Helixi342 – 350Combined sources9
Beta strandi353 – 360Combined sources8
Turni361 – 364Combined sources4
Beta strandi365 – 370Combined sources6
Turni371 – 374Combined sources4
Beta strandi375 – 378Combined sources4
Helixi382 – 394Combined sources13
Beta strandi399 – 403Combined sources5
Helixi405 – 407Combined sources3
Helixi413 – 423Combined sources11
Helixi445 – 447Combined sources3
Beta strandi467 – 470Combined sources4
Beta strandi473 – 480Combined sources8
Turni486 – 488Combined sources3
Beta strandi492 – 497Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E6NX-ray2.25A/B1-497[»]
1GOIX-ray1.45A/B1-497[»]
1H0GX-ray2.00A/B1-497[»]
1H0IX-ray2.00A/B1-497[»]
1O6IX-ray1.70A/B1-497[»]
1OGBX-ray1.85A/B1-497[»]
1OGGX-ray1.97A/B1-497[»]
3WD0X-ray1.70A2-499[»]
3WD1X-ray2.30A2-499[»]
3WD2X-ray2.20A2-499[»]
3WD3X-ray2.20A2-499[»]
3WD4X-ray2.00A2-499[»]
4Z2GX-ray2.60A2-499[»]
4Z2HX-ray2.35A2-499[»]
4Z2IX-ray2.00A2-499[»]
4Z2JX-ray2.60A2-499[»]
4Z2KX-ray2.30A2-499[»]
4Z2LX-ray2.30A2-499[»]
ProteinModelPortaliP11797.
SMRiP11797.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11797.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini438 – 498Chitin-binding type-3Add BLAST61

Sequence similaritiesi

Contains 1 chitin-binding type-3 domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.10.10.20. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR003610. CBM_fam5/12.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00495. ChtBD3. 1 hit.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51055. SSF51055. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiPS01095. CHITINASE_18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRKAVIGY YFIPTNQINN YTETDTSVVP FPVSNITPAK AKQLTHINFS
60 70 80 90 100
FLDINSNLEC AWDPATNDAK ARDVVNRLTA LKAHNPSLRI MFSIGGWYYS
110 120 130 140 150
NDLGVSHANY VNAVKTPAAR TKFAQSCVRI MKDYGFDGVD IDWEYPQAAE
160 170 180 190 200
VDGFIAALQE IRTLLNQQTI ADGRQALPYQ LTIAGAGGAF FLSRYYSKLA
210 220 230 240 250
QIVAPLDYIN LMTYDLAGPW EKITNHQAAL FGDAAGPTFY NALREANLGW
260 270 280 290 300
SWEELTRAFP SPFSLTVDAA VQQHLMMEGV PSAKIVMGVP FYGRAFKGVS
310 320 330 340 350
GGNGGQYSSH STPGEDPYPN ADYWLVGCDE CVRDKDPRIA SYRQLEQMLQ
360 370 380 390 400
GNYGYQRLWN DKTKTPYLYH AQNGLFVTYD DAESFKYKAK YIKQQQLGGV
410 420 430 440 450
MFWHLGQDNR NGDLLAALDR YFNAADYDDS QLDMGTGLRY TGVGPGNLPI
460 470 480 490
MTAPAYVPGT TYAQGALVSY QGYVWQTKWG YITSAPGSDS AWLKVGRLA
Length:499
Mass (Da):55,464
Last modified:October 1, 1989 - v1
Checksum:iFFD674916109D1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15208 Genomic DNA. Translation: CAA33278.1.
AB015997 Genomic DNA. Translation: BAA31568.1.
PIRiS04856.
RefSeqiWP_016926761.1. NZ_KN050642.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15208 Genomic DNA. Translation: CAA33278.1.
AB015997 Genomic DNA. Translation: BAA31568.1.
PIRiS04856.
RefSeqiWP_016926761.1. NZ_KN050642.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E6NX-ray2.25A/B1-497[»]
1GOIX-ray1.45A/B1-497[»]
1H0GX-ray2.00A/B1-497[»]
1H0IX-ray2.00A/B1-497[»]
1O6IX-ray1.70A/B1-497[»]
1OGBX-ray1.85A/B1-497[»]
1OGGX-ray1.97A/B1-497[»]
3WD0X-ray1.70A2-499[»]
3WD1X-ray2.30A2-499[»]
3WD2X-ray2.20A2-499[»]
3WD3X-ray2.20A2-499[»]
3WD4X-ray2.00A2-499[»]
4Z2GX-ray2.60A2-499[»]
4Z2HX-ray2.35A2-499[»]
4Z2IX-ray2.00A2-499[»]
4Z2JX-ray2.60A2-499[»]
4Z2KX-ray2.30A2-499[»]
4Z2LX-ray2.30A2-499[»]
ProteinModelPortaliP11797.
SMRiP11797.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP11797.
ChEMBLiCHEMBL5348.

Protein family/group databases

CAZyiCBM5. Carbohydrate-Binding Module Family 5.
GH18. Glycoside Hydrolase Family 18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17689.
BRENDAi3.2.1.14. 5690.
SABIO-RKP11797.

Miscellaneous databases

EvolutionaryTraceiP11797.

Family and domain databases

Gene3Di2.10.10.20. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR003610. CBM_fam5/12.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00495. ChtBD3. 1 hit.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51055. SSF51055. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiPS01095. CHITINASE_18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHIB_SERMA
AccessioniPrimary (citable) accession number: P11797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.