P11796 (SODM_NICPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn], mitochondrial
EC=1.15.1.1

Gene names

Name:

SODA

Organism

Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)

Taxonomic identifier

4092 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 manganese ion per subunit By similarity.
Subunit structure	Homotetramer.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Manganese Metal-binding
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial matrix Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 24	24	Mitochondrion Ref.2
	Chain	25 – 228	204	Superoxide dismutase [Mn], mitochondrial		PRO_0000032899
Sites
	Metal binding	52	1	Manganese By similarity
	Metal binding	100	1	Manganese By similarity
	Metal binding	189	1	Manganese By similarity
	Metal binding	193	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	P11796 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 9F4D75B2ADDAD7F6	FASTA	228	25,504
	10 20 30 40 50 60 MALRTLVSRR TLATGLGFRQ QLRGLQTFSL PDLPYDYGAL EPAISGDIMQ LHHQNHHQTY 70 80 90 100 110 120 VTNYNKALEQ LHDAISKGDA PTVAKLHSAI KFNGGGHINH SIFWKNLAPV REGGGEPPKG 130 140 150 160 170 180 SLGWAIDTNF GSLEALVQKM NAEGAALQGS GWVWLGVDKE LKRLVIETTA NQDPLVSKGA 190 200 210 220 NLVPLLGIDV WEHAYYLQYK NVRPDYLKNI WKVMNWKYAN EVYEKECP

References

[1]	"The induction of manganese superoxide dismutase in response to stress in Nicotiana plumbaginifolia." Bowler C., Alliotte T., de Loose M., van Montagu M., Inze D. EMBO J. 8:31-38(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. P2.
[2]	"Alterations in the phenotype of plant cells studied by NH2-terminal amino acid-sequence analysis of proteins electroblotted from two-dimensional gel-separated total extracts." Bauw G., de Loose M., Inze D., van Montagu M., Vandekerckhove J. Proc. Natl. Acad. Sci. U.S.A. 84:4806-4810(1987) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-47.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14482 mRNA. Translation: CAA32643.1.
PIR	I28027. S03639.
3D structure databases
ProteinModelPortal	P11796.
SMR	P11796. Positions 27-225.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001189. Mn/Fe_SOD. IPR019833. Mn/Fe_SOD_BS. IPR019832. Mn/Fe_SOD_C. IPR019831. Mn/Fe_SOD_N. [Graphical view]
PANTHER	PTHR11404. PTHR11404. 1 hit.
Pfam	PF02777. Sod_Fe_C. 1 hit. PF00081. Sod_Fe_N. 1 hit. [Graphical view]
PIRSF	PIRSF000349. SODismutase. 1 hit.
PRINTS	PR01703. MNSODISMTASE.
SUPFAM	SSF46609. SODismutase. 1 hit. SSF54719. SODismutase. 1 hit.
PROSITE	PS00088. SOD_MN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODM_NICPL

Accession

Primary (citable) accession number: P11796

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program