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P11795

- CAPSD_TBSVB

UniProt

P11795 - CAPSD_TBSVB

Protein

Capsid protein

Gene

ORF2

Organism
Tomato bushy stunt virus (strain BS-3) (TBSV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW
    2. structural molecule activity Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsid protein
    Alternative name(s):
    Coat protein
    p41
    Gene namesi
    ORF Names:ORF2
    OrganismiTomato bushy stunt virus (strain BS-3) (TBSV)
    Taxonomic identifieri12146 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
    Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
    Malus [TaxID: 3749]
    Pyrus (pears) [TaxID: 3766]
    Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
    Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
    Tolmiea menziesii [TaxID: 29777]
    Tulipa [TaxID: 13305]

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. T=3 icosahedral viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, T=3 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 388387Capsid proteinPRO_0000222866Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.Curated

    Interactioni

    Subunit structurei

    Homomultimer.Curated

    Structurei

    Secondary structure

    1
    388
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi109 – 1168
    Beta strandi119 – 1235
    Turni124 – 1263
    Beta strandi134 – 1363
    Helixi145 – 1473
    Turni148 – 1503
    Beta strandi151 – 16818
    Helixi192 – 1954
    Beta strandi206 – 2083
    Beta strandi210 – 2134
    Beta strandi224 – 2263
    Turni231 – 2344
    Beta strandi240 – 2456
    Beta strandi247 – 2493
    Beta strandi251 – 26313
    Beta strandi272 – 2765
    Beta strandi280 – 2834
    Beta strandi292 – 2943
    Beta strandi304 – 3085
    Beta strandi310 – 31910
    Beta strandi325 – 3317
    Beta strandi333 – 3408
    Beta strandi343 – 3453
    Beta strandi347 – 3559
    Beta strandi360 – 3656
    Beta strandi371 – 3766

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2TBVX-ray2.90A/B/C2-388[»]
    ProteinModelPortaliP11795.
    SMRiP11795. Positions 68-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11795.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 102101R domain, interaction with RNAAdd
    BLAST
    Regioni57 – 637Involved in encapsidationBy similarity
    Regioni103 – 264162S domain, virion shellAdd
    BLAST
    Regioni265 – 388124P domain, projectingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 104Poly-Asn

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.60.120.20. 1 hit.
    InterProiIPR000937. Capsid_prot_S-dom_vir.
    IPR029053. Viral_coat.
    [Graphical view]
    PfamiPF00729. Viral_coat. 1 hit.
    [Graphical view]
    PRINTSiPR00233. ICOSAHEDRAL.
    PROSITEiPS00555. ICOSAH_VIR_COAT_S. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11795-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMTTRNNNN VLAISKKQLG VLAASAAVGA LRNHISESSP ALLQSAVGLG    50
    KKALNKVRNR RKQGNQQIIT HVGGVGGSIM APVAVSRQLV GSKPKFTGRT 100
    SGSVTVTHRE YLTQVNNSSG FVVNGGIVGN LLQLNPSNGT LFSWLPAIAS 150
    NFDQYSFNSV VLHYVPLCGT TEVGRVALYF DKDSQDPEPA DRVELANFGV 200
    LKETAPWAEA MLRIPTDKVK RYCNDSATVD QKLIDLGQLG IATYGGAGTN 250
    AVGDVFISYS VTLYFPQPTN TLLSTRRLDL TGSLADATGP GYLVLTRTPT 300
    VLTHTFRVTG TFNLSGGLRC LTSLTLGATG AVVINDILAI DNVGTASAYF 350
    LNCTVSSLPA TVTFTTTGIS SATVNVVRGT RANVVNLL 388
    Length:388
    Mass (Da):40,911
    Last modified:October 5, 2010 - v2
    Checksum:i008DF490F253B79E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141I → V AA sequence (PubMed:6481803)Curated
    Sequence conflicti34 – 363HIS → YIG AA sequence (PubMed:6481803)Curated
    Sequence conflicti107 – 1071T → TG AA sequence (PubMed:6481803)Curated
    Sequence conflicti131 – 1311L → S AA sequence (PubMed:6481803)Curated
    Sequence conflicti148 – 1481I → L AA sequence (PubMed:6481803)Curated
    Sequence conflicti163 – 1631H → D AA sequence (PubMed:6481803)Curated
    Sequence conflicti249 – 2502TN → AD AA sequence (PubMed:6481803)Curated
    Sequence conflicti254 – 2596DVFISY → ELFLAR AA sequence (PubMed:6481803)Curated
    Sequence conflicti275 – 2762TR → SK AA sequence (PubMed:6481803)Curated
    Sequence conflicti308 – 3081V → A AA sequence (PubMed:6481803)Curated
    Sequence conflicti348 – 3481A → D AA sequence (PubMed:6481803)Curated
    Sequence conflicti366 – 38015TTGIS…VVRGT → VSGVAAGILLVGRA AA sequence (PubMed:6481803)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271328 mRNA. Translation: CAB66390.1.
    PIRiS07259.

    Cross-referencesi

    Web resourcesi

    Virus Particle ExploreR db

    Icosahedral capsid structure

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271328 mRNA. Translation: CAB66390.1 .
    PIRi S07259.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2TBV X-ray 2.90 A/B/C 2-388 [» ]
    ProteinModelPortali P11795.
    SMRi P11795. Positions 68-388.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P11795.

    Family and domain databases

    Gene3Di 2.60.120.20. 1 hit.
    InterProi IPR000937. Capsid_prot_S-dom_vir.
    IPR029053. Viral_coat.
    [Graphical view ]
    Pfami PF00729. Viral_coat. 1 hit.
    [Graphical view ]
    PRINTSi PR00233. ICOSAHEDRAL.
    PROSITEi PS00555. ICOSAH_VIR_COAT_S. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a tombusvirus associated with a disease of statice (Goniolimon tataricum (L.) Boiss.)."
      Galetzka D., Russo M., Rubino L., Krczal G.
      J. Plant Pathol. 82:151-155(2000)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of tomato bushy stunt virus. V. Coat protein sequence determination and its structural implications."
      Hopper P., Harrison S.C., Sauer R.T.
      J. Mol. Biol. 177:701-713(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-388.
    3. "Structure of tomato bushy stunt virus IV. The virus particle at 2.9-A resolution."
      Olson A.J., Bricogne G., Harrison S.C.
      J. Mol. Biol. 171:61-93(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    4. "Tomato bushy stunt virus at 2.9 A resolution."
      Harrison S.C., Olson A.J., Schutt C.E., Winkler F.K., Bricogne G.
      Nature 276:368-373(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).

    Entry informationi

    Entry nameiCAPSD_TBSVB
    AccessioniPrimary (citable) accession number: P11795
    Secondary accession number(s): Q9IW10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3