Reviewed, UniProtKB/Swiss-Prot P11733 (CU07_LOCMI)

Names and origin

Protein names	Recommended name:     Cuticle protein 7 Alternative name(s):     LM-ACP 7       Short name=LM-7
Organism	Locusta migratoria (Migratory locust)
Taxonomic identifier	7004 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Orthopteroidea › Orthoptera › Caelifera › Acridomorpha › Acridoidea › Acrididae › Oedipodinae › Locusta

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the cuticle of migratory locust which contains more than 100 different structural proteins.
Domain	The tetrapeptide (A-A-P-[AV]) repeats found throughout the protein are also present in many proteins constituting the protective envelope of other species.
Sequence similarities	Contains 1 chitin-binding type R&R domain.
Mass spectrometry	Molecular weight is 13423.3 Da from positions 1 - 131. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Cuticle
Domain	Repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	structural constituent of cuticle Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Cuticle protein 7		PRO_0000196092
Regions
	Repeat	9 – 12	4	1
	Repeat	15 – 18	4	2
	Domain	31 – 101	71	Chitin-binding type R&R
	Repeat	109 – 112	4	3
	Repeat	116 – 119	4	4
	Repeat	122 – 125	4	5
Experimental info
	Sequence conflict	18 – 20	3	AYA → PAY AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P11733-1 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: D0E475DFBDDDC612	FASTA	131	13,423
	10 20 30 40 50 60 GVISAGYAAA PAYAAAPAYA AAAAPIEYDP NPHYSFEYSV SDAHTGDQKA QHETREGDVV 70 80 90 100 110 120 QGSYSLVEPD GSVRTVEYTA DPHNGFNAVV HRQAGAHPAP APVAVAKVAA PVAYAAAPAY 130 AAAPAYGYKH L

References

[1]	"Primary structure of proteins from the wing cuticle of the migratory locust, Locusta migratoria." Krogh T.N., Skou L., Roepstorff P., Andersen S.O., Hoejrup P. Insect Biochem. Mol. Biol. 25:319-329(1995) [PubMed: 7773253] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Wing.
[2]	"Isolation, characterization, and N-terminal sequence studies of cuticular proteins from the migratory locust, Locusta migratoria." Hoejrup P., Andersen S.O., Roepstorff P. Eur. J. Biochem. 154:153-159(1986) [PubMed: 3943519] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-24.

Cross-references

Sequence databases
PIR	A24802.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR000618. Insect_cuticle. [Graphical view]
Pfam	PF00379. Chitin_bind_4. 1 hit. [Graphical view]
PRINTS	PR00947. CUTICLE.
PROSITE	PS00233. CHIT_BIND_RR_1. 1 hit. PS51155. CHIT_BIND_RR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CU07_LOCMI

Accession

Primary (citable) accession number: P11733

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)