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Reviewed, UniProtKB/Swiss-Prot P11730 (KCC2G_RAT)

Last modified October 13, 2009. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Calcium/calmodulin-dependent protein kinase type II gamma chain
      Short name=CaM-kinase II gamma chain
      Short name=CaM kinase II subunit gamma
      Short name=CaMK-II subunit gamma
    EC=2.7.11.17
Gene names
Name: Camk2g
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.

Subunit structure

CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Contains 1 protein kinase domain.

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform A (identifier: P11730-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P11730-2)

The sequence of this isoform differs from the canonical sequence as follows:
     316-336: Missing.
     351-361: KKRKSSSSVHL → PEQQQKQSRKPSPRARDPLQTA
Isoform C (identifier: P11730-3)

The sequence of this isoform differs from the canonical sequence as follows:
     316-336: Missing.
     352-362: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Calcium/calmodulin-dependent protein kinase type II gamma chain
PRO_0000086103

Regions

Domain14 – 272259Protein kinase
Nucleotide binding20 – 289ATP By similarity
Region291 – 30111Calmodulin-binding By similarity

Sites

Active site1361Proton acceptor By similarity
Binding site431ATP By similarity

Amino acid modifications

Modified residue2351Phosphoserine By similarity
Modified residue2871Phosphothreonine By similarity
Modified residue3111Phosphoserine By similarity
Modified residue3151Phosphoserine By similarity
Modified residue3401Phosphoserine By similarity
Modified residue3461Phosphoserine By similarity
Modified residue3821Phosphoserine By similarity

Natural variations

Alternative sequence316 – 33621Missing in isoform B and isoform C.
VSP_004781
Alternative sequence351 – 36111KKRKSSSSVHL → PEQQQKQSRKPSPRARDPLQ TA in isoform B.
VSP_004782
Alternative sequence352 – 36211Missing in isoform C.
VSP_004783

Experimental info

Sequence conflict21A → E in AAB30670. Ref.2
Sequence conflict21A → E in AAB30671. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 58DBF1B72F64FA31

FASTA52759,038
        10         20         30         40         50         60 
MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 

        70         80         90        100        110        120 
EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 

       130        140        150        160        170        180 
LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 

       190        200        210        220        230        240 
LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 

       250        260        270        280        290        300 
VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 

       310        320        330        340        350        360 
KGAILTTMLV SRNFSVGRQS SAPASPAASA AGLAGQAAKS LLNKKSDGGV KKRKSSSSVH 

       370        380        390        400        410        420 
LMEPQTTVVH NATDGIKGST ESCNTTTEDE DLKVRKQEII KITEQLIEAI NNGDFEAYTK 

       430        440        450        460        470        480 
ICDPGLTSFE PEALGNLVEG MDFHKFYFEN LLSKNSKPIH TTILNPHVHV IGEDAACIAY 

       490        500        510        520 
IRLTQYIDGQ GRPRTSQSEE TRVWHRRDGK WLNVHYHCSG APAAPLQ

« Hide

Isoform B.

Checksum: 2F5FF73C9BDCBF0D
Show »

FASTA51758,493
Isoform C.

Checksum: 168EA409723DF4C4
Show »

FASTA49555,961

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References

[1]"Molecular cloning of the cDNA encoding the third polypeptide (gamma) of brain calmodulin-dependent protein kinase II."
Tobimatsu T., Kameshita I., Fujisawa H.
J. Biol. Chem. 263:16082-16086(1988) [PubMed: 2846534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
Tissue: Brain.
[2]"New isoforms of Ca2+/calmodulin-dependent protein kinase II in smooth muscle."
Zhou Z.L., Ikebe M.
Biochem. J. 299:489-495(1994) [PubMed: 8172610] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
Tissue: Aortic smooth muscle.
+Additional computationally mapped references.

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Cross-references

Sequence databases

J04063 mRNA. Translation: AAA41857.1.
S71570 mRNA. Translation: AAB30670.1.
S71571 mRNA. Translation: AAB30671.1.
IPIIPI00196730.
IPI00231086.
IPI00231087.
PIRA31908.
S43845.
RefSeqNP_598289.1.
UniGeneRn.10961

3D structure databases

HSSPHSSP built from PDB template 1HKX based on UniProtKB P11798.
SMRP11730. Positions 8-315, 385-521.
ModBaseSearch...

Protein-protein interaction databases

STRINGP11730.

PTM databases

PhosphoSiteP11730.

Proteomic databases

PRIDEP11730.

Genome annotation databases

EnsemblENSRNOT00000005359; ENSRNOP00000005359; ENSRNOG00000004005; Rattus norvegicus. [Genome view]
ENSRNOT00000057234; ENSRNOP00000054060; ENSRNOG00000004005; Rattus norvegicus. [Genome view]
GeneID171140.
KEGGrno:171140.

Organism-specific databases

CTD171140.
RGD621802. Camk2g.

Phylogenomic databases

HOVERGENP11730.

Enzyme and pathway databases

BRENDA2.7.11.17. 248.

Gene expression databases

GenevestigatorP11730.

Family and domain databases

InterProIPR015742. Ca/calmodulin-dep_kinase.
IPR013543. Ca/calmodulin-dep_kinase-assoc.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PANTHERPTHR22982:SF64. CaMKII. 1 hit.
PfamPF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio621932.

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Entry information

Entry nameKCC2G_RAT
AccessionPrimary (citable) accession number: P11730
Secondary accession number(s): Q64003, Q64004
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 13, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents