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Reviewed, UniProtKB/Swiss-Prot P11717 (MPRI_HUMAN)

Last modified November 25, 2008. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cation-independent mannose-6-phosphate receptor
      Short name=CI Man-6-P receptor
      Short name=CI-MPR
      Short name=M6PR
Alternative name(s):
    Insulin-like growth factor 2 receptor
    Insulin-like growth factor II receptor
      Short name=IGF-II receptor
    M6P/IGF2 receptor
      Short name=M6P/IGF2R
    300 kDa mannose 6-phosphate receptor
    MPR 300
    CD_antigen=CD222
Gene names
Name: IGF2R
Synonyms: MPRI
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2491 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

Subunit structure

Binds GGA1, GGA2 and GGA3.

Subcellular location

Lysosome membrane; Single-pass type I membrane protein.

Domain

Contains 15 repeating units of approximately 147 AA. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.

Sequence similarities

Belongs to the MRL1/IGF2R family.

Contains 1 fibronectin type-II domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040
Chain41 – 24912451Cation-independent mannose-6-phosphate receptor
PRO_0000019229

Regions

Topological domain41 – 23042264Lumenal Potential
Transmembrane2305 – 232723 Potential
Topological domain2328 – 2491164Cytoplasmic Potential
Repeat40 – 1891501
Repeat190 – 3441552
Repeat345 – 4891453
Repeat490 – 6431544
Repeat644 – 7831405
Repeat784 – 9501676
Repeat951 – 10991497
Repeat1100 – 12431448
Repeat1244 – 13841419
Repeat1385 – 153214810
Repeat1533 – 166613411
Repeat1667 – 182015412
Repeat1821 – 200818813
Domain1898 – 194447Fibronectin type-II
Repeat2009 – 213712914
Repeat2165 – 228912515

Amino acid modifications

Modified residue24091Phosphoserine
Modified residue24791Phosphoserine
Modified residue24841Phosphoserine
Glycosylation1121N-linked (GlcNAc...)
Glycosylation4001N-linked (GlcNAc...) Potential
Glycosylation4351N-linked (GlcNAc...) Potential
Glycosylation5431N-linked (GlcNAc...) Potential
Glycosylation5811N-linked (GlcNAc...)
Glycosylation6261N-linked (GlcNAc...) Potential
Glycosylation7471N-linked (GlcNAc...)
Glycosylation8711N-linked (GlcNAc...) Potential
Glycosylation9511N-linked (GlcNAc...) Potential
Glycosylation9571N-linked (GlcNAc...) Potential
Glycosylation11641N-linked (GlcNAc...) Potential
Glycosylation12461N-linked (GlcNAc...)
Glycosylation13121N-linked (GlcNAc...) Potential
Glycosylation16561N-linked (GlcNAc...) Potential
Glycosylation17571N-linked (GlcNAc...) Potential
Glycosylation18161N-linked (GlcNAc...) Potential
Glycosylation20851N-linked (GlcNAc...) Potential
Glycosylation21361N-linked (GlcNAc...) Potential
Disulfide bond1903 ↔ 1927 By similarity
Disulfide bond1917 ↔ 1942 By similarity

Natural variations

Natural variant911R → H: dbSNP rs8191704.
VAR_021304
Natural variant2031P → L: dbSNP rs8191746.
VAR_020470
Natural variant2311G → D: dbSNP rs8191753.
VAR_021305
Natural variant2521L → V: dbSNP rs8191754.
VAR_020471
Natural variant2731D → G: dbSNP rs8191758.
VAR_021306
Natural variant5121K → Q: dbSNP rs8191776.
VAR_021307
Natural variant5291R → Q: dbSNP rs6413489.
VAR_020472
Natural variant6041G → S: dbSNP rs8191797.
VAR_020473
Natural variant7241A → T: dbSNP rs6413491.
VAR_020474
Natural variant8171L → V: dbSNP rs8191808.
VAR_021308
Natural variant8561G → S: dbSNP rs8191819.
VAR_020475
Natural variant11071T → M: dbSNP rs8191842.
VAR_020476
Natural variant11241V → I: dbSNP rs8191843.
VAR_021309
Natural variant11841T → S: dbSNP rs8191844.
VAR_020477
Natural variant13151G → E: dbSNP rs8191859.
VAR_021310
Natural variant13351R → H: dbSNP rs8191860.
VAR_021311
Natural variant16191G → R: dbSNP rs629849.
VAR_021312
Natural variant18321R → H: dbSNP rs8191904.
VAR_021313
Natural variant18601G → D: dbSNP rs8191905.
VAR_021314
Natural variant19081I → M: dbSNP rs8191908.
VAR_021315
Natural variant20201N → S: dbSNP rs1805075.
VAR_014722
Natural variant24591A → V: dbSNP rs8191955.
VAR_021316

Experimental info

Sequence conflict2541L → V in AAA59866. Ref.2
Sequence conflict5101E → K in AAA59866. Ref.2
Sequence conflict6121H → R Ref.1 Ref.3
Sequence conflict8451V → A in AAA59866. Ref.2
Sequence conflict14891S → N in AAA59866. Ref.2
Sequence conflict17031G → A Ref.1 Ref.3
Sequence conflict20261I → M in AAA59866. Ref.2
Sequence conflict20751T → M in AAA59866. Ref.2
Sequence conflict21561K → N in AAA59866. Ref.2
Sequence conflict21601A → E in AAA59866. Ref.2
Sequence conflict21761Q → L in AAA59866. Ref.2
Sequence conflict23301E → K in AAA59866. Ref.2
Sequence conflict23351V → M in AAA59866. Ref.2
Sequence conflict23411T → S in AAA59866. Ref.2
Sequence conflict24101E → T in AAA59866. Ref.2

Secondary structure

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