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Protein

Cation-independent mannose-6-phosphate receptor

Gene

IGF2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.1 Publication

GO - Molecular functioni

  • glycoprotein binding Source: UniProtKB
  • G-protein coupled receptor activity Source: Ensembl
  • insulin-like growth factor-activated receptor activity Source: ProtInc
  • mannose binding Source: Ensembl
  • phosphoprotein binding Source: UniProtKB
  • receptor activity Source: ProtInc
  • retinoic acid binding Source: Ensembl
  • transporter activity Source: InterPro

GO - Biological processi

  • animal organ regeneration Source: Ensembl
  • liver development Source: Ensembl
  • positive regulation of apoptotic process Source: Ensembl
  • post-embryonic development Source: Ensembl
  • receptor-mediated endocytosis Source: ProtInc
  • response to retinoic acid Source: Ensembl
  • signal transduction Source: ProtInc
  • spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:G66-33795-MONOMER.
ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SignaLinkiP11717.
SIGNORiP11717.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-independent mannose-6-phosphate receptor
Short name:
CI Man-6-P receptor
Short name:
CI-MPR
Short name:
M6PR
Alternative name(s):
300 kDa mannose 6-phosphate receptor
Short name:
MPR 300
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
Short name:
IGF-II receptor
M6P/IGF2 receptor
Short name:
M6P/IGF2R
CD_antigen: CD222
Gene namesi
Name:IGF2R
Synonyms:MPRI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:5467. IGF2R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 2304LumenalSequence analysisAdd BLAST2264
Transmembranei2305 – 2327HelicalSequence analysisAdd BLAST23
Topological domaini2328 – 2491CytoplasmicSequence analysisAdd BLAST164

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • clathrin coat Source: Ensembl
  • early endosome Source: UniProtKB
  • endocytic vesicle Source: UniProtKB
  • endosome Source: MGI
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: Ensembl
  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • late endosome Source: MGI
  • lysosomal membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • nuclear envelope lumen Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
  • trans-Golgi network Source: UniProtKB
  • trans-Golgi network membrane Source: Reactome
  • trans-Golgi network transport vesicle Source: MGI
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3482.
MalaCardsiIGF2R.
OpenTargetsiENSG00000197081.
PharmGKBiPA29701.

Chemistry databases

ChEMBLiCHEMBL3240.
DrugBankiDB01277. Mecasermin.

Polymorphism and mutation databases

BioMutaiIGF2R.
DMDMi317373416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Add BLAST40
ChainiPRO_000001922941 – 2491Cation-independent mannose-6-phosphate receptorAdd BLAST2451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 69PROSITE-ProRule annotation
Disulfide bondi77 ↔ 84PROSITE-ProRule annotation
Glycosylationi112N-linked (GlcNAc...)1 Publication1
Disulfide bondi117 ↔ 149PROSITE-ProRule annotation
Disulfide bondi134 ↔ 161PROSITE-ProRule annotation
Disulfide bondi174 ↔ 212PROSITE-ProRule annotation
Disulfide bondi228 ↔ 235PROSITE-ProRule annotation
Disulfide bondi275 ↔ 306PROSITE-ProRule annotation
Disulfide bondi288 ↔ 318PROSITE-ProRule annotation
Disulfide bondi328 ↔ 366PROSITE-ProRule annotation
Disulfide bondi374 ↔ 382PROSITE-ProRule annotation
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi420 ↔ 454PROSITE-ProRule annotation
Disulfide bondi434 ↔ 466PROSITE-ProRule annotation
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1
Glycosylationi543N-linked (GlcNAc...)Sequence analysis1
Glycosylationi581N-linked (GlcNAc...)1 Publication1
Glycosylationi626N-linked (GlcNAc...)1 Publication1
Disulfide bondi627 ↔ 664PROSITE-ProRule annotation
Disulfide bondi672 ↔ 679PROSITE-ProRule annotation
Disulfide bondi731 ↔ 760PROSITE-ProRule annotation
Glycosylationi747N-linked (GlcNAc...)2 Publications1
Glycosylationi871N-linked (GlcNAc...)Sequence analysis1
Glycosylationi951N-linked (GlcNAc...)Sequence analysis1
Glycosylationi957N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1246N-linked (GlcNAc...)1 Publication1
Glycosylationi1312N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1516 ↔ 1553PROSITE-ProRule annotation1 Publication
Disulfide bondi1559 ↔ 1566PROSITE-ProRule annotation1 Publication
Disulfide bondi1598 ↔ 1634PROSITE-ProRule annotation1 Publication
Disulfide bondi1614 ↔ 1646PROSITE-ProRule annotation1 Publication
Disulfide bondi1652 ↔ 1695PROSITE-ProRule annotation1 Publication
Glycosylationi1656N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1706 ↔ 1713PROSITE-ProRule annotation1 Publication
Disulfide bondi1750 ↔ 1783PROSITE-ProRule annotation1 Publication
Glycosylationi1757N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1766 ↔ 1795PROSITE-ProRule annotation1 Publication
Disulfide bondi1804 ↔ 1839PROSITE-ProRule annotation1 Publication
Glycosylationi1816N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1850 ↔ 1856PROSITE-ProRule annotation1 Publication
Disulfide bondi1893 ↔ 1975PROSITE-ProRule annotation1 Publication
Disulfide bondi1903 ↔ 1927PROSITE-ProRule annotation1 Publication
Disulfide bondi1917 ↔ 1942PROSITE-ProRule annotation1 Publication
Disulfide bondi1957 ↔ 1987PROSITE-ProRule annotation1 Publication
Disulfide bondi1994 ↔ 2029PROSITE-ProRule annotation1 Publication
Disulfide bondi2039 ↔ 2046PROSITE-ProRule annotation1 Publication
Disulfide bondi2082 ↔ 2113PROSITE-ProRule annotation1 Publication
Glycosylationi2085N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2096 ↔ 2125PROSITE-ProRule annotation1 Publication
Glycosylationi2136N-linked (GlcNAc...)Sequence analysis1
Modified residuei2352N6-acetyllysineCombined sources1
Modified residuei2409PhosphoserineCombined sources1
Modified residuei2425Omega-N-methylarginineBy similarity1
Modified residuei2479PhosphoserineCombined sources1
Modified residuei2484PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiP11717.
MaxQBiP11717.
PaxDbiP11717.
PeptideAtlasiP11717.
PRIDEiP11717.

PTM databases

iPTMnetiP11717.
PhosphoSitePlusiP11717.
SwissPalmiP11717.

Expressioni

Gene expression databases

BgeeiENSG00000197081.
CleanExiHS_IGF2R.
ExpressionAtlasiP11717. baseline and differential.
GenevisibleiP11717. HS.

Organism-specific databases

HPAiCAB009661.
HPA011332.

Interactioni

Subunit structurei

Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-1048580,EBI-1048580
GGA1Q9UJY52EBI-1048580,EBI-447141
IGF2P0134417EBI-1048580,EBI-7178764
PACS1Q6VY072EBI-1048580,EBI-2555014

GO - Molecular functioni

  • phosphoprotein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109703. 30 interactors.
DIPiDIP-6027N.
IntActiP11717. 34 interactors.
MINTiMINT-5004044.
STRINGi9606.ENSP00000349437.

Chemistry databases

BindingDBiP11717.

Structurei

Secondary structure

12491
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1512 – 1514Combined sources3
Beta strandi1517 – 1519Combined sources3
Turni1521 – 1523Combined sources3
Beta strandi1526 – 1528Combined sources3
Helixi1530 – 1532Combined sources3
Beta strandi1533 – 1536Combined sources4
Beta strandi1538 – 1542Combined sources5
Turni1543 – 1545Combined sources3
Beta strandi1546 – 1550Combined sources5
Beta strandi1552 – 1554Combined sources3
Beta strandi1558 – 1560Combined sources3
Beta strandi1563 – 1567Combined sources5
Turni1568 – 1570Combined sources3
Beta strandi1573 – 1576Combined sources4
Beta strandi1582 – 1584Combined sources3
Beta strandi1587 – 1592Combined sources6
Beta strandi1596 – 1598Combined sources3
Beta strandi1599 – 1601Combined sources3
Beta strandi1607 – 1614Combined sources8
Beta strandi1616 – 1618Combined sources3
Beta strandi1625 – 1630Combined sources6
Turni1631 – 1634Combined sources4
Beta strandi1635 – 1642Combined sources8
Helixi1643 – 1645Combined sources3
Beta strandi1653 – 1656Combined sources4
Beta strandi1659 – 1662Combined sources4
Helixi1664 – 1666Combined sources3
Beta strandi1669 – 1671Combined sources3
Beta strandi1673 – 1675Combined sources3
Beta strandi1690 – 1692Combined sources3
Beta strandi1694 – 1696Combined sources3
Beta strandi1711 – 1714Combined sources4
Beta strandi1717 – 1719Combined sources3
Beta strandi1722 – 1727Combined sources6
Beta strandi1732 – 1734Combined sources3
Beta strandi1735 – 1737Combined sources3
Beta strandi1743 – 1745Combined sources3
Beta strandi1759 – 1766Combined sources8
Beta strandi1775 – 1777Combined sources3
Turni1781 – 1783Combined sources3
Beta strandi1784 – 1791Combined sources8
Helixi1792 – 1794Combined sources3
Turni1801 – 1804Combined sources4
Beta strandi1805 – 1807Combined sources3
Turni1809 – 1811Combined sources3
Beta strandi1814 – 1816Combined sources3
Helixi1818 – 1821Combined sources4
Beta strandi1825 – 1829Combined sources5
Beta strandi1832 – 1836Combined sources5
Beta strandi1838 – 1840Combined sources3
Turni1845 – 1847Combined sources3
Beta strandi1850 – 1858Combined sources9
Beta strandi1863 – 1876Combined sources14
Turni1878 – 1880Combined sources3
Beta strandi1883 – 1888Combined sources6
Beta strandi1905 – 1909Combined sources5
Beta strandi1912 – 1916Combined sources5
Beta strandi1920 – 1924Combined sources5
Beta strandi1926 – 1932Combined sources7
Helixi1933 – 1936Combined sources4
Beta strandi1939 – 1943Combined sources5
Beta strandi1950 – 1957Combined sources8
Beta strandi1967 – 1972Combined sources6
Turni1973 – 1975Combined sources3
Beta strandi1976 – 1984Combined sources9
Beta strandi1995 – 2000Combined sources6
Beta strandi2002 – 2004Combined sources3
Helixi2005 – 2007Combined sources3
Beta strandi2011 – 2013Combined sources3
Beta strandi2015 – 2019Combined sources5
Beta strandi2022 – 2026Combined sources5
Beta strandi2043 – 2048Combined sources6
Beta strandi2054 – 2059Combined sources6
Helixi2060 – 2062Combined sources3
Beta strandi2064 – 2068Combined sources5
Beta strandi2071 – 2076Combined sources6
Beta strandi2089 – 2096Combined sources8
Beta strandi2098 – 2109Combined sources12
Turni2110 – 2113Combined sources4
Beta strandi2114 – 2121Combined sources8
Helixi2122 – 2124Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E6FX-ray1.75A/B1508-1650[»]
1GP0X-ray1.40A1508-1650[»]
1GP3X-ray1.95A1508-1650[»]
1GQBX-ray1.80A/B1508-1650[»]
1JPLX-ray2.40E/F/G/H2480-2491[»]
1JWGX-ray2.00C/D2479-2491[»]
1LF8X-ray2.30E/F/G/H2480-2491[»]
2CNJNMR-D1508-1650[»]
2L29NMR-A1508-1647[»]
2L2ANMR-A1508-1647[»]
2M68NMR-A1508-1647[»]
2M6TNMR-A1508-1647[»]
2V5NX-ray3.20A1508-1799[»]
2V5OX-ray2.91A1508-2128[»]
2V5PX-ray4.10A/B1508-1992[»]
5IEIX-ray2.80A1508-1647[»]
ProteinModelPortaliP11717.
SMRiP11717.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11717.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati40 – 1891Add BLAST150
Repeati190 – 3442Add BLAST155
Repeati345 – 4893Add BLAST145
Repeati490 – 6434Add BLAST154
Repeati644 – 7835Add BLAST140
Repeati784 – 9506Add BLAST167
Repeati951 – 10997Add BLAST149
Repeati1100 – 12438Add BLAST144
Repeati1244 – 13849Add BLAST141
Repeati1385 – 153210Add BLAST148
Repeati1533 – 166611Add BLAST134
Repeati1667 – 182012Add BLAST154
Repeati1821 – 200813Add BLAST188
Domaini1898 – 1944Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST47
Repeati2009 – 213714Add BLAST129
Repeati2165 – 228915Add BLAST125

Domaini

Sequence similaritiesi

Belongs to the MRL1/IGF2R family.Curated
Contains 1 fibronectin type-II domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4504. Eukaryota.
ENOG410ZWHP. LUCA.
GeneTreeiENSGT00390000013943.
HOGENOMiHOG000113638.
HOVERGENiHBG000334.
InParanoidiP11717.
KOiK06564.
OMAiVDCQVTD.
OrthoDBiEOG091G116D.
PhylomeDBiP11717.
TreeFamiTF328963.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di2.10.10.10. 1 hit.
2.70.130.10. 16 hits.
InterProiIPR000479. CIMR.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
[Graphical view]
PfamiPF00878. CIMR. 15 hits.
PF00040. fn2. 1 hit.
[Graphical view]
SMARTiSM01404. CIMR. 14 hits.
SM00059. FN2. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 16 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAAGRSPH LGPAPARRPQ RSLLLLQLLL LVAAPGSTQA QAAPFPELCS
60 70 80 90 100
YTWEAVDTKN NVLYKINICG SVDIVQCGPS SAVCMHDLKT RTYHSVGDSV
110 120 130 140 150
LRSATRSLLE FNTTVSCDQQ GTNHRVQSSI AFLCGKTLGT PEFVTATECV
160 170 180 190 200
HYFEWRTTAA CKKDIFKANK EVPCYVFDEE LRKHDLNPLI KLSGAYLVDD
210 220 230 240 250
SDPDTSLFIN VCRDIDTLRD PGSQLRACPP GTAACLVRGH QAFDVGQPRD
260 270 280 290 300
GLKLVRKDRL VLSYVREEAG KLDFCDGHSP AVTITFVCPS ERREGTIPKL
310 320 330 340 350
TAKSNCRYEI EWITEYACHR DYLESKTCSL SGEQQDVSID LTPLAQSGGS
360 370 380 390 400
SYISDGKEYL FYLNVCGETE IQFCNKKQAA VCQVKKSDTS QVKAAGRYHN
410 420 430 440 450
QTLRYSDGDL TLIYFGGDEC SSGFQRMSVI NFECNKTAGN DGKGTPVFTG
460 470 480 490 500
EVDCTYFFTW DTEYACVKEK EDLLCGATDG KKRYDLSALV RHAEPEQNWE
510 520 530 540 550
AVDGSQTETE KKHFFINICH RVLQEGKARG CPEDAAVCAV DKNGSKNLGK
560 570 580 590 600
FISSPMKEKG NIQLSYSDGD DCGHGKKIKT NITLVCKPGD LESAPVLRTS
610 620 630 640 650
GEGGCFYEFE WHTAAACVLS KTEGENCTVF DSQAGFSFDL SPLTKKNGAY
660 670 680 690 700
KVETKKYDFY INVCGPVSVS PCQPDSGACQ VAKSDEKTWN LGLSNAKLSY
710 720 730 740 750
YDGMIQLNYR GGTPYNNERH TPRATLITFL CDRDAGVGFP EYQEEDNSTY
760 770 780 790 800
NFRWYTSYAC PEEPLECVVT DPSTLEQYDL SSLAKSEGGL GGNWYAMDNS
810 820 830 840 850
GEHVTWRKYY INVCRPLNPV PGCNRYASAC QMKYEKDQGS FTEVVSISNL
860 870 880 890 900
GMAKTGPVVE DSGSLLLEYV NGSACTTSDG RQTTYTTRIH LVCSRGRLNS
910 920 930 940 950
HPIFSLNWEC VVSFLWNTEA ACPIQTTTDT DQACSIRDPN SGFVFNLNPL
960 970 980 990 1000
NSSQGYNVSG IGKIFMFNVC GTMPVCGTIL GKPASGCEAE TQTEELKNWK
1010 1020 1030 1040 1050
PARPVGIEKS LQLSTEGFIT LTYKGPLSAK GTADAFIVRF VCNDDVYSGP
1060 1070 1080 1090 1100
LKFLHQDIDS GQGIRNTYFE FETALACVPS PVDCQVTDLA GNEYDLTGLS
1110 1120 1130 1140 1150
TVRKPWTAVD TSVDGRKRTF YLSVCNPLPY IPGCQGSAVG SCLVSEGNSW
1160 1170 1180 1190 1200
NLGVVQMSPQ AAANGSLSIM YVNGDKCGNQ RFSTRITFEC AQISGSPAFQ
1210 1220 1230 1240 1250
LQDGCEYVFI WRTVEACPVV RVEGDNCEVK DPRHGNLYDL KPLGLNDTIV
1260 1270 1280 1290 1300
SAGEYTYYFR VCGKLSSDVC PTSDKSKVVS SCQEKREPQG FHKVAGLLTQ
1310 1320 1330 1340 1350
KLTYENGLLK MNFTGGDTCH KVYQRSTAIF FYCDRGTQRP VFLKETSDCS
1360 1370 1380 1390 1400
YLFEWRTQYA CPPFDLTECS FKDGAGNSFD LSSLSRYSDN WEAITGTGDP
1410 1420 1430 1440 1450
EHYLINVCKS LAPQAGTEPC PPEAAACLLG GSKPVNLGRV RDGPQWRDGI
1460 1470 1480 1490 1500
IVLKYVDGDL CPDGIRKKST TIRFTCSESQ VNSRPMFISA VEDCEYTFAW
1510 1520 1530 1540 1550
PTATACPMKS NEHDDCQVTN PSTGHLFDLS SLSGRAGFTA AYSEKGLVYM
1560 1570 1580 1590 1600
SICGENENCP PGVGACFGQT RISVGKANKR LRYVDQVLQL VYKDGSPCPS
1610 1620 1630 1640 1650
KSGLSYKSVI SFVCRPEARP TNRPMLISLD KQTCTLFFSW HTPLACEQAT
1660 1670 1680 1690 1700
ECSVRNGSSI VDLSPLIHRT GGYEAYDESE DDASDTNPDF YINICQPLNP
1710 1720 1730 1740 1750
MHGVPCPAGA AVCKVPIDGP PIDIGRVAGP PILNPIANEI YLNFESSTPC
1760 1770 1780 1790 1800
LADKHFNYTS LIAFHCKRGV SMGTPKLLRT SECDFVFEWE TPVVCPDEVR
1810 1820 1830 1840 1850
MDGCTLTDEQ LLYSFNLSSL STSTFKVTRD SRTYSVGVCT FAVGPEQGGC
1860 1870 1880 1890 1900
KDGGVCLLSG TKGASFGRLQ SMKLDYRHQD EAVVLSYVNG DRCPPETDDG
1910 1920 1930 1940 1950
VPCVFPFIFN GKSYEECIIE SRAKLWCSTT ADYDRDHEWG FCRHSNSYRT
1960 1970 1980 1990 2000
SSIIFKCDED EDIGRPQVFS EVRGCDVTFE WKTKVVCPPK KLECKFVQKH
2010 2020 2030 2040 2050
KTYDLRLLSS LTGSWSLVHN GVSYYINLCQ KIYKGPLGCS ERASICRRTT
2060 2070 2080 2090 2100
TGDVQVLGLV HTQKLGVIGD KVVVTYSKGY PCGGNKTASS VIELTCTKTV
2110 2120 2130 2140 2150
GRPAFKRFDI DSCTYYFSWD SRAACAVKPQ EVQMVNGTIT NPINGKSFSL
2160 2170 2180 2190 2200
GDIYFKLFRA SGDMRTNGDN YLYEIQLSSI TSSRNPACSG ANICQVKPND
2210 2220 2230 2240 2250
QHFSRKVGTS DKTKYYLQDG DLDVVFASSS KCGKDKTKSV SSTIFFHCDP
2260 2270 2280 2290 2300
LVEDGIPEFS HETADCQYLF SWYTSAVCPL GVGFDSENPG DDGQMHKGLS
2310 2320 2330 2340 2350
ERSQAVGAVL SLLLVALTCC LLALLLYKKE RRETVISKLT TCCRRSSNVS
2360 2370 2380 2390 2400
YKYSKVNKEE ETDENETEWL MEEIQLPPPR QGKEGQENGH ITTKSVKALS
2410 2420 2430 2440 2450
SLHGDDQDSE DEVLTIPEVK VHSGRGAGAE SSHPVRNAQS NALQEREDDR
2460 2470 2480 2490
VGLVRGEKAR KGKSSSAQQK TVSSTKLVSF HDDSDEDLLH I
Length:2,491
Mass (Da):274,375
Last modified:January 11, 2011 - v3
Checksum:i3841ADE559B48057
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254L → V in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti510E → K in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti612H → R in CAA68395 (PubMed:2957598).Curated1
Sequence conflicti612H → R in AAF16870 (Ref. 3) Curated1
Sequence conflicti845V → A in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti1489S → N in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti1703G → A in CAA68395 (PubMed:2957598).Curated1
Sequence conflicti1703G → A in AAF16870 (Ref. 3) Curated1
Sequence conflicti2026I → M in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2075T → M in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2156K → N in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2160A → E in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2176Q → L in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2330E → K in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2335V → M in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2341T → S in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2410E → T in AAA59866 (PubMed:2963003).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02130491R → H.1 PublicationCorresponds to variant rs8191704dbSNPEnsembl.1
Natural variantiVAR_020470203P → L.1 PublicationCorresponds to variant rs8191746dbSNPEnsembl.1
Natural variantiVAR_021305231G → D.1 PublicationCorresponds to variant rs8191753dbSNPEnsembl.1
Natural variantiVAR_020471252L → V.1 PublicationCorresponds to variant rs8191754dbSNPEnsembl.1
Natural variantiVAR_021306273D → G.1 PublicationCorresponds to variant rs8191758dbSNPEnsembl.1
Natural variantiVAR_021307512K → Q.1 PublicationCorresponds to variant rs8191776dbSNPEnsembl.1
Natural variantiVAR_020472529R → Q.Corresponds to variant rs6413489dbSNPEnsembl.1
Natural variantiVAR_020473604G → S.1 PublicationCorresponds to variant rs8191797dbSNPEnsembl.1
Natural variantiVAR_020474724A → T.1 PublicationCorresponds to variant rs6413491dbSNPEnsembl.1
Natural variantiVAR_021308817L → V.1 PublicationCorresponds to variant rs8191808dbSNPEnsembl.1
Natural variantiVAR_020475856G → S.1 PublicationCorresponds to variant rs8191819dbSNPEnsembl.1
Natural variantiVAR_0204761107T → M.1 PublicationCorresponds to variant rs8191842dbSNPEnsembl.1
Natural variantiVAR_0213091124V → I.1 PublicationCorresponds to variant rs8191843dbSNPEnsembl.1
Natural variantiVAR_0204771184T → S.1 PublicationCorresponds to variant rs8191844dbSNPEnsembl.1
Natural variantiVAR_0504281254E → A.Corresponds to variant rs2230043dbSNPEnsembl.1
Natural variantiVAR_0213101315G → E.1 PublicationCorresponds to variant rs8191859dbSNPEnsembl.1
Natural variantiVAR_0213111335R → H.1 PublicationCorresponds to variant rs8191860dbSNPEnsembl.1
Natural variantiVAR_0504291395T → S.Corresponds to variant rs2230048dbSNPEnsembl.1
Natural variantiVAR_0213121619R → G.4 PublicationsCorresponds to variant rs629849dbSNPEnsembl.1
Natural variantiVAR_0504301696Q → R.Corresponds to variant rs11552587dbSNPEnsembl.1
Natural variantiVAR_0213131832R → H.1 PublicationCorresponds to variant rs8191904dbSNPEnsembl.1
Natural variantiVAR_0213141860G → D.1 PublicationCorresponds to variant rs8191905dbSNPEnsembl.1
Natural variantiVAR_0213151908I → M.1 PublicationCorresponds to variant rs8191908dbSNPEnsembl.1
Natural variantiVAR_0147222020N → S.1 PublicationCorresponds to variant rs1805075dbSNPEnsembl.1
Natural variantiVAR_0213162459A → V.1 PublicationCorresponds to variant rs8191955dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00285 mRNA. Translation: CAA68395.1.
J03528 mRNA. Translation: AAA59866.1.
AF109291
, AF109244, AF109245, AF109246, AF109247, AF109248, AF109249, AF109250, AF109251, AF109252, AF109253, AF109254, AF109255, AF109256, AF109257, AF109258, AF109259, AF109260, AF109261, AF109262, AF109263, AF109264, AF109265, AF109266, AF109267, AF109268, AF109269, AF109270, AF109271, AF109272, AF109273, AF109274, AF109275, AF109276, AF109277, AF109278, AF109279, AF109280, AF109281, AF109282, AF109283, AF109284, AF109285, AF109286, AF109287, AF109288, AF109289, AF109290 Genomic DNA. Translation: AAF16870.1.
AF069333 Genomic DNA. Translation: AAL04402.1.
AY293855 Genomic DNA. Translation: AAP37954.1.
AL353625, AL035691 Genomic DNA. Translation: CAH72014.1.
AL035691, AL353625 Genomic DNA. Translation: CAI19940.1.
CCDSiCCDS5273.1.
PIRiA28372.
RefSeqiNP_000867.2. NM_000876.3.
UniGeneiHs.487062.
Hs.673278.

Genome annotation databases

EnsembliENST00000356956; ENSP00000349437; ENSG00000197081.
GeneIDi3482.
KEGGihsa:3482.
UCSCiuc003qta.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00285 mRNA. Translation: CAA68395.1.
J03528 mRNA. Translation: AAA59866.1.
AF109291
, AF109244, AF109245, AF109246, AF109247, AF109248, AF109249, AF109250, AF109251, AF109252, AF109253, AF109254, AF109255, AF109256, AF109257, AF109258, AF109259, AF109260, AF109261, AF109262, AF109263, AF109264, AF109265, AF109266, AF109267, AF109268, AF109269, AF109270, AF109271, AF109272, AF109273, AF109274, AF109275, AF109276, AF109277, AF109278, AF109279, AF109280, AF109281, AF109282, AF109283, AF109284, AF109285, AF109286, AF109287, AF109288, AF109289, AF109290 Genomic DNA. Translation: AAF16870.1.
AF069333 Genomic DNA. Translation: AAL04402.1.
AY293855 Genomic DNA. Translation: AAP37954.1.
AL353625, AL035691 Genomic DNA. Translation: CAH72014.1.
AL035691, AL353625 Genomic DNA. Translation: CAI19940.1.
CCDSiCCDS5273.1.
PIRiA28372.
RefSeqiNP_000867.2. NM_000876.3.
UniGeneiHs.487062.
Hs.673278.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E6FX-ray1.75A/B1508-1650[»]
1GP0X-ray1.40A1508-1650[»]
1GP3X-ray1.95A1508-1650[»]
1GQBX-ray1.80A/B1508-1650[»]
1JPLX-ray2.40E/F/G/H2480-2491[»]
1JWGX-ray2.00C/D2479-2491[»]
1LF8X-ray2.30E/F/G/H2480-2491[»]
2CNJNMR-D1508-1650[»]
2L29NMR-A1508-1647[»]
2L2ANMR-A1508-1647[»]
2M68NMR-A1508-1647[»]
2M6TNMR-A1508-1647[»]
2V5NX-ray3.20A1508-1799[»]
2V5OX-ray2.91A1508-2128[»]
2V5PX-ray4.10A/B1508-1992[»]
5IEIX-ray2.80A1508-1647[»]
ProteinModelPortaliP11717.
SMRiP11717.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109703. 30 interactors.
DIPiDIP-6027N.
IntActiP11717. 34 interactors.
MINTiMINT-5004044.
STRINGi9606.ENSP00000349437.

Chemistry databases

BindingDBiP11717.
ChEMBLiCHEMBL3240.
DrugBankiDB01277. Mecasermin.

PTM databases

iPTMnetiP11717.
PhosphoSitePlusiP11717.
SwissPalmiP11717.

Polymorphism and mutation databases

BioMutaiIGF2R.
DMDMi317373416.

Proteomic databases

EPDiP11717.
MaxQBiP11717.
PaxDbiP11717.
PeptideAtlasiP11717.
PRIDEiP11717.

Protocols and materials databases

DNASUi3482.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356956; ENSP00000349437; ENSG00000197081.
GeneIDi3482.
KEGGihsa:3482.
UCSCiuc003qta.4. human.

Organism-specific databases

CTDi3482.
DisGeNETi3482.
GeneCardsiIGF2R.
HGNCiHGNC:5467. IGF2R.
HPAiCAB009661.
HPA011332.
MalaCardsiIGF2R.
MIMi147280. gene.
neXtProtiNX_P11717.
OpenTargetsiENSG00000197081.
PharmGKBiPA29701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4504. Eukaryota.
ENOG410ZWHP. LUCA.
GeneTreeiENSGT00390000013943.
HOGENOMiHOG000113638.
HOVERGENiHBG000334.
InParanoidiP11717.
KOiK06564.
OMAiVDCQVTD.
OrthoDBiEOG091G116D.
PhylomeDBiP11717.
TreeFamiTF328963.

Enzyme and pathway databases

BioCyciZFISH:G66-33795-MONOMER.
ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SignaLinkiP11717.
SIGNORiP11717.

Miscellaneous databases

ChiTaRSiIGF2R. human.
EvolutionaryTraceiP11717.
GeneWikiiInsulin-like_growth_factor_2_receptor.
GenomeRNAii3482.
PROiP11717.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197081.
CleanExiHS_IGF2R.
ExpressionAtlasiP11717. baseline and differential.
GenevisibleiP11717. HS.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di2.10.10.10. 1 hit.
2.70.130.10. 16 hits.
InterProiIPR000479. CIMR.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
[Graphical view]
PfamiPF00878. CIMR. 15 hits.
PF00040. fn2. 1 hit.
[Graphical view]
SMARTiSM01404. CIMR. 14 hits.
SM00059. FN2. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 16 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPRI_HUMAN
AccessioniPrimary (citable) accession number: P11717
Secondary accession number(s): Q7Z7G9, Q96PT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 189 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.