Cytochrome P450 2D9 - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (?) or add your own

P11714 (CP2D9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome P450 2D9
EC=1.14.14.1

Alternative name(s):
CYPIID9
Cytochrome P450-16-alpha
Cytochrome P450CA
Testosterone 16-alpha hydroxylase

Gene names

Name:	Cyp2d9
Synonyms:	Cyp2d-9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 504

504

Cytochrome P450 2D9

PRO_0000051734

Sites

Metal binding

446

Iron (heme axial ligand)

Amino acid modifications

Modified residue

138

Phosphoserine Ref.6

Experimental info

Sequence conflict

54 – 55

LG → QD in AAA39876. Ref.2

Sequence conflict

281

E → Q in AAA40428. Ref.1

Sequence conflict

281

E → Q in AAA40427. Ref.1

Sequence conflict

281

E → Q in AAA39876. Ref.2

Sequence conflict

281

E → Q in AAA75462. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P11714 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 6DC93B3985EFB8A2
Show »

FASTA

504

56,950

        10         20         30         40         50         60 
MELLTGTDLW PVAIFTVIFI LLVDLTHQRQ RWTSRYPPGP VPWPVLGNLL QVDLGNMPYS 

        70         80         90        100        110        120 
LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED TADRPPVPIF EYLGVKPGSQ 

       130        140        150        160        170        180 
GVVLAPYGPE WREQRRFSVS TLRNFGLGKK SLEDWVTKEA NHLCDAFTAQ AGQPINPNPM 

       190        200        210        220        230        240 
LNKSTCNVIA SLIFARRFEY EDPFLIRMLK VLEQSLTEVS GLIPEVLNAF PILLRIPRLA 

       250        260        270        280        290        300 
DKALQGQKSF IAILDNLLTE NRTTWDPVQA PRNLTDAFLA EIEKAKGNPE SSFNDENLLM 

       310        320        330        340        350        360 
VVRDLFGAGM LTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVRHPEM ADQAHMPYTN 

       370        380        390        400        410        420 
AVIHEVQRFG DIVPVNLPRI TSHDIEVQDF LIPKGTILLP NMSSMLKDES VWEKPLRFHP 

       430        440        450        460        470        480 
EHFLDAQGHF VKPEAFMPFS AGRRSCLGEA LARMELFLFF TCLLQRFSFS VPDGQPQPSN 

       490        500 
SGVYGILVAP SPYQLCAVVR DQGH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen." Wong G., Kawajiri K., Negishi M. Biochemistry 26:8683-8690(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins." Ichikawa T., Itakura T., Negishi M. Biochemistry 28:4779-4784(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/J. Tissue: Liver.
[3]	"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization." Wong G., Itakura T., Kawajiri K., Skow L., Negishi M. J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[6]	"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis." Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H. J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M23998 mRNA. Translation: AAA40427.1. M23997 mRNA. Translation: AAA40428.1. Sequence problems. M27168 mRNA. Translation: AAA39876.1. M24267, M24262 Genomic DNA. Translation: AAA75462.1. CH466550 Genomic DNA. Translation: EDL04501.1. BC010593 mRNA. Translation: AAH10593.1. BC094015 mRNA. Translation: AAH94015.1.
IPI	IPI00116572.
PIR	B27384. A27384. S15806.
RefSeq	NP_034136.2. NM_010006.2.
UniGene	Mm.226708.
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
ProteinModelPortal	P11714.
SMR	P11714. Positions 51-500.
ModBase	Search...
Proteomic databases
PaxDb	P11714.
PRIDE	P11714.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000089129; ENSMUSP00000086530; ENSMUSG00000068086.
GeneID	13105.
KEGG	mmu:13105.
Organism-specific databases
CTD	13105.
MGI	MGI:88606. Cyp2d9.
Phylogenomic databases
eggNOG	COG2124.
GeneTree	ENSGT00670000097712.
HOGENOM	HOG000036991.
HOVERGEN	HBG015789.
InParanoid	Q921V1.
KO	K07414.
OrthoDB	EOG40VVPH.
Gene expression databases
Bgee	P11714.
Genevestigator	P11714.
GermOnline	ENSMUSG00000068086. Mus musculus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008069. Cyt_P450_E_grp-I_CYP2D-like. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01686. EP450ICYP2D. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283098.
SOURCE	Search...

Entry information

Entry name

CP2D9_MOUSE

Accession

Primary (citable) accession number: P11714
Secondary accession number(s): Q64489, Q921V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents