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P11714 (CP2D9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D9

EC=1.14.14.1
Alternative name(s):
CYPIID9
Cytochrome P450-16-alpha
Cytochrome P450CA
Testosterone 16-alpha hydroxylase
Gene names
Name:Cyp2d9
Synonyms:Cyp2d-9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 2D9
PRO_0000051734

Sites

Metal binding4461Iron (heme axial ligand)

Experimental info

Sequence conflict54 – 552LG → QD in AAA39876. Ref.2
Sequence conflict2811E → Q in AAA40428. Ref.1
Sequence conflict2811E → Q in AAA40427. Ref.1
Sequence conflict2811E → Q in AAA39876. Ref.2
Sequence conflict2811E → Q in AAA75462. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P11714 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 6DC93B3985EFB8A2

FASTA50456,950
        10         20         30         40         50         60 
MELLTGTDLW PVAIFTVIFI LLVDLTHQRQ RWTSRYPPGP VPWPVLGNLL QVDLGNMPYS 

        70         80         90        100        110        120 
LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED TADRPPVPIF EYLGVKPGSQ 

       130        140        150        160        170        180 
GVVLAPYGPE WREQRRFSVS TLRNFGLGKK SLEDWVTKEA NHLCDAFTAQ AGQPINPNPM 

       190        200        210        220        230        240 
LNKSTCNVIA SLIFARRFEY EDPFLIRMLK VLEQSLTEVS GLIPEVLNAF PILLRIPRLA 

       250        260        270        280        290        300 
DKALQGQKSF IAILDNLLTE NRTTWDPVQA PRNLTDAFLA EIEKAKGNPE SSFNDENLLM 

       310        320        330        340        350        360 
VVRDLFGAGM LTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVRHPEM ADQAHMPYTN 

       370        380        390        400        410        420 
AVIHEVQRFG DIVPVNLPRI TSHDIEVQDF LIPKGTILLP NMSSMLKDES VWEKPLRFHP 

       430        440        450        460        470        480 
EHFLDAQGHF VKPEAFMPFS AGRRSCLGEA LARMELFLFF TCLLQRFSFS VPDGQPQPSN 

       490        500 
SGVYGILVAP SPYQLCAVVR DQGH 

« Hide

References

« Hide 'large scale' references
[1]"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen."
Wong G., Kawajiri K., Negishi M.
Biochemistry 26:8683-8690(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins."
Ichikawa T., Itakura T., Negishi M.
Biochemistry 28:4779-4784(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/J.
Tissue: Liver.
[3]"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M23998 mRNA. Translation: AAA40427.1.
M23997 mRNA. Translation: AAA40428.1. Sequence problems.
M27168 mRNA. Translation: AAA39876.1.
M24267, M24262 Genomic DNA. Translation: AAA75462.1.
CH466550 Genomic DNA. Translation: EDL04501.1.
BC010593 mRNA. Translation: AAH10593.1.
BC094015 mRNA. Translation: AAH94015.1.
PIRB27384.
A27384. S15806.
RefSeqNP_034136.2. NM_010006.2.
UniGeneMm.226708.

3D structure databases

ProteinModelPortalP11714.
SMRP11714. Positions 51-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP11714. 1 interaction.
MINTMINT-4122639.

Proteomic databases

PaxDbP11714.
PRIDEP11714.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089129; ENSMUSP00000086530; ENSMUSG00000068086.
GeneID13105.
KEGGmmu:13105.
UCSCuc007wzg.2. mouse.

Organism-specific databases

CTD13105.
MGIMGI:88606. Cyp2d9.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117392.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidQ921V1.
KOK07414.
OrthoDBEOG7RBZ85.
TreeFamTF352043.

Gene expression databases

BgeeP11714.
GenevestigatorP11714.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283098.
PROP11714.
SOURCESearch...

Entry information

Entry nameCP2D9_MOUSE
AccessionPrimary (citable) accession number: P11714
Secondary accession number(s): Q64489, Q921V1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot