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P11714

- CP2D9_MOUSE

UniProt

P11714 - CP2D9_MOUSE

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Protein

Cytochrome P450 2D9

Gene

Cyp2d9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D9 (EC:1.14.14.1)
Alternative name(s):
CYPIID9
Cytochrome P450-16-alpha
Cytochrome P450CA
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2d9
Synonyms:Cyp2d-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:88606. Cyp2d9.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2D9PRO_0000051734Add
BLAST

Proteomic databases

PaxDbiP11714.
PRIDEiP11714.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiP11714.
GenevestigatoriP11714.

Interactioni

Protein-protein interaction databases

IntActiP11714. 1 interaction.
MINTiMINT-4122639.

Structurei

3D structure databases

ProteinModelPortaliP11714.
SMRiP11714. Positions 51-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP11714.
KOiK07414.
OMAiYARASAM.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11714-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLTGTDLW PVAIFTVIFI LLVDLTHQRQ RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QVDLGNMPYS LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED
110 120 130 140 150
TADRPPVPIF EYLGVKPGSQ GVVLAPYGPE WREQRRFSVS TLRNFGLGKK
160 170 180 190 200
SLEDWVTKEA NHLCDAFTAQ AGQPINPNPM LNKSTCNVIA SLIFARRFEY
210 220 230 240 250
EDPFLIRMLK VLEQSLTEVS GLIPEVLNAF PILLRIPRLA DKALQGQKSF
260 270 280 290 300
IAILDNLLTE NRTTWDPVQA PRNLTDAFLA EIEKAKGNPE SSFNDENLLM
310 320 330 340 350
VVRDLFGAGM LTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVRHPEM
360 370 380 390 400
ADQAHMPYTN AVIHEVQRFG DIVPVNLPRI TSHDIEVQDF LIPKGTILLP
410 420 430 440 450
NMSSMLKDES VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGRRSCLGEA
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPDGQPQPSN SGVYGILVAP SPYQLCAVVR

DQGH
Length:504
Mass (Da):56,950
Last modified:July 27, 2011 - v2
Checksum:i6DC93B3985EFB8A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 552LG → QD in AAA39876. (PubMed:2788458)Curated
Sequence conflicti281 – 2811E → Q in AAA40428. (PubMed:2831949)Curated
Sequence conflicti281 – 2811E → Q in AAA40427. (PubMed:2831949)Curated
Sequence conflicti281 – 2811E → Q in AAA39876. (PubMed:2788458)Curated
Sequence conflicti281 – 2811E → Q in AAA75462. (PubMed:2914938)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23998 mRNA. Translation: AAA40427.1.
M23997 mRNA. Translation: AAA40428.1. Sequence problems.
M27168 mRNA. Translation: AAA39876.1.
M24267, M24262 Genomic DNA. Translation: AAA75462.1.
CH466550 Genomic DNA. Translation: EDL04501.1.
BC010593 mRNA. Translation: AAH10593.1.
BC094015 mRNA. Translation: AAH94015.1.
CCDSiCCDS27691.1.
PIRiB27384.
S15806. A27384.
RefSeqiNP_034136.2. NM_010006.2.
UniGeneiMm.226708.

Genome annotation databases

EnsembliENSMUST00000089129; ENSMUSP00000086530; ENSMUSG00000068086.
GeneIDi13105.
KEGGimmu:13105.
UCSCiuc007wzg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23998 mRNA. Translation: AAA40427.1 .
M23997 mRNA. Translation: AAA40428.1 . Sequence problems.
M27168 mRNA. Translation: AAA39876.1 .
M24267 , M24262 Genomic DNA. Translation: AAA75462.1 .
CH466550 Genomic DNA. Translation: EDL04501.1 .
BC010593 mRNA. Translation: AAH10593.1 .
BC094015 mRNA. Translation: AAH94015.1 .
CCDSi CCDS27691.1.
PIRi B27384.
S15806. A27384.
RefSeqi NP_034136.2. NM_010006.2.
UniGenei Mm.226708.

3D structure databases

ProteinModelPortali P11714.
SMRi P11714. Positions 51-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P11714. 1 interaction.
MINTi MINT-4122639.

Proteomic databases

PaxDbi P11714.
PRIDEi P11714.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089129 ; ENSMUSP00000086530 ; ENSMUSG00000068086 .
GeneIDi 13105.
KEGGi mmu:13105.
UCSCi uc007wzg.2. mouse.

Organism-specific databases

CTDi 13105.
MGIi MGI:88606. Cyp2d9.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi P11714.
KOi K07414.
OMAi YARASAM.
OrthoDBi EOG7RBZ85.
TreeFami TF352043.

Miscellaneous databases

NextBioi 283098.
PROi P11714.
SOURCEi Search...

Gene expression databases

Bgeei P11714.
Genevestigatori P11714.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen."
    Wong G., Kawajiri K., Negishi M.
    Biochemistry 26:8683-8690(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins."
    Ichikawa T., Itakura T., Negishi M.
    Biochemistry 28:4779-4784(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/J.
    Tissue: Liver.
  3. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
    Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
    J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCP2D9_MOUSE
AccessioniPrimary (citable) accession number: P11714
Secondary accession number(s): Q64489, Q921V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3