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P11714

- CP2D9_MOUSE

UniProt

P11714 - CP2D9_MOUSE

Protein

Cytochrome P450 2D9

Gene

Cyp2d9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D9 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID9
    Cytochrome P450-16-alpha
    Cytochrome P450CA
    Testosterone 16-alpha hydroxylase
    Gene namesi
    Name:Cyp2d9
    Synonyms:Cyp2d-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:88606. Cyp2d9.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 2D9PRO_0000051734Add
    BLAST

    Proteomic databases

    PaxDbiP11714.
    PRIDEiP11714.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiP11714.
    GenevestigatoriP11714.

    Interactioni

    Protein-protein interaction databases

    IntActiP11714. 1 interaction.
    MINTiMINT-4122639.

    Structurei

    3D structure databases

    ProteinModelPortaliP11714.
    SMRiP11714. Positions 51-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117392.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiQ921V1.
    KOiK07414.
    OMAiYARASAM.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11714-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLTGTDLW PVAIFTVIFI LLVDLTHQRQ RWTSRYPPGP VPWPVLGNLL    50
    QVDLGNMPYS LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED 100
    TADRPPVPIF EYLGVKPGSQ GVVLAPYGPE WREQRRFSVS TLRNFGLGKK 150
    SLEDWVTKEA NHLCDAFTAQ AGQPINPNPM LNKSTCNVIA SLIFARRFEY 200
    EDPFLIRMLK VLEQSLTEVS GLIPEVLNAF PILLRIPRLA DKALQGQKSF 250
    IAILDNLLTE NRTTWDPVQA PRNLTDAFLA EIEKAKGNPE SSFNDENLLM 300
    VVRDLFGAGM LTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVRHPEM 350
    ADQAHMPYTN AVIHEVQRFG DIVPVNLPRI TSHDIEVQDF LIPKGTILLP 400
    NMSSMLKDES VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGRRSCLGEA 450
    LARMELFLFF TCLLQRFSFS VPDGQPQPSN SGVYGILVAP SPYQLCAVVR 500
    DQGH 504
    Length:504
    Mass (Da):56,950
    Last modified:July 27, 2011 - v2
    Checksum:i6DC93B3985EFB8A2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 552LG → QD in AAA39876. (PubMed:2788458)Curated
    Sequence conflicti281 – 2811E → Q in AAA40428. (PubMed:2831949)Curated
    Sequence conflicti281 – 2811E → Q in AAA40427. (PubMed:2831949)Curated
    Sequence conflicti281 – 2811E → Q in AAA39876. (PubMed:2788458)Curated
    Sequence conflicti281 – 2811E → Q in AAA75462. (PubMed:2914938)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23998 mRNA. Translation: AAA40427.1.
    M23997 mRNA. Translation: AAA40428.1. Sequence problems.
    M27168 mRNA. Translation: AAA39876.1.
    M24267, M24262 Genomic DNA. Translation: AAA75462.1.
    CH466550 Genomic DNA. Translation: EDL04501.1.
    BC010593 mRNA. Translation: AAH10593.1.
    BC094015 mRNA. Translation: AAH94015.1.
    CCDSiCCDS27691.1.
    PIRiB27384.
    S15806. A27384.
    RefSeqiNP_034136.2. NM_010006.2.
    UniGeneiMm.226708.

    Genome annotation databases

    EnsembliENSMUST00000089129; ENSMUSP00000086530; ENSMUSG00000068086.
    GeneIDi13105.
    KEGGimmu:13105.
    UCSCiuc007wzg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23998 mRNA. Translation: AAA40427.1 .
    M23997 mRNA. Translation: AAA40428.1 . Sequence problems.
    M27168 mRNA. Translation: AAA39876.1 .
    M24267 , M24262 Genomic DNA. Translation: AAA75462.1 .
    CH466550 Genomic DNA. Translation: EDL04501.1 .
    BC010593 mRNA. Translation: AAH10593.1 .
    BC094015 mRNA. Translation: AAH94015.1 .
    CCDSi CCDS27691.1.
    PIRi B27384.
    S15806. A27384.
    RefSeqi NP_034136.2. NM_010006.2.
    UniGenei Mm.226708.

    3D structure databases

    ProteinModelPortali P11714.
    SMRi P11714. Positions 51-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P11714. 1 interaction.
    MINTi MINT-4122639.

    Proteomic databases

    PaxDbi P11714.
    PRIDEi P11714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089129 ; ENSMUSP00000086530 ; ENSMUSG00000068086 .
    GeneIDi 13105.
    KEGGi mmu:13105.
    UCSCi uc007wzg.2. mouse.

    Organism-specific databases

    CTDi 13105.
    MGIi MGI:88606. Cyp2d9.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117392.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi Q921V1.
    KOi K07414.
    OMAi YARASAM.
    OrthoDBi EOG7RBZ85.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 283098.
    PROi P11714.
    SOURCEi Search...

    Gene expression databases

    Bgeei P11714.
    Genevestigatori P11714.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen."
      Wong G., Kawajiri K., Negishi M.
      Biochemistry 26:8683-8690(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins."
      Ichikawa T., Itakura T., Negishi M.
      Biochemistry 28:4779-4784(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/J.
      Tissue: Liver.
    3. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
      Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
      J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCP2D9_MOUSE
    AccessioniPrimary (citable) accession number: P11714
    Secondary accession number(s): Q64489, Q921V1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3