Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450 2D9

Gene

Cyp2d9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions
R-MMU-9027307 Biosynthesis of maresin-like SPMs

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D9 (EC:1.14.14.1)
Alternative name(s):
CYPIID9
Cytochrome P450-16-alpha
Cytochrome P450CA
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2d9
Synonyms:Cyp2d-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88606 Cyp2d9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517341 – 504Cytochrome P450 2D9Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP11714
PaxDbiP11714
PeptideAtlasiP11714
PRIDEiP11714

PTM databases

iPTMnetiP11714
PhosphoSitePlusiP11714
SwissPalmiP11714

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000068086
GenevisibleiP11714 MM

Interactioni

Protein-protein interaction databases

IntActiP11714, 1 interactor
MINTiP11714
STRINGi10090.ENSMUSP00000086530

Structurei

3D structure databases

ProteinModelPortaliP11714
SMRiP11714
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiP11714
KOiK07414
OMAiARGTLYD
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P11714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTGTDLW PVAIFTVIFI LLVDLTHQRQ RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QVDLGNMPYS LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED
110 120 130 140 150
TADRPPVPIF EYLGVKPGSQ GVVLAPYGPE WREQRRFSVS TLRNFGLGKK
160 170 180 190 200
SLEDWVTKEA NHLCDAFTAQ AGQPINPNPM LNKSTCNVIA SLIFARRFEY
210 220 230 240 250
EDPFLIRMLK VLEQSLTEVS GLIPEVLNAF PILLRIPRLA DKALQGQKSF
260 270 280 290 300
IAILDNLLTE NRTTWDPVQA PRNLTDAFLA EIEKAKGNPE SSFNDENLLM
310 320 330 340 350
VVRDLFGAGM LTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVRHPEM
360 370 380 390 400
ADQAHMPYTN AVIHEVQRFG DIVPVNLPRI TSHDIEVQDF LIPKGTILLP
410 420 430 440 450
NMSSMLKDES VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGRRSCLGEA
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPDGQPQPSN SGVYGILVAP SPYQLCAVVR

DQGH
Length:504
Mass (Da):56,950
Last modified:July 27, 2011 - v2
Checksum:i6DC93B3985EFB8A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54 – 55LG → QD in AAA39876 (PubMed:2788458).Curated2
Sequence conflicti281E → Q in AAA40428 (PubMed:2831949).Curated1
Sequence conflicti281E → Q in AAA40427 (PubMed:2831949).Curated1
Sequence conflicti281E → Q in AAA39876 (PubMed:2788458).Curated1
Sequence conflicti281E → Q in AAA75462 (PubMed:2914938).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23998 mRNA Translation: AAA40427.1
M23997 mRNA Translation: AAA40428.1 Sequence problems.
M27168 mRNA Translation: AAA39876.1
M24267, M24262 Genomic DNA Translation: AAA75462.1
CH466550 Genomic DNA Translation: EDL04501.1
BC010593 mRNA Translation: AAH10593.1
BC094015 mRNA Translation: AAH94015.1
CCDSiCCDS27691.1
PIRiB27384
S15806 A27384
RefSeqiNP_034136.2, NM_010006.2
UniGeneiMm.226708

Genome annotation databases

EnsembliENSMUST00000089129; ENSMUSP00000086530; ENSMUSG00000068086
GeneIDi13105
KEGGimmu:13105
UCSCiuc007wzg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCP2D9_MOUSE
AccessioniPrimary (citable) accession number: P11714
Secondary accession number(s): Q64489, Q921V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health