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P11712

- CP2C9_HUMAN

UniProt

P11712 - CP2C9_HUMAN

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Protein
Cytochrome P450 2C9
Gene
CYP2C9, CYP2C10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.

Catalytic activityi

+-(R)-limonene + NADPH + O2 = (+)-trans-carveol + NADP+ + H2O.
--(S)-limonene + NADPH + O2 = (-)-trans-carveol + NADP+ + H2O.
--(S)-limonene + NADPH + O2 = (-)-perillyl alcohol + NADP+ + H2O.

Cofactori

Heme group.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)

GO - Molecular functioni

  1. (R)-limonene 6-monooxygenase activity Source: UniProtKB-EC
  2. (S)-limonene 6-monooxygenase activity Source: UniProtKB-EC
  3. (S)-limonene 7-monooxygenase activity Source: UniProtKB-EC
  4. caffeine oxidase activity Source: BHF-UCL
  5. drug binding Source: BHF-UCL
  6. heme binding Source: InterPro
  7. iron ion binding Source: InterPro
  8. monooxygenase activity Source: UniProtKB
  9. oxidoreductase activity Source: BHF-UCL
  10. steroid hydroxylase activity Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. arachidonic acid metabolic process Source: Reactome
  2. cellular amide metabolic process Source: BHF-UCL
  3. drug catabolic process Source: BHF-UCL
  4. drug metabolic process Source: UniProtKB
  5. epoxygenase P450 pathway Source: Reactome
  6. exogenous drug catabolic process Source: BHF-UCL
  7. monocarboxylic acid metabolic process Source: BHF-UCL
  8. monoterpenoid metabolic process Source: BHF-UCL
  9. omega-hydroxylase P450 pathway Source: Reactome
  10. oxidation-reduction process Source: BHF-UCL
  11. oxidative demethylation Source: BHF-UCL
  12. small molecule metabolic process Source: Reactome
  13. steroid metabolic process Source: BHF-UCL
  14. urea metabolic process Source: BHF-UCL
  15. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiREACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
SABIO-RKP11712.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C9 (EC:1.14.13.-)
Alternative name(s):
(R)-limonene 6-monooxygenase (EC:1.14.13.80)
(S)-limonene 6-monooxygenase (EC:1.14.13.48)
(S)-limonene 7-monooxygenase (EC:1.14.13.49)
CYPIIC9
Cytochrome P-450MP
Cytochrome P450 MP-4
Cytochrome P450 MP-8
Cytochrome P450 PB-1
S-mephenytoin 4-hydroxylase
Gene namesi
Name:CYP2C9
Synonyms:CYP2C10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:2623. CYP2C9.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. intracellular membrane-bounded organelle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

Orphaneti240843. Acenocoumarol toxicity.
240859. Carbutamide toxicity.
240873. Fluindione toxicity.
240875. Glibenclamide toxicity.
240877. Gliclazide toxicity.
240879. Glimepiride toxicity.
240881. Glipizide toxicity.
240897. Phenprocoumon toxicity.
240991. Susceptibility to bleeding due to acenocoumarol treatment.
240993. Susceptibility to bleeding due to fluindione treatment.
240995. Susceptibility to bleeding due to phenprocoumon treatment.
240997. Susceptibility to bleeding due to warfarine treatment.
241007. Susceptibility to hypoglycemia due to carbutamide treatment.
241009. Susceptibility to hypoglycemia due to glibenclamide treatment.
241011. Susceptibility to hypoglycemia due to gliclazide treatment.
241013. Susceptibility to hypoglycemia due to glimepiride treatment.
241015. Susceptibility to hypoglycemia due to glipizide treatment.
241045. Warfarine dose selection in the treatment of venous thrombosis and atrial fibrillation.
240923. Warfarine toxicity.
PharmGKBiPA126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C9
PRO_0000051700Add
BLAST

Proteomic databases

PaxDbiP11712.
PRIDEiP11712.

PTM databases

PhosphoSiteiP11712.

Expressioni

Inductioni

By rifampicin.

Gene expression databases

ArrayExpressiP11712.
BgeeiP11712.
CleanExiHS_CYP2C9.
GenevestigatoriP11712.

Organism-specific databases

HPAiCAB016123.
HPA015066.

Interactioni

Protein-protein interaction databases

BioGridi107937. 9 interactions.
IntActiP11712. 6 interactions.
STRINGi9606.ENSP00000260682.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353
Turni37 – 393
Helixi42 – 454
Helixi47 – 6115
Beta strandi63 – 719
Beta strandi73 – 775
Helixi80 – 878
Turni88 – 947
Turni105 – 1073
Beta strandi111 – 1144
Helixi117 – 13115
Beta strandi134 – 1363
Helixi141 – 15717
Turni158 – 1614
Helixi167 – 18317
Helixi192 – 20817
Helixi213 – 2186
Helixi222 – 2254
Helixi230 – 25324
Helixi263 – 27412
Beta strandi275 – 2773
Helixi284 – 31532
Helixi317 – 33014
Beta strandi333 – 3353
Helixi339 – 3446
Helixi346 – 35914
Beta strandi374 – 3763
Beta strandi379 – 3813
Beta strandi386 – 3894
Helixi392 – 3954
Turni398 – 4003
Beta strandi401 – 4033
Helixi409 – 4124
Beta strandi415 – 4173
Helixi431 – 4333
Helixi438 – 45518
Beta strandi456 – 4627
Helixi464 – 4663
Beta strandi475 – 4773
Beta strandi485 – 4895

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OG2X-ray2.60A/B30-490[»]
1OG5X-ray2.55A/B30-490[»]
1R9OX-ray2.00A18-490[»]
ProteinModelPortaliP11712.
SMRiP11712. Positions 44-490.

Miscellaneous databases

EvolutionaryTraceiP11712.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP11712.
KOiK17719.
OMAiNVAFMKS.
OrthoDBiEOG7RBZ85.
PhylomeDBiP11712.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P11712-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI    50
SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF 100
PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 150
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK 200
LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE 250
HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE 300
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA 350
VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE 400
FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT 450
SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV 490
Length:490
Mass (Da):55,628
Last modified:May 30, 2000 - v3
Checksum:i4FDFC395303A4E3E
GO
Isoform 2 (identifier: P11712-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-162: AS → GG
     163-490: Missing.

Note: No experimental confirmation available.

Show »
Length:162
Mass (Da):18,005
Checksum:iB59C8888ED45AD09
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191L → I in allele CYP2C9*7.
VAR_018862
Natural varianti144 – 1441R → C in allele CYP2C9*2. 6 Publications
Corresponds to variant rs1799853 [ dbSNP | Ensembl ].
VAR_008343
Natural varianti150 – 1501R → H in allele CYP2C9*8. 2 Publications
Corresponds to variant rs7900194 [ dbSNP | Ensembl ].
VAR_018863
Natural varianti251 – 2511H → R in allele CYP2C9*9. 2 Publications
Corresponds to variant rs2256871 [ dbSNP | Ensembl ].
VAR_018864
Natural varianti272 – 2721E → G in allele CYP2C9*10. 1 Publication
Corresponds to variant rs9332130 [ dbSNP | Ensembl ].
VAR_018865
Natural varianti335 – 3351R → W in allele CYP2C9*11. 2 Publications
Corresponds to variant rs28371685 [ dbSNP | Ensembl ].
VAR_018866
Natural varianti358 – 3581Y → C.3 Publications
Corresponds to variant rs1057909 [ dbSNP | Ensembl ].
VAR_008344
Natural varianti359 – 3591I → L in allele CYP2C9*3; responsible for the tolbutamide poor metabolizer phenotype. 4 Publications
Corresponds to variant rs1057910 [ dbSNP | Ensembl ].
VAR_008345
Natural varianti359 – 3591I → T in allele CYP2C9*4. 1 Publication
Corresponds to variant rs56165452 [ dbSNP | Ensembl ].
VAR_013515
Natural varianti360 – 3601D → E in allele CYP2C9*5; increases the K(m) value for substrates tested. 2 Publications
Corresponds to variant rs28371686 [ dbSNP | Ensembl ].
VAR_013516
Natural varianti413 – 4131L → P.1 Publication
Corresponds to variant rs28371687 [ dbSNP | Ensembl ].
VAR_024717
Natural varianti417 – 4171G → D.3 Publications
VAR_008346
Natural varianti489 – 4891P → S in allele CYP2C9*12. 1 Publication
Corresponds to variant rs9332239 [ dbSNP | Ensembl ].
VAR_018867

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 1622AS → GG in isoform 2.
VSP_055573
Alternative sequencei163 – 490328Missing in isoform 2.
VSP_055574Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41L → I no nucleotide entry 1 Publication
Sequence conflicti6 – 61V → S no nucleotide entry 1 Publication
Sequence conflicti14 – 141L → M in AAB23864. 1 Publication
Sequence conflicti175 – 1751C → Y no nucleotide entry 1 Publication
Sequence conflicti239 – 2391F → L no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY341248 Genomic DNA. Translation: AAP88931.1.
AY702706 Genomic DNA. Translation: AAT94065.1.
AK289420 mRNA. Translation: BAF82109.1.
AL359672 Genomic DNA. Translation: CAH71303.1.
CH471066 Genomic DNA. Translation: EAW50019.1.
CH471066 Genomic DNA. Translation: EAW50020.1.
BC020754 mRNA. Translation: AAH20754.1.
BC070317 mRNA. Translation: AAH70317.1.
BC125054 mRNA. Translation: AAI25055.1.
D00173 mRNA. Translation: BAA00123.1.
M15331 mRNA. Translation: AAA52157.1.
M21939 mRNA. Translation: AAA52158.1.
M21940 mRNA. Translation: AAA52159.1.
S46963 mRNA. Translation: AAB23864.2. Sequence problems.
CCDSiCCDS7437.1.
PIRiB38462.
D28951.
RefSeqiNP_000762.2. NM_000771.3.
UniGeneiHs.282624.

Genome annotation databases

EnsembliENST00000260682; ENSP00000260682; ENSG00000138109.
GeneIDi1559.
KEGGihsa:1559.
UCSCiuc001kka.4. human.

Polymorphism databases

DMDMi6686268.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C9 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY341248 Genomic DNA. Translation: AAP88931.1 .
AY702706 Genomic DNA. Translation: AAT94065.1 .
AK289420 mRNA. Translation: BAF82109.1 .
AL359672 Genomic DNA. Translation: CAH71303.1 .
CH471066 Genomic DNA. Translation: EAW50019.1 .
CH471066 Genomic DNA. Translation: EAW50020.1 .
BC020754 mRNA. Translation: AAH20754.1 .
BC070317 mRNA. Translation: AAH70317.1 .
BC125054 mRNA. Translation: AAI25055.1 .
D00173 mRNA. Translation: BAA00123.1 .
M15331 mRNA. Translation: AAA52157.1 .
M21939 mRNA. Translation: AAA52158.1 .
M21940 mRNA. Translation: AAA52159.1 .
S46963 mRNA. Translation: AAB23864.2 . Sequence problems.
CCDSi CCDS7437.1.
PIRi B38462.
D28951.
RefSeqi NP_000762.2. NM_000771.3.
UniGenei Hs.282624.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OG2 X-ray 2.60 A/B 30-490 [» ]
1OG5 X-ray 2.55 A/B 30-490 [» ]
1R9O X-ray 2.00 A 18-490 [» ]
ProteinModelPortali P11712.
SMRi P11712. Positions 44-490.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107937. 9 interactions.
IntActi P11712. 6 interactions.
STRINGi 9606.ENSP00000260682.

Chemistry

BindingDBi P11712.
ChEMBLi CHEMBL3397.
DrugBanki DB01418. Acenocoumarol.
DB00969. Alosetron.
DB01118. Amiodarone.
DB00025. Antihemophilic Factor.
DB00673. Aprepitant.
DB00559. Bosentan.
DB00821. Carprofen.
DB01136. Carvedilol.
DB00482. Celecoxib.
DB01242. Clomipramine.
DB00250. Dapsone.
DB00705. Delavirdine.
DB00967. Desloratadine.
DB00304. Desogestrel.
DB00586. Diclofenac.
DB00736. Esomeprazole.
DB00749. Etodolac.
DB00196. Fluconazole.
DB00472. Fluoxetine.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00983. Formoterol.
DB01241. Gemfibrozil.
DB01381. Ginkgo biloba.
DB01016. Glibenclamide.
DB00222. Glimepiride.
DB01067. Glipizide.
DB01018. Guanfacine.
DB00327. Hydromorphone.
DB01050. Ibuprofen.
DB00458. Imipramine.
DB01029. Irbesartan.
DB01026. Ketoconazole.
DB00448. Lansoprazole.
DB00678. Losartan.
DB01283. Lumiracoxib.
DB00470. Marinol.
DB00784. Mefenamic acid.
DB00814. Meloxicam.
DB00532. Mephenytoin.
DB00916. Metronidazole.
DB01110. Miconazole.
DB00683. Midazolam.
DB00471. Montelukast.
DB00731. Nateglinide.
DB00220. Nelfinavir.
DB00622. Nicardipine.
DB01192. Oxymorphone.
DB00213. Pantoprazole.
DB00617. Paramethadione.
DB00946. Phenprocoumon.
DB00252. Phenytoin.
DB00175. Pravastatin.
DB00908. Quinidine.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB01104. Sertraline.
DB00203. Sildenafil.
DB01015. Sulfamethoxazole.
DB00870. Suprofen.
DB00675. Tamoxifen.
DB00469. Tenoxicam.
DB00342. Terfenadine.
DB01124. Tolbutamide.
DB00214. Torasemide.
DB01361. Troleandomycin.
DB00580. Valdecoxib.
DB00177. Valsartan.
DB00582. Voriconazole.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB00744. Zileuton.

PTM databases

PhosphoSitei P11712.

Polymorphism databases

DMDMi 6686268.

Proteomic databases

PaxDbi P11712.
PRIDEi P11712.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260682 ; ENSP00000260682 ; ENSG00000138109 .
GeneIDi 1559.
KEGGi hsa:1559.
UCSCi uc001kka.4. human.

Organism-specific databases

CTDi 1559.
GeneCardsi GC10P096688.
HGNCi HGNC:2623. CYP2C9.
HPAi CAB016123.
HPA015066.
MIMi 601130. gene.
neXtProti NX_P11712.
Orphaneti 240843. Acenocoumarol toxicity.
240859. Carbutamide toxicity.
240873. Fluindione toxicity.
240875. Glibenclamide toxicity.
240877. Gliclazide toxicity.
240879. Glimepiride toxicity.
240881. Glipizide toxicity.
240897. Phenprocoumon toxicity.
240991. Susceptibility to bleeding due to acenocoumarol treatment.
240993. Susceptibility to bleeding due to fluindione treatment.
240995. Susceptibility to bleeding due to phenprocoumon treatment.
240997. Susceptibility to bleeding due to warfarine treatment.
241007. Susceptibility to hypoglycemia due to carbutamide treatment.
241009. Susceptibility to hypoglycemia due to glibenclamide treatment.
241011. Susceptibility to hypoglycemia due to gliclazide treatment.
241013. Susceptibility to hypoglycemia due to glimepiride treatment.
241015. Susceptibility to hypoglycemia due to glipizide treatment.
241045. Warfarine dose selection in the treatment of venous thrombosis and atrial fibrillation.
240923. Warfarine toxicity.
PharmGKBi PA126.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P11712.
KOi K17719.
OMAi NVAFMKS.
OrthoDBi EOG7RBZ85.
PhylomeDBi P11712.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
SABIO-RK P11712.

Miscellaneous databases

ChiTaRSi CYP2C9. human.
EvolutionaryTracei P11712.
GeneWikii CYP2C9.
GenomeRNAii 1559.
NextBioi 6438.
PROi P11712.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11712.
Bgeei P11712.
CleanExi HS_CYP2C9.
Genevestigatori P11712.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10."
    Meehan R.R., Gosden J.R., Rout D., Hastie N.D., Friedberg T., Adesnik M., Buckland R., van Heyningen V., Fletcher J.M., Spurr N.K., Sweeney J., Wolf C.R.
    Am. J. Hum. Genet. 42:26-37(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-144.
  2. "cDNA and amino acid sequences of two members of the human P450IIC gene subfamily."
    Kimura S., Pastewka J., Gelboin H.V., Gonzalez F.J.
    Nucleic Acids Res. 15:10053-10054(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-144.
  3. NIEHS SNPs program
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-144; HIS-150; ARG-251; GLY-272; LEU-359 AND SER-489.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT CYS-144.
    Tissue: Liver.
  8. "Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form."
    Yasumori T., Kawano S., Nagata K., Shimada M., Yamazoe Y., Kato R.
    J. Biochem. 102:1075-1082(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-490 (ISOFORM 1).
    Tissue: Liver.
  9. "Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase."
    Umbenhauer D.R., Martin M.V., Lloyd R.S., Guengerich F.P.
    Biochemistry 26:1094-1099(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490 (ISOFORM 1), VARIANTS CYS-358 AND ASP-417.
    Tissue: Liver.
  10. "Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase."
    Ged C., Umbenhauer D.R., Bellew T.M., Bork R.W., Srivastava P.K., Shinriki N., Lloyd R.S., Guengerich F.P.
    Biochemistry 27:6929-6940(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490 (ISOFORM 1), VARIANTS CYS-358 AND ASP-417.
  11. "Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity."
    Ohgiya S., Komori M., Ohi H., Shiramatsu K., Shinriki N., Kamataki T.
    Biochem. Int. 27:1073-1081(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-490 (ISOFORM 1).
  12. "Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction."
    Shimada T., Misono K.S., Guengerich F.P.
    J. Biol. Chem. 261:909-921(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-29, CHARACTERIZATION.
  13. "Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization."
    Komori M., Hashizume T., Ohi H., Miura T., Kitada M., Nagashima K., Kamataki T.
    J. Biochem. 104:912-916(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-25.
  14. "Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes."
    Srivastava P.K., Yun C.H., Beaune P.H., Ged C., Guengerich F.P.
    Mol. Pharmacol. 40:69-79(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  15. "Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms."
    Haining R.L., Hunter A.P., Veronese M.E., Trager W.F., Rettie A.E.
    Arch. Biochem. Biophys. 333:447-458(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-9; 21-157; 169-249; 264-424; 426-476 AND 484-487.
  16. "Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity."
    Sandhu P., Baba T., Guengerich F.P.
    Arch. Biochem. Biophys. 306:443-450(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-20.
  17. "Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes."
    Miyazawa M., Shindo M., Shimada T.
    Drug Metab. Dispos. 30:602-607(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  18. "Crystal structure of human cytochrome P450 2C9 with bound warfarin."
    Williams P.A., Cosme J., Ward A., Angove H.C., Matak-Vinkovic D., Jhoti H.
    Nature 424:464-468(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 30-490.
  19. "Genetic analysis of the human cytochrome P450 CYP2C9 locus."
    Stubbins M.J., Harries L.W., Smith G., Tarbit M.H., Wolf C.R.
    Pharmacogenetics 6:429-439(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYP2C9*2 CYS-144 AND CYP2C9*3 LEU-359.
  20. "Allelic and functional variability of cytochrome P4502C9."
    Bhasker C.R., Miners J.O., Coulter S., Birkett D.J.
    Pharmacogenetics 7:51-58(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYP2C9*2 CYS-144; CYS-358; CYP2C9*3 LEU-359 AND ASP-417.
  21. "Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus."
    Imai J., Ieiri I., Mamiya K., Miyahara S., Furuumi H., Nanba E., Yamane M., Fukumaki Y., Ninomiya H., Tashiro N., Otsubo K., Higuchi S.
    Pharmacogenetics 10:85-89(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2C9*4 THR-359.
  22. "Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans."
    Dickmann L.J., Rettie A.E., Kneller M.B., Kim R.B., Wood A.J., Stein C.M., Wilkinson G.R., Schwarz U.I.
    Mol. Pharmacol. 60:382-387(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2C9*5 GLU-360.
  23. "Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy."
    Higashi M.K., Veenstra D.L., Kondo L.M., Wittkowsky A.K., Srinouanprachanh S.L., Farin F.M., Rettie A.E.
    JAMA 287:1690-1698(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2C9*11 TRP-335.
  24. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
    Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
    Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYS-144; HIS-150; ARG-251; TRP-335; LEU-359; GLU-360 AND PRO-413.

Entry informationi

Entry nameiCP2C9_HUMAN
AccessioniPrimary (citable) accession number: P11712
Secondary accession number(s): P11713
, Q16756, Q16872, Q5VX92, Q6IRV8, Q8WW80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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