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Protein

Cytochrome P450 2C9

Gene

CYP2C9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).1 Publication

Catalytic activityi

+-(R)-limonene + [reduced NADPH--hemoprotein reductase] + O2 = (+)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O2 = (-)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O2 = (-)-perillyl alcohol + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication
Cholesterol + [reduced NADPH--hemoprotein reductase] + O2 = 25-hydroxycholesterol + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

Kineticsi

  1. KM=1.25 mM for S-mephenytoin1 Publication
  2. KM=46.24 µM for tolbutamide1 Publication
  3. KM=4.73 µM for diclofenac1 Publication
  4. KM=1.58 µM for losartan1 Publication
  1. Vmax=9.22 pmol/min/pmol enzyme with tolbutamide as substrate1 Publication
  2. Vmax=17.16 pmol/min/pmol enzyme with diclofenac as substrate1 Publication
  3. Vmax=210.30 pmol/min/pmol enzyme with losartan as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)1

GO - Molecular functioni

  • arachidonic acid epoxygenase activity Source: GO_Central
  • caffeine oxidase activity Source: BHF-UCL
  • drug binding Source: BHF-UCL
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: BHF-UCL
  • oxidoreductase activity Source: BHF-UCL
  • oxygen binding Source: Reactome
  • steroid hydroxylase activity Source: BHF-UCL

GO - Biological processi

  • cellular amide metabolic process Source: BHF-UCL
  • drug catabolic process Source: BHF-UCL
  • drug metabolic process Source: BHF-UCL
  • epoxygenase P450 pathway Source: GO_Central
  • exogenous drug catabolic process Source: BHF-UCL
  • monocarboxylic acid metabolic process Source: BHF-UCL
  • monoterpenoid metabolic process Source: BHF-UCL
  • omega-hydroxylase P450 pathway Source: Reactome
  • oxidation-reduction process Source: BHF-UCL
  • oxidative demethylation Source: BHF-UCL
  • steroid metabolic process Source: BHF-UCL
  • urea metabolic process Source: BHF-UCL
  • xenobiotic metabolic process Source: Reactome

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06458-MONOMER
BRENDAi1.14.99.38 2681
ReactomeiR-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
SABIO-RKiP11712
SIGNORiP11712

Chemistry databases

SwissLipidsiSLP:000001203

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C9 (EC:1.14.14.-1 Publication)
Alternative name(s):
(R)-limonene 6-monooxygenase (EC:1.14.14.531 Publication)
(S)-limonene 6-monooxygenase (EC:1.14.14.511 Publication)
(S)-limonene 7-monooxygenase (EC:1.14.14.521 Publication)
CYPIIC9
Cholesterol 25-hydroxylase1 Publication (EC:1.14.14.-1 Publication)
Cytochrome P-450MP
Cytochrome P450 MP-4
Cytochrome P450 MP-8
Cytochrome P450 PB-1
S-mephenytoin 4-hydroxylase1 Publication
Gene namesi
Name:CYP2C9
Synonyms:CYP2C10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138109.9
HGNCiHGNC:2623 CYP2C9
MIMi601130 gene
neXtProtiNX_P11712

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1559
MalaCardsiCYP2C9
OpenTargetsiENSG00000138109
Orphaneti413681 Oral antidiabetic drugs toxicity or dose selection
413674 Vitamin K antagonists toxicity or dose selection
PharmGKBiPA126

Chemistry databases

ChEMBLiCHEMBL3397
DrugBankiDB02507 4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One
DB05812 Abiraterone
DB06736 Aceclofenac
DB01418 Acenocoumarol
DB00316 Acetaminophen
DB00945 Acetylsalicylic acid
DB06594 Agomelatine
DB00969 Alosetron
DB00404 Alprazolam
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00613 Amodiaquine
DB00701 Amprenavir
DB01217 Anastrozole
DB01435 Antipyrine
DB06605 Apixaban
DB00673 Aprepitant
DB04557 Arachidonic Acid
DB01274 Arformoterol
DB06413 Armodafinil
DB06697 Artemether
DB01072 Atazanavir
DB01076 Atorvastatin
DB01117 Atovaquone
DB00972 Azelastine
DB00307 Bexarotene
DB01128 Bicalutamide
DB00188 Bortezomib
DB00559 Bosentan
DB00835 Brompheniramine
DB00921 Buprenorphine
DB01156 Bupropion
DB08875 Cabozantinib
DB00201 Caffeine
DB00796 Candesartan
DB01101 Capecitabine
DB00564 Carbamazepine
DB00748 Carbinoxamine
DB01136 Carvedilol
DB00482 Celecoxib
DB09063 Ceritinib
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB00672 Chlorpropamide
DB00169 Cholecalciferol
DB00501 Cimetidine
DB00568 Cinnarizine
DB00604 Cisapride
DB00515 Cisplatin
DB04920 Clevidipine
DB00758 Clopidogrel
DB00257 Clotrimazole
DB00363 Clozapine
DB00907 Cocaine
DB01394 Colchicine
DB05219 Crisaborole
DB01176 Cyclizine
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB06292 Dapagliflozin
DB00250 Dapsone
DB00705 Delavirdine
DB00967 Desloratadine
DB01234 Dexamethasone
DB01191 Dexfenfluramine
DB04856 Dexloxiglumide
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB00829 Diazepam
DB00586 Diclofenac
DB01144 Diclofenamide
DB00266 Dicoumarol
DB00255 Diethylstilbestrol
DB00343 Diltiazem
DB01075 Diphenhydramine
DB00822 Disulfiram
DB00757 Dolasetron
DB00843 Donepezil
DB00988 Dopamine
DB00869 Dorzolamide
DB01142 Doxepin
DB00470 Dronabinol
DB00625 Efavirenz
DB00216 Eletriptan
DB08899 Enzalutamide
DB00668 Epinephrine
DB01240 Epoprostenol
DB00876 Eprosartan
DB00783 Estradiol
DB00655 Estrone
DB04574 Estrone sulfate
DB00402 Eszopiclone
DB00898 Ethanol
DB00749 Etodolac
DB01628 Etoricoxib
DB06414 Etravirine
DB01023 Felodipine
DB01039 Fenofibrate
DB01195 Flecainide
DB00322 Floxuridine
DB00196 Fluconazole
DB04841 Flunarizine
DB01544 Flunitrazepam
DB00544 Fluorouracil
DB00472 Fluoxetine
DB00712 Flurbiprofen
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB00983 Formoterol
DB01320 Fosphenytoin
DB06741 Gavestinel
DB00317 Gefitinib
DB01241 Gemfibrozil
DB01381 Ginkgo biloba
DB01120 Gliclazide
DB00222 Glimepiride
DB01067 Glipizide
DB01016 Glyburide
DB01018 Guanfacine
DB00502 Haloperidol
DB01159 Halothane
DB03317 Heme C
DB01355 Hexobarbital
DB05381 Histamine
DB00062 Human Serum Albumin
DB00327 Hydromorphone
DB01050 Ibuprofen
DB01177 Idarubicin
DB01181 Ifosfamide
DB00619 Imatinib
DB00224 Indinavir
DB00328 Indomethacin
DB01029 Irbesartan
DB00951 Isoniazid
DB09570 Ixazomib
DB01221 Ketamine
DB06738 Ketobemidone
DB01026 Ketoconazole
DB01009 Ketoprofen
DB00448 Lansoprazole
DB01097 Leflunomide
DB11560 Lesinurad
DB04725 Licofelone
DB00281 Lidocaine
DB01601 Lopinavir
DB00455 Loratadine
DB06725 Lornoxicam
DB00678 Losartan
DB00227 Lovastatin
DB09280 Lumacaftor
DB01283 Lumiracoxib
DB00603 Medroxyprogesterone acetate
DB00784 Mefenamic acid
DB01065 Melatonin
DB00814 Meloxicam
DB00532 Mephenytoin
DB01357 Mestranol
DB00333 Methadone
DB00703 Methazolamide
DB00763 Methimazole
DB01028 Methoxyflurane
DB00916 Metronidazole
DB01110 Miconazole
DB00370 Mirtazapine
DB01171 Moclobemide
DB00745 Modafinil
DB00471 Montelukast
DB11605 Myrrh
DB00788 Naproxen
DB00731 Nateglinide
DB00220 Nelfinavir
DB09048 Netupitant
DB00238 Nevirapine
DB00622 Nicardipine
DB06803 Niclosamide
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00665 Nilutamide
DB06712 Nilvadipine
DB00540 Nortriptyline
DB00334 Olanzapine
DB09080 Olodaterol
DB00338 Omeprazole
DB00904 Ondansetron
DB04938 Ospemifene
DB00991 Oxaprozin
DB01229 Paclitaxel
DB00213 Pantoprazole
DB00617 Paramethadione
DB08439 Parecoxib
DB00715 Paroxetine
DB00850 Perphenazine
DB03783 Phenacetin
DB01174 Phenobarbital
DB00946 Phenprocoumon
DB00191 Phentermine
DB00812 Phenylbutazone
DB00252 Phenytoin
DB01132 Pioglitazone
DB00554 Piroxicam
DB08860 Pitavastatin
DB01411 Pranlukast
DB06209 Prasugrel
DB00175 Pravastatin
DB00794 Primidone
DB01032 Probenecid
DB00396 Progesterone
DB01131 Proguanil
DB00420 Promazine
DB01069 Promethazine
DB01182 Propafenone
DB00818 Propofol
DB09396 Propoxyphene napsylate
DB00205 Pyrimethamine
DB01589 Quazepam
DB00908 Quinidine
DB00468 Quinine
DB01129 Rabeprazole
DB08896 Regorafenib
DB01045 Rifampicin
DB01201 Rifapentine
DB00503 Ritonavir
DB00533 Rofecoxib
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB01698 Rutin
DB00936 Salicylic acid
DB01232 Saquinavir
DB00418 Secobarbital
DB01037 Selegiline
DB01104 Sertraline
DB00203 Sildenafil
DB00641 Simvastatin
DB06268 Sitaxentan
DB00398 Sorafenib
DB06820 Sulconazole
DB00359 Sulfadiazine
DB06150 Sulfadimethoxine
DB00576 Sulfamethizole
DB01015 Sulfamethoxazole
DB08798 Sulfamoxole
DB00259 Sulfanilamide
DB06729 Sulfaphenazole
DB00891 Sulfapyridine
DB01138 Sulfinpyrazone
DB00263 Sulfisoxazole
DB00870 Suprofen
DB00675 Tamoxifen
DB06204 Tapentadol
DB01079 Tegaserod
DB00231 Temazepam
DB00444 Teniposide
DB00469 Tenoxicam
DB00857 Terbinafine
DB00342 Terfenadine
DB00624 Testosterone
DB01041 Thalidomide
DB00277 Theophylline
DB01154 Thiamylal
DB00679 Thioridazine
DB08816 Ticagrelor
DB00208 Ticlopidine
DB04831 Ticrynafen
DB01007 Tioconazole
DB01124 Tolbutamide
DB00323 Tolcapone
DB01036 Tolterodine
DB00214 Torasemide
DB05109 Trabectedin
DB00752 Tranylcypromine
DB00374 Treprostinil
DB00755 Tretinoin
DB00897 Triazolam
DB00347 Trimethadione
DB00440 Trimethoprim
DB00726 Trimipramine
DB00197 Troglitazone
DB01361 Troleandomycin
DB00580 Valdecoxib
DB00313 Valproic Acid
DB00177 Valsartan
DB00285 Venlafaxine
DB00661 Verapamil
DB08828 Vismodegib
DB00582 Voriconazole
DB09068 Vortioxetine
DB00682 Warfarin
DB04898 Ximelagatran
DB00549 Zafirlukast
DB00943 Zalcitabine
DB06737 Zaltoprofen
DB00495 Zidovudine
DB00744 Zileuton
DB00425 Zolpidem
DB01198 Zopiclone
GuidetoPHARMACOLOGYi1326

Polymorphism and mutation databases

BioMutaiCYP2C9
DMDMi6686268

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517001 – 490Cytochrome P450 2C9Add BLAST490

Proteomic databases

EPDiP11712
PaxDbiP11712
PeptideAtlasiP11712
PRIDEiP11712

PTM databases

iPTMnetiP11712
PhosphoSitePlusiP11712

Expressioni

Inductioni

By rifampicin.

Gene expression databases

BgeeiENSG00000138109
CleanExiHS_CYP2C9
ExpressionAtlasiP11712 baseline and differential
GenevisibleiP11712 HS

Organism-specific databases

HPAiCAB016123
HPA015066

Interactioni

Protein-protein interaction databases

BioGridi107937, 14 interactors
IntActiP11712, 6 interactors
STRINGi9606.ENSP00000260682

Chemistry databases

BindingDBiP11712

Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 35Combined sources3
Turni37 – 39Combined sources3
Helixi42 – 44Combined sources3
Helixi47 – 61Combined sources15
Beta strandi63 – 71Combined sources9
Beta strandi73 – 77Combined sources5
Helixi80 – 87Combined sources8
Turni88 – 94Combined sources7
Beta strandi95 – 97Combined sources3
Turni105 – 107Combined sources3
Beta strandi111 – 114Combined sources4
Helixi117 – 131Combined sources15
Beta strandi134 – 136Combined sources3
Beta strandi137 – 139Combined sources3
Helixi141 – 157Combined sources17
Turni158 – 161Combined sources4
Helixi167 – 183Combined sources17
Helixi192 – 208Combined sources17
Helixi211 – 214Combined sources4
Helixi216 – 218Combined sources3
Helixi222 – 224Combined sources3
Turni227 – 229Combined sources3
Helixi230 – 253Combined sources24
Helixi263 – 274Combined sources12
Beta strandi275 – 277Combined sources3
Helixi284 – 315Combined sources32
Helixi317 – 330Combined sources14
Beta strandi333 – 335Combined sources3
Helixi339 – 344Combined sources6
Helixi346 – 359Combined sources14
Beta strandi374 – 376Combined sources3
Beta strandi379 – 381Combined sources3
Beta strandi386 – 389Combined sources4
Helixi392 – 395Combined sources4
Turni398 – 400Combined sources3
Beta strandi401 – 403Combined sources3
Helixi409 – 412Combined sources4
Beta strandi415 – 417Combined sources3
Helixi431 – 433Combined sources3
Helixi438 – 455Combined sources18
Beta strandi456 – 462Combined sources7
Helixi464 – 466Combined sources3
Beta strandi475 – 477Combined sources3
Beta strandi485 – 489Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OG2X-ray2.60A/B30-490[»]
1OG5X-ray2.55A/B30-490[»]
1R9OX-ray2.00A18-490[»]
4NZ2X-ray2.45A/B30-490[»]
5A5IX-ray2.00A23-489[»]
5A5JX-ray2.90A23-489[»]
5K7KX-ray2.30A23-489[»]
5W0CX-ray2.00A18-489[»]
5X23X-ray2.00A19-490[»]
5X24X-ray2.48A19-490[»]
5XXIX-ray2.30A28-489[»]
ProteinModelPortaliP11712
SMRiP11712
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11712

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP11712
KOiK17719
OMAiICNNFSP
OrthoDBiEOG091G0BT8
PhylomeDBiP11712
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11712-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI
60 70 80 90 100
SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF
110 120 130 140 150
PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK
210 220 230 240 250
LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE
260 270 280 290 300
HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE
410 420 430 440 450
FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT
460 470 480 490
SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV
Length:490
Mass (Da):55,628
Last modified:May 30, 2000 - v3
Checksum:i4FDFC395303A4E3E
GO
Isoform 2 (identifier: P11712-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-162: AS → GG
     163-490: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,005
Checksum:iB59C8888ED45AD09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → I no nucleotide entry (PubMed:3697070).Curated1
Sequence conflicti6V → S no nucleotide entry (PubMed:3697070).Curated1
Sequence conflicti14L → M in AAB23864 (PubMed:1445376).Curated1
Sequence conflicti175C → Y no nucleotide entry (PubMed:2827463).Curated1
Sequence conflicti239F → L no nucleotide entry (PubMed:2827463).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01886219L → I in allele CYP2C9*7. Corresponds to variant dbSNP:rs67807361Ensembl.1
Natural variantiVAR_075286125R → H in allele CYP2C9*35. 1 PublicationCorresponds to variant dbSNP:rs72558189Ensembl.1
Natural variantiVAR_075287125R → L in allele CYP2C9*14. 1 Publication1
Natural variantiVAR_008343144R → C in allele CYP2C9*2. 7 PublicationsCorresponds to variant dbSNP:rs1799853Ensembl.1
Natural variantiVAR_018863150R → H in allele CYP2C9*8. 2 PublicationsCorresponds to variant dbSNP:rs7900194Ensembl.1
Natural variantiVAR_075288204N → H in allele CYP2C9*57. 1 Publication1
Natural variantiVAR_018864251H → R in allele CYP2C9*9. 2 PublicationsCorresponds to variant dbSNP:rs2256871Ensembl.1
Natural variantiVAR_018865272E → G in allele CYP2C9*10. 1 PublicationCorresponds to variant dbSNP:rs9332130Ensembl.1
Natural variantiVAR_018866335R → W in allele CYP2C9*11. 2 PublicationsCorresponds to variant dbSNP:rs28371685Ensembl.1
Natural variantiVAR_008344358Y → C3 PublicationsCorresponds to variant dbSNP:rs1057909Ensembl.1
Natural variantiVAR_008345359I → L in allele CYP2C9*3; responsible for the tolbutamide poor metabolizer phenotype. 4 PublicationsCorresponds to variant dbSNP:rs1057910Ensembl.1
Natural variantiVAR_013515359I → T in allele CYP2C9*4. 1 PublicationCorresponds to variant dbSNP:rs56165452Ensembl.1
Natural variantiVAR_013516360D → E in allele CYP2C9*5; increases the K(m) value for substrates tested. 2 PublicationsCorresponds to variant dbSNP:rs28371686Ensembl.1
Natural variantiVAR_024717413L → P1 PublicationCorresponds to variant dbSNP:rs28371687Ensembl.1
Natural variantiVAR_008346417G → D3 Publications1
Natural variantiVAR_075289434I → F in allele CYP2C9*59; produces warfarin hypersensitivity; increases affinity but highly decreases enzymatic activity for tolbutamide; no effect on affinity but decreases enzymatic activity for diclofenac; decreases affinity and highly decreases enzymatic activity for losartan. 1 Publication1
Natural variantiVAR_018867489P → S in allele CYP2C9*12. 1 PublicationCorresponds to variant dbSNP:rs9332239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055573161 – 162AS → GG in isoform 2. 1 Publication2
Alternative sequenceiVSP_055574163 – 490Missing in isoform 2. 1 PublicationAdd BLAST328

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341248 Genomic DNA Translation: AAP88931.1
AY702706 Genomic DNA Translation: AAT94065.1
AK289420 mRNA Translation: BAF82109.1
AL359672 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50019.1
CH471066 Genomic DNA Translation: EAW50020.1
BC020754 mRNA Translation: AAH20754.1
BC070317 mRNA Translation: AAH70317.1
BC125054 mRNA Translation: AAI25055.1
D00173 mRNA Translation: BAA00123.1
M15331 mRNA Translation: AAA52157.1
M21939 mRNA Translation: AAA52158.1
M21940 mRNA Translation: AAA52159.1
S46963 mRNA Translation: AAB23864.2 Sequence problems.
CCDSiCCDS7437.1 [P11712-1]
PIRiB38462
D28951
RefSeqiNP_000762.2, NM_000771.3 [P11712-1]
XP_016871247.1, XM_017015758.1 [P11712-1]
UniGeneiHs.282624

Genome annotation databases

EnsembliENST00000260682; ENSP00000260682; ENSG00000138109 [P11712-1]
GeneIDi1559
KEGGihsa:1559

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCP2C9_HUMAN
AccessioniPrimary (citable) accession number: P11712
Secondary accession number(s): P11713
, Q16756, Q16872, Q5VX92, Q6IRV8, Q8WW80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 205 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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