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Protein

Cytochrome P450 2C9

Gene

CYP2C9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).1 Publication

Catalytic activityi

+-(R)-limonene + NADPH + O2 = (+)-trans-carveol + NADP+ + H2O.1 Publication
--(S)-limonene + NADPH + O2 = (-)-trans-carveol + NADP+ + H2O.1 Publication
--(S)-limonene + NADPH + O2 = (-)-perillyl alcohol + NADP+ + H2O.1 Publication
Cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O.1 Publication

Cofactori

Kineticsi

  1. KM=1.25 mM for S-mephenytoin1 Publication
  2. KM=46.24 µM for tolbutamide1 Publication
  3. KM=4.73 µM for diclofenac1 Publication
  4. KM=1.58 µM for losartan1 Publication
  1. Vmax=9.22 pmol/min/pmol enzyme with tolbutamide as substrate1 Publication
  2. Vmax=17.16 pmol/min/pmol enzyme with diclofenac as substrate1 Publication
  3. Vmax=210.30 pmol/min/pmol enzyme with losartan as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)1

GO - Molecular functioni

  • (R)-limonene 6-monooxygenase activity Source: UniProtKB-EC
  • (S)-limonene 6-monooxygenase activity Source: UniProtKB-EC
  • (S)-limonene 7-monooxygenase activity Source: UniProtKB-EC
  • arachidonic acid epoxygenase activity Source: GO_Central
  • caffeine oxidase activity Source: BHF-UCL
  • cholesterol 25-hydroxylase activity Source: UniProtKB-EC
  • drug binding Source: BHF-UCL
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: UniProtKB
  • oxidoreductase activity Source: BHF-UCL
  • oxygen binding Source: Reactome
  • steroid hydroxylase activity Source: BHF-UCL

GO - Biological processi

  • cellular amide metabolic process Source: BHF-UCL
  • drug catabolic process Source: BHF-UCL
  • drug metabolic process Source: UniProtKB
  • epoxygenase P450 pathway Source: GO_Central
  • exogenous drug catabolic process Source: BHF-UCL
  • monocarboxylic acid metabolic process Source: BHF-UCL
  • monoterpenoid metabolic process Source: BHF-UCL
  • omega-hydroxylase P450 pathway Source: Reactome
  • oxidation-reduction process Source: BHF-UCL
  • oxidative demethylation Source: BHF-UCL
  • steroid metabolic process Source: BHF-UCL
  • urea metabolic process Source: BHF-UCL
  • xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyciZFISH:HS06458-MONOMER.
BRENDAi1.14.99.38. 2681.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP11712.
SIGNORiP11712.

Chemistry databases

SwissLipidsiSLP:000001203.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C9 (EC:1.14.13.-1 Publication)
Alternative name(s):
(R)-limonene 6-monooxygenase (EC:1.14.13.801 Publication)
(S)-limonene 6-monooxygenase (EC:1.14.13.481 Publication)
(S)-limonene 7-monooxygenase (EC:1.14.13.491 Publication)
CYPIIC9
Cholesterol 25-hydroxylase1 Publication (EC:1.14.99.381 Publication)
Cytochrome P-450MP
Cytochrome P450 MP-4
Cytochrome P450 MP-8
Cytochrome P450 PB-1
S-mephenytoin 4-hydroxylase1 Publication
Gene namesi
Name:CYP2C9
Synonyms:CYP2C10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2623. CYP2C9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1559.
MalaCardsiCYP2C9.
OpenTargetsiENSG00000138109.
Orphaneti413681. Oral antidiabetic drugs toxicity or dose selection.
413674. Vitamin K antagonists toxicity or dose selection.
PharmGKBiPA126.

Chemistry databases

ChEMBLiCHEMBL3397.
DrugBankiDB01418. Acenocoumarol.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB06594. Agomelatine.
DB00969. Alosetron.
DB00404. Alprazolam.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB00701. Amprenavir.
DB01217. Anastrozole.
DB01435. Antipyrine.
DB06605. Apixaban.
DB00673. Aprepitant.
DB01274. Arformoterol.
DB06413. Armodafinil.
DB06697. Artemether.
DB01072. Atazanavir.
DB01076. Atorvastatin.
DB01117. Atovaquone.
DB00972. Azelastine.
DB00307. Bexarotene.
DB01128. Bicalutamide.
DB00188. Bortezomib.
DB00559. Bosentan.
DB00835. Brompheniramine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB08875. Cabozantinib.
DB00201. Caffeine.
DB00796. Candesartan.
DB01101. Capecitabine.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB01136. Carvedilol.
DB00482. Celecoxib.
DB00446. Chloramphenicol.
DB00672. Chlorpropamide.
DB00169. Cholecalciferol.
DB00501. Cimetidine.
DB00568. Cinnarizine.
DB00604. Cisapride.
DB00515. Cisplatin.
DB04920. Clevidipine.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB01394. Colchicine.
DB01176. Cyclizine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB06292. Dapagliflozin.
DB00250. Dapsone.
DB00705. Delavirdine.
DB00967. Desloratadine.
DB01234. Dexamethasone.
DB01191. Dexfenfluramine.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB01144. Diclofenamide.
DB00266. Dicoumarol.
DB00255. Diethylstilbestrol.
DB00343. Diltiazem.
DB01075. Diphenhydramine.
DB00822. Disulfiram.
DB00757. Dolasetron.
DB00843. Donepezil.
DB00988. Dopamine.
DB00869. Dorzolamide.
DB01142. Doxepin.
DB00470. Dronabinol.
DB00625. Efavirenz.
DB00216. Eletriptan.
DB08899. Enzalutamide.
DB00668. Epinephrine.
DB01240. Epoprostenol.
DB00876. Eprosartan.
DB00783. Estradiol.
DB00655. Estrone.
DB04574. Estropipate.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00749. Etodolac.
DB01628. Etoricoxib.
DB06414. Etravirine.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB01195. Flecainide.
DB00196. Fluconazole.
DB04841. Flunarizine.
DB01544. Flunitrazepam.
DB00544. Fluorouracil.
DB00472. Fluoxetine.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00983. Formoterol.
DB01320. Fosphenytoin.
DB00317. Gefitinib.
DB01241. Gemfibrozil.
DB01381. Ginkgo biloba.
DB01120. Gliclazide.
DB00222. Glimepiride.
DB01067. Glipizide.
DB01016. Glyburide.
DB01018. Guanfacine.
DB00502. Haloperidol.
DB01159. Halothane.
DB01355. Hexobarbital.
DB00667. Histamine Phosphate.
DB00062. Human Serum Albumin.
DB00327. Hydromorphone.
DB01050. Ibuprofen.
DB01177. Idarubicin.
DB01181. Ifosfamide.
DB00619. Imatinib.
DB00224. Indinavir.
DB00328. Indomethacin.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB09570. Ixazomib.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00448. Lansoprazole.
DB01097. Leflunomide.
DB00281. Lidocaine.
DB01601. Lopinavir.
DB00455. Loratadine.
DB06725. Lornoxicam.
DB00678. Losartan.
DB00227. Lovastatin.
DB01283. Lumiracoxib.
DB00603. Medroxyprogesterone Acetate.
DB00784. Mefenamic acid.
DB01065. Melatonin.
DB00814. Meloxicam.
DB01357. Mestranol.
DB00333. Methadone.
DB00703. Methazolamide.
DB00763. Methimazole.
DB01028. Methoxyflurane.
DB00916. Metronidazole.
DB01110. Miconazole.
DB00370. Mirtazapine.
DB01171. Moclobemide.
DB00745. Modafinil.
DB00471. Montelukast.
DB00788. Naproxen.
DB00731. Nateglinide.
DB00220. Nelfinavir.
DB09048. Netupitant.
DB00238. Nevirapine.
DB00622. Nicardipine.
DB06803. Niclosamide.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB09080. Olodaterol.
DB00338. Omeprazole.
DB00904. Ondansetron.
DB04938. Ospemifene.
DB00991. Oxaprozin.
DB01229. Paclitaxel.
DB00213. Pantoprazole.
DB00617. Paramethadione.
DB08439. Parecoxib.
DB00715. Paroxetine.
DB00850. Perphenazine.
DB01174. Phenobarbital.
DB00946. Phenprocoumon.
DB00191. Phentermine.
DB00812. Phenylbutazone.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00554. Piroxicam.
DB08860. Pitavastatin.
DB01411. Pranlukast.
DB06209. Prasugrel.
DB00175. Pravastatin.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01131. Proguanil.
DB00420. Promazine.
DB01069. Promethazine.
DB01182. Propafenone.
DB00818. Propofol.
DB00205. Pyrimethamine.
DB01589. Quazepam.
DB00908. Quinidine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB08896. Regorafenib.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB01098. Rosuvastatin.
DB00936. Salicylic acid.
DB01232. Saquinavir.
DB00418. Secobarbital.
DB01037. Selegiline.
DB01104. Sertraline.
DB00203. Sildenafil.
DB00641. Simvastatin.
DB06268. Sitaxentan.
DB00398. Sorafenib.
DB06820. Sulconazole.
DB00359. Sulfadiazine.
DB06150. Sulfadimethoxine.
DB00576. Sulfamethizole.
DB01015. Sulfamethoxazole.
DB08798. Sulfamoxole.
DB00259. Sulfanilamide.
DB06729. Sulfaphenazole.
DB00891. Sulfapyridine.
DB01138. Sulfinpyrazone.
DB00263. Sulfisoxazole.
DB00870. Suprofen.
DB00675. Tamoxifen.
DB06204. Tapentadol.
DB00231. Temazepam.
DB00444. Teniposide.
DB00469. Tenoxicam.
DB00857. Terbinafine.
DB00624. Testosterone.
DB01041. Thalidomide.
DB00277. Theophylline.
DB01154. Thiamylal.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB01124. Tolbutamide.
DB00323. Tolcapone.
DB01036. Tolterodine.
DB00214. Torasemide.
DB05109. Trabectedin.
DB00752. Tranylcypromine.
DB00374. Treprostinil.
DB00755. Tretinoin.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00177. Valsartan.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB08828. Vismodegib.
DB00582. Voriconazole.
DB09068. Vortioxetine.
DB00682. Warfarin.
DB04898. Ximelagatran.
DB00549. Zafirlukast.
DB00943. Zalcitabine.
DB00495. Zidovudine.
DB00744. Zileuton.
DB00425. Zolpidem.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi1326.

Polymorphism and mutation databases

BioMutaiCYP2C9.
DMDMi6686268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517001 – 490Cytochrome P450 2C9Add BLAST490

Proteomic databases

EPDiP11712.
PaxDbiP11712.
PeptideAtlasiP11712.
PRIDEiP11712.

PTM databases

iPTMnetiP11712.
PhosphoSitePlusiP11712.

Expressioni

Inductioni

By rifampicin.

Gene expression databases

BgeeiENSG00000138109.
CleanExiHS_CYP2C9.
ExpressionAtlasiP11712. baseline and differential.
GenevisibleiP11712. HS.

Organism-specific databases

HPAiCAB016123.
HPA015066.

Interactioni

Protein-protein interaction databases

BioGridi107937. 13 interactors.
IntActiP11712. 6 interactors.
STRINGi9606.ENSP00000260682.

Chemistry databases

BindingDBiP11712.

Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 35Combined sources3
Turni37 – 39Combined sources3
Helixi42 – 45Combined sources4
Helixi47 – 61Combined sources15
Beta strandi63 – 71Combined sources9
Beta strandi73 – 77Combined sources5
Helixi80 – 87Combined sources8
Turni88 – 94Combined sources7
Turni105 – 107Combined sources3
Beta strandi111 – 114Combined sources4
Helixi117 – 131Combined sources15
Beta strandi134 – 136Combined sources3
Helixi141 – 157Combined sources17
Turni158 – 161Combined sources4
Helixi167 – 183Combined sources17
Helixi192 – 208Combined sources17
Helixi211 – 213Combined sources3
Helixi214 – 218Combined sources5
Helixi222 – 225Combined sources4
Helixi230 – 253Combined sources24
Helixi263 – 274Combined sources12
Beta strandi275 – 277Combined sources3
Helixi284 – 315Combined sources32
Helixi317 – 330Combined sources14
Beta strandi333 – 335Combined sources3
Helixi339 – 344Combined sources6
Helixi346 – 359Combined sources14
Beta strandi374 – 376Combined sources3
Beta strandi379 – 381Combined sources3
Beta strandi386 – 389Combined sources4
Helixi392 – 395Combined sources4
Turni398 – 400Combined sources3
Beta strandi401 – 403Combined sources3
Helixi409 – 412Combined sources4
Beta strandi415 – 417Combined sources3
Helixi431 – 433Combined sources3
Helixi438 – 455Combined sources18
Beta strandi456 – 462Combined sources7
Helixi464 – 466Combined sources3
Beta strandi475 – 477Combined sources3
Beta strandi485 – 489Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OG2X-ray2.60A/B30-490[»]
1OG5X-ray2.55A/B30-490[»]
1R9OX-ray2.00A18-490[»]
4NZ2X-ray2.45A/B30-490[»]
5A5IX-ray2.00A23-489[»]
5A5JX-ray2.90A23-489[»]
ProteinModelPortaliP11712.
SMRiP11712.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11712.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP11712.
KOiK17719.
OMAiKHNQPSE.
OrthoDBiEOG091G0BT8.
PhylomeDBiP11712.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11712-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI
60 70 80 90 100
SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF
110 120 130 140 150
PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK
210 220 230 240 250
LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE
260 270 280 290 300
HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE
410 420 430 440 450
FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT
460 470 480 490
SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV
Length:490
Mass (Da):55,628
Last modified:May 30, 2000 - v3
Checksum:i4FDFC395303A4E3E
GO
Isoform 2 (identifier: P11712-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-162: AS → GG
     163-490: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,005
Checksum:iB59C8888ED45AD09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → I no nucleotide entry (PubMed:3697070).Curated1
Sequence conflicti6V → S no nucleotide entry (PubMed:3697070).Curated1
Sequence conflicti14L → M in AAB23864 (PubMed:1445376).Curated1
Sequence conflicti175C → Y no nucleotide entry (PubMed:2827463).Curated1
Sequence conflicti239F → L no nucleotide entry (PubMed:2827463).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01886219L → I in allele CYP2C9*7. Corresponds to variant rs67807361dbSNPEnsembl.1
Natural variantiVAR_075286125R → H in allele CYP2C9*35. 1 PublicationCorresponds to variant rs72558189dbSNPEnsembl.1
Natural variantiVAR_075287125R → L in allele CYP2C9*14. 1 Publication1
Natural variantiVAR_008343144R → C in allele CYP2C9*2. 7 PublicationsCorresponds to variant rs1799853dbSNPEnsembl.1
Natural variantiVAR_018863150R → H in allele CYP2C9*8. 2 PublicationsCorresponds to variant rs7900194dbSNPEnsembl.1
Natural variantiVAR_075288204N → H in allele CYP2C9*57. 1 Publication1
Natural variantiVAR_018864251H → R in allele CYP2C9*9. 2 PublicationsCorresponds to variant rs2256871dbSNPEnsembl.1
Natural variantiVAR_018865272E → G in allele CYP2C9*10. 1 PublicationCorresponds to variant rs9332130dbSNPEnsembl.1
Natural variantiVAR_018866335R → W in allele CYP2C9*11. 2 PublicationsCorresponds to variant rs28371685dbSNPEnsembl.1
Natural variantiVAR_008344358Y → C.3 PublicationsCorresponds to variant rs1057909dbSNPEnsembl.1
Natural variantiVAR_008345359I → L in allele CYP2C9*3; responsible for the tolbutamide poor metabolizer phenotype. 4 PublicationsCorresponds to variant rs1057910dbSNPEnsembl.1
Natural variantiVAR_013515359I → T in allele CYP2C9*4. 1 PublicationCorresponds to variant rs56165452dbSNPEnsembl.1
Natural variantiVAR_013516360D → E in allele CYP2C9*5; increases the K(m) value for substrates tested. 2 PublicationsCorresponds to variant rs28371686dbSNPEnsembl.1
Natural variantiVAR_024717413L → P.1 PublicationCorresponds to variant rs28371687dbSNPEnsembl.1
Natural variantiVAR_008346417G → D.3 Publications1
Natural variantiVAR_075289434I → F in allele CYP2C9*59; produces warfarin hypersensitivity; increases affinity but highly decreases enzymatic acitivty for tolbutamide; no effect on affinity but decreases enzymatic activity for diclofenac; decreases affinity and highly decreases enzymatic activity for losartan. 1 Publication1
Natural variantiVAR_018867489P → S in allele CYP2C9*12. 1 PublicationCorresponds to variant rs9332239dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055573161 – 162AS → GG in isoform 2. 1 Publication2
Alternative sequenceiVSP_055574163 – 490Missing in isoform 2. 1 PublicationAdd BLAST328

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341248 Genomic DNA. Translation: AAP88931.1.
AY702706 Genomic DNA. Translation: AAT94065.1.
AK289420 mRNA. Translation: BAF82109.1.
AL359672 Genomic DNA. Translation: CAH71303.1.
CH471066 Genomic DNA. Translation: EAW50019.1.
CH471066 Genomic DNA. Translation: EAW50020.1.
BC020754 mRNA. Translation: AAH20754.1.
BC070317 mRNA. Translation: AAH70317.1.
BC125054 mRNA. Translation: AAI25055.1.
D00173 mRNA. Translation: BAA00123.1.
M15331 mRNA. Translation: AAA52157.1.
M21939 mRNA. Translation: AAA52158.1.
M21940 mRNA. Translation: AAA52159.1.
S46963 mRNA. Translation: AAB23864.2. Sequence problems.
CCDSiCCDS7437.1. [P11712-1]
PIRiB38462.
D28951.
RefSeqiNP_000762.2. NM_000771.3. [P11712-1]
XP_016871247.1. XM_017015758.1. [P11712-1]
UniGeneiHs.282624.

Genome annotation databases

EnsembliENST00000260682; ENSP00000260682; ENSG00000138109. [P11712-1]
GeneIDi1559.
KEGGihsa:1559.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C9 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341248 Genomic DNA. Translation: AAP88931.1.
AY702706 Genomic DNA. Translation: AAT94065.1.
AK289420 mRNA. Translation: BAF82109.1.
AL359672 Genomic DNA. Translation: CAH71303.1.
CH471066 Genomic DNA. Translation: EAW50019.1.
CH471066 Genomic DNA. Translation: EAW50020.1.
BC020754 mRNA. Translation: AAH20754.1.
BC070317 mRNA. Translation: AAH70317.1.
BC125054 mRNA. Translation: AAI25055.1.
D00173 mRNA. Translation: BAA00123.1.
M15331 mRNA. Translation: AAA52157.1.
M21939 mRNA. Translation: AAA52158.1.
M21940 mRNA. Translation: AAA52159.1.
S46963 mRNA. Translation: AAB23864.2. Sequence problems.
CCDSiCCDS7437.1. [P11712-1]
PIRiB38462.
D28951.
RefSeqiNP_000762.2. NM_000771.3. [P11712-1]
XP_016871247.1. XM_017015758.1. [P11712-1]
UniGeneiHs.282624.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OG2X-ray2.60A/B30-490[»]
1OG5X-ray2.55A/B30-490[»]
1R9OX-ray2.00A18-490[»]
4NZ2X-ray2.45A/B30-490[»]
5A5IX-ray2.00A23-489[»]
5A5JX-ray2.90A23-489[»]
ProteinModelPortaliP11712.
SMRiP11712.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107937. 13 interactors.
IntActiP11712. 6 interactors.
STRINGi9606.ENSP00000260682.

Chemistry databases

BindingDBiP11712.
ChEMBLiCHEMBL3397.
DrugBankiDB01418. Acenocoumarol.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB06594. Agomelatine.
DB00969. Alosetron.
DB00404. Alprazolam.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB00701. Amprenavir.
DB01217. Anastrozole.
DB01435. Antipyrine.
DB06605. Apixaban.
DB00673. Aprepitant.
DB01274. Arformoterol.
DB06413. Armodafinil.
DB06697. Artemether.
DB01072. Atazanavir.
DB01076. Atorvastatin.
DB01117. Atovaquone.
DB00972. Azelastine.
DB00307. Bexarotene.
DB01128. Bicalutamide.
DB00188. Bortezomib.
DB00559. Bosentan.
DB00835. Brompheniramine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB08875. Cabozantinib.
DB00201. Caffeine.
DB00796. Candesartan.
DB01101. Capecitabine.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB01136. Carvedilol.
DB00482. Celecoxib.
DB00446. Chloramphenicol.
DB00672. Chlorpropamide.
DB00169. Cholecalciferol.
DB00501. Cimetidine.
DB00568. Cinnarizine.
DB00604. Cisapride.
DB00515. Cisplatin.
DB04920. Clevidipine.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB01394. Colchicine.
DB01176. Cyclizine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB06292. Dapagliflozin.
DB00250. Dapsone.
DB00705. Delavirdine.
DB00967. Desloratadine.
DB01234. Dexamethasone.
DB01191. Dexfenfluramine.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB01144. Diclofenamide.
DB00266. Dicoumarol.
DB00255. Diethylstilbestrol.
DB00343. Diltiazem.
DB01075. Diphenhydramine.
DB00822. Disulfiram.
DB00757. Dolasetron.
DB00843. Donepezil.
DB00988. Dopamine.
DB00869. Dorzolamide.
DB01142. Doxepin.
DB00470. Dronabinol.
DB00625. Efavirenz.
DB00216. Eletriptan.
DB08899. Enzalutamide.
DB00668. Epinephrine.
DB01240. Epoprostenol.
DB00876. Eprosartan.
DB00783. Estradiol.
DB00655. Estrone.
DB04574. Estropipate.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00749. Etodolac.
DB01628. Etoricoxib.
DB06414. Etravirine.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB01195. Flecainide.
DB00196. Fluconazole.
DB04841. Flunarizine.
DB01544. Flunitrazepam.
DB00544. Fluorouracil.
DB00472. Fluoxetine.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00983. Formoterol.
DB01320. Fosphenytoin.
DB00317. Gefitinib.
DB01241. Gemfibrozil.
DB01381. Ginkgo biloba.
DB01120. Gliclazide.
DB00222. Glimepiride.
DB01067. Glipizide.
DB01016. Glyburide.
DB01018. Guanfacine.
DB00502. Haloperidol.
DB01159. Halothane.
DB01355. Hexobarbital.
DB00667. Histamine Phosphate.
DB00062. Human Serum Albumin.
DB00327. Hydromorphone.
DB01050. Ibuprofen.
DB01177. Idarubicin.
DB01181. Ifosfamide.
DB00619. Imatinib.
DB00224. Indinavir.
DB00328. Indomethacin.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB09570. Ixazomib.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00448. Lansoprazole.
DB01097. Leflunomide.
DB00281. Lidocaine.
DB01601. Lopinavir.
DB00455. Loratadine.
DB06725. Lornoxicam.
DB00678. Losartan.
DB00227. Lovastatin.
DB01283. Lumiracoxib.
DB00603. Medroxyprogesterone Acetate.
DB00784. Mefenamic acid.
DB01065. Melatonin.
DB00814. Meloxicam.
DB01357. Mestranol.
DB00333. Methadone.
DB00703. Methazolamide.
DB00763. Methimazole.
DB01028. Methoxyflurane.
DB00916. Metronidazole.
DB01110. Miconazole.
DB00370. Mirtazapine.
DB01171. Moclobemide.
DB00745. Modafinil.
DB00471. Montelukast.
DB00788. Naproxen.
DB00731. Nateglinide.
DB00220. Nelfinavir.
DB09048. Netupitant.
DB00238. Nevirapine.
DB00622. Nicardipine.
DB06803. Niclosamide.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB09080. Olodaterol.
DB00338. Omeprazole.
DB00904. Ondansetron.
DB04938. Ospemifene.
DB00991. Oxaprozin.
DB01229. Paclitaxel.
DB00213. Pantoprazole.
DB00617. Paramethadione.
DB08439. Parecoxib.
DB00715. Paroxetine.
DB00850. Perphenazine.
DB01174. Phenobarbital.
DB00946. Phenprocoumon.
DB00191. Phentermine.
DB00812. Phenylbutazone.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00554. Piroxicam.
DB08860. Pitavastatin.
DB01411. Pranlukast.
DB06209. Prasugrel.
DB00175. Pravastatin.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01131. Proguanil.
DB00420. Promazine.
DB01069. Promethazine.
DB01182. Propafenone.
DB00818. Propofol.
DB00205. Pyrimethamine.
DB01589. Quazepam.
DB00908. Quinidine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB08896. Regorafenib.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB01098. Rosuvastatin.
DB00936. Salicylic acid.
DB01232. Saquinavir.
DB00418. Secobarbital.
DB01037. Selegiline.
DB01104. Sertraline.
DB00203. Sildenafil.
DB00641. Simvastatin.
DB06268. Sitaxentan.
DB00398. Sorafenib.
DB06820. Sulconazole.
DB00359. Sulfadiazine.
DB06150. Sulfadimethoxine.
DB00576. Sulfamethizole.
DB01015. Sulfamethoxazole.
DB08798. Sulfamoxole.
DB00259. Sulfanilamide.
DB06729. Sulfaphenazole.
DB00891. Sulfapyridine.
DB01138. Sulfinpyrazone.
DB00263. Sulfisoxazole.
DB00870. Suprofen.
DB00675. Tamoxifen.
DB06204. Tapentadol.
DB00231. Temazepam.
DB00444. Teniposide.
DB00469. Tenoxicam.
DB00857. Terbinafine.
DB00624. Testosterone.
DB01041. Thalidomide.
DB00277. Theophylline.
DB01154. Thiamylal.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB01124. Tolbutamide.
DB00323. Tolcapone.
DB01036. Tolterodine.
DB00214. Torasemide.
DB05109. Trabectedin.
DB00752. Tranylcypromine.
DB00374. Treprostinil.
DB00755. Tretinoin.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00177. Valsartan.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB08828. Vismodegib.
DB00582. Voriconazole.
DB09068. Vortioxetine.
DB00682. Warfarin.
DB04898. Ximelagatran.
DB00549. Zafirlukast.
DB00943. Zalcitabine.
DB00495. Zidovudine.
DB00744. Zileuton.
DB00425. Zolpidem.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi1326.
SwissLipidsiSLP:000001203.

PTM databases

iPTMnetiP11712.
PhosphoSitePlusiP11712.

Polymorphism and mutation databases

BioMutaiCYP2C9.
DMDMi6686268.

Proteomic databases

EPDiP11712.
PaxDbiP11712.
PeptideAtlasiP11712.
PRIDEiP11712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260682; ENSP00000260682; ENSG00000138109. [P11712-1]
GeneIDi1559.
KEGGihsa:1559.

Organism-specific databases

CTDi1559.
DisGeNETi1559.
GeneCardsiCYP2C9.
HGNCiHGNC:2623. CYP2C9.
HPAiCAB016123.
HPA015066.
MalaCardsiCYP2C9.
MIMi601130. gene.
neXtProtiNX_P11712.
OpenTargetsiENSG00000138109.
Orphaneti413681. Oral antidiabetic drugs toxicity or dose selection.
413674. Vitamin K antagonists toxicity or dose selection.
PharmGKBiPA126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP11712.
KOiK17719.
OMAiKHNQPSE.
OrthoDBiEOG091G0BT8.
PhylomeDBiP11712.
TreeFamiTF352043.

Enzyme and pathway databases

BioCyciZFISH:HS06458-MONOMER.
BRENDAi1.14.99.38. 2681.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP11712.
SIGNORiP11712.

Miscellaneous databases

ChiTaRSiCYP2C9. human.
EvolutionaryTraceiP11712.
GeneWikiiCYP2C9.
GenomeRNAii1559.
PROiP11712.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138109.
CleanExiHS_CYP2C9.
ExpressionAtlasiP11712. baseline and differential.
GenevisibleiP11712. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2C9_HUMAN
AccessioniPrimary (citable) accession number: P11712
Secondary accession number(s): P11713
, Q16756, Q16872, Q5VX92, Q6IRV8, Q8WW80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 190 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.