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Protein

Cytochrome P450 2C9

Gene

CYP2C9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.

Catalytic activityi

+-(R)-limonene + NADPH + O2 = (+)-trans-carveol + NADP+ + H2O.1 Publication
--(S)-limonene + NADPH + O2 = (-)-trans-carveol + NADP+ + H2O.1 Publication
--(S)-limonene + NADPH + O2 = (-)-perillyl alcohol + NADP+ + H2O.1 Publication
Cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O.1 Publication

Cofactori

Kineticsi

  1. KM=1.25 mM for S-mephenytoin1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)

    GO - Molecular functioni

    GO - Biological processi

    • arachidonic acid metabolic process Source: Reactome
    • cellular amide metabolic process Source: BHF-UCL
    • drug catabolic process Source: BHF-UCL
    • drug metabolic process Source: UniProtKB
    • epoxygenase P450 pathway Source: GO_Central
    • exogenous drug catabolic process Source: BHF-UCL
    • monocarboxylic acid metabolic process Source: BHF-UCL
    • monoterpenoid metabolic process Source: BHF-UCL
    • omega-hydroxylase P450 pathway Source: Reactome
    • oxidation-reduction process Source: BHF-UCL
    • oxidative demethylation Source: BHF-UCL
    • small molecule metabolic process Source: Reactome
    • steroid metabolic process Source: BHF-UCL
    • urea metabolic process Source: BHF-UCL
    • xenobiotic metabolic process Source: GO_Central
    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Lipid metabolism, Steroid metabolism, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    BRENDAi1.14.99.38. 2681.
    ReactomeiR-HSA-211981. Xenobiotics.
    R-HSA-211999. CYP2E1 reactions.
    R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    SABIO-RKP11712.

    Chemistry

    SwissLipidsiSLP:000001203.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C9 (EC:1.14.13.-1 Publication)
    Alternative name(s):
    (R)-limonene 6-monooxygenase (EC:1.14.13.801 Publication)
    (S)-limonene 6-monooxygenase (EC:1.14.13.481 Publication)
    (S)-limonene 7-monooxygenase (EC:1.14.13.491 Publication)
    CYPIIC9
    Cholesterol 25-hydroxylase1 Publication (EC:1.14.99.381 Publication)
    Cytochrome P-450MP
    Cytochrome P450 MP-4
    Cytochrome P450 MP-8
    Cytochrome P450 PB-1
    S-mephenytoin 4-hydroxylase1 Publication
    Gene namesi
    Name:CYP2C9
    Synonyms:CYP2C10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:2623. CYP2C9.

    Subcellular locationi

    GO - Cellular componenti

    • cytoplasm Source: GO_Central
    • endoplasmic reticulum membrane Source: Reactome
    • intracellular membrane-bounded organelle Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    MalaCardsiCYP2C9.
    Orphaneti413681. Oral antidiabetic drugs toxicity or dose selection.
    413674. Vitamin K antagonists toxicity or dose selection.
    PharmGKBiPA126.

    Chemistry

    ChEMBLiCHEMBL3397.
    DrugBankiDB01418. Acenocoumarol.
    DB00316. Acetaminophen.
    DB00945. Acetylsalicylic acid.
    DB06594. Agomelatine.
    DB00969. Alosetron.
    DB00404. Alprazolam.
    DB01424. Aminophenazone.
    DB01118. Amiodarone.
    DB00321. Amitriptyline.
    DB00381. Amlodipine.
    DB00613. Amodiaquine.
    DB00701. Amprenavir.
    DB01217. Anastrozole.
    DB01435. Antipyrine.
    DB06605. Apixaban.
    DB00673. Aprepitant.
    DB01274. Arformoterol.
    DB06697. Artemether.
    DB01072. Atazanavir.
    DB01076. Atorvastatin.
    DB01117. Atovaquone.
    DB00972. Azelastine.
    DB00307. Bexarotene.
    DB01128. Bicalutamide.
    DB00188. Bortezomib.
    DB00559. Bosentan.
    DB00835. Brompheniramine.
    DB00921. Buprenorphine.
    DB01156. Bupropion.
    DB08875. Cabozantinib.
    DB00201. Caffeine.
    DB00796. Candesartan.
    DB01101. Capecitabine.
    DB00564. Carbamazepine.
    DB00748. Carbinoxamine.
    DB01136. Carvedilol.
    DB00482. Celecoxib.
    DB00446. Chloramphenicol.
    DB00672. Chlorpropamide.
    DB00169. Cholecalciferol.
    DB00501. Cimetidine.
    DB00568. Cinnarizine.
    DB00604. Cisapride.
    DB00515. Cisplatin.
    DB04920. Clevidipine.
    DB00758. Clopidogrel.
    DB00257. Clotrimazole.
    DB00363. Clozapine.
    DB00907. Cocaine.
    DB01394. Colchicine.
    DB01176. Cyclizine.
    DB00531. Cyclophosphamide.
    DB00091. Cyclosporine.
    DB06292. Dapagliflozin.
    DB00250. Dapsone.
    DB00705. Delavirdine.
    DB00967. Desloratadine.
    DB01234. Dexamethasone.
    DB01191. Dexfenfluramine.
    DB00514. Dextromethorphan.
    DB00647. Dextropropoxyphene.
    DB00829. Diazepam.
    DB00586. Diclofenac.
    DB01144. Diclofenamide.
    DB00266. Dicoumarol.
    DB00255. Diethylstilbestrol.
    DB00343. Diltiazem.
    DB01075. Diphenhydramine.
    DB00822. Disulfiram.
    DB00757. Dolasetron.
    DB00843. Donepezil.
    DB00988. Dopamine.
    DB00869. Dorzolamide.
    DB01142. Doxepin.
    DB00470. Dronabinol.
    DB00625. Efavirenz.
    DB00216. Eletriptan.
    DB08899. Enzalutamide.
    DB00668. Epinephrine.
    DB01240. Epoprostenol.
    DB00876. Eprosartan.
    DB00783. Estradiol.
    DB00655. Estrone.
    DB04574. Estropipate.
    DB00402. Eszopiclone.
    DB00898. Ethanol.
    DB00749. Etodolac.
    DB01628. Etoricoxib.
    DB06414. Etravirine.
    DB01023. Felodipine.
    DB01039. Fenofibrate.
    DB01195. Flecainide.
    DB00196. Fluconazole.
    DB04841. Flunarizine.
    DB01544. Flunitrazepam.
    DB00544. Fluorouracil.
    DB00472. Fluoxetine.
    DB00712. Flurbiprofen.
    DB01095. Fluvastatin.
    DB00176. Fluvoxamine.
    DB00983. Formoterol.
    DB01320. Fosphenytoin.
    DB00317. Gefitinib.
    DB01241. Gemfibrozil.
    DB01381. Ginkgo biloba.
    DB01120. Gliclazide.
    DB00222. Glimepiride.
    DB01067. Glipizide.
    DB01016. Glyburide.
    DB01018. Guanfacine.
    DB00502. Haloperidol.
    DB01159. Halothane.
    DB01355. Hexobarbital.
    DB00667. Histamine Phosphate.
    DB00062. Human Serum Albumin.
    DB00327. Hydromorphone.
    DB01050. Ibuprofen.
    DB01177. Idarubicin.
    DB01181. Ifosfamide.
    DB00619. Imatinib.
    DB00224. Indinavir.
    DB00328. Indomethacin.
    DB01029. Irbesartan.
    DB00951. Isoniazid.
    DB01221. Ketamine.
    DB06738. Ketobemidone.
    DB01026. Ketoconazole.
    DB01009. Ketoprofen.
    DB00448. Lansoprazole.
    DB01097. Leflunomide.
    DB00281. Lidocaine.
    DB01601. Lopinavir.
    DB00455. Loratadine.
    DB06725. Lornoxicam.
    DB00678. Losartan.
    DB00227. Lovastatin.
    DB01283. Lumiracoxib.
    DB00603. Medroxyprogesterone Acetate.
    DB00784. Mefenamic acid.
    DB01065. Melatonin.
    DB00814. Meloxicam.
    DB01357. Mestranol.
    DB00333. Methadone.
    DB00703. Methazolamide.
    DB00763. Methimazole.
    DB01028. Methoxyflurane.
    DB00916. Metronidazole.
    DB01110. Miconazole.
    DB00370. Mirtazapine.
    DB01171. Moclobemide.
    DB00745. Modafinil.
    DB00471. Montelukast.
    DB00788. Naproxen.
    DB00731. Nateglinide.
    DB00220. Nelfinavir.
    DB09048. Netupitant.
    DB00238. Nevirapine.
    DB00622. Nicardipine.
    DB06803. Niclosamide.
    DB00184. Nicotine.
    DB01115. Nifedipine.
    DB04868. Nilotinib.
    DB00665. Nilutamide.
    DB06712. Nilvadipine.
    DB00540. Nortriptyline.
    DB00334. Olanzapine.
    DB09080. Olodaterol.
    DB00338. Omeprazole.
    DB00904. Ondansetron.
    DB04938. Ospemifene.
    DB00991. Oxaprozin.
    DB01229. Paclitaxel.
    DB00213. Pantoprazole.
    DB00617. Paramethadione.
    DB08439. Parecoxib.
    DB00715. Paroxetine.
    DB00850. Perphenazine.
    DB01174. Phenobarbital.
    DB00946. Phenprocoumon.
    DB00191. Phentermine.
    DB00812. Phenylbutazone.
    DB00252. Phenytoin.
    DB01132. Pioglitazone.
    DB00554. Piroxicam.
    DB08860. Pitavastatin.
    DB01411. Pranlukast.
    DB06209. Prasugrel.
    DB00175. Pravastatin.
    DB00794. Primidone.
    DB01032. Probenecid.
    DB00396. Progesterone.
    DB01131. Proguanil.
    DB00420. Promazine.
    DB01069. Promethazine.
    DB01182. Propafenone.
    DB00818. Propofol.
    DB00205. Pyrimethamine.
    DB01589. Quazepam.
    DB00908. Quinidine.
    DB00468. Quinine.
    DB01129. Rabeprazole.
    DB08896. Regorafenib.
    DB01045. Rifampicin.
    DB01201. Rifapentine.
    DB00503. Ritonavir.
    DB00412. Rosiglitazone.
    DB01098. Rosuvastatin.
    DB00936. Salicylic acid.
    DB01232. Saquinavir.
    DB00418. Secobarbital.
    DB01037. Selegiline.
    DB01104. Sertraline.
    DB00203. Sildenafil.
    DB00641. Simvastatin.
    DB06268. Sitaxentan.
    DB00398. Sorafenib.
    DB00359. Sulfadiazine.
    DB06150. Sulfadimethoxine.
    DB00576. Sulfamethizole.
    DB01015. Sulfamethoxazole.
    DB08798. Sulfamoxole.
    DB00259. Sulfanilamide.
    DB06729. Sulfaphenazole.
    DB00891. Sulfapyridine.
    DB01138. Sulfinpyrazone.
    DB00263. Sulfisoxazole.
    DB00870. Suprofen.
    DB00675. Tamoxifen.
    DB06204. Tapentadol.
    DB00231. Temazepam.
    DB00444. Teniposide.
    DB00469. Tenoxicam.
    DB00857. Terbinafine.
    DB00624. Testosterone.
    DB01041. Thalidomide.
    DB00277. Theophylline.
    DB01154. Thiamylal.
    DB00679. Thioridazine.
    DB00208. Ticlopidine.
    DB01007. Tioconazole.
    DB01124. Tolbutamide.
    DB00323. Tolcapone.
    DB01036. Tolterodine.
    DB00214. Torasemide.
    DB05109. Trabectedin.
    DB00752. Tranylcypromine.
    DB00374. Treprostinil.
    DB00755. Tretinoin.
    DB00897. Triazolam.
    DB00347. Trimethadione.
    DB00440. Trimethoprim.
    DB00726. Trimipramine.
    DB01361. Troleandomycin.
    DB00313. Valproic Acid.
    DB00177. Valsartan.
    DB00285. Venlafaxine.
    DB00661. Verapamil.
    DB08828. Vismodegib.
    DB00582. Voriconazole.
    DB00682. Warfarin.
    DB04898. Ximelagatran.
    DB00549. Zafirlukast.
    DB00943. Zalcitabine.
    DB00495. Zidovudine.
    DB00744. Zileuton.
    DB00425. Zolpidem.
    DB01198. Zopiclone.
    GuidetoPHARMACOLOGYi1326.

    Polymorphism and mutation databases

    BioMutaiCYP2C9.
    DMDMi6686268.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C9PRO_0000051700Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei249 – 2491N6-acetyllysineBy similarity
    Modified residuei375 – 3751N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP11712.
    PRIDEiP11712.

    PTM databases

    iPTMnetiP11712.
    PhosphoSiteiP11712.

    Expressioni

    Inductioni

    By rifampicin.

    Gene expression databases

    BgeeiP11712.
    CleanExiHS_CYP2C9.
    ExpressionAtlasiP11712. baseline and differential.
    GenevisibleiP11712. HS.

    Organism-specific databases

    HPAiCAB016123.
    HPA015066.

    Interactioni

    Protein-protein interaction databases

    BioGridi107937. 13 interactions.
    IntActiP11712. 6 interactions.
    STRINGi9606.ENSP00000260682.

    Chemistry

    BindingDBiP11712.

    Structurei

    Secondary structure

    1
    490
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi33 – 353Combined sources
    Turni37 – 393Combined sources
    Helixi42 – 454Combined sources
    Helixi47 – 6115Combined sources
    Beta strandi63 – 719Combined sources
    Beta strandi73 – 775Combined sources
    Helixi80 – 878Combined sources
    Turni88 – 947Combined sources
    Turni105 – 1073Combined sources
    Beta strandi112 – 1143Combined sources
    Helixi117 – 13115Combined sources
    Beta strandi134 – 1363Combined sources
    Helixi141 – 15717Combined sources
    Turni158 – 1614Combined sources
    Helixi167 – 18317Combined sources
    Helixi192 – 20817Combined sources
    Helixi211 – 2133Combined sources
    Helixi214 – 2185Combined sources
    Helixi222 – 2254Combined sources
    Helixi230 – 25324Combined sources
    Helixi263 – 27412Combined sources
    Beta strandi275 – 2773Combined sources
    Helixi284 – 31532Combined sources
    Helixi317 – 33014Combined sources
    Beta strandi333 – 3353Combined sources
    Helixi339 – 3446Combined sources
    Helixi346 – 35914Combined sources
    Beta strandi374 – 3763Combined sources
    Beta strandi379 – 3813Combined sources
    Beta strandi386 – 3894Combined sources
    Helixi392 – 3954Combined sources
    Turni398 – 4003Combined sources
    Beta strandi401 – 4033Combined sources
    Helixi409 – 4124Combined sources
    Beta strandi415 – 4173Combined sources
    Helixi431 – 4333Combined sources
    Helixi438 – 45518Combined sources
    Beta strandi456 – 4627Combined sources
    Helixi464 – 4663Combined sources
    Beta strandi475 – 4773Combined sources
    Beta strandi485 – 4895Combined sources

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OG2X-ray2.60A/B30-490[»]
    1OG5X-ray2.55A/B30-490[»]
    1R9OX-ray2.00A18-490[»]
    4NZ2X-ray2.45A/B30-490[»]
    ProteinModelPortaliP11712.
    SMRiP11712. Positions 44-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11712.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiKOG0156. Eukaryota.
    COG2124. LUCA.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP11712.
    KOiK17719.
    OMAiKHNQPSE.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP11712.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: P11712-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI
    60 70 80 90 100
    SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF
    110 120 130 140 150
    PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
    160 170 180 190 200
    CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK
    210 220 230 240 250
    LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE
    260 270 280 290 300
    HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE
    310 320 330 340 350
    TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA
    360 370 380 390 400
    VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE
    410 420 430 440 450
    FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT
    460 470 480 490
    SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV
    Length:490
    Mass (Da):55,628
    Last modified:May 30, 2000 - v3
    Checksum:i4FDFC395303A4E3E
    GO
    Isoform 2 (identifier: P11712-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         161-162: AS → GG
         163-490: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:162
    Mass (Da):18,005
    Checksum:iB59C8888ED45AD09
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41L → I no nucleotide entry (PubMed:3697070).Curated
    Sequence conflicti6 – 61V → S no nucleotide entry (PubMed:3697070).Curated
    Sequence conflicti14 – 141L → M in AAB23864 (PubMed:1445376).Curated
    Sequence conflicti175 – 1751C → Y no nucleotide entry (PubMed:2827463).Curated
    Sequence conflicti239 – 2391F → L no nucleotide entry (PubMed:2827463).Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191L → I in allele CYP2C9*7.
    VAR_018862
    Natural varianti144 – 1441R → C in allele CYP2C9*2. 7 Publications
    Corresponds to variant rs1799853 [ dbSNP | Ensembl ].
    VAR_008343
    Natural varianti150 – 1501R → H in allele CYP2C9*8. 2 Publications
    Corresponds to variant rs7900194 [ dbSNP | Ensembl ].
    VAR_018863
    Natural varianti251 – 2511H → R in allele CYP2C9*9. 2 Publications
    Corresponds to variant rs2256871 [ dbSNP | Ensembl ].
    VAR_018864
    Natural varianti272 – 2721E → G in allele CYP2C9*10. 1 Publication
    Corresponds to variant rs9332130 [ dbSNP | Ensembl ].
    VAR_018865
    Natural varianti335 – 3351R → W in allele CYP2C9*11. 2 Publications
    Corresponds to variant rs28371685 [ dbSNP | Ensembl ].
    VAR_018866
    Natural varianti358 – 3581Y → C.3 Publications
    Corresponds to variant rs1057909 [ dbSNP | Ensembl ].
    VAR_008344
    Natural varianti359 – 3591I → L in allele CYP2C9*3; responsible for the tolbutamide poor metabolizer phenotype. 4 Publications
    Corresponds to variant rs1057910 [ dbSNP | Ensembl ].
    VAR_008345
    Natural varianti359 – 3591I → T in allele CYP2C9*4. 1 Publication
    Corresponds to variant rs56165452 [ dbSNP | Ensembl ].
    VAR_013515
    Natural varianti360 – 3601D → E in allele CYP2C9*5; increases the K(m) value for substrates tested. 2 Publications
    Corresponds to variant rs28371686 [ dbSNP | Ensembl ].
    VAR_013516
    Natural varianti413 – 4131L → P.1 Publication
    Corresponds to variant rs28371687 [ dbSNP | Ensembl ].
    VAR_024717
    Natural varianti417 – 4171G → D.3 Publications
    VAR_008346
    Natural varianti489 – 4891P → S in allele CYP2C9*12. 1 Publication
    Corresponds to variant rs9332239 [ dbSNP | Ensembl ].
    VAR_018867

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei161 – 1622AS → GG in isoform 2. 1 PublicationVSP_055573
    Alternative sequencei163 – 490328Missing in isoform 2. 1 PublicationVSP_055574Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY341248 Genomic DNA. Translation: AAP88931.1.
    AY702706 Genomic DNA. Translation: AAT94065.1.
    AK289420 mRNA. Translation: BAF82109.1.
    AL359672 Genomic DNA. Translation: CAH71303.1.
    CH471066 Genomic DNA. Translation: EAW50019.1.
    CH471066 Genomic DNA. Translation: EAW50020.1.
    BC020754 mRNA. Translation: AAH20754.1.
    BC070317 mRNA. Translation: AAH70317.1.
    BC125054 mRNA. Translation: AAI25055.1.
    D00173 mRNA. Translation: BAA00123.1.
    M15331 mRNA. Translation: AAA52157.1.
    M21939 mRNA. Translation: AAA52158.1.
    M21940 mRNA. Translation: AAA52159.1.
    S46963 mRNA. Translation: AAB23864.2. Sequence problems.
    CCDSiCCDS7437.1. [P11712-1]
    PIRiB38462.
    D28951.
    RefSeqiNP_000762.2. NM_000771.3. [P11712-1]
    UniGeneiHs.282624.

    Genome annotation databases

    EnsembliENST00000260682; ENSP00000260682; ENSG00000138109. [P11712-1]
    GeneIDi1559.
    KEGGihsa:1559.
    UCSCiuc001kjz.3. human.
    uc001kka.4. human. [P11712-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP2C9 alleles

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY341248 Genomic DNA. Translation: AAP88931.1.
    AY702706 Genomic DNA. Translation: AAT94065.1.
    AK289420 mRNA. Translation: BAF82109.1.
    AL359672 Genomic DNA. Translation: CAH71303.1.
    CH471066 Genomic DNA. Translation: EAW50019.1.
    CH471066 Genomic DNA. Translation: EAW50020.1.
    BC020754 mRNA. Translation: AAH20754.1.
    BC070317 mRNA. Translation: AAH70317.1.
    BC125054 mRNA. Translation: AAI25055.1.
    D00173 mRNA. Translation: BAA00123.1.
    M15331 mRNA. Translation: AAA52157.1.
    M21939 mRNA. Translation: AAA52158.1.
    M21940 mRNA. Translation: AAA52159.1.
    S46963 mRNA. Translation: AAB23864.2. Sequence problems.
    CCDSiCCDS7437.1. [P11712-1]
    PIRiB38462.
    D28951.
    RefSeqiNP_000762.2. NM_000771.3. [P11712-1]
    UniGeneiHs.282624.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OG2X-ray2.60A/B30-490[»]
    1OG5X-ray2.55A/B30-490[»]
    1R9OX-ray2.00A18-490[»]
    4NZ2X-ray2.45A/B30-490[»]
    ProteinModelPortaliP11712.
    SMRiP11712. Positions 44-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi107937. 13 interactions.
    IntActiP11712. 6 interactions.
    STRINGi9606.ENSP00000260682.

    Chemistry

    BindingDBiP11712.
    ChEMBLiCHEMBL3397.
    DrugBankiDB01418. Acenocoumarol.
    DB00316. Acetaminophen.
    DB00945. Acetylsalicylic acid.
    DB06594. Agomelatine.
    DB00969. Alosetron.
    DB00404. Alprazolam.
    DB01424. Aminophenazone.
    DB01118. Amiodarone.
    DB00321. Amitriptyline.
    DB00381. Amlodipine.
    DB00613. Amodiaquine.
    DB00701. Amprenavir.
    DB01217. Anastrozole.
    DB01435. Antipyrine.
    DB06605. Apixaban.
    DB00673. Aprepitant.
    DB01274. Arformoterol.
    DB06697. Artemether.
    DB01072. Atazanavir.
    DB01076. Atorvastatin.
    DB01117. Atovaquone.
    DB00972. Azelastine.
    DB00307. Bexarotene.
    DB01128. Bicalutamide.
    DB00188. Bortezomib.
    DB00559. Bosentan.
    DB00835. Brompheniramine.
    DB00921. Buprenorphine.
    DB01156. Bupropion.
    DB08875. Cabozantinib.
    DB00201. Caffeine.
    DB00796. Candesartan.
    DB01101. Capecitabine.
    DB00564. Carbamazepine.
    DB00748. Carbinoxamine.
    DB01136. Carvedilol.
    DB00482. Celecoxib.
    DB00446. Chloramphenicol.
    DB00672. Chlorpropamide.
    DB00169. Cholecalciferol.
    DB00501. Cimetidine.
    DB00568. Cinnarizine.
    DB00604. Cisapride.
    DB00515. Cisplatin.
    DB04920. Clevidipine.
    DB00758. Clopidogrel.
    DB00257. Clotrimazole.
    DB00363. Clozapine.
    DB00907. Cocaine.
    DB01394. Colchicine.
    DB01176. Cyclizine.
    DB00531. Cyclophosphamide.
    DB00091. Cyclosporine.
    DB06292. Dapagliflozin.
    DB00250. Dapsone.
    DB00705. Delavirdine.
    DB00967. Desloratadine.
    DB01234. Dexamethasone.
    DB01191. Dexfenfluramine.
    DB00514. Dextromethorphan.
    DB00647. Dextropropoxyphene.
    DB00829. Diazepam.
    DB00586. Diclofenac.
    DB01144. Diclofenamide.
    DB00266. Dicoumarol.
    DB00255. Diethylstilbestrol.
    DB00343. Diltiazem.
    DB01075. Diphenhydramine.
    DB00822. Disulfiram.
    DB00757. Dolasetron.
    DB00843. Donepezil.
    DB00988. Dopamine.
    DB00869. Dorzolamide.
    DB01142. Doxepin.
    DB00470. Dronabinol.
    DB00625. Efavirenz.
    DB00216. Eletriptan.
    DB08899. Enzalutamide.
    DB00668. Epinephrine.
    DB01240. Epoprostenol.
    DB00876. Eprosartan.
    DB00783. Estradiol.
    DB00655. Estrone.
    DB04574. Estropipate.
    DB00402. Eszopiclone.
    DB00898. Ethanol.
    DB00749. Etodolac.
    DB01628. Etoricoxib.
    DB06414. Etravirine.
    DB01023. Felodipine.
    DB01039. Fenofibrate.
    DB01195. Flecainide.
    DB00196. Fluconazole.
    DB04841. Flunarizine.
    DB01544. Flunitrazepam.
    DB00544. Fluorouracil.
    DB00472. Fluoxetine.
    DB00712. Flurbiprofen.
    DB01095. Fluvastatin.
    DB00176. Fluvoxamine.
    DB00983. Formoterol.
    DB01320. Fosphenytoin.
    DB00317. Gefitinib.
    DB01241. Gemfibrozil.
    DB01381. Ginkgo biloba.
    DB01120. Gliclazide.
    DB00222. Glimepiride.
    DB01067. Glipizide.
    DB01016. Glyburide.
    DB01018. Guanfacine.
    DB00502. Haloperidol.
    DB01159. Halothane.
    DB01355. Hexobarbital.
    DB00667. Histamine Phosphate.
    DB00062. Human Serum Albumin.
    DB00327. Hydromorphone.
    DB01050. Ibuprofen.
    DB01177. Idarubicin.
    DB01181. Ifosfamide.
    DB00619. Imatinib.
    DB00224. Indinavir.
    DB00328. Indomethacin.
    DB01029. Irbesartan.
    DB00951. Isoniazid.
    DB01221. Ketamine.
    DB06738. Ketobemidone.
    DB01026. Ketoconazole.
    DB01009. Ketoprofen.
    DB00448. Lansoprazole.
    DB01097. Leflunomide.
    DB00281. Lidocaine.
    DB01601. Lopinavir.
    DB00455. Loratadine.
    DB06725. Lornoxicam.
    DB00678. Losartan.
    DB00227. Lovastatin.
    DB01283. Lumiracoxib.
    DB00603. Medroxyprogesterone Acetate.
    DB00784. Mefenamic acid.
    DB01065. Melatonin.
    DB00814. Meloxicam.
    DB01357. Mestranol.
    DB00333. Methadone.
    DB00703. Methazolamide.
    DB00763. Methimazole.
    DB01028. Methoxyflurane.
    DB00916. Metronidazole.
    DB01110. Miconazole.
    DB00370. Mirtazapine.
    DB01171. Moclobemide.
    DB00745. Modafinil.
    DB00471. Montelukast.
    DB00788. Naproxen.
    DB00731. Nateglinide.
    DB00220. Nelfinavir.
    DB09048. Netupitant.
    DB00238. Nevirapine.
    DB00622. Nicardipine.
    DB06803. Niclosamide.
    DB00184. Nicotine.
    DB01115. Nifedipine.
    DB04868. Nilotinib.
    DB00665. Nilutamide.
    DB06712. Nilvadipine.
    DB00540. Nortriptyline.
    DB00334. Olanzapine.
    DB09080. Olodaterol.
    DB00338. Omeprazole.
    DB00904. Ondansetron.
    DB04938. Ospemifene.
    DB00991. Oxaprozin.
    DB01229. Paclitaxel.
    DB00213. Pantoprazole.
    DB00617. Paramethadione.
    DB08439. Parecoxib.
    DB00715. Paroxetine.
    DB00850. Perphenazine.
    DB01174. Phenobarbital.
    DB00946. Phenprocoumon.
    DB00191. Phentermine.
    DB00812. Phenylbutazone.
    DB00252. Phenytoin.
    DB01132. Pioglitazone.
    DB00554. Piroxicam.
    DB08860. Pitavastatin.
    DB01411. Pranlukast.
    DB06209. Prasugrel.
    DB00175. Pravastatin.
    DB00794. Primidone.
    DB01032. Probenecid.
    DB00396. Progesterone.
    DB01131. Proguanil.
    DB00420. Promazine.
    DB01069. Promethazine.
    DB01182. Propafenone.
    DB00818. Propofol.
    DB00205. Pyrimethamine.
    DB01589. Quazepam.
    DB00908. Quinidine.
    DB00468. Quinine.
    DB01129. Rabeprazole.
    DB08896. Regorafenib.
    DB01045. Rifampicin.
    DB01201. Rifapentine.
    DB00503. Ritonavir.
    DB00412. Rosiglitazone.
    DB01098. Rosuvastatin.
    DB00936. Salicylic acid.
    DB01232. Saquinavir.
    DB00418. Secobarbital.
    DB01037. Selegiline.
    DB01104. Sertraline.
    DB00203. Sildenafil.
    DB00641. Simvastatin.
    DB06268. Sitaxentan.
    DB00398. Sorafenib.
    DB00359. Sulfadiazine.
    DB06150. Sulfadimethoxine.
    DB00576. Sulfamethizole.
    DB01015. Sulfamethoxazole.
    DB08798. Sulfamoxole.
    DB00259. Sulfanilamide.
    DB06729. Sulfaphenazole.
    DB00891. Sulfapyridine.
    DB01138. Sulfinpyrazone.
    DB00263. Sulfisoxazole.
    DB00870. Suprofen.
    DB00675. Tamoxifen.
    DB06204. Tapentadol.
    DB00231. Temazepam.
    DB00444. Teniposide.
    DB00469. Tenoxicam.
    DB00857. Terbinafine.
    DB00624. Testosterone.
    DB01041. Thalidomide.
    DB00277. Theophylline.
    DB01154. Thiamylal.
    DB00679. Thioridazine.
    DB00208. Ticlopidine.
    DB01007. Tioconazole.
    DB01124. Tolbutamide.
    DB00323. Tolcapone.
    DB01036. Tolterodine.
    DB00214. Torasemide.
    DB05109. Trabectedin.
    DB00752. Tranylcypromine.
    DB00374. Treprostinil.
    DB00755. Tretinoin.
    DB00897. Triazolam.
    DB00347. Trimethadione.
    DB00440. Trimethoprim.
    DB00726. Trimipramine.
    DB01361. Troleandomycin.
    DB00313. Valproic Acid.
    DB00177. Valsartan.
    DB00285. Venlafaxine.
    DB00661. Verapamil.
    DB08828. Vismodegib.
    DB00582. Voriconazole.
    DB00682. Warfarin.
    DB04898. Ximelagatran.
    DB00549. Zafirlukast.
    DB00943. Zalcitabine.
    DB00495. Zidovudine.
    DB00744. Zileuton.
    DB00425. Zolpidem.
    DB01198. Zopiclone.
    GuidetoPHARMACOLOGYi1326.
    SwissLipidsiSLP:000001203.

    PTM databases

    iPTMnetiP11712.
    PhosphoSiteiP11712.

    Polymorphism and mutation databases

    BioMutaiCYP2C9.
    DMDMi6686268.

    Proteomic databases

    PaxDbiP11712.
    PRIDEiP11712.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000260682; ENSP00000260682; ENSG00000138109. [P11712-1]
    GeneIDi1559.
    KEGGihsa:1559.
    UCSCiuc001kjz.3. human.
    uc001kka.4. human. [P11712-1]

    Organism-specific databases

    CTDi1559.
    GeneCardsiCYP2C9.
    HGNCiHGNC:2623. CYP2C9.
    HPAiCAB016123.
    HPA015066.
    MalaCardsiCYP2C9.
    MIMi601130. gene.
    neXtProtiNX_P11712.
    Orphaneti413681. Oral antidiabetic drugs toxicity or dose selection.
    413674. Vitamin K antagonists toxicity or dose selection.
    PharmGKBiPA126.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0156. Eukaryota.
    COG2124. LUCA.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP11712.
    KOiK17719.
    OMAiKHNQPSE.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP11712.
    TreeFamiTF352043.

    Enzyme and pathway databases

    BRENDAi1.14.99.38. 2681.
    ReactomeiR-HSA-211981. Xenobiotics.
    R-HSA-211999. CYP2E1 reactions.
    R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    SABIO-RKP11712.

    Miscellaneous databases

    ChiTaRSiCYP2C9. human.
    EvolutionaryTraceiP11712.
    GeneWikiiCYP2C9.
    GenomeRNAii1559.
    NextBioi6438.
    PROiP11712.
    SOURCEiSearch...

    Gene expression databases

    BgeeiP11712.
    CleanExiHS_CYP2C9.
    ExpressionAtlasiP11712. baseline and differential.
    GenevisibleiP11712. HS.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10."
      Meehan R.R., Gosden J.R., Rout D., Hastie N.D., Friedberg T., Adesnik M., Buckland R., van Heyningen V., Fletcher J.M., Spurr N.K., Sweeney J., Wolf C.R.
      Am. J. Hum. Genet. 42:26-37(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-144.
    2. "cDNA and amino acid sequences of two members of the human P450IIC gene subfamily."
      Kimura S., Pastewka J., Gelboin H.V., Gonzalez F.J.
      Nucleic Acids Res. 15:10053-10054(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-144.
    3. NIEHS SNPs program
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-144; HIS-150; ARG-251; GLY-272; LEU-359 AND SER-489.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT CYS-144.
      Tissue: Liver.
    8. "Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form."
      Yasumori T., Kawano S., Nagata K., Shimada M., Yamazoe Y., Kato R.
      J. Biochem. 102:1075-1082(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-490 (ISOFORM 1).
      Tissue: Liver.
    9. "Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase."
      Umbenhauer D.R., Martin M.V., Lloyd R.S., Guengerich F.P.
      Biochemistry 26:1094-1099(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490 (ISOFORM 1), VARIANTS CYS-358 AND ASP-417.
      Tissue: Liver.
    10. "Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase."
      Ged C., Umbenhauer D.R., Bellew T.M., Bork R.W., Srivastava P.K., Shinriki N., Lloyd R.S., Guengerich F.P.
      Biochemistry 27:6929-6940(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490 (ISOFORM 1), VARIANTS CYS-358 AND ASP-417.
    11. "Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity."
      Ohgiya S., Komori M., Ohi H., Shiramatsu K., Shinriki N., Kamataki T.
      Biochem. Int. 27:1073-1081(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-490 (ISOFORM 1).
    12. "Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction."
      Shimada T., Misono K.S., Guengerich F.P.
      J. Biol. Chem. 261:909-921(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-29, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, CHARACTERIZATION.
    13. "Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization."
      Komori M., Hashizume T., Ohi H., Miura T., Kitada M., Nagashima K., Kamataki T.
      J. Biochem. 104:912-916(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-25, CATALYTIC ACTIVITY.
    14. "Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes."
      Srivastava P.K., Yun C.H., Beaune P.H., Ged C., Guengerich F.P.
      Mol. Pharmacol. 40:69-79(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
    15. "Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms."
      Haining R.L., Hunter A.P., Veronese M.E., Trager W.F., Rettie A.E.
      Arch. Biochem. Biophys. 333:447-458(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-9; 21-157; 169-249; 264-424; 426-476 AND 484-487.
    16. "Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity."
      Sandhu P., Baba T., Guengerich F.P.
      Arch. Biochem. Biophys. 306:443-450(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-20.
    17. "Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes."
      Miyazawa M., Shindo M., Shimada T.
      Drug Metab. Dispos. 30:602-607(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY.
    18. Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
      Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
      J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    20. "Crystal structure of human cytochrome P450 2C9 with bound warfarin."
      Williams P.A., Cosme J., Ward A., Angove H.C., Matak-Vinkovic D., Jhoti H.
      Nature 424:464-468(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 30-490.
    21. "Genetic analysis of the human cytochrome P450 CYP2C9 locus."
      Stubbins M.J., Harries L.W., Smith G., Tarbit M.H., Wolf C.R.
      Pharmacogenetics 6:429-439(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYP2C9*2 CYS-144 AND CYP2C9*3 LEU-359.
    22. "Allelic and functional variability of cytochrome P4502C9."
      Bhasker C.R., Miners J.O., Coulter S., Birkett D.J.
      Pharmacogenetics 7:51-58(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYP2C9*2 CYS-144; CYS-358; CYP2C9*3 LEU-359 AND ASP-417.
    23. "Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus."
      Imai J., Ieiri I., Mamiya K., Miyahara S., Furuumi H., Nanba E., Yamane M., Fukumaki Y., Ninomiya H., Tashiro N., Otsubo K., Higuchi S.
      Pharmacogenetics 10:85-89(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYP2C9*4 THR-359.
    24. "Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans."
      Dickmann L.J., Rettie A.E., Kneller M.B., Kim R.B., Wood A.J., Stein C.M., Wilkinson G.R., Schwarz U.I.
      Mol. Pharmacol. 60:382-387(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYP2C9*5 GLU-360.
    25. "Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy."
      Higashi M.K., Veenstra D.L., Kondo L.M., Wittkowsky A.K., Srinouanprachanh S.L., Farin F.M., Rettie A.E.
      JAMA 287:1690-1698(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYP2C9*11 TRP-335.
    26. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
      Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYS-144; HIS-150; ARG-251; TRP-335; LEU-359; GLU-360 AND PRO-413.

    Entry informationi

    Entry nameiCP2C9_HUMAN
    AccessioniPrimary (citable) accession number: P11712
    Secondary accession number(s): P11713
    , Q16756, Q16872, Q5VX92, Q6IRV8, Q8WW80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: May 30, 2000
    Last modified: January 20, 2016
    This is version 181 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.