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Protein

Cytochrome P450 2C9

Gene

CYP2C9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.

Catalytic activityi

+-(R)-limonene + NADPH + O2 = (+)-trans-carveol + NADP+ + H2O.
--(S)-limonene + NADPH + O2 = (-)-trans-carveol + NADP+ + H2O.
--(S)-limonene + NADPH + O2 = (-)-perillyl alcohol + NADP+ + H2O.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)

GO - Molecular functioni

GO - Biological processi

  • arachidonic acid metabolic process Source: Reactome
  • cellular amide metabolic process Source: BHF-UCL
  • drug catabolic process Source: BHF-UCL
  • drug metabolic process Source: UniProtKB
  • epoxygenase P450 pathway Source: GO_Central
  • exogenous drug catabolic process Source: BHF-UCL
  • monocarboxylic acid metabolic process Source: BHF-UCL
  • monoterpenoid metabolic process Source: BHF-UCL
  • omega-hydroxylase P450 pathway Source: Reactome
  • oxidation-reduction process Source: BHF-UCL
  • oxidative demethylation Source: BHF-UCL
  • small molecule metabolic process Source: Reactome
  • steroid metabolic process Source: BHF-UCL
  • urea metabolic process Source: BHF-UCL
  • xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.14.99.38. 2681.
ReactomeiREACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
SABIO-RKP11712.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C9 (EC:1.14.13.-)
Alternative name(s):
(R)-limonene 6-monooxygenase (EC:1.14.13.80)
(S)-limonene 6-monooxygenase (EC:1.14.13.48)
(S)-limonene 7-monooxygenase (EC:1.14.13.49)
CYPIIC9
Cytochrome P-450MP
Cytochrome P450 MP-4
Cytochrome P450 MP-8
Cytochrome P450 PB-1
S-mephenytoin 4-hydroxylase
Gene namesi
Name:CYP2C9
Synonyms:CYP2C10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2623. CYP2C9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • endoplasmic reticulum membrane Source: Reactome
  • intracellular membrane-bounded organelle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

Orphaneti413681. Oral antidiabetic drugs toxicity or dose selection.
413674. Vitamin K antagonists toxicity or dose selection.
PharmGKBiPA126.

Chemistry

DrugBankiDB01418. Acenocoumarol.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB06594. Agomelatine.
DB00969. Alosetron.
DB00404. Alprazolam.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB00701. Amprenavir.
DB01217. Anastrozole.
DB01435. Antipyrine.
DB06605. Apixaban.
DB00673. Aprepitant.
DB01274. Arformoterol.
DB06697. Artemether.
DB01072. Atazanavir.
DB01076. Atorvastatin.
DB01117. Atovaquone.
DB00972. Azelastine.
DB00307. Bexarotene.
DB01128. Bicalutamide.
DB00188. Bortezomib.
DB00559. Bosentan.
DB00835. Brompheniramine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB08875. Cabozantinib.
DB00201. Caffeine.
DB00796. Candesartan.
DB01101. Capecitabine.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB01136. Carvedilol.
DB00482. Celecoxib.
DB00446. Chloramphenicol.
DB00672. Chlorpropamide.
DB00169. Cholecalciferol.
DB00501. Cimetidine.
DB00568. Cinnarizine.
DB00604. Cisapride.
DB00515. Cisplatin.
DB04920. Clevidipine.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB01394. Colchicine.
DB01176. Cyclizine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB06292. Dapagliflozin.
DB00250. Dapsone.
DB00705. Delavirdine.
DB00967. Desloratadine.
DB01234. Dexamethasone.
DB01191. Dexfenfluramine.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB01144. Diclofenamide.
DB00266. Dicoumarol.
DB00255. Diethylstilbestrol.
DB00343. Diltiazem.
DB01075. Diphenhydramine.
DB00822. Disulfiram.
DB00757. Dolasetron.
DB00843. Donepezil.
DB00988. Dopamine.
DB00869. Dorzolamide.
DB01142. Doxepin.
DB00470. Dronabinol.
DB00625. Efavirenz.
DB00216. Eletriptan.
DB08899. Enzalutamide.
DB00668. Epinephrine.
DB01240. Epoprostenol.
DB00876. Eprosartan.
DB00783. Estradiol.
DB00655. Estrone.
DB04574. Estropipate.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00749. Etodolac.
DB01628. Etoricoxib.
DB06414. Etravirine.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB01195. Flecainide.
DB00196. Fluconazole.
DB04841. Flunarizine.
DB01544. Flunitrazepam.
DB00544. Fluorouracil.
DB00472. Fluoxetine.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00983. Formoterol.
DB01320. Fosphenytoin.
DB00317. Gefitinib.
DB01241. Gemfibrozil.
DB01381. Ginkgo biloba.
DB01120. Gliclazide.
DB00222. Glimepiride.
DB01067. Glipizide.
DB01016. Glyburide.
DB01018. Guanfacine.
DB00502. Haloperidol.
DB01159. Halothane.
DB01355. Hexobarbital.
DB00667. Histamine Phosphate.
DB00062. Human Serum Albumin.
DB00327. Hydromorphone.
DB01050. Ibuprofen.
DB01177. Idarubicin.
DB01181. Ifosfamide.
DB00619. Imatinib.
DB00224. Indinavir.
DB00328. Indomethacin.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00448. Lansoprazole.
DB01097. Leflunomide.
DB00281. Lidocaine.
DB01601. Lopinavir.
DB00455. Loratadine.
DB06725. Lornoxicam.
DB00678. Losartan.
DB00227. Lovastatin.
DB01283. Lumiracoxib.
DB00603. Medroxyprogesterone Acetate.
DB00784. Mefenamic acid.
DB01065. Melatonin.
DB00814. Meloxicam.
DB01357. Mestranol.
DB00333. Methadone.
DB00703. Methazolamide.
DB00763. Methimazole.
DB01028. Methoxyflurane.
DB00916. Metronidazole.
DB01110. Miconazole.
DB00370. Mirtazapine.
DB01171. Moclobemide.
DB00745. Modafinil.
DB00471. Montelukast.
DB00788. Naproxen.
DB00731. Nateglinide.
DB00220. Nelfinavir.
DB00238. Nevirapine.
DB00622. Nicardipine.
DB06803. Niclosamide.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00338. Omeprazole.
DB00904. Ondansetron.
DB04938. Ospemifene.
DB00991. Oxaprozin.
DB01229. Paclitaxel.
DB00213. Pantoprazole.
DB00617. Paramethadione.
DB00715. Paroxetine.
DB00850. Perphenazine.
DB01174. Phenobarbital.
DB00946. Phenprocoumon.
DB00191. Phentermine.
DB00812. Phenylbutazone.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00554. Piroxicam.
DB08860. Pitavastatin.
DB01411. Pranlukast.
DB06209. Prasugrel.
DB00175. Pravastatin.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01131. Proguanil.
DB00420. Promazine.
DB01069. Promethazine.
DB01182. Propafenone.
DB00818. Propofol.
DB00205. Pyrimethamine.
DB01589. Quazepam.
DB00908. Quinidine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB08896. Regorafenib.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB01098. Rosuvastatin.
DB00936. Salicylic acid.
DB01232. Saquinavir.
DB00418. Secobarbital.
DB01037. Selegiline.
DB01104. Sertraline.
DB00203. Sildenafil.
DB00641. Simvastatin.
DB06268. Sitaxentan.
DB00398. Sorafenib.
DB00359. Sulfadiazine.
DB06150. Sulfadimethoxine.
DB00576. Sulfamethizole.
DB01015. Sulfamethoxazole.
DB08798. Sulfamoxole.
DB00259. Sulfanilamide.
DB06729. Sulfaphenazole.
DB00891. Sulfapyridine.
DB01138. Sulfinpyrazone.
DB00263. Sulfisoxazole.
DB00870. Suprofen.
DB00675. Tamoxifen.
DB06204. Tapentadol.
DB00231. Temazepam.
DB00444. Teniposide.
DB00469. Tenoxicam.
DB00857. Terbinafine.
DB00624. Testosterone.
DB01041. Thalidomide.
DB00277. Theophylline.
DB01154. Thiamylal.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB01124. Tolbutamide.
DB00323. Tolcapone.
DB01036. Tolterodine.
DB00214. Torasemide.
DB05109. Trabectedin.
DB00752. Tranylcypromine.
DB00374. Treprostinil.
DB00755. Tretinoin.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00177. Valsartan.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB08828. Vismodegib.
DB00582. Voriconazole.
DB00682. Warfarin.
DB04898. Ximelagatran.
DB00549. Zafirlukast.
DB00943. Zalcitabine.
DB00495. Zidovudine.
DB00744. Zileuton.
DB00425. Zolpidem.
DB01198. Zopiclone.

Polymorphism and mutation databases

BioMutaiCYP2C9.
DMDMi6686268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C9PRO_0000051700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-acetyllysineBy similarity
Modified residuei375 – 3751N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP11712.
PRIDEiP11712.

PTM databases

PhosphoSiteiP11712.

Expressioni

Inductioni

By rifampicin.

Gene expression databases

BgeeiP11712.
CleanExiHS_CYP2C9.
ExpressionAtlasiP11712. baseline and differential.
GenevestigatoriP11712.

Organism-specific databases

HPAiCAB016123.
HPA015066.

Interactioni

Protein-protein interaction databases

BioGridi107937. 10 interactions.
IntActiP11712. 6 interactions.
STRINGi9606.ENSP00000260682.

Structurei

Secondary structure

1
490
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353Combined sources
Turni37 – 393Combined sources
Helixi42 – 454Combined sources
Helixi47 – 6115Combined sources
Beta strandi63 – 719Combined sources
Beta strandi73 – 775Combined sources
Helixi80 – 878Combined sources
Turni88 – 947Combined sources
Turni105 – 1073Combined sources
Beta strandi112 – 1143Combined sources
Helixi117 – 13115Combined sources
Beta strandi134 – 1363Combined sources
Helixi141 – 15717Combined sources
Turni158 – 1614Combined sources
Helixi167 – 18317Combined sources
Helixi192 – 20817Combined sources
Helixi211 – 2133Combined sources
Helixi214 – 2185Combined sources
Helixi222 – 2254Combined sources
Helixi230 – 25324Combined sources
Helixi263 – 27412Combined sources
Beta strandi275 – 2773Combined sources
Helixi284 – 31532Combined sources
Helixi317 – 33014Combined sources
Beta strandi333 – 3353Combined sources
Helixi339 – 3446Combined sources
Helixi346 – 35914Combined sources
Beta strandi374 – 3763Combined sources
Beta strandi379 – 3813Combined sources
Beta strandi386 – 3894Combined sources
Helixi392 – 3954Combined sources
Turni398 – 4003Combined sources
Beta strandi401 – 4033Combined sources
Helixi409 – 4124Combined sources
Beta strandi415 – 4173Combined sources
Helixi431 – 4333Combined sources
Helixi438 – 45518Combined sources
Beta strandi456 – 4627Combined sources
Helixi464 – 4663Combined sources
Beta strandi475 – 4773Combined sources
Beta strandi485 – 4895Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OG2X-ray2.60A/B30-490[»]
1OG5X-ray2.55A/B30-490[»]
1R9OX-ray2.00A18-490[»]
4NZ2X-ray2.45A/B30-490[»]
ProteinModelPortaliP11712.
SMRiP11712. Positions 44-490.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11712.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP11712.
KOiK17719.
OMAiKHNQPSE.
OrthoDBiEOG7RBZ85.
PhylomeDBiP11712.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11712-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI
60 70 80 90 100
SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF
110 120 130 140 150
PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK
210 220 230 240 250
LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE
260 270 280 290 300
HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE
410 420 430 440 450
FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT
460 470 480 490
SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV
Length:490
Mass (Da):55,628
Last modified:May 30, 2000 - v3
Checksum:i4FDFC395303A4E3E
GO
Isoform 2 (identifier: P11712-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-162: AS → GG
     163-490: Missing.

Note: No experimental confirmation available.

Show »
Length:162
Mass (Da):18,005
Checksum:iB59C8888ED45AD09
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41L → I no nucleotide entry (PubMed:3697070).Curated
Sequence conflicti6 – 61V → S no nucleotide entry (PubMed:3697070).Curated
Sequence conflicti14 – 141L → M in AAB23864 (PubMed:1445376).Curated
Sequence conflicti175 – 1751C → Y no nucleotide entry (PubMed:2827463).Curated
Sequence conflicti239 – 2391F → L no nucleotide entry (PubMed:2827463).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191L → I in allele CYP2C9*7.
VAR_018862
Natural varianti144 – 1441R → C in allele CYP2C9*2. 7 Publications
Corresponds to variant rs1799853 [ dbSNP | Ensembl ].
VAR_008343
Natural varianti150 – 1501R → H in allele CYP2C9*8. 2 Publications
Corresponds to variant rs7900194 [ dbSNP | Ensembl ].
VAR_018863
Natural varianti251 – 2511H → R in allele CYP2C9*9. 2 Publications
Corresponds to variant rs2256871 [ dbSNP | Ensembl ].
VAR_018864
Natural varianti272 – 2721E → G in allele CYP2C9*10. 1 Publication
Corresponds to variant rs9332130 [ dbSNP | Ensembl ].
VAR_018865
Natural varianti335 – 3351R → W in allele CYP2C9*11. 2 Publications
Corresponds to variant rs28371685 [ dbSNP | Ensembl ].
VAR_018866
Natural varianti358 – 3581Y → C.3 Publications
Corresponds to variant rs1057909 [ dbSNP | Ensembl ].
VAR_008344
Natural varianti359 – 3591I → L in allele CYP2C9*3; responsible for the tolbutamide poor metabolizer phenotype. 4 Publications
Corresponds to variant rs1057910 [ dbSNP | Ensembl ].
VAR_008345
Natural varianti359 – 3591I → T in allele CYP2C9*4. 1 Publication
Corresponds to variant rs56165452 [ dbSNP | Ensembl ].
VAR_013515
Natural varianti360 – 3601D → E in allele CYP2C9*5; increases the K(m) value for substrates tested. 2 Publications
Corresponds to variant rs28371686 [ dbSNP | Ensembl ].
VAR_013516
Natural varianti413 – 4131L → P.1 Publication
Corresponds to variant rs28371687 [ dbSNP | Ensembl ].
VAR_024717
Natural varianti417 – 4171G → D.3 Publications
VAR_008346
Natural varianti489 – 4891P → S in allele CYP2C9*12. 1 Publication
Corresponds to variant rs9332239 [ dbSNP | Ensembl ].
VAR_018867

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 1622AS → GG in isoform 2. 1 PublicationVSP_055573
Alternative sequencei163 – 490328Missing in isoform 2. 1 PublicationVSP_055574Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341248 Genomic DNA. Translation: AAP88931.1.
AY702706 Genomic DNA. Translation: AAT94065.1.
AK289420 mRNA. Translation: BAF82109.1.
AL359672 Genomic DNA. Translation: CAH71303.1.
CH471066 Genomic DNA. Translation: EAW50019.1.
CH471066 Genomic DNA. Translation: EAW50020.1.
BC020754 mRNA. Translation: AAH20754.1.
BC070317 mRNA. Translation: AAH70317.1.
BC125054 mRNA. Translation: AAI25055.1.
D00173 mRNA. Translation: BAA00123.1.
M15331 mRNA. Translation: AAA52157.1.
M21939 mRNA. Translation: AAA52158.1.
M21940 mRNA. Translation: AAA52159.1.
S46963 mRNA. Translation: AAB23864.2. Sequence problems.
CCDSiCCDS7437.1. [P11712-1]
PIRiB38462.
D28951.
RefSeqiNP_000762.2. NM_000771.3. [P11712-1]
UniGeneiHs.282624.

Genome annotation databases

EnsembliENST00000260682; ENSP00000260682; ENSG00000138109. [P11712-1]
GeneIDi1559.
KEGGihsa:1559.
UCSCiuc001kjz.3. human.
uc001kka.4. human. [P11712-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C9 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341248 Genomic DNA. Translation: AAP88931.1.
AY702706 Genomic DNA. Translation: AAT94065.1.
AK289420 mRNA. Translation: BAF82109.1.
AL359672 Genomic DNA. Translation: CAH71303.1.
CH471066 Genomic DNA. Translation: EAW50019.1.
CH471066 Genomic DNA. Translation: EAW50020.1.
BC020754 mRNA. Translation: AAH20754.1.
BC070317 mRNA. Translation: AAH70317.1.
BC125054 mRNA. Translation: AAI25055.1.
D00173 mRNA. Translation: BAA00123.1.
M15331 mRNA. Translation: AAA52157.1.
M21939 mRNA. Translation: AAA52158.1.
M21940 mRNA. Translation: AAA52159.1.
S46963 mRNA. Translation: AAB23864.2. Sequence problems.
CCDSiCCDS7437.1. [P11712-1]
PIRiB38462.
D28951.
RefSeqiNP_000762.2. NM_000771.3. [P11712-1]
UniGeneiHs.282624.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OG2X-ray2.60A/B30-490[»]
1OG5X-ray2.55A/B30-490[»]
1R9OX-ray2.00A18-490[»]
4NZ2X-ray2.45A/B30-490[»]
ProteinModelPortaliP11712.
SMRiP11712. Positions 44-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107937. 10 interactions.
IntActiP11712. 6 interactions.
STRINGi9606.ENSP00000260682.

Chemistry

BindingDBiP11712.
ChEMBLiCHEMBL3397.
DrugBankiDB01418. Acenocoumarol.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB06594. Agomelatine.
DB00969. Alosetron.
DB00404. Alprazolam.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB00701. Amprenavir.
DB01217. Anastrozole.
DB01435. Antipyrine.
DB06605. Apixaban.
DB00673. Aprepitant.
DB01274. Arformoterol.
DB06697. Artemether.
DB01072. Atazanavir.
DB01076. Atorvastatin.
DB01117. Atovaquone.
DB00972. Azelastine.
DB00307. Bexarotene.
DB01128. Bicalutamide.
DB00188. Bortezomib.
DB00559. Bosentan.
DB00835. Brompheniramine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB08875. Cabozantinib.
DB00201. Caffeine.
DB00796. Candesartan.
DB01101. Capecitabine.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB01136. Carvedilol.
DB00482. Celecoxib.
DB00446. Chloramphenicol.
DB00672. Chlorpropamide.
DB00169. Cholecalciferol.
DB00501. Cimetidine.
DB00568. Cinnarizine.
DB00604. Cisapride.
DB00515. Cisplatin.
DB04920. Clevidipine.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB01394. Colchicine.
DB01176. Cyclizine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB06292. Dapagliflozin.
DB00250. Dapsone.
DB00705. Delavirdine.
DB00967. Desloratadine.
DB01234. Dexamethasone.
DB01191. Dexfenfluramine.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB01144. Diclofenamide.
DB00266. Dicoumarol.
DB00255. Diethylstilbestrol.
DB00343. Diltiazem.
DB01075. Diphenhydramine.
DB00822. Disulfiram.
DB00757. Dolasetron.
DB00843. Donepezil.
DB00988. Dopamine.
DB00869. Dorzolamide.
DB01142. Doxepin.
DB00470. Dronabinol.
DB00625. Efavirenz.
DB00216. Eletriptan.
DB08899. Enzalutamide.
DB00668. Epinephrine.
DB01240. Epoprostenol.
DB00876. Eprosartan.
DB00783. Estradiol.
DB00655. Estrone.
DB04574. Estropipate.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00749. Etodolac.
DB01628. Etoricoxib.
DB06414. Etravirine.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB01195. Flecainide.
DB00196. Fluconazole.
DB04841. Flunarizine.
DB01544. Flunitrazepam.
DB00544. Fluorouracil.
DB00472. Fluoxetine.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00983. Formoterol.
DB01320. Fosphenytoin.
DB00317. Gefitinib.
DB01241. Gemfibrozil.
DB01381. Ginkgo biloba.
DB01120. Gliclazide.
DB00222. Glimepiride.
DB01067. Glipizide.
DB01016. Glyburide.
DB01018. Guanfacine.
DB00502. Haloperidol.
DB01159. Halothane.
DB01355. Hexobarbital.
DB00667. Histamine Phosphate.
DB00062. Human Serum Albumin.
DB00327. Hydromorphone.
DB01050. Ibuprofen.
DB01177. Idarubicin.
DB01181. Ifosfamide.
DB00619. Imatinib.
DB00224. Indinavir.
DB00328. Indomethacin.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00448. Lansoprazole.
DB01097. Leflunomide.
DB00281. Lidocaine.
DB01601. Lopinavir.
DB00455. Loratadine.
DB06725. Lornoxicam.
DB00678. Losartan.
DB00227. Lovastatin.
DB01283. Lumiracoxib.
DB00603. Medroxyprogesterone Acetate.
DB00784. Mefenamic acid.
DB01065. Melatonin.
DB00814. Meloxicam.
DB01357. Mestranol.
DB00333. Methadone.
DB00703. Methazolamide.
DB00763. Methimazole.
DB01028. Methoxyflurane.
DB00916. Metronidazole.
DB01110. Miconazole.
DB00370. Mirtazapine.
DB01171. Moclobemide.
DB00745. Modafinil.
DB00471. Montelukast.
DB00788. Naproxen.
DB00731. Nateglinide.
DB00220. Nelfinavir.
DB00238. Nevirapine.
DB00622. Nicardipine.
DB06803. Niclosamide.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00338. Omeprazole.
DB00904. Ondansetron.
DB04938. Ospemifene.
DB00991. Oxaprozin.
DB01229. Paclitaxel.
DB00213. Pantoprazole.
DB00617. Paramethadione.
DB00715. Paroxetine.
DB00850. Perphenazine.
DB01174. Phenobarbital.
DB00946. Phenprocoumon.
DB00191. Phentermine.
DB00812. Phenylbutazone.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00554. Piroxicam.
DB08860. Pitavastatin.
DB01411. Pranlukast.
DB06209. Prasugrel.
DB00175. Pravastatin.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01131. Proguanil.
DB00420. Promazine.
DB01069. Promethazine.
DB01182. Propafenone.
DB00818. Propofol.
DB00205. Pyrimethamine.
DB01589. Quazepam.
DB00908. Quinidine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB08896. Regorafenib.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB01098. Rosuvastatin.
DB00936. Salicylic acid.
DB01232. Saquinavir.
DB00418. Secobarbital.
DB01037. Selegiline.
DB01104. Sertraline.
DB00203. Sildenafil.
DB00641. Simvastatin.
DB06268. Sitaxentan.
DB00398. Sorafenib.
DB00359. Sulfadiazine.
DB06150. Sulfadimethoxine.
DB00576. Sulfamethizole.
DB01015. Sulfamethoxazole.
DB08798. Sulfamoxole.
DB00259. Sulfanilamide.
DB06729. Sulfaphenazole.
DB00891. Sulfapyridine.
DB01138. Sulfinpyrazone.
DB00263. Sulfisoxazole.
DB00870. Suprofen.
DB00675. Tamoxifen.
DB06204. Tapentadol.
DB00231. Temazepam.
DB00444. Teniposide.
DB00469. Tenoxicam.
DB00857. Terbinafine.
DB00624. Testosterone.
DB01041. Thalidomide.
DB00277. Theophylline.
DB01154. Thiamylal.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB01124. Tolbutamide.
DB00323. Tolcapone.
DB01036. Tolterodine.
DB00214. Torasemide.
DB05109. Trabectedin.
DB00752. Tranylcypromine.
DB00374. Treprostinil.
DB00755. Tretinoin.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00177. Valsartan.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB08828. Vismodegib.
DB00582. Voriconazole.
DB00682. Warfarin.
DB04898. Ximelagatran.
DB00549. Zafirlukast.
DB00943. Zalcitabine.
DB00495. Zidovudine.
DB00744. Zileuton.
DB00425. Zolpidem.
DB01198. Zopiclone.

PTM databases

PhosphoSiteiP11712.

Polymorphism and mutation databases

BioMutaiCYP2C9.
DMDMi6686268.

Proteomic databases

PaxDbiP11712.
PRIDEiP11712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260682; ENSP00000260682; ENSG00000138109. [P11712-1]
GeneIDi1559.
KEGGihsa:1559.
UCSCiuc001kjz.3. human.
uc001kka.4. human. [P11712-1]

Organism-specific databases

CTDi1559.
GeneCardsiGC10P096688.
HGNCiHGNC:2623. CYP2C9.
HPAiCAB016123.
HPA015066.
MIMi601130. gene.
neXtProtiNX_P11712.
Orphaneti413681. Oral antidiabetic drugs toxicity or dose selection.
413674. Vitamin K antagonists toxicity or dose selection.
PharmGKBiPA126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP11712.
KOiK17719.
OMAiKHNQPSE.
OrthoDBiEOG7RBZ85.
PhylomeDBiP11712.
TreeFamiTF352043.

Enzyme and pathway databases

BRENDAi1.14.99.38. 2681.
ReactomeiREACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
SABIO-RKP11712.

Miscellaneous databases

ChiTaRSiCYP2C9. human.
EvolutionaryTraceiP11712.
GeneWikiiCYP2C9.
GenomeRNAii1559.
NextBioi6438.
PROiP11712.
SOURCEiSearch...

Gene expression databases

BgeeiP11712.
CleanExiHS_CYP2C9.
ExpressionAtlasiP11712. baseline and differential.
GenevestigatoriP11712.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10."
    Meehan R.R., Gosden J.R., Rout D., Hastie N.D., Friedberg T., Adesnik M., Buckland R., van Heyningen V., Fletcher J.M., Spurr N.K., Sweeney J., Wolf C.R.
    Am. J. Hum. Genet. 42:26-37(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-144.
  2. "cDNA and amino acid sequences of two members of the human P450IIC gene subfamily."
    Kimura S., Pastewka J., Gelboin H.V., Gonzalez F.J.
    Nucleic Acids Res. 15:10053-10054(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-144.
  3. NIEHS SNPs program
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-144; HIS-150; ARG-251; GLY-272; LEU-359 AND SER-489.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT CYS-144.
    Tissue: Liver.
  8. "Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form."
    Yasumori T., Kawano S., Nagata K., Shimada M., Yamazoe Y., Kato R.
    J. Biochem. 102:1075-1082(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-490 (ISOFORM 1).
    Tissue: Liver.
  9. "Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase."
    Umbenhauer D.R., Martin M.V., Lloyd R.S., Guengerich F.P.
    Biochemistry 26:1094-1099(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490 (ISOFORM 1), VARIANTS CYS-358 AND ASP-417.
    Tissue: Liver.
  10. "Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase."
    Ged C., Umbenhauer D.R., Bellew T.M., Bork R.W., Srivastava P.K., Shinriki N., Lloyd R.S., Guengerich F.P.
    Biochemistry 27:6929-6940(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490 (ISOFORM 1), VARIANTS CYS-358 AND ASP-417.
  11. "Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity."
    Ohgiya S., Komori M., Ohi H., Shiramatsu K., Shinriki N., Kamataki T.
    Biochem. Int. 27:1073-1081(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-490 (ISOFORM 1).
  12. "Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction."
    Shimada T., Misono K.S., Guengerich F.P.
    J. Biol. Chem. 261:909-921(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-29, CHARACTERIZATION.
  13. "Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization."
    Komori M., Hashizume T., Ohi H., Miura T., Kitada M., Nagashima K., Kamataki T.
    J. Biochem. 104:912-916(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-25.
  14. "Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes."
    Srivastava P.K., Yun C.H., Beaune P.H., Ged C., Guengerich F.P.
    Mol. Pharmacol. 40:69-79(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  15. "Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms."
    Haining R.L., Hunter A.P., Veronese M.E., Trager W.F., Rettie A.E.
    Arch. Biochem. Biophys. 333:447-458(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-9; 21-157; 169-249; 264-424; 426-476 AND 484-487.
  16. "Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity."
    Sandhu P., Baba T., Guengerich F.P.
    Arch. Biochem. Biophys. 306:443-450(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-20.
  17. "Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes."
    Miyazawa M., Shindo M., Shimada T.
    Drug Metab. Dispos. 30:602-607(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  19. "Crystal structure of human cytochrome P450 2C9 with bound warfarin."
    Williams P.A., Cosme J., Ward A., Angove H.C., Matak-Vinkovic D., Jhoti H.
    Nature 424:464-468(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 30-490.
  20. "Genetic analysis of the human cytochrome P450 CYP2C9 locus."
    Stubbins M.J., Harries L.W., Smith G., Tarbit M.H., Wolf C.R.
    Pharmacogenetics 6:429-439(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYP2C9*2 CYS-144 AND CYP2C9*3 LEU-359.
  21. "Allelic and functional variability of cytochrome P4502C9."
    Bhasker C.R., Miners J.O., Coulter S., Birkett D.J.
    Pharmacogenetics 7:51-58(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYP2C9*2 CYS-144; CYS-358; CYP2C9*3 LEU-359 AND ASP-417.
  22. "Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus."
    Imai J., Ieiri I., Mamiya K., Miyahara S., Furuumi H., Nanba E., Yamane M., Fukumaki Y., Ninomiya H., Tashiro N., Otsubo K., Higuchi S.
    Pharmacogenetics 10:85-89(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2C9*4 THR-359.
  23. "Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans."
    Dickmann L.J., Rettie A.E., Kneller M.B., Kim R.B., Wood A.J., Stein C.M., Wilkinson G.R., Schwarz U.I.
    Mol. Pharmacol. 60:382-387(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2C9*5 GLU-360.
  24. "Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy."
    Higashi M.K., Veenstra D.L., Kondo L.M., Wittkowsky A.K., Srinouanprachanh S.L., Farin F.M., Rettie A.E.
    JAMA 287:1690-1698(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2C9*11 TRP-335.
  25. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
    Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
    Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYS-144; HIS-150; ARG-251; TRP-335; LEU-359; GLU-360 AND PRO-413.

Entry informationi

Entry nameiCP2C9_HUMAN
AccessioniPrimary (citable) accession number: P11712
Secondary accession number(s): P11713
, Q16756, Q16872, Q5VX92, Q6IRV8, Q8WW80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 30, 2000
Last modified: April 29, 2015
This is version 174 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.