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Protein

Nuclear fusion protein FUS1

Gene

FUS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for cell fusion. Negatively regulates Sho1p signaling to ensure efficient cell fusion.1 Publication
Interacts with SHO1.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cortical protein anchoring Source: SGD
  • cytogamy Source: SGD
  • regulation of termination of mating projection growth Source: SGD
  • vesicle-mediated transport Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29288-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fusion protein FUS1
Gene namesi
Name:FUS1
Ordered Locus Names:YCL027W
ORF Names:YCL27W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL027W.
SGDiS000000532. FUS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 96HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

  • cell cortex Source: GOC
  • integral component of plasma membrane Source: SGD
  • mating projection tip Source: SGD
  • trans-Golgi network Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873841 – 512Nuclear fusion protein FUS1Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphothreonineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei281PhosphothreonineCombined sources1
Modified residuei424PhosphothreonineCombined sources1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP11710.

PTM databases

iPTMnetiP11710.

Expressioni

Inductioni

FUS1 remains essentially unexpressed in vegetative cells, but is strongly induced by incubation of haploid cells with the appropriate mating pheromone.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BNR1P404505EBI-7179,EBI-3711
HAA1Q127533EBI-7179,EBI-8118
PEA2P400915EBI-7179,EBI-13106
SHO1P400737EBI-7179,EBI-18140
STE5P329172EBI-7179,EBI-18373

Protein-protein interaction databases

BioGridi30956. 51 interactors.
DIPiDIP-670N.
IntActiP11710. 48 interactors.
MINTiMINT-522625.

Structurei

3D structure databases

ProteinModelPortaliP11710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini436 – 512SH3PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 512HydrophilicAdd BLAST416

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 71Ser/Thr-richAdd BLAST71

Sequence similaritiesi

Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000893.
InParanoidiP11710.
KOiK11243.
OMAiHTDGWCL.
OrthoDBiEOG092C23KE.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATIMQTTT TVLTTVAAMS TTLASNYISS QASSSTSVTT VTTIATSIRS
60 70 80 90 100
TPSNLLFSNV AAQPKSSSAS TIGLSIGLPI GIFCFGLLIL LCYFYLKRNS
110 120 130 140 150
VSISNPPMSA TIPREEEYCR RTNWFSRLFW QSKCEDQNSY SNRDIEKYND
160 170 180 190 200
TQWTSGDNMS SKIQYKISKP IIPQHILTPK KTVKNPYAWS GKNISLDPKV
210 220 230 240 250
NEMEEEKVVD AFLYTKPPNI VHIESSMPSY NDLPSQKTVS SKKTALKTSE
260 270 280 290 300
KWSYESPLSR WFLRGSTYFK DYGLSKTSLK TPTGAPQLKQ MKMLSRISKG
310 320 330 340 350
YFNESDIMPD ERSPILEYNN TPLDANDSVN NLGNTTPDSQ ITSYRNNNID
360 370 380 390 400
LITARPHSVI YGTTAQQTLE TNFNDHHDCN KSTEKHELII PTPSKPLKKR
410 420 430 440 450
KKRRQSKMYQ HLQHLSRSKP LPLTPNSKYN GEASVQLGKT YTVIQDYEPR
460 470 480 490 500
LTDEIRISLG EKVKILATHT DGWCLVEKCN TQKGSIHVSV DDKRYLNEDR
510
GIVPGDCLQE YD
Length:512
Mass (Da):57,779
Last modified:September 26, 2001 - v3
Checksum:i705241556DAD5D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17199 Genomic DNA. Translation: AAA34612.1.
M16717 Genomic DNA. Translation: AAA34616.1.
X59720 Genomic DNA. Translation: CAA42358.2.
BK006937 Genomic DNA. Translation: DAA07457.1.
PIRiS19354.
RefSeqiNP_009903.2. NM_001178672.1.

Genome annotation databases

EnsemblFungiiCAA42358; CAA42358; CAA42358.
YCL027W; YCL027W; YCL027W.
GeneIDi850330.
KEGGisce:YCL027W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17199 Genomic DNA. Translation: AAA34612.1.
M16717 Genomic DNA. Translation: AAA34616.1.
X59720 Genomic DNA. Translation: CAA42358.2.
BK006937 Genomic DNA. Translation: DAA07457.1.
PIRiS19354.
RefSeqiNP_009903.2. NM_001178672.1.

3D structure databases

ProteinModelPortaliP11710.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30956. 51 interactors.
DIPiDIP-670N.
IntActiP11710. 48 interactors.
MINTiMINT-522625.

PTM databases

iPTMnetiP11710.

Proteomic databases

PRIDEiP11710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42358; CAA42358; CAA42358.
YCL027W; YCL027W; YCL027W.
GeneIDi850330.
KEGGisce:YCL027W.

Organism-specific databases

EuPathDBiFungiDB:YCL027W.
SGDiS000000532. FUS1.

Phylogenomic databases

HOGENOMiHOG000000893.
InParanoidiP11710.
KOiK11243.
OMAiHTDGWCL.
OrthoDBiEOG092C23KE.

Enzyme and pathway databases

BioCyciYEAST:G3O-29288-MONOMER.

Miscellaneous databases

PROiP11710.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUS1_YEAST
AccessioniPrimary (citable) accession number: P11710
Secondary accession number(s): D6VQY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.