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Protein

Nuclear fusion protein BIK1

Gene

BIK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for nuclear fusion, chromosome disjunction, and nuclear segregation during mitosis. Probably required for the formation or stabilization of microtubules during mitosis and for spindle pole body fusion during conjugation.

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • microtubule binding Source: SGD
  • protein homodimerization activity Source: SGD

GO - Biological processi

  • 2-micrometer plasmid partitioning Source: SGD
  • cell division Source: UniProtKB-KW
  • karyogamy involved in conjugation with cellular fusion Source: SGD
  • mitotic spindle elongation Source: SGD
  • negative regulation of microtubule polymerization Source: SGD
  • nuclear migration involved in conjugation with cellular fusion Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29290-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fusion protein BIK1
Gene namesi
Name:BIK1
Ordered Locus Names:YCL029C
ORF Names:YCL29C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL029C
SGDiS000000534 BIK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835131 – 440Nuclear fusion protein BIK1Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP11709
PaxDbiP11709
PRIDEiP11709
TopDownProteomicsiP11709

PTM databases

iPTMnetiP11709

Interactioni

GO - Molecular functioni

  • microtubule binding Source: SGD
  • protein homodimerization activity Source: SGD

Protein-protein interaction databases

BioGridi30954, 231 interactors
DIPiDIP-2341N
IntActiP11709, 5 interactors
MINTiP11709
STRINGi4932.YCL029C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FC6X-ray1.80A1-100[»]
ProteinModelPortaliP11709
SMRiP11709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 69CAP-GlyPROSITE-ProRule annotationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 397Sequence analysisAdd BLAST208

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi416 – 429CCHC-boxAdd BLAST14

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00840000132181
HOGENOMiHOG000057099
InParanoidiP11709
OMAiNIGKNDG
OrthoDBiEOG092C2WGB

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P11709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRYQRKIGC FIQIPNLGRG QLKYVGPVDT KAGMFAGVDL LANIGKNDGS
60 70 80 90 100
FMGKKYFQTE YPQSGLFIQL QKVASLIEKA SISQTSRRTT MEPLSIPKNR
110 120 130 140 150
SIVRLTNQFS PMDDPKSPTP MRSFRITSRH SGNQQSMDQE ASDHHQQQEF
160 170 180 190 200
GYDNREDRME VDSILSSDRK ANHNTTSDWK PDNGHMNDLN SSEVTIELRE
210 220 230 240 250
AQLTIEKLQR KQLHYKRLLD DQRMVLEEVQ PTFDRYEATI QEREKEIDHL
260 270 280 290 300
KQQLELERRQ QAKQKQFFDA ENEQLLAVVS QLHEEIKENE ERNLSHNQPT
310 320 330 340 350
GANEDVELLK KQLEQLRNIE DQFELHKTKW AKEREQLKMH NDSLSKEYQN
360 370 380 390 400
LSKELFLTKP QDSSSEEVAS LTKKLEEANE KIKQLEQAQA QTAVESLPIF
410 420 430 440
DPPAPVDTTA GRQQWCEHCD TMGHNTAECP HHNPDNQQFF
Length:440
Mass (Da):51,092
Last modified:October 1, 1989 - v1
Checksum:i9E098B25C431619B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16717 Genomic DNA Translation: AAA34614.1
X59720 Genomic DNA Translation: CAA42356.1
BK006937 Genomic DNA Translation: DAA07455.1
PIRiB27061
RefSeqiNP_009901.1, NM_001178674.1

Genome annotation databases

EnsemblFungiiCAA42356; CAA42356; CAA42356
YCL029C; YCL029C; YCL029C
GeneIDi850328
KEGGisce:YCL029C

Similar proteinsi

Entry informationi

Entry nameiBIK1_YEAST
AccessioniPrimary (citable) accession number: P11709
Secondary accession number(s): D6VQY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

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