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Protein

Nuclear fusion protein BIK1

Gene

BIK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for nuclear fusion, chromosome disjunction, and nuclear segregation during mitosis. Probably required for the formation or stabilization of microtubules during mitosis and for spindle pole body fusion during conjugation.

GO - Molecular functioni

  • microtubule binding Source: SGD
  • protein homodimerization activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • karyogamy involved in conjugation with cellular fusion Source: SGD
  • mitotic spindle elongation Source: SGD
  • negative regulation of microtubule polymerization Source: SGD
  • nuclear migration involved in conjugation with cellular fusion Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fusion protein BIK1
Gene namesi
Name:BIK1
Ordered Locus Names:YCL029C
ORF Names:YCL29C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL029C.
SGDiS000000534. BIK1.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: SGD
  • condensed nuclear chromosome kinetochore Source: SGD
  • kinetochore Source: SGD
  • mating projection tip Source: SGD
  • microtubule plus-end Source: SGD
  • spindle Source: SGD
  • spindle microtubule Source: SGD
  • spindle pole body Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835131 – 440Nuclear fusion protein BIK1Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP11709.
PRIDEiP11709.
TopDownProteomicsiP11709.

PTM databases

iPTMnetiP11709.

Interactioni

GO - Molecular functioni

  • microtubule binding Source: SGD
  • protein homodimerization activity Source: SGD

Protein-protein interaction databases

BioGridi30954. 156 interactors.
DIPiDIP-2341N.
IntActiP11709. 4 interactors.
MINTiMINT-437612.

Structurei

3D structure databases

ProteinModelPortaliP11709.
SMRiP11709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 69CAP-GlyPROSITE-ProRule annotationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 397Sequence analysisAdd BLAST208

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi416 – 429CCHC-boxAdd BLAST14

Sequence similaritiesi

Contains 1 CAP-Gly domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00840000132181.
HOGENOMiHOG000057099.
InParanoidiP11709.
OMAiPYENDIF.
OrthoDBiEOG092C2WGB.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRYQRKIGC FIQIPNLGRG QLKYVGPVDT KAGMFAGVDL LANIGKNDGS
60 70 80 90 100
FMGKKYFQTE YPQSGLFIQL QKVASLIEKA SISQTSRRTT MEPLSIPKNR
110 120 130 140 150
SIVRLTNQFS PMDDPKSPTP MRSFRITSRH SGNQQSMDQE ASDHHQQQEF
160 170 180 190 200
GYDNREDRME VDSILSSDRK ANHNTTSDWK PDNGHMNDLN SSEVTIELRE
210 220 230 240 250
AQLTIEKLQR KQLHYKRLLD DQRMVLEEVQ PTFDRYEATI QEREKEIDHL
260 270 280 290 300
KQQLELERRQ QAKQKQFFDA ENEQLLAVVS QLHEEIKENE ERNLSHNQPT
310 320 330 340 350
GANEDVELLK KQLEQLRNIE DQFELHKTKW AKEREQLKMH NDSLSKEYQN
360 370 380 390 400
LSKELFLTKP QDSSSEEVAS LTKKLEEANE KIKQLEQAQA QTAVESLPIF
410 420 430 440
DPPAPVDTTA GRQQWCEHCD TMGHNTAECP HHNPDNQQFF
Length:440
Mass (Da):51,092
Last modified:October 1, 1989 - v1
Checksum:i9E098B25C431619B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16717 Genomic DNA. Translation: AAA34614.1.
X59720 Genomic DNA. Translation: CAA42356.1.
BK006937 Genomic DNA. Translation: DAA07455.1.
PIRiB27061.
RefSeqiNP_009901.1. NM_001178674.1.

Genome annotation databases

EnsemblFungiiCAA42356; CAA42356; CAA42356.
YCL029C; YCL029C; YCL029C.
GeneIDi850328.
KEGGisce:YCL029C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16717 Genomic DNA. Translation: AAA34614.1.
X59720 Genomic DNA. Translation: CAA42356.1.
BK006937 Genomic DNA. Translation: DAA07455.1.
PIRiB27061.
RefSeqiNP_009901.1. NM_001178674.1.

3D structure databases

ProteinModelPortaliP11709.
SMRiP11709.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30954. 156 interactors.
DIPiDIP-2341N.
IntActiP11709. 4 interactors.
MINTiMINT-437612.

PTM databases

iPTMnetiP11709.

Proteomic databases

MaxQBiP11709.
PRIDEiP11709.
TopDownProteomicsiP11709.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42356; CAA42356; CAA42356.
YCL029C; YCL029C; YCL029C.
GeneIDi850328.
KEGGisce:YCL029C.

Organism-specific databases

EuPathDBiFungiDB:YCL029C.
SGDiS000000534. BIK1.

Phylogenomic databases

GeneTreeiENSGT00840000132181.
HOGENOMiHOG000057099.
InParanoidiP11709.
OMAiPYENDIF.
OrthoDBiEOG092C2WGB.

Enzyme and pathway databases

BioCyciYEAST:G3O-29290-MONOMER.

Miscellaneous databases

PROiP11709.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIK1_YEAST
AccessioniPrimary (citable) accession number: P11709
Secondary accession number(s): D6VQY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.