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P11707 (CP3A6_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A6

EC=1.14.14.1
Alternative name(s):
CYPIIIA6
Cytochrome P450-3C
Gene names
Name:CYP3A6
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Exhibits progesterone 6 beta-hydroxylase activity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By rifampicin.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Cytochrome P450 3A6
PRO_0000051789

Sites

Metal binding4401Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict54 – 552GI → VIN in AAA31430. Ref.1
Sequence conflict165 – 1695GKPVD → ASPST in AAA31430. Ref.1
Sequence conflict3931Missing in AAA31430. Ref.1
Sequence conflict494 – 4952RD → ES in AAA31430. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P11707 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 251D21061863ACFB

FASTA50157,450
        10         20         30         40         50         60 
MDLIFSLETW VLLAASLVLL YLYGTSTHGL FKKMGIPGPT PLPFIGTILE YRKGIWDFDI 

        70         80         90        100        110        120 
ECRKKYGKMW GLFDGRQPLM VITDPDMIKT VLVKECYSVF TNRRSFGPVG FMKKAVSISE 

       130        140        150        160        170        180 
DEDWKRVRTL LSPTFTSGKL KEMLPIIAQY GDVLVKNLRQ EAEKGKPVDL KEIFGAYSMD 

       190        200        210        220        230        240 
VITGTSFGVN IDSLRNPQDP FVKNVRRLLK FSFFDPLLLS ITLFPFLTPI FEALHISMFP 

       250        260        270        280        290        300 
KDVMDFLKTS VEKIKDDRLK DKQKRRVDFL QLMINSQNSK EIDSHKALDD IEVVAQSIII 

       310        320        330        340        350        360 
LFAGYETTSS TLSFIMHLLA THPDVQQKLQ EEIDTLLPNK ELATYDTLVK MEYLDMVVNE 

       370        380        390        400        410        420 
TLRLYPIAGR LERVCKKDVD INGTFIPKGT IVMMPTYALH RDPQHWTEPD EFRPERFSKK 

       430        440        450        460        470        480 
NKDNINPYIY HPFGAGPRNC LGMRFALMNI KLALVRLMQN FSFKLCKETQ VPLKLGKQGL 

       490        500 
LQPEKPIVLK VVSRDGIIRG A 

« Hide

References

[1]"Complete sequence of cytochrome P450 3c cDNA and presence of two mRNA species with 3' untranslated regions of different lengths."
Dalet C., Clair P., Daujat M., Fort P., Blanchard J.-M., Maurel P.
DNA 7:39-46(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Regulation of the rabbit cytochrome P-450 3c gene. Age-dependent expression and transcriptional activation by rifampicin."
Potenza C.L., Pendurthi U.R., Strom D.K., Tukey R.H., Griffin K.J., Schwab G.E., Johnson E.F.
J. Biol. Chem. 264:16222-16228(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19139 mRNA. Translation: AAA31430.1.
J05034 mRNA. Translation: AAA31178.1.
PIRA29487.
A34236.
RefSeqNP_001164739.1. NM_001171268.2.
UniGeneOcu.1831.

3D structure databases

ProteinModelPortalP11707.
SMRP11707. Positions 28-494.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000016348.

Chemistry

ChEMBLCHEMBL1743541.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328954.

Organism-specific databases

CTD100328954.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000039127.
HOVERGENHBG108567.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3A6_RABIT
AccessionPrimary (citable) accession number: P11707
Secondary accession number(s): Q29506
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1999
Last modified: December 11, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families