P11707 (CP3A6_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 3A6
EC=1.14.14.1

Alternative name(s):
CYPIIIA6
Cytochrome P450-3C

Gene names

Name:

CYP3A6

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Exhibits progesterone 6 beta-hydroxylase activity.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	By rifampicin.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Cytochrome P450 3A6		PRO_0000051789
Sites
	Metal binding	440	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	54 – 55	2	GI → VIN in AAA31430. Ref.1
	Sequence conflict	165 – 169	5	GKPVD → ASPST in AAA31430. Ref.1
	Sequence conflict	393	1	Missing in AAA31430. Ref.1
	Sequence conflict	494 – 495	2	RD → ES in AAA31430. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P11707 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 251D21061863ACFB	FASTA	501	57,450
	10 20 30 40 50 60 MDLIFSLETW VLLAASLVLL YLYGTSTHGL FKKMGIPGPT PLPFIGTILE YRKGIWDFDI 70 80 90 100 110 120 ECRKKYGKMW GLFDGRQPLM VITDPDMIKT VLVKECYSVF TNRRSFGPVG FMKKAVSISE 130 140 150 160 170 180 DEDWKRVRTL LSPTFTSGKL KEMLPIIAQY GDVLVKNLRQ EAEKGKPVDL KEIFGAYSMD 190 200 210 220 230 240 VITGTSFGVN IDSLRNPQDP FVKNVRRLLK FSFFDPLLLS ITLFPFLTPI FEALHISMFP 250 260 270 280 290 300 KDVMDFLKTS VEKIKDDRLK DKQKRRVDFL QLMINSQNSK EIDSHKALDD IEVVAQSIII 310 320 330 340 350 360 LFAGYETTSS TLSFIMHLLA THPDVQQKLQ EEIDTLLPNK ELATYDTLVK MEYLDMVVNE 370 380 390 400 410 420 TLRLYPIAGR LERVCKKDVD INGTFIPKGT IVMMPTYALH RDPQHWTEPD EFRPERFSKK 430 440 450 460 470 480 NKDNINPYIY HPFGAGPRNC LGMRFALMNI KLALVRLMQN FSFKLCKETQ VPLKLGKQGL 490 500 LQPEKPIVLK VVSRDGIIRG A

References

[1]	"Complete sequence of cytochrome P450 3c cDNA and presence of two mRNA species with 3' untranslated regions of different lengths." Dalet C., Clair P., Daujat M., Fort P., Blanchard J.-M., Maurel P. DNA 7:39-46(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Regulation of the rabbit cytochrome P-450 3c gene. Age-dependent expression and transcriptional activation by rifampicin." Potenza C.L., Pendurthi U.R., Strom D.K., Tukey R.H., Griffin K.J., Schwab G.E., Johnson E.F. J. Biol. Chem. 264:16222-16228(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M19139 mRNA. Translation: AAA31430.1. J05034 mRNA. Translation: AAA31178.1.
PIR	A29487. A34236.
RefSeq	NP_001164739.1. NM_001171268.2.
UniGene	Ocu.1831.
3D structure databases
ProteinModelPortal	P11707.
SMR	P11707. Positions 28-494.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000016348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100328954.
Organism-specific databases
CTD	100328954.
Phylogenomic databases
eggNOG	COG2124.
HOGENOM	HOG000039127.
HOVERGEN	HBG108567.
OrthoDB	EOG4ZW59X.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR008072. Cyt_P450_E_CYP3A. IPR002402. Cyt_P450_E_grp-II. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00464. EP450II. PR01689. EP450IICYP3A. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1743541.

Entry information

Entry name

CP3A6_RABIT

Accession

Primary (citable) accession number: P11707
Secondary accession number(s): Q29506

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	July 15, 1999
Last modified:	April 3, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program