Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P11707

- CP3A6_RABIT

UniProt

P11707 - CP3A6_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome P450 3A6

Gene

CYP3A6

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Exhibits progesterone 6 beta-hydroxylase activity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi440 – 4401Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A6 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA6
Cytochrome P450-3C
Gene namesi
Name:CYP3A6
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 3A6PRO_0000051789Add
BLAST

Expressioni

Inductioni

By rifampicin.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016348.

Structurei

3D structure databases

ProteinModelPortaliP11707.
SMRiP11707. Positions 28-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP11707.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11707-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIFSLETW VLLAASLVLL YLYGTSTHGL FKKMGIPGPT PLPFIGTILE
60 70 80 90 100
YRKGIWDFDI ECRKKYGKMW GLFDGRQPLM VITDPDMIKT VLVKECYSVF
110 120 130 140 150
TNRRSFGPVG FMKKAVSISE DEDWKRVRTL LSPTFTSGKL KEMLPIIAQY
160 170 180 190 200
GDVLVKNLRQ EAEKGKPVDL KEIFGAYSMD VITGTSFGVN IDSLRNPQDP
210 220 230 240 250
FVKNVRRLLK FSFFDPLLLS ITLFPFLTPI FEALHISMFP KDVMDFLKTS
260 270 280 290 300
VEKIKDDRLK DKQKRRVDFL QLMINSQNSK EIDSHKALDD IEVVAQSIII
310 320 330 340 350
LFAGYETTSS TLSFIMHLLA THPDVQQKLQ EEIDTLLPNK ELATYDTLVK
360 370 380 390 400
MEYLDMVVNE TLRLYPIAGR LERVCKKDVD INGTFIPKGT IVMMPTYALH
410 420 430 440 450
RDPQHWTEPD EFRPERFSKK NKDNINPYIY HPFGAGPRNC LGMRFALMNI
460 470 480 490 500
KLALVRLMQN FSFKLCKETQ VPLKLGKQGL LQPEKPIVLK VVSRDGIIRG

A
Length:501
Mass (Da):57,450
Last modified:July 15, 1999 - v2
Checksum:i251D21061863ACFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 552GI → VIN in AAA31430. (PubMed:3349903)Curated
Sequence conflicti165 – 1695GKPVD → ASPST in AAA31430. (PubMed:3349903)Curated
Sequence conflicti393 – 3931Missing in AAA31430. (PubMed:3349903)Curated
Sequence conflicti494 – 4952RD → ES in AAA31430. (PubMed:3349903)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19139 mRNA. Translation: AAA31430.1.
J05034 mRNA. Translation: AAA31178.1.
PIRiA29487.
A34236.
RefSeqiNP_001164739.1. NM_001171268.2.
UniGeneiOcu.1831.

Genome annotation databases

GeneIDi100328954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19139 mRNA. Translation: AAA31430.1 .
J05034 mRNA. Translation: AAA31178.1 .
PIRi A29487.
A34236.
RefSeqi NP_001164739.1. NM_001171268.2.
UniGenei Ocu.1831.

3D structure databases

ProteinModelPortali P11707.
SMRi P11707. Positions 28-494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000016348.

Chemistry

BindingDBi P11707.
ChEMBLi CHEMBL1743541.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328954.

Organism-specific databases

CTDi 100328954.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi P11707.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of cytochrome P450 3c cDNA and presence of two mRNA species with 3' untranslated regions of different lengths."
    Dalet C., Clair P., Daujat M., Fort P., Blanchard J.-M., Maurel P.
    DNA 7:39-46(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Regulation of the rabbit cytochrome P-450 3c gene. Age-dependent expression and transcriptional activation by rifampicin."
    Potenza C.L., Pendurthi U.R., Strom D.K., Tukey R.H., Griffin K.J., Schwab G.E., Johnson E.F.
    J. Biol. Chem. 264:16222-16228(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP3A6_RABIT
AccessioniPrimary (citable) accession number: P11707
Secondary accession number(s): Q29506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1999
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3