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P11707

- CP3A6_RABIT

UniProt

P11707 - CP3A6_RABIT

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Protein
Cytochrome P450 3A6
Gene
CYP3A6
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Exhibits progesterone 6 beta-hydroxylase activity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi440 – 4401Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A6 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA6
    Cytochrome P450-3C
    Gene namesi
    Name:CYP3A6
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Cytochrome P450 3A6
    PRO_0000051789Add
    BLAST

    Expressioni

    Inductioni

    By rifampicin.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000016348.

    Structurei

    3D structure databases

    ProteinModelPortaliP11707.
    SMRiP11707. Positions 28-494.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11707-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLIFSLETW VLLAASLVLL YLYGTSTHGL FKKMGIPGPT PLPFIGTILE    50
    YRKGIWDFDI ECRKKYGKMW GLFDGRQPLM VITDPDMIKT VLVKECYSVF 100
    TNRRSFGPVG FMKKAVSISE DEDWKRVRTL LSPTFTSGKL KEMLPIIAQY 150
    GDVLVKNLRQ EAEKGKPVDL KEIFGAYSMD VITGTSFGVN IDSLRNPQDP 200
    FVKNVRRLLK FSFFDPLLLS ITLFPFLTPI FEALHISMFP KDVMDFLKTS 250
    VEKIKDDRLK DKQKRRVDFL QLMINSQNSK EIDSHKALDD IEVVAQSIII 300
    LFAGYETTSS TLSFIMHLLA THPDVQQKLQ EEIDTLLPNK ELATYDTLVK 350
    MEYLDMVVNE TLRLYPIAGR LERVCKKDVD INGTFIPKGT IVMMPTYALH 400
    RDPQHWTEPD EFRPERFSKK NKDNINPYIY HPFGAGPRNC LGMRFALMNI 450
    KLALVRLMQN FSFKLCKETQ VPLKLGKQGL LQPEKPIVLK VVSRDGIIRG 500
    A 501
    Length:501
    Mass (Da):57,450
    Last modified:July 15, 1999 - v2
    Checksum:i251D21061863ACFB
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 552GI → VIN in AAA31430. 1 Publication
    Sequence conflicti165 – 1695GKPVD → ASPST in AAA31430. 1 Publication
    Sequence conflicti393 – 3931Missing in AAA31430. 1 Publication
    Sequence conflicti494 – 4952RD → ES in AAA31430. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19139 mRNA. Translation: AAA31430.1.
    J05034 mRNA. Translation: AAA31178.1.
    PIRiA29487.
    A34236.
    RefSeqiNP_001164739.1. NM_001171268.2.
    UniGeneiOcu.1831.

    Genome annotation databases

    GeneIDi100328954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19139 mRNA. Translation: AAA31430.1 .
    J05034 mRNA. Translation: AAA31178.1 .
    PIRi A29487.
    A34236.
    RefSeqi NP_001164739.1. NM_001171268.2.
    UniGenei Ocu.1831.

    3D structure databases

    ProteinModelPortali P11707.
    SMRi P11707. Positions 28-494.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000016348.

    Chemistry

    ChEMBLi CHEMBL1743541.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100328954.

    Organism-specific databases

    CTDi 100328954.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of cytochrome P450 3c cDNA and presence of two mRNA species with 3' untranslated regions of different lengths."
      Dalet C., Clair P., Daujat M., Fort P., Blanchard J.-M., Maurel P.
      DNA 7:39-46(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Regulation of the rabbit cytochrome P-450 3c gene. Age-dependent expression and transcriptional activation by rifampicin."
      Potenza C.L., Pendurthi U.R., Strom D.K., Tukey R.H., Griffin K.J., Schwab G.E., Johnson E.F.
      J. Biol. Chem. 264:16222-16228(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP3A6_RABIT
    AccessioniPrimary (citable) accession number: P11707
    Secondary accession number(s): Q29506
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: July 15, 1999
    Last modified: June 11, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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