P11701 (SACB_STRMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Levansucrase
EC=2.4.1.10

Alternative name(s):
Beta-D-fructofuranosyl transferase
Sucrose 6-fructosyl transferase

Gene names

Name:	ftf
Synonyms:	sacB
Ordered Locus Names:	SMU_2028

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	795 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Sucrose + (6)-beta-D-fructofuranosyl-(2->)(n) alpha-D-glucopyranoside = glucose + (6)-beta-D-fructofuranosyl-(2->)(n+1) alpha-D-glucopyranoside.
Subcellular location	Secreted.
Sequence similarities	Belongs to the glycosyl hydrolase 68 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate utilization Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	levansucrase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34
	Chain	35 – 795	761	Levansucrase		PRO_0000012250
Experimental info
	Sequence conflict	69	1	D → A in AAA88584. Ref.1
	Sequence conflict	74	1	K → Q in AAA88584. Ref.1
	Sequence conflict	120	1	S → A in AAA88584. Ref.1
	Sequence conflict	131	1	E → EKD in AAA88584. Ref.1
	Sequence conflict	375 – 377	3	GDG → VMA in AAA88584. Ref.1
	Sequence conflict	641	1	S → P in AAA88584. Ref.1
	Sequence conflict	739	1	Y → S in AAA88584. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P11701 [UniParc]. Last modified November 28, 2002. Version 2. Checksum: 4012469148B34914	FASTA	795	87,385
	10 20 30 40 50 60 METKVRKKMY KKGKFWVVAT ITTAMLTGIG LSSVQADEAN STQVSSELAE RSQVQENTTA 70 80 90 100 110 120 SSSAAENQDK TEVKETPSTN PAAATVENTD QTTKVITDNA AVESKASKTK DQAATVTKTS 130 140 150 160 170 180 ASTPEVGQTN EKAKATKEAD ITTPKNTIDE YGLTEQARKI ATEAGINLSS LTQKQVEALN 190 200 210 220 230 240 KVKLTSDAQT GHQMTYQEFD KIAQTLIAQD ERYAIPYFNA KAIKNMKAAT TRDAQTGQIA 250 260 270 280 290 300 DLDVWDSWPV QDAKTGEVIN WNGYQLVVAM MGIPNTNDNH IYLLYNKYGD NNFDHWKNAG 310 320 330 340 350 360 SIFGYNETPL TQEWSGSATV NEDGSLQLFY TKVDTSDKNS NNQRLATATV NLGFDDQDVR 370 380 390 400 410 420 ILSVENDKVL TPEGGDGYHY QSYQQWRSTF TGADNIAMRD PHVIEDENGD RYLVFEASTG 430 440 450 460 470 480 TENYQGEDQI YNFTNYGGSS AYNVKSLFRF LDDQDMYNRA SWANAAIGIL KLKGDKKTPE 490 500 510 520 530 540 VDQFYTPLLS STMVSDELER PNVVKLGDKY YLFTASRLNH GSNNDAWNKA NEVVGDNVVM 550 560 570 580 590 600 LGYVSDQLTN GYKPLNNSGV VLTASVPADW RTATYSYYAV PVAGSSDTLL MTAYMTNRNE 610 620 630 640 650 660 VAGKGKNSTW APSFLIQVLP DGTTKVLAEM TQQGDWIWDE SSRTTDTVGT LDTAYLPGEN 670 680 690 700 710 720 DGYIDWNVIG GYGLKPHTPG QYQPTVPSTP IHTDDIISFE VSFDGHLVIK PVKVNNDSAG 730 740 750 760 770 780 RIDQSRNSGG SLNVAFNVYA GGNISVKPSQ KSINNTKETK KAHHVSTEKK QKKGNSFFAA 790 LLALFSAFCV SIGFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the Streptococcus mutans fructosyltransferase gene and flanking regions." Shiroza T., Kuramitsu H.K. J. Bacteriol. 170:810-816(1988) [PubMed: 2828325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GS-5.
[2]	"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18954 Genomic DNA. Translation: AAA88584.1. AE014133 Genomic DNA. Translation: AAN59631.1.
PIR	B28551.
RefSeq	NP_722325.1. NC_004350.2.
3D structure databases
ProteinModelPortal	P11701.
ModBase	Search...
Protein family/group databases
CAZy	GH68. Glycoside Hydrolase Family 68.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000012567; EBSTRP00000012049; EBSTRG00000012567.
GeneID	1029219.
GenomeReviews	Gene locus SMU_2028 in contig AE014133_GR.
KEGG	smu:SMU_2028.
NMPDR	fig|210007.1.peg.1838.
PATRIC	19666017. VBIStrMut61772_1808.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000029575.
OMA	ADNIAMR.
ProtClustDB	CLSK2756519.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_2028-MONOMER.
Family and domain databases
InterPro	IPR023296. Glyco_hydro_43_beta-prop. IPR003469. Glyco_hydro_68. IPR022263. Signal_pep_KxYKxGKxW_motif. [Graphical view]
Gene3D	G3DSA:2.115.10.20. Glyco_hydro_43_beta-prop. 2 hits.
KO	K00692.
Pfam	PF02435. Glyco_hydro_68. 1 hit. [Graphical view]
SUPFAM	SSF75005. Glyco_hydro_43_beta-prop. 1 hit.
TIGRFAMs	TIGR03715. KxYKxGKxW. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SACB_STRMU

Accession

Primary (citable) accession number: P11701

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	November 28, 2002
Last modified:	January 25, 2012
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program