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Protein

Movement protein

Gene
N/A
Organism
Tomato bushy stunt virus (strain Cherry) (TBSV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Displays RNA-binding activity.1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. transport of virus in host, cell to cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Viral movement protein

Keywords - Biological processi

Host-virus interaction, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Movement protein
Alternative name(s):
p22
OrganismiTomato bushy stunt virus (strain Cherry) (TBSV)
Taxonomic identifieri12147 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
Malus [TaxID: 3749]
Pyrus (pears) [TaxID: 3766]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Tolmiea menziesii [TaxID: 29777]
Tulipa [TaxID: 13305]
ProteomesiUP000001666: Genome

Subcellular locationi

Host membrane 1 Publication

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
  3. viral capsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 65DTEYE → ATAYA: Movement defective. No effect on interaction with host protein HFI22. No effect on association with host membrane. 1 Publication
Mutagenesisi32 – 354EDQE → AAQA: Movement defective. Loss of interaction with host protein HFI22. 1 Publication
Mutagenesisi103 – 1031E → A: Movement defective. Loss of interaction with host protein HFI22. No effect on association with host membrane. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Movement proteinPRO_0000222891Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with host protein HFI22.1 Publication

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR005332. TBSV_p22.
[Graphical view]
PfamiPF03558. TBSV_P22. 1 hit.
[Graphical view]
ProDomiPD005327. TBSV_P22. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P11691-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTEYEQVNK PWNELYKETT LGNKLTVNVG MEDQEVPLLP SNFLTKVRVG
60 70 80 90 100
LSGGYITMRR IRIKIIPLVS RKAGVSGKLY LRDISDTTGR KLHCTESLDL
110 120 130 140 150
GREIRLTMQH LDFSVSTRSD VPIVFGFEEL VSPFLEGREL FSISVRWQFG
160 170 180
LSKNCYSLPQ SKWKVMYQED ALKVLRPSKK KASKTDSSV
Length:189
Mass (Da):21,608
Last modified:October 1, 1989 - v1
Checksum:iB9DE1C79465652F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21958 Genomic RNA. Translation: AAB02537.1.
PIRiJA0115. NKVGTB.
RefSeqiNP_062900.1. NC_001554.1.

Genome annotation databases

GeneIDi1493954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21958 Genomic RNA. Translation: AAB02537.1.
PIRiJA0115. NKVGTB.
RefSeqiNP_062900.1. NC_001554.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1493954.

Family and domain databases

InterProiIPR005332. TBSV_p22.
[Graphical view]
PfamiPF03558. TBSV_P22. 1 hit.
[Graphical view]
ProDomiPD005327. TBSV_P22. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Organization of tomato bushy stunt virus genome: characterization of the coat protein gene and the 3' terminus."
    Hillman B.I., Hearne P.Q., Rochon D., Morris T.J.
    Virology 169:42-50(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "The complete genome structure and synthesis of infectious RNA from clones of tomato bushy stunt virus."
    Hearne P.Q., Knorr D.A., Hillman B.I., Morris T.J.
    Virology 177:141-151(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "A novel plant homeodomain protein interacts in a functionally relevant manner with a virus movement protein."
    Desvoyes B., Faure-Rabasse S., Chen M.H., Park J.W., Scholthof H.B.
    Plant Physiol. 129:1521-1532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, RNA-BINDING, PHOSPHORYLATION, MUTAGENESIS OF 2-ASP--GLU-6; 32-GLU--GLU-35 AND GLU-103, INTERACTION WITH NICOTIANA BENTHAMIANA PROTEIN HFI22.

Entry informationi

Entry nameiMVP_TBSVC
AccessioniPrimary (citable) accession number: P11691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.