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P11690

- P19_TBSVC

UniProt

P11690 - P19_TBSVC

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Protein
RNA silencing suppressor p19
Gene
ORF4
Organism
Tomato bushy stunt virus (strain Cherry) (TBSV)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA By similarity.1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Suppressor of RNA silencing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene namesi
ORF Names:ORF4
OrganismiTomato bushy stunt virus (strain Cherry) (TBSV)
Taxonomic identifieri12147 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
Malus [TaxID: 3749]
Pyrus (pears) [TaxID: 3766]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Tolmiea menziesii [TaxID: 29777]
Tulipa [TaxID: 13305]
ProteomesiUP000001666: Genome

Subcellular locationi

GO - Cellular componenti

  1. virion Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172RNA silencing suppressor p19
PRO_0000222881Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi39 – 4810
Beta strandi57 – 659
Beta strandi68 – 758
Helixi80 – 878
Helixi92 – 1009
Beta strandi109 – 1168
Beta strandi119 – 1268
Helixi127 – 1293
Helixi130 – 14516

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R9FX-ray1.85A27-158[»]
ProteinModelPortaliP11690.

Miscellaneous databases

EvolutionaryTraceiP11690.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004905. Tombusvirus_p19.
[Graphical view]
PfamiPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomiPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF103145. SSF103145. 1 hit.

Sequencei

Sequence statusi: Complete.

P11690-1 [UniParc]FASTAAdd to Basket

« Hide

MERAIQGNDA REQANSERWD GGSGGTTSPF KLPDESPSWT EWRLHNDETN    50
SNQDNPLGFK ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS 100
RFFGFDQIGC TYSIRFRGVS ITVSGGSRTL QHLCEMAIRS KQELLQLAPI 150
EVESNVSRGC PEGTETFEKE SE 172
Length:172
Mass (Da):19,395
Last modified:October 1, 1989 - v1
Checksum:iC6CDD00B5C90AB96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21958 Genomic RNA. Translation: AAB02538.1.
PIRiJA0116. NKVGTD.
RefSeqiNP_062901.1. NC_001554.1.

Genome annotation databases

GeneIDi1493957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21958 Genomic RNA. Translation: AAB02538.1 .
PIRi JA0116. NKVGTD.
RefSeqi NP_062901.1. NC_001554.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1R9F X-ray 1.85 A 27-158 [» ]
ProteinModelPortali P11690.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1493957.

Miscellaneous databases

EvolutionaryTracei P11690.

Family and domain databases

InterProi IPR004905. Tombusvirus_p19.
[Graphical view ]
Pfami PF03220. Tombus_P19. 1 hit.
[Graphical view ]
ProDomi PD005743. Tombus_P19. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF103145. SSF103145. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Organization of tomato bushy stunt virus genome: characterization of the coat protein gene and the 3' terminus."
    Hillman B.I., Hearne P.Q., Rochon D., Morris T.J.
    Virology 169:42-50(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "The complete genome structure and synthesis of infectious RNA from clones of tomato bushy stunt virus."
    Hearne P.Q., Knorr D.A., Hillman B.I., Morris T.J.
    Virology 177:141-151(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants."
    Voinnet O., Pinto Y.M., Baulcombe D.C.
    Proc. Natl. Acad. Sci. U.S.A. 96:14147-14152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Recognition of small interfering RNA by a viral suppressor of RNA silencing."
    Ye K., Malinina L., Patel D.J.
    Nature 426:874-878(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 23-158.

Entry informationi

Entry nameiP19_TBSVC
AccessioniPrimary (citable) accession number: P11690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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