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Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Tomato bushy stunt virus (strain Cherry) (TBSV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA (By similarity).By similarity1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene namesi
ORF Names:ORF4
OrganismiTomato bushy stunt virus (strain Cherry) (TBSV)
Taxonomic identifieri12147 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
Malus [TaxID: 3749]
Pyrus (pears) [TaxID: 3766]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Tolmiea menziesii [TaxID: 29777]
Tulipa [TaxID: 13305]
Proteomesi
  • UP000001666 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002228811 – 172RNA silencing suppressor p19Add BLAST172

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 48Combined sources10
Beta strandi57 – 65Combined sources9
Beta strandi68 – 75Combined sources8
Helixi80 – 87Combined sources8
Helixi92 – 100Combined sources9
Beta strandi109 – 116Combined sources8
Beta strandi119 – 126Combined sources8
Helixi127 – 129Combined sources3
Helixi130 – 145Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R9FX-ray1.85A27-158[»]
ProteinModelPortaliP11690
SMRiP11690
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11690

Family & Domainsi

Sequence similaritiesi

Belongs to the tombusviruses protein p19 family.Curated

Phylogenomic databases

OrthoDBiVOG0900014I

Family and domain databases

Gene3Di2.60.40.1810, 1 hit
InterProiView protein in InterPro
IPR004905 Tombusvirus_p19
IPR036131 VP19_sf
PfamiView protein in Pfam
PF03220 Tombus_P19, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005743 Tombus_P19, 1 hit
SUPFAMiSSF103145 SSF103145, 1 hit

Sequencei

Sequence statusi: Complete.

P11690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERAIQGNDA REQANSERWD GGSGGTTSPF KLPDESPSWT EWRLHNDETN
60 70 80 90 100
SNQDNPLGFK ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS
110 120 130 140 150
RFFGFDQIGC TYSIRFRGVS ITVSGGSRTL QHLCEMAIRS KQELLQLAPI
160 170
EVESNVSRGC PEGTETFEKE SE
Length:172
Mass (Da):19,395
Last modified:October 1, 1989 - v1
Checksum:iC6CDD00B5C90AB96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21958 Genomic RNA Translation: AAB02538.1
PIRiJA0116 NKVGTD
RefSeqiNP_062901.1, NC_001554.1

Genome annotation databases

GeneIDi1493957
KEGGivg:1493957

Similar proteinsi

Entry informationi

Entry nameiP19_TBSVC
AccessioniPrimary (citable) accession number: P11690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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