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P11690

- P19_TBSVC

UniProt

P11690 - P19_TBSVC

Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Tomato bushy stunt virus (strain Cherry) (TBSV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Suppressor of RNA silencing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA silencing suppressor p19
    Alternative name(s):
    19 kDa symptom severity modulator
    Gene namesi
    ORF Names:ORF4
    OrganismiTomato bushy stunt virus (strain Cherry) (TBSV)
    Taxonomic identifieri12147 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
    Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
    Malus [TaxID: 3749]
    Pyrus (pears) [TaxID: 3766]
    Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
    Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
    Tolmiea menziesii [TaxID: 29777]
    Tulipa [TaxID: 13305]
    ProteomesiUP000001666: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. virion Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 172172RNA silencing suppressor p19PRO_0000222881Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    Secondary structure

    1
    172
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi39 – 4810
    Beta strandi57 – 659
    Beta strandi68 – 758
    Helixi80 – 878
    Helixi92 – 1009
    Beta strandi109 – 1168
    Beta strandi119 – 1268
    Helixi127 – 1293
    Helixi130 – 14516

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1R9FX-ray1.85A27-158[»]
    ProteinModelPortaliP11690.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11690.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tombusviruses protein p19 family.Curated

    Family and domain databases

    InterProiIPR004905. Tombusvirus_p19.
    [Graphical view]
    PfamiPF03220. Tombus_P19. 1 hit.
    [Graphical view]
    ProDomiPD005743. Tombus_P19. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF103145. SSF103145. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P11690-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERAIQGNDA REQANSERWD GGSGGTTSPF KLPDESPSWT EWRLHNDETN    50
    SNQDNPLGFK ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS 100
    RFFGFDQIGC TYSIRFRGVS ITVSGGSRTL QHLCEMAIRS KQELLQLAPI 150
    EVESNVSRGC PEGTETFEKE SE 172
    Length:172
    Mass (Da):19,395
    Last modified:October 1, 1989 - v1
    Checksum:iC6CDD00B5C90AB96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21958 Genomic RNA. Translation: AAB02538.1.
    PIRiJA0116. NKVGTD.
    RefSeqiNP_062901.1. NC_001554.1.

    Genome annotation databases

    GeneIDi1493957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21958 Genomic RNA. Translation: AAB02538.1 .
    PIRi JA0116. NKVGTD.
    RefSeqi NP_062901.1. NC_001554.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1R9F X-ray 1.85 A 27-158 [» ]
    ProteinModelPortali P11690.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1493957.

    Miscellaneous databases

    EvolutionaryTracei P11690.

    Family and domain databases

    InterProi IPR004905. Tombusvirus_p19.
    [Graphical view ]
    Pfami PF03220. Tombus_P19. 1 hit.
    [Graphical view ]
    ProDomi PD005743. Tombus_P19. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF103145. SSF103145. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Organization of tomato bushy stunt virus genome: characterization of the coat protein gene and the 3' terminus."
      Hillman B.I., Hearne P.Q., Rochon D., Morris T.J.
      Virology 169:42-50(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "The complete genome structure and synthesis of infectious RNA from clones of tomato bushy stunt virus."
      Hearne P.Q., Knorr D.A., Hillman B.I., Morris T.J.
      Virology 177:141-151(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants."
      Voinnet O., Pinto Y.M., Baulcombe D.C.
      Proc. Natl. Acad. Sci. U.S.A. 96:14147-14152(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Recognition of small interfering RNA by a viral suppressor of RNA silencing."
      Ye K., Malinina L., Patel D.J.
      Nature 426:874-878(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 23-158.

    Entry informationi

    Entry nameiP19_TBSVC
    AccessioniPrimary (citable) accession number: P11690
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3