Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P11690 (P19_TBSVC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene names
ORF Names:ORF4
OrganismTomato bushy stunt virus (strain Cherry) (TBSV) [Reference proteome]
Taxonomic identifier12147 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostCapsicum annuum (Bell pepper) [TaxID: 4072]
Malus [TaxID: 3749]
Pyrus (pears) [TaxID: 3766]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Tolmiea menziesii [TaxID: 29777]
Tulipa [TaxID: 13305]

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA By similarity. Ref.3

Subunit structure

Homodimer.

Sequence similarities

Belongs to the tombusviruses protein p19 family.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionSuppressor of RNA silencing
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentvirion

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172RNA silencing suppressor p19
PRO_0000222881

Secondary structure

................. 172
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P11690 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: C6CDD00B5C90AB96

FASTA17219,395
        10         20         30         40         50         60 
MERAIQGNDA REQANSERWD GGSGGTTSPF KLPDESPSWT EWRLHNDETN SNQDNPLGFK 

        70         80         90        100        110        120 
ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS RFFGFDQIGC TYSIRFRGVS 

       130        140        150        160        170 
ITVSGGSRTL QHLCEMAIRS KQELLQLAPI EVESNVSRGC PEGTETFEKE SE 

« Hide

References

[1]"Organization of tomato bushy stunt virus genome: characterization of the coat protein gene and the 3' terminus."
Hillman B.I., Hearne P.Q., Rochon D., Morris T.J.
Virology 169:42-50(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"The complete genome structure and synthesis of infectious RNA from clones of tomato bushy stunt virus."
Hearne P.Q., Knorr D.A., Hillman B.I., Morris T.J.
Virology 177:141-151(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants."
Voinnet O., Pinto Y.M., Baulcombe D.C.
Proc. Natl. Acad. Sci. U.S.A. 96:14147-14152(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Recognition of small interfering RNA by a viral suppressor of RNA silencing."
Ye K., Malinina L., Patel D.J.
Nature 426:874-878(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 23-158.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21958 Genomic RNA. Translation: AAB02538.1.
PIRNKVGTD. JA0116.
RefSeqNP_062901.1. NC_001554.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1R9FX-ray1.85A27-158[»]
ProteinModelPortalP11690.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1493957.

Family and domain databases

InterProIPR004905. Tombusvirus_p19.
[Graphical view]
PfamPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF103145. SSF103145. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP11690.

Entry information

Entry nameP19_TBSVC
AccessionPrimary (citable) accession number: P11690
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references