P11686 (PSPC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pulmonary surfactant-associated protein C
Short name=SP-C

Alternative name(s):
Pulmonary surfactant-associated proteolipid SPL(Val)
SP5

Gene names

Name:	SFTPC
Synonyms:	SFTP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
Subcellular location	Secreted › extracellular space › surface film.
Involvement in disease	Pulmonary surfactant metabolism dysfunction 2 (SMDP2) [MIM:610913]: A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15 Ref.16 Ref.18 Ref.19 Ref.21 Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.17
Miscellaneous	Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
Sequence similarities	Contains 1 BRICHOS domain.

Ontologies

Keywords
Biological process	Gaseous exchange
Cellular component	Secreted Surface film
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
PTM	Disulfide bond Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara cellular response to nitric oxide Inferred from electronic annotation. Source: Compara circadian rhythm Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: Compara respiratory gaseous exchange Inferred from electronic annotation. Source: UniProtKB-KW response to cAMP Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to glucose stimulus Inferred from electronic annotation. Source: Compara response to growth factor stimulus Inferred from electronic annotation. Source: Compara response to hyperoxia Inferred from electronic annotation. Source: Compara response to interleukin-6 Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to retinoic acid Inferred from electronic annotation. Source: Compara response to vitamin A Inferred from electronic annotation. Source: Compara
Cellular_component	alveolar lamellar body Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell multivesicular body Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P11686-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P11686-2)

Also known as: C1;

The sequence of this isoform differs from the canonical sequence as follows:
     146-151: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Propeptide

1 – 23

23

PRO_0000033477

Chain

24 – 58

35

Pulmonary surfactant-associated protein C

PRO_0000033478

Propeptide

59 – 197

139

PRO_0000033479

Regions

Domain

94 – 197

104

BRICHOS

Amino acid modifications

Lipidation

28

1

S-palmitoyl cysteine Ref.13

Lipidation

29

1

S-palmitoyl cysteine Ref.13

Disulfide bond

121 ↔ 189

Ref.14

Natural variations

Alternative sequence

146 – 151

6

Missing in isoform 2.

VSP_006311

Natural variant

66

1

E → K in SMDP2; targeted abnormally to early endosomes and likely to result in a toxic gain of function. Ref.21

VAR_036855

Natural variant

73

1

I → T in SMDP2; abnormal trafficking and accumulation of aberrantly processed proSPC within alveoli. Ref.16 Ref.18 Ref.19

VAR_026753

Natural variant

116

1

A → D in SMDP2. Ref.20

VAR_026754

Natural variant

138

1

N → T Influences susceptibility to RDS in premature infants. Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Ref.9 Ref.10 Ref.17
Corresponds to variant rs4715 [ dbSNP | Ensembl ].

VAR_007453

Natural variant

167

1

R → Q in SMDP2. Ref.16
Corresponds to variant rs34957318 [ dbSNP | Ensembl ].

VAR_026755

Natural variant

186

1

N → S Influences susceptibility to RDS in premature infants. Ref.4 Ref.5 Ref.6 Ref.8 Ref.9 Ref.10 Ref.17
Corresponds to variant rs1124 [ dbSNP | Ensembl ].

VAR_016175

Natural variant

188

1

L → Q in SMDP2. Ref.15

VAR_026756

Experimental info

Sequence conflict

14

1

P → PPCQ in AAB60332. Ref.4

Sequence conflict

45

1

L → S in AAB60332. Ref.4

Sequence conflict

65 – 67

3

TEM → FPQ in AAB60332. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

197

Helix Strand Turn

Details...

Beta strand

91 – 96

6

Turn

97 – 99

3

Beta strand

100 – 105

6

Turn

106 – 109

4

Beta strand

110 – 116

7

Beta strand

121 – 125

5

Helix

134 – 143

10

Helix

183 – 189

7

Beta strand

194 – 197

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 1, 1990. Version 2. Checksum: C26A21E33C60AA78	FASTA	197	21,053
	10 20 30 40 50 60 MDVGSKEVLM ESPPDYSAAP RGRFGIPCCP VHLKRLLIVV VVVVLIVVVI VGALLMGLHM 70 80 90 100 110 120 SQKHTEMVLE MSIGAPEAQQ RLALSEHLVT TATFSIGSTG LVVYDYQQLL IAYKPAPGTC 130 140 150 160 170 180 CYIMKIAPES IPSLEALNRK VHNFQMECSL QAKPAVPTSK LGQAEGRDAG SAPSGGDPAF 190 LGMAVNTLCG EVPLYYI
	Isoform 2 (C1) [UniParc]. Checksum: 4C45300448DE03FA	FASTA	191	20,361
	10 20 30 40 50 60 MDVGSKEVLM ESPPDYSAAP RGRFGIPCCP VHLKRLLIVV VVVVLIVVVI VGALLMGLHM 70 80 90 100 110 120 SQKHTEMVLE MSIGAPEAQQ RLALSEHLVT TATFSIGSTG LVVYDYQQLL IAYKPAPGTC 130 140 150 160 170 180 CYIMKIAPES IPSLEALNRK VHNFQAKPAV PTSKLGQAEG RDAGSAPSGG DPAFLGMAVN 190 TLCGEVPLYY I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences." Warr R.G., Hawgood S., Buckley D.I., Crisp T.M., Schilling J., Benson B.J., Ballard P.L., Clements J.A., White R.T. Proc. Natl. Acad. Sci. U.S.A. 84:7915-7919(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal)." Glasser S.W., Korfhagen T.R., Weaver T.E., Clark J.C., Pilot-Matias T., Meuth J., Fox J.L., Whitsett J.A. J. Biol. Chem. 263:9-12(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 26-42.
[3]	"Two SP-C genes encoding human pulmonary surfactant proteolipid." Glasser S.W., Korfhagen T.R., Perme C.M., Pilot-Matias T.J., Kister S.E., Whitsett J.A. J. Biol. Chem. 263:10326-10331(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANT THR-138.
[4]	"Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species." Hatzis D., Deiter G., deMello D.E., Floros J. Exp. Lung Res. 20:57-72(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS THR-138 AND SER-186.
[5]	Frerking I., Stevens P., Pison U., Witt H. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS THR-138 AND SER-186.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-138 AND SER-186. Tissue: Lung.
[7]	"A computer system platform used to predict novel genes." Yu Z., Zheng Z., Tang T., Fu Y. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[8]	SeattleSNPs variation discovery resource Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-138 AND SER-186.
[9]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS THR-138 AND SER-186.
[10]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS THR-138 AND SER-186.
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[12]	"Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms." Johansson J., Joernvall H., Eklund A., Christensen N., Robertson B., Curstedt T. FEBS Lett. 232:61-64(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-58.
[13]	"Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups." Curstedt T., Johansson J., Persson P., Eklund A., Robertson B., Loewenadler B., Joernvall H. Proc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PALMITOYLATION AT CYS-28 AND CYS-29.
[14]	"High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C." Willander H., Askarieh G., Landreh M., Westermark P., Nordling K., Keranen H., Hermansson E., Hamvas A., Nogee L.M., Bergman T., Saenz A., Casals C., Aqvistg J., Jornvall H., Berglund H., Presto J., Knight S.D., Johansson J. Proc. Natl. Acad. Sci. U.S.A. 109:2325-2329(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 59-197, DISULFIDE BOND.
[15]	"Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred." Thomas A.Q., Lane K., Phillips J.A. III, Prince M., Markin C., Speer M., Schwartz D.A., Gaddipati R., Marney A., Johnson J., Roberts R., Haines J., Stahlman M., Loyd J.E. Am. J. Respir. Crit. Care Med. 165:1322-1328(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SMDP2 GLN-188.
[16]	"Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease." Tredano M., Griese M., Brasch F., Schumacher S., de Blic J., Marque S., Houdayer C., Elion J., Couderc R., Bahuau M. Am. J. Med. Genet. A 126:18-26(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS SMDP2 THR-73 AND GLN-167.
[17]	"Surfactant protein C gene variation in the Finnish population -association with perinatal respiratory disease." Lahti M., Marttila R., Hallman M. Eur. J. Hum. Genet. 12:312-320(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS THR-138 AND SER-186, INVOLVEMENT IN RDS.
[18]	"Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene." Brasch F., Griese M., Tredano M., Johnen G., Ochs M., Rieger C., Mulugeta S., Mueller K.M., Bahuau M., Beers M.F. Eur. Respir. J. 24:30-39(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SMDP2 THR-73, CHARACTERIZATION OF VARIANT SMDP2 THR-73.
[19]	"Variable phenotype associated with SP-C gene mutations: fatal case with the I73T mutation." Percopo S., Cameron H.S., Nogee L.M., Pettinato G., Montella S., Santamaria F. Eur. Respir. J. 24:1072-1073(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SMDP2 THR-73.
[20]	"Hydroxychloroquine and surfactant protein C deficiency." Rosen D.M., Waltz D.A. N. Engl. J. Med. 352:207-208(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SURFACTANT PROTEIN C DEFICIENCY ASP-116.
[21]	"Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene." Stevens P.A., Pettenazzo A., Brasch F., Mulugeta S., Baritussio A., Ochs M., Morrison L., Russo S.J., Beers M.F. Pediatr. Res. 57:89-98(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SMDP2 LYS-66, CHARACTERIZATION OF VARIANT SMDP2 LYS-66.
+	Additional computationally mapped references.

Web resources

GeneReviews

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J03553 mRNA. Translation: AAA36631.1.
J03517 mRNA. Translation: AAA36634.1.
J03890 Genomic DNA. Translation: AAC32022.1.
J03890 Genomic DNA. Translation: AAC32023.1.
U02948 Genomic DNA. Translation: AAB60332.1.
AY357924 Genomic DNA. Translation: AAQ67734.1.
AK315742 mRNA. Translation: BAG38097.1.
DQ884411 mRNA. Translation: ABI63378.1.
AY337315 Genomic DNA. Translation: AAP88034.1.
AC105206 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63707.1.
BC005913 mRNA. Translation: AAH05913.1.

IPI

IPI00006707.
IPI00218499.

PIR

LNHUC. A28801.

RefSeq

NP_001165828.1. NM_001172357.1.
NP_001165881.1. NM_001172410.1.
NP_003009.2. NM_003018.3.

UniGene

Hs.1074.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YAD	X-ray	2.20	A/B/C/D/E/F	59-197	[»]

ProteinModelPortal

P11686.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000316152.

PTM databases

PhosphoSite

P11686.

Polymorphism databases

DMDM

131425.

Proteomic databases

PaxDb

P11686.

PRIDE

P11686.

Protocols and materials databases

DNASU

6440.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000318561; ENSP00000316152; ENSG00000168484.

GeneID

6440.

KEGG

hsa:6440.

UCSC

uc003xax.4. human.

Organism-specific databases

CTD

6440.

GeneCards

GC08P022019.

H-InvDB

HIX0007365.

HGNC

HGNC:10802. SFTPC.

HPA

CAB009313.
HPA010928.

MIM

178620. gene.
267450. phenotype.
610913. phenotype.

neXtProt

NX_P11686.

Orphanet

217566. Chronic respiratory distress with surfactant metabolism deficiency.
264675. Congenital pulmonary alveolar proteinosis.
98852. Desquamative interstitial pneumonia.
2032. Idiopathic pulmonary fibrosis.
70587. Infant acute respiratory distress syndrome.
217563. Neonatal acute respiratory distress with surfactant metabolism deficiency.

PharmGKB

PA35714.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG47102.

HOGENOM

HOG000115746.

HOVERGEN

HBG000160.

InParanoid

P11686.

Gene expression databases

ArrayExpress

P11686.

Bgee

P11686.

CleanEx

HS_SFTPC.

Genevestigator

P11686.

GermOnline

ENSG00000168484. Homo sapiens.

Family and domain databases

InterPro

IPR007084. BRICHOS_dom.
IPR001729. Pulm_surfact_AP.
IPR018051. SP-C_palmitoylation_site.
IPR015091. Surfactant_protein_propep.
[Graphical view]

Pfam

PF04089. BRICHOS. 1 hit.
PF08999. SP_C-Propep. 1 hit.
[Graphical view]

SMART

SM01039. BRICHOS. 1 hit.
SM00019. SF_P. 1 hit.
[Graphical view]

PROSITE

PS50869. BRICHOS. 1 hit.
PS00341. SURFACT_PALMYTOYL. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

SFTPC. human.

GenomeRNAi

6440.

NextBio

25027.

SOURCE

Search...

Entry information

Entry name

PSPC_HUMAN

Accession

Primary (citable) accession number: P11686
Secondary accession number(s): A6XNE4 , B2RE00, P11687, Q12793, Q7Z5D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	April 1, 1990
Last modified:	May 1, 2013
This is version 143 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.