Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P11686 (PSPC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 155. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pulmonary surfactant-associated protein C

Short name=SP-C
Alternative name(s):
Pulmonary surfactant-associated proteolipid SPL(Val)
SP5
Gene names
Name:SFTPC
Synonyms:SFTP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

Subcellular location

Secretedextracellular spacesurface film.

Involvement in disease

Pulmonary surfactant metabolism dysfunction 2 (SMDP2) [MIM:610913]: A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15 Ref.16 Ref.18 Ref.19 Ref.21

Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.17

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Sequence similarities

Contains 1 BRICHOS domain.

Ontologies

Keywords
   Biological processGaseous exchange
   Cellular componentSecreted
Surface film
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
   PTMDisulfide bond
Lipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to nitric oxide

Inferred from electronic annotation. Source: Ensembl

circadian rhythm

Inferred from electronic annotation. Source: Ensembl

protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

respiratory gaseous exchange

Inferred from electronic annotation. Source: UniProtKB-KW

response to cAMP

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to glucose

Inferred from electronic annotation. Source: Ensembl

response to growth factor

Inferred from electronic annotation. Source: Ensembl

response to hyperoxia

Inferred from electronic annotation. Source: Ensembl

response to interleukin-6

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

response to vitamin A

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentalveolar lamellar body

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

multivesicular body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 19815549. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P11686-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P11686-2)

Also known as: C1;

The sequence of this isoform differs from the canonical sequence as follows:
     146-151: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 2323
PRO_0000033477
Chain24 – 5835Pulmonary surfactant-associated protein C
PRO_0000033478
Propeptide59 – 197139
PRO_0000033479

Regions

Domain94 – 197104BRICHOS

Amino acid modifications

Lipidation281S-palmitoyl cysteine Ref.13
Lipidation291S-palmitoyl cysteine Ref.13
Disulfide bond120 ↔ 148 Ref.14
Disulfide bond121 ↔ 189 Ref.14

Natural variations

Alternative sequence146 – 1516Missing in isoform 2.
VSP_006311
Natural variant661E → K in SMDP2; targeted abnormally to early endosomes and likely to result in a toxic gain of function. Ref.21
VAR_036855
Natural variant731I → T in SMDP2; abnormal trafficking and accumulation of aberrantly processed proSPC within alveoli. Ref.16 Ref.18 Ref.19
VAR_026753
Natural variant1161A → D in SMDP2. Ref.20
VAR_026754
Natural variant1381N → T Influences susceptibility to RDS in premature infants. Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Ref.9 Ref.10 Ref.17
Corresponds to variant rs4715 [ dbSNP | Ensembl ].
VAR_007453
Natural variant1671R → Q in SMDP2. Ref.16
Corresponds to variant rs34957318 [ dbSNP | Ensembl ].
VAR_026755
Natural variant1861N → S Influences susceptibility to RDS in premature infants. Ref.4 Ref.5 Ref.6 Ref.8 Ref.9 Ref.10 Ref.17
Corresponds to variant rs1124 [ dbSNP | Ensembl ].
VAR_016175
Natural variant1881L → Q in SMDP2. Ref.15
VAR_026756

Experimental info

Sequence conflict141P → PPCQ in AAB60332. Ref.4
Sequence conflict451L → S in AAB60332. Ref.4
Sequence conflict65 – 673TEM → FPQ in AAB60332. Ref.4

Secondary structure

.............. 197
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 1, 1990. Version 2.
Checksum: C26A21E33C60AA78

FASTA19721,053
        10         20         30         40         50         60 
MDVGSKEVLM ESPPDYSAAP RGRFGIPCCP VHLKRLLIVV VVVVLIVVVI VGALLMGLHM 

        70         80         90        100        110        120 
SQKHTEMVLE MSIGAPEAQQ RLALSEHLVT TATFSIGSTG LVVYDYQQLL IAYKPAPGTC 

       130        140        150        160        170        180 
CYIMKIAPES IPSLEALNRK VHNFQMECSL QAKPAVPTSK LGQAEGRDAG SAPSGGDPAF 

       190 
LGMAVNTLCG EVPLYYI 

« Hide

Isoform 2 (C1) [UniParc].

Checksum: 4C45300448DE03FA
Show »

FASTA19120,361

References

« Hide 'large scale' references
[1]"Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences."
Warr R.G., Hawgood S., Buckley D.I., Crisp T.M., Schilling J., Benson B.J., Ballard P.L., Clements J.A., White R.T.
Proc. Natl. Acad. Sci. U.S.A. 84:7915-7919(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal)."
Glasser S.W., Korfhagen T.R., Weaver T.E., Clark J.C., Pilot-Matias T., Meuth J., Fox J.L., Whitsett J.A.
J. Biol. Chem. 263:9-12(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 26-42.
[3]"Two SP-C genes encoding human pulmonary surfactant proteolipid."
Glasser S.W., Korfhagen T.R., Perme C.M., Pilot-Matias T.J., Kister S.E., Whitsett J.A.
J. Biol. Chem. 263:10326-10331(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANT THR-138.
[4]"Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species."
Hatzis D., Deiter G., deMello D.E., Floros J.
Exp. Lung Res. 20:57-72(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS THR-138 AND SER-186.
[5]Frerking I., Stevens P., Pison U., Witt H.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS THR-138 AND SER-186.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-138 AND SER-186.
Tissue: Lung.
[7]"A computer system platform used to predict novel genes."
Yu Z., Zheng Z., Tang T., Fu Y.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[8]SeattleSNPs variation discovery resource
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-138 AND SER-186.
[9]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS THR-138 AND SER-186.
[10]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS THR-138 AND SER-186.
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[12]"Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms."
Johansson J., Joernvall H., Eklund A., Christensen N., Robertson B., Curstedt T.
FEBS Lett. 232:61-64(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-58.
[13]"Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups."
Curstedt T., Johansson J., Persson P., Eklund A., Robertson B., Loewenadler B., Joernvall H.
Proc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION AT CYS-28 AND CYS-29.
[14]"High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C."
Willander H., Askarieh G., Landreh M., Westermark P., Nordling K., Keranen H., Hermansson E., Hamvas A., Nogee L.M., Bergman T., Saenz A., Casals C., Aqvistg J., Jornvall H., Berglund H., Presto J., Knight S.D., Johansson J.
Proc. Natl. Acad. Sci. U.S.A. 109:2325-2329(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 59-197, DISULFIDE BONDS.
[15]"Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred."
Thomas A.Q., Lane K., Phillips J.A. III, Prince M., Markin C., Speer M., Schwartz D.A., Gaddipati R., Marney A., Johnson J., Roberts R., Haines J., Stahlman M., Loyd J.E.
Am. J. Respir. Crit. Care Med. 165:1322-1328(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SMDP2 GLN-188.
[16]"Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease."
Tredano M., Griese M., Brasch F., Schumacher S., de Blic J., Marque S., Houdayer C., Elion J., Couderc R., Bahuau M.
Am. J. Med. Genet. A 126:18-26(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS SMDP2 THR-73 AND GLN-167.
[17]"Surfactant protein C gene variation in the Finnish population -association with perinatal respiratory disease."
Lahti M., Marttila R., Hallman M.
Eur. J. Hum. Genet. 12:312-320(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS THR-138 AND SER-186, INVOLVEMENT IN RDS.
[18]"Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene."
Brasch F., Griese M., Tredano M., Johnen G., Ochs M., Rieger C., Mulugeta S., Mueller K.M., Bahuau M., Beers M.F.
Eur. Respir. J. 24:30-39(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SMDP2 THR-73, CHARACTERIZATION OF VARIANT SMDP2 THR-73.
[19]"Variable phenotype associated with SP-C gene mutations: fatal case with the I73T mutation."
Percopo S., Cameron H.S., Nogee L.M., Pettinato G., Montella S., Santamaria F.
Eur. Respir. J. 24:1072-1073(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SMDP2 THR-73.
[20]"Hydroxychloroquine and surfactant protein C deficiency."
Rosen D.M., Waltz D.A.
N. Engl. J. Med. 352:207-208(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SURFACTANT PROTEIN C DEFICIENCY ASP-116.
[21]"Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene."
Stevens P.A., Pettenazzo A., Brasch F., Mulugeta S., Baritussio A., Ochs M., Morrison L., Russo S.J., Beers M.F.
Pediatr. Res. 57:89-98(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SMDP2 LYS-66, CHARACTERIZATION OF VARIANT SMDP2 LYS-66.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03553 mRNA. Translation: AAA36631.1.
J03517 mRNA. Translation: AAA36634.1.
J03890 Genomic DNA. Translation: AAC32022.1.
J03890 Genomic DNA. Translation: AAC32023.1.
U02948 Genomic DNA. Translation: AAB60332.1.
AY357924 Genomic DNA. Translation: AAQ67734.1.
AK315742 mRNA. Translation: BAG38097.1.
DQ884411 mRNA. Translation: ABI63378.1.
AY337315 Genomic DNA. Translation: AAP88034.1.
AC105206 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63707.1.
BC005913 mRNA. Translation: AAH05913.1.
CCDSCCDS43722.1. [P11686-1]
CCDS55209.1. [P11686-2]
PIRLNHUC. A28801.
RefSeqNP_001165828.1. NM_001172357.1.
NP_001165881.1. NM_001172410.1.
NP_003009.2. NM_003018.3.
UniGeneHs.1074.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YADX-ray2.20A/B/C/D/E/F59-197[»]
ProteinModelPortalP11686.
SMRP11686. Positions 87-197.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112338. 9 interactions.
STRING9606.ENSP00000316152.

PTM databases

PhosphoSiteP11686.

Polymorphism databases

DMDM131425.

Proteomic databases

PaxDbP11686.
PRIDEP11686.

Protocols and materials databases

DNASU6440.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318561; ENSP00000316152; ENSG00000168484.
GeneID6440.
KEGGhsa:6440.
UCSCuc003xax.4. human. [P11686-1]

Organism-specific databases

CTD6440.
GeneCardsGC08P022019.
GeneReviewsSFTPC.
H-InvDBHIX0007365.
HGNCHGNC:10802. SFTPC.
HPACAB009313.
HPA010928.
MIM178620. gene.
267450. phenotype.
610913. phenotype.
neXtProtNX_P11686.
Orphanet217566. Chronic respiratory distress with surfactant metabolism deficiency.
264675. Congenital pulmonary alveolar proteinosis.
98852. Desquamative interstitial pneumonia.
2032. Idiopathic pulmonary fibrosis.
70587. Infant acute respiratory distress syndrome.
PharmGKBPA35714.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47102.
HOGENOMHOG000115746.
HOVERGENHBG000160.
InParanoidP11686.
OrthoDBEOG7QVM46.
PhylomeDBP11686.
TreeFamTF337317.

Gene expression databases

ArrayExpressP11686.
BgeeP11686.
CleanExHS_SFTPC.
GenevestigatorP11686.

Family and domain databases

InterProIPR007084. BRICHOS_dom.
IPR001729. Pulm_surfact_AP.
IPR018051. SP-C_palmitoylation_site.
IPR015091. Surfactant_protein_propep.
[Graphical view]
PfamPF04089. BRICHOS. 1 hit.
PF08999. SP_C-Propep. 1 hit.
[Graphical view]
SMARTSM01039. BRICHOS. 1 hit.
SM00019. SF_P. 1 hit.
[Graphical view]
PROSITEPS50869. BRICHOS. 1 hit.
PS00341. SURFACT_PALMITOYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSFTPC. human.
GeneWikiPulmonary_surfactant-associated_protein_C.
GenomeRNAi6440.
NextBio25027.
PROP11686.
SOURCESearch...

Entry information

Entry namePSPC_HUMAN
AccessionPrimary (citable) accession number: P11686
Secondary accession number(s): A6XNE4 expand/collapse secondary AC list , B2RE00, E9PGX3, P11687, Q12793, Q7Z5D0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM