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Protein

Pulmonary surfactant-associated protein C

Gene

Sftpc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

GO - Biological processi

  • cellular response to mechanical stimulus Source: RGD
  • cellular response to nitric oxide Source: RGD
  • circadian rhythm Source: RGD
  • protein homooligomerization Source: RGD
  • regulation of liquid surface tension Source: RGD
  • respiratory gaseous exchange Source: UniProtKB-KW
  • response to cAMP Source: RGD
  • response to glucocorticoid Source: RGD
  • response to glucose Source: RGD
  • response to growth factor Source: RGD
  • response to hormone Source: RGD
  • response to hyperoxia Source: RGD
  • response to interleukin-6 Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic substance Source: RGD
  • response to retinoic acid Source: RGD
  • response to vitamin A Source: RGD
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Enzyme and pathway databases

ReactomeiR-RNO-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein C
Short name:
SP-C
Alternative name(s):
Pulmonary surfactant-associated proteolipid SPL(Val)
Gene namesi
Name:Sftpc
Synonyms:Sftp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3666. Sftpc.

Subcellular locationi

GO - Cellular componenti

  • alveolar lamellar body Source: RGD
  • extracellular space Source: RGD
  • multivesicular body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 2323By similarityPRO_0000033492Add
BLAST
Chaini24 – 5835Pulmonary surfactant-associated protein CPRO_0000033493Add
BLAST
Propeptidei59 – 194136PRO_0000033494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi28 – 281S-palmitoyl cysteineBy similarity
Lipidationi29 – 291S-palmitoyl cysteineBy similarity
Disulfide bondi122 ↔ 186By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP11685.
PRIDEiP11685.

Expressioni

Gene expression databases

GenevisibleiP11685. RN.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015032.

Structurei

3D structure databases

ProteinModelPortaliP11685.
SMRiP11685. Positions 24-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 194100BRICHOSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IY85. Eukaryota.
ENOG41118MZ. LUCA.
HOGENOMiHOG000115746.
HOVERGENiHBG000160.
InParanoidiP11685.
OMAiRKVQNFQ.
OrthoDBiEOG7QVM46.
PhylomeDBiP11685.
TreeFamiTF337317.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
IPR001729. SP-C.
IPR018051. SP-C_palmitoylation_site.
IPR015091. Surfactant_protein_propep.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
PF08999. SP_C-Propep. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
SM00019. SF_P. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
PS00341. SURFACT_PALMITOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMGSKEVLM ESPPDYSTGP RSQFRIPCCP VHLKRLLIVV VVVVLVVVVI
60 70 80 90 100
VGALLMGLHM SQKHTEMVLE MSIGGAPETQ KRLALSEHTD TIATFSIGST
110 120 130 140 150
GIVLYDYQRL LTAYKPAPGT YCYIMKMAPE SIPSLEALAR KFKNFQAKSS
160 170 180 190
TPTSKLGQEE GHSAGSDSDS SGRDLAFLGL AVSTLCGELP LYYI
Length:194
Mass (Da):21,043
Last modified:October 1, 1989 - v1
Checksum:i51A75A18E4C95E67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881E → V in AAA92788 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14221 mRNA. Translation: CAA32440.1.
U07796 Genomic DNA. Translation: AAA92788.1.
BC072693 mRNA. Translation: AAH72693.1.
PIRiS03994. LNRTC.
RefSeqiNP_059038.1. NM_017342.2.
UniGeneiRn.3926.

Genome annotation databases

GeneIDi50683.
KEGGirno:50683.
UCSCiRGD:3666. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14221 mRNA. Translation: CAA32440.1.
U07796 Genomic DNA. Translation: AAA92788.1.
BC072693 mRNA. Translation: AAH72693.1.
PIRiS03994. LNRTC.
RefSeqiNP_059038.1. NM_017342.2.
UniGeneiRn.3926.

3D structure databases

ProteinModelPortaliP11685.
SMRiP11685. Positions 24-58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015032.

Proteomic databases

PaxDbiP11685.
PRIDEiP11685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50683.
KEGGirno:50683.
UCSCiRGD:3666. rat.

Organism-specific databases

CTDi6440.
RGDi3666. Sftpc.

Phylogenomic databases

eggNOGiENOG410IY85. Eukaryota.
ENOG41118MZ. LUCA.
HOGENOMiHOG000115746.
HOVERGENiHBG000160.
InParanoidiP11685.
OMAiRKVQNFQ.
OrthoDBiEOG7QVM46.
PhylomeDBiP11685.
TreeFamiTF337317.

Enzyme and pathway databases

ReactomeiR-RNO-5683826. Surfactant metabolism.

Miscellaneous databases

NextBioi610528.
PROiP11685.

Gene expression databases

GenevisibleiP11685. RN.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
IPR001729. SP-C.
IPR018051. SP-C_palmitoylation_site.
IPR015091. Surfactant_protein_propep.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
PF08999. SP_C-Propep. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
SM00019. SF_P. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
PS00341. SURFACT_PALMITOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide and deduced amino acid sequence of the hydrophobic surfactant protein SP-C from rat: expression in alveolar type II cells and homology with SP-C from other species."
    Fisher J.H., Shannon J.M., Hatmann T., Mason R.J.
    Biochim. Biophys. Acta 995:225-230(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Lung.
  2. Rishi A.K., Gulamhussein A.I., Albanese S., Williams M.C., Brody J.S.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiPSPC_RAT
AccessioniPrimary (citable) accession number: P11685
Secondary accession number(s): Q52MA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.