ID UTER_HUMAN Reviewed; 91 AA. AC P11684; B2R5F2; Q6FHH3; Q9UCM2; Q9UCM4; DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 1. DT 24-JAN-2024, entry version 195. DE RecName: Full=Uteroglobin; DE AltName: Full=Club cell phospholipid-binding protein; DE Short=CCPBP; DE AltName: Full=Club cells 10 kDa secretory protein; DE Short=CC10; DE AltName: Full=Secretoglobin family 1A member 1; DE AltName: Full=Urinary protein 1; DE Short=UP-1; DE Short=UP1; DE Short=Urine protein 1; DE Flags: Precursor; GN Name=SCGB1A1; Synonyms=CC10, CCSP, UGB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung; RX PubMed=3167058; DOI=10.1016/0167-4781(88)90129-7; RA Singh G., Katyal S.L., Brown W.E., Phillips S., Kennedy A.L., Anthony J., RA Squeglia N.; RT "Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa RT protein."; RL Biochim. Biophys. Acta 950:329-337(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC TISSUE=Lung; RX PubMed=7733299; DOI=10.1152/ajplung.1995.268.4.l565; RA Hay J.G., Danel C., Chu C., Crystal R.G.; RT "Human CC10 gene expression in airway epithelium and subchromosomal locus RT suggest linkage to airway disease."; RL Am. J. Physiol. 268:L565-L575(1995). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Tongue; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18. RX PubMed=1284526; DOI=10.1093/hmg/1.6.371; RA Wolf M., Klug J., Hackenberg R., Gessler M., Grzeschik K.-H., Beato M., RA Suske G.; RT "Human CC10, the homologue of rabbit uteroglobin: genomic cloning, RT chromosomal localization and expression in endometrial cell lines."; RL Hum. Mol. Genet. 1:371-378(1992). RN [8] RP PROTEIN SEQUENCE OF 22-74. RC TISSUE=Urine; RX PubMed=1400743; DOI=10.1016/0378-4347(92)80595-h; RA Okutani R., Itoh Y., Hirata H., Kasahara T., Mukaida N., Kawai T.; RT "Simple and high-yield purification of urine protein 1 using immunoaffinity RT chromatography: evidence for the identity of urine protein 1 and human RT Clara cell 10-kilodalton protein."; RL J. Chromatogr. A 577:25-35(1992). RN [9] RP PROTEIN SEQUENCE OF 22-45. RC TISSUE=Urine; RX PubMed=1395029; DOI=10.1016/0009-8981(92)90122-7; RA Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A., RA van Damme J., de Ley M.; RT "Human urinary protein 1: evidence for identity with the Clara cell protein RT and occurrence in respiratory tract and urogenital secretions."; RL Clin. Chim. Acta 207:239-249(1992). RN [10] RP PROTEIN SEQUENCE OF 22-33. RX PubMed=11788998; RX DOI=10.1002/1615-9861(200201)2:1<112::aid-prot112>3.3.co;2-e; RA Ghafouri B., Stahlbom B., Tagesson C., Lindahl M.; RT "Newly identified proteins in human nasal lavage fluid from non-smokers and RT smokers using two-dimensional gel electrophoresis and peptide mass RT fingerprinting."; RL Proteomics 2:112-120(2002). RN [11] RP INTERACTION WITH LMBR1L. RX PubMed=16423471; DOI=10.1016/j.gene.2005.10.027; RA Zhang Z., Kim S.J., Chowdhury B., Wang J., Lee Y.C., Tsai P.C., Choi M., RA Mukherjee A.B.; RT "Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer RT cell motility and invasion."; RL Gene 369:66-71(2006). RN [12] RP ABSENCE OF INTERACTION WITH LMBR1L. RX PubMed=23964685; DOI=10.3109/09687688.2013.823018; RA Hesselink R.W., Findlay J.B.; RT "Expression, characterization and ligand specificity of lipocalin-1 RT interacting membrane receptor (LIMR)."; RL Mol. Membr. Biol. 30:327-337(2013). RN [13] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), AND SUBUNIT. RX PubMed=7664082; DOI=10.1038/nsb0894-538; RA Umland T.C., Swaminathan S., Singh G., Warty V., Furey W., Pletcher J., RA Sax M.; RT "Structure of a human Clara cell phospholipid-binding protein-ligand RT complex at 1.9-A resolution."; RL Nat. Struct. Biol. 1:538-545(1994). CC -!- FUNCTION: Binds phosphatidylcholine, phosphatidylinositol, CC polychlorinated biphenyls (PCB) and weakly progesterone, potent CC inhibitor of phospholipase A2. CC -!- SUBUNIT: Antiparallel homodimer; disulfide-linked (PubMed:7664082). CC Interaction with LMBR1L has been observed in PubMed:16423471, but not CC in PubMed:23964685 (PubMed:16423471, PubMed:23964685). CC {ECO:0000269|PubMed:16423471, ECO:0000269|PubMed:23964685, CC ECO:0000269|PubMed:7664082}. CC -!- INTERACTION: CC P11684; Q13520: AQP6; NbExp=3; IntAct=EBI-7797649, EBI-13059134; CC P11684; P02751: FN1; NbExp=3; IntAct=EBI-7797649, EBI-1220319; CC P11684; P01100: FOS; NbExp=3; IntAct=EBI-7797649, EBI-852851; CC P11684; P50440: GATM; NbExp=3; IntAct=EBI-7797649, EBI-2552594; CC P11684; Q00613: HSF1; NbExp=3; IntAct=EBI-7797649, EBI-719620; CC P11684; Q9BTV4: TMEM43; NbExp=3; IntAct=EBI-7797649, EBI-721293; CC P11684; Q13049: TRIM32; NbExp=8; IntAct=EBI-7797649, EBI-742790; CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Club cells (nonciliated cells of the surface CC epithelium of the pulmonary airways). CC -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X13197; CAA31584.1; -; mRNA. DR EMBL; U01101; AAA81885.1; -; mRNA. DR EMBL; U01102; AAA18297.1; -; Genomic_DNA. DR EMBL; CR541780; CAG46579.1; -; mRNA. DR EMBL; AK312165; BAG35099.1; -; mRNA. DR EMBL; CH471076; EAW74018.1; -; Genomic_DNA. DR EMBL; BC004481; AAH04481.1; -; mRNA. DR EMBL; X59875; CAA42532.1; -; Genomic_DNA. DR CCDS; CCDS8020.1; -. DR PIR; JS0036; JS0036. DR PIR; S26651; S26651. DR RefSeq; NP_003348.1; NM_003357.4. DR PDB; 7VF3; X-ray; 2.29 A; B/D=21-91. DR PDB; 7VG7; X-ray; 2.50 A; B=21-89. DR PDBsum; 7VF3; -. DR PDBsum; 7VG7; -. DR AlphaFoldDB; P11684; -. DR SMR; P11684; -. DR BioGRID; 113203; 13. DR IntAct; P11684; 11. DR MINT; P11684; -. DR STRING; 9606.ENSP00000278282; -. DR DrugBank; DB08373; 4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL. DR iPTMnet; P11684; -. DR PhosphoSitePlus; P11684; -. DR BioMuta; SCGB1A1; -. DR DMDM; 112672; -. DR jPOST; P11684; -. DR MassIVE; P11684; -. DR MaxQB; P11684; -. DR PaxDb; 9606-ENSP00000278282; -. DR PeptideAtlas; P11684; -. DR ProteomicsDB; 52798; -. DR Antibodypedia; 14807; 518 antibodies from 37 providers. DR DNASU; 7356; -. DR Ensembl; ENST00000278282.3; ENSP00000278282.2; ENSG00000149021.7. DR GeneID; 7356; -. DR KEGG; hsa:7356; -. DR MANE-Select; ENST00000278282.3; ENSP00000278282.2; NM_003357.5; NP_003348.1. DR UCSC; uc001ntj.4; human. DR AGR; HGNC:12523; -. DR CTD; 7356; -. DR DisGeNET; 7356; -. DR GeneCards; SCGB1A1; -. DR HGNC; HGNC:12523; SCGB1A1. DR HPA; ENSG00000149021; Tissue enriched (lung). DR MIM; 192020; gene. DR neXtProt; NX_P11684; -. DR OpenTargets; ENSG00000149021; -. DR PharmGKB; PA34989; -. DR VEuPathDB; HostDB:ENSG00000149021; -. DR eggNOG; ENOG502SXFT; Eukaryota. DR GeneTree; ENSGT00940000155073; -. DR HOGENOM; CLU_166234_1_0_1; -. DR InParanoid; P11684; -. DR OMA; MKIAITI; -. DR OrthoDB; 4862909at2759; -. DR PhylomeDB; P11684; -. DR TreeFam; TF338407; -. DR PathwayCommons; P11684; -. DR SignaLink; P11684; -. DR BioGRID-ORCS; 7356; 13 hits in 1153 CRISPR screens. DR ChiTaRS; SCGB1A1; human. DR GeneWiki; Uteroglobin; -. DR GenomeRNAi; 7356; -. DR Pharos; P11684; Tbio. DR PRO; PR:P11684; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; P11684; Protein. DR Bgee; ENSG00000149021; Expressed in bronchial epithelial cell and 117 other cell types or tissues. DR ExpressionAtlas; P11684; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB. DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl. DR GO; GO:0030141; C:secretory granule; IEA:Ensembl. DR GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW. DR GO; GO:0097160; F:polychlorinated biphenyl binding; IEA:Ensembl. DR GO; GO:0007566; P:embryo implantation; TAS:ProtInc. DR GO; GO:0007565; P:female pregnancy; NAS:ProtInc. DR GO; GO:0032696; P:negative regulation of interleukin-13 production; IEA:Ensembl. DR GO; GO:0032713; P:negative regulation of interleukin-4 production; IEA:Ensembl. DR GO; GO:0032714; P:negative regulation of interleukin-5 production; IEA:Ensembl. DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of type II interferon production; IEA:Ensembl. DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0043488; P:regulation of mRNA stability; IEA:Ensembl. DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl. DR GO; GO:0071774; P:response to fibroblast growth factor; IEA:Ensembl. DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl. DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl. DR GO; GO:0010193; P:response to ozone; IEA:Ensembl. DR GO; GO:0034021; P:response to silicon dioxide; IEA:Ensembl. DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; NAS:ProtInc. DR GO; GO:0042098; P:T cell proliferation; IEA:Ensembl. DR CDD; cd00633; Secretoglobin; 1. DR Gene3D; 1.10.210.10; Secretoglobin; 1. DR InterPro; IPR016126; Secretoglobin. DR InterPro; IPR043215; Secretoglobin_1C-like. DR InterPro; IPR035960; Secretoglobin_sf. DR InterPro; IPR000329; Uteroglobin. DR PANTHER; PTHR10136; SECRETOGLOBIN FAMILY 1 MEMBER; 1. DR PANTHER; PTHR10136:SF6; UTEROGLOBIN; 1. DR Pfam; PF01099; Uteroglobin; 1. DR PRINTS; PR00486; UTEROGLOBIN. DR SMART; SM00096; UTG; 1. DR SUPFAM; SSF48201; Uteroglobin-like; 1. DR PROSITE; PS51311; SCGB; 1. DR Genevisible; P11684; HS. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Disulfide bond; KW Phospholipase A2 inhibitor; Reference proteome; Secreted; Signal. FT SIGNAL 1..21 FT /evidence="ECO:0000269|PubMed:11788998, FT ECO:0000269|PubMed:1395029, ECO:0000269|PubMed:1400743" FT CHAIN 22..91 FT /note="Uteroglobin" FT /id="PRO_0000036365" FT DISULFID 24 FT /note="Interchain (with C-90)" FT DISULFID 90 FT /note="Interchain (with C-24)" FT VARIANT 56 FT /note="R -> G (in dbSNP:rs1802634)" FT /id="VAR_012045" FT VARIANT 68 FT /note="T -> A (in dbSNP:rs1802632)" FT /id="VAR_012046" FT CONFLICT 24 FT /note="C -> E (in Ref. 10; AA sequence)" FT /evidence="ECO:0000305" FT HELIX 25..35 FT /evidence="ECO:0007829|PDB:7VG7" FT HELIX 39..47 FT /evidence="ECO:0007829|PDB:7VG7" FT HELIX 54..67 FT /evidence="ECO:0007829|PDB:7VG7" FT HELIX 71..84 FT /evidence="ECO:0007829|PDB:7VG7" SQ SEQUENCE 91 AA; 9994 MW; FE65ACA678F12ABD CRC64; MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N //