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P11684

- UTER_HUMAN

UniProt

P11684 - UTER_HUMAN

Protein

Uteroglobin

Gene

SCGB1A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

    GO - Molecular functioni

    1. phospholipase A2 inhibitor activity Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. embryo implantation Source: ProtInc
    2. female pregnancy Source: ProtInc
    3. negative regulation of interferon-gamma production Source: Ensembl
    4. negative regulation of interleukin-13 production Source: Ensembl
    5. negative regulation of interleukin-4 production Source: Ensembl
    6. negative regulation of interleukin-5 production Source: Ensembl
    7. negative regulation of T cell proliferation Source: Ensembl
    8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. regulation of inflammatory response Source: Ensembl
    10. regulation of mRNA stability Source: Ensembl
    11. response to cytokine Source: Ensembl
    12. response to drug Source: Ensembl
    13. response to fibroblast growth factor Source: Ensembl
    14. response to glucocorticoid Source: Ensembl
    15. response to lipopolysaccharide Source: Ensembl
    16. response to ozone Source: Ensembl
    17. response to silicon dioxide Source: Ensembl
    18. response to xenobiotic stimulus Source: Ensembl
    19. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Phospholipase A2 inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uteroglobin
    Alternative name(s):
    Clara cell phospholipid-binding protein
    Short name:
    CCPBP
    Clara cells 10 kDa secretory protein
    Short name:
    CC10
    Secretoglobin family 1A member 1
    Urinary protein 1
    Short name:
    UP-1
    Short name:
    UP1
    Short name:
    Urine protein 1
    Gene namesi
    Name:SCGB1A1
    Synonyms:CC10, CCSP, UGB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:12523. SCGB1A1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. nuclear envelope Source: Ensembl
    3. rough endoplasmic reticulum Source: Ensembl
    4. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34989.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21213 PublicationsAdd
    BLAST
    Chaini22 – 9170UteroglobinPRO_0000036365Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 – 24Interchain (with C-90)
    Disulfide bondi90 – 90Interchain (with C-24)

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiP11684.
    PaxDbiP11684.
    PeptideAtlasiP11684.
    PRIDEiP11684.

    PTM databases

    PhosphoSiteiP11684.

    Expressioni

    Tissue specificityi

    Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

    Gene expression databases

    ArrayExpressiP11684.
    BgeeiP11684.
    CleanExiHS_SCGB1A1.
    GenevestigatoriP11684.

    Organism-specific databases

    HPAiCAB025686.
    HPA031828.

    Interactioni

    Subunit structurei

    Homodimer; antiparallel disulfide-linked.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FN1P027513EBI-7797649,EBI-1220319

    Protein-protein interaction databases

    BioGridi113203. 2 interactions.
    IntActiP11684. 2 interactions.
    STRINGi9606.ENSP00000278282.

    Structurei

    3D structure databases

    ProteinModelPortaliP11684.
    SMRiP11684. Positions 23-90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the secretoglobin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39130.
    HOGENOMiHOG000220914.
    HOVERGENiHBG018062.
    InParanoidiP11684.
    OMAiFSPDQDM.
    PhylomeDBiP11684.
    TreeFamiTF338407.

    Family and domain databases

    InterProiIPR016126. Secretoglobin.
    IPR000329. Uteroglobin.
    [Graphical view]
    PfamiPF01099. Uteroglobin. 1 hit.
    [Graphical view]
    PRINTSiPR00486. UTEROGLOBIN.
    SMARTiSM00096. UTG. 1 hit.
    [Graphical view]
    SUPFAMiSSF48201. SSF48201. 1 hit.
    PROSITEiPS51311. SCGB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11684-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS   50
    PDQDMREAGA QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N 91
    Length:91
    Mass (Da):9,994
    Last modified:October 1, 1989 - v1
    Checksum:iFE65ACA678F12ABD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241C → E AA sequence (PubMed:11788998)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561R → G.
    Corresponds to variant rs1802634 [ dbSNP | Ensembl ].
    VAR_012045
    Natural varianti68 – 681T → A.
    Corresponds to variant rs1802632 [ dbSNP | Ensembl ].
    VAR_012046

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13197 mRNA. Translation: CAA31584.1.
    U01101 mRNA. Translation: AAA81885.1.
    U01102 Genomic DNA. Translation: AAA18297.1.
    CR541780 mRNA. Translation: CAG46579.1.
    AK312165 mRNA. Translation: BAG35099.1.
    CH471076 Genomic DNA. Translation: EAW74018.1.
    BC004481 mRNA. Translation: AAH04481.1.
    X59875 Genomic DNA. Translation: CAA42532.1.
    CCDSiCCDS8020.1.
    PIRiJS0036.
    S26651.
    RefSeqiNP_003348.1. NM_003357.4.
    UniGeneiHs.523732.

    Genome annotation databases

    EnsembliENST00000278282; ENSP00000278282; ENSG00000149021.
    GeneIDi7356.
    KEGGihsa:7356.
    UCSCiuc001ntj.3. human.

    Polymorphism databases

    DMDMi112672.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13197 mRNA. Translation: CAA31584.1 .
    U01101 mRNA. Translation: AAA81885.1 .
    U01102 Genomic DNA. Translation: AAA18297.1 .
    CR541780 mRNA. Translation: CAG46579.1 .
    AK312165 mRNA. Translation: BAG35099.1 .
    CH471076 Genomic DNA. Translation: EAW74018.1 .
    BC004481 mRNA. Translation: AAH04481.1 .
    X59875 Genomic DNA. Translation: CAA42532.1 .
    CCDSi CCDS8020.1.
    PIRi JS0036.
    S26651.
    RefSeqi NP_003348.1. NM_003357.4.
    UniGenei Hs.523732.

    3D structure databases

    ProteinModelPortali P11684.
    SMRi P11684. Positions 23-90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113203. 2 interactions.
    IntActi P11684. 2 interactions.
    STRINGi 9606.ENSP00000278282.

    PTM databases

    PhosphoSitei P11684.

    Polymorphism databases

    DMDMi 112672.

    Proteomic databases

    MaxQBi P11684.
    PaxDbi P11684.
    PeptideAtlasi P11684.
    PRIDEi P11684.

    Protocols and materials databases

    DNASUi 7356.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278282 ; ENSP00000278282 ; ENSG00000149021 .
    GeneIDi 7356.
    KEGGi hsa:7356.
    UCSCi uc001ntj.3. human.

    Organism-specific databases

    CTDi 7356.
    GeneCardsi GC11P062188.
    HGNCi HGNC:12523. SCGB1A1.
    HPAi CAB025686.
    HPA031828.
    MIMi 192020. gene.
    neXtProti NX_P11684.
    PharmGKBi PA34989.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39130.
    HOGENOMi HOG000220914.
    HOVERGENi HBG018062.
    InParanoidi P11684.
    OMAi FSPDQDM.
    PhylomeDBi P11684.
    TreeFami TF338407.

    Miscellaneous databases

    ChiTaRSi SCGB1A1. human.
    GeneWikii Uteroglobin.
    GenomeRNAii 7356.
    NextBioi 28804.
    PROi P11684.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11684.
    Bgeei P11684.
    CleanExi HS_SCGB1A1.
    Genevestigatori P11684.

    Family and domain databases

    InterProi IPR016126. Secretoglobin.
    IPR000329. Uteroglobin.
    [Graphical view ]
    Pfami PF01099. Uteroglobin. 1 hit.
    [Graphical view ]
    PRINTSi PR00486. UTEROGLOBIN.
    SMARTi SM00096. UTG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48201. SSF48201. 1 hit.
    PROSITEi PS51311. SCGB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein."
      Singh G., Katyal S.L., Brown W.E., Phillips S., Kennedy A.L., Anthony J., Squeglia N.
      Biochim. Biophys. Acta 950:329-337(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease."
      Hay J.G., Danel C., Chu C., Crystal R.G.
      Am. J. Physiol. 268:L565-L575(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Lung.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    7. "Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines."
      Wolf M., Klug J., Hackenberg R., Gessler M., Grzeschik K.-H., Beato M., Suske G.
      Hum. Mol. Genet. 1:371-378(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
    8. "Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein."
      Okutani R., Itoh Y., Hirata H., Kasahara T., Mukaida N., Kawai T.
      J. Chromatogr. A 577:25-35(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-74.
      Tissue: Urine.
    9. "Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions."
      Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A., van Damme J., de Ley M.
      Clin. Chim. Acta 207:239-249(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-45.
      Tissue: Urine.
    10. "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting."
      Ghafouri B., Stahlbom B., Tagesson C., Lindahl M.
      Proteomics 2:112-120(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-33.
    11. "Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9-A resolution."
      Umland T.C., Swaminathan S., Singh G., Warty V., Furey W., Pletcher J., Sax M.
      Nat. Struct. Biol. 1:538-545(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

    Entry informationi

    Entry nameiUTER_HUMAN
    AccessioniPrimary (citable) accession number: P11684
    Secondary accession number(s): B2R5F2
    , Q6FHH3, Q9UCM2, Q9UCM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3