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Protein

Uteroglobin

Gene

SCGB1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

GO - Molecular functioni

  1. phospholipase A2 inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. embryo implantation Source: ProtInc
  2. female pregnancy Source: ProtInc
  3. negative regulation of interferon-gamma production Source: Ensembl
  4. negative regulation of interleukin-13 production Source: Ensembl
  5. negative regulation of interleukin-4 production Source: Ensembl
  6. negative regulation of interleukin-5 production Source: Ensembl
  7. negative regulation of T cell proliferation Source: Ensembl
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. regulation of inflammatory response Source: Ensembl
  10. regulation of mRNA stability Source: Ensembl
  11. response to cytokine Source: Ensembl
  12. response to drug Source: Ensembl
  13. response to fibroblast growth factor Source: Ensembl
  14. response to glucocorticoid Source: Ensembl
  15. response to lipopolysaccharide Source: Ensembl
  16. response to ozone Source: Ensembl
  17. response to silicon dioxide Source: Ensembl
  18. response to xenobiotic stimulus Source: Ensembl
  19. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Clara cell phospholipid-binding protein
Short name:
CCPBP
Clara cells 10 kDa secretory protein
Short name:
CC10
Secretoglobin family 1A member 1
Urinary protein 1
Short name:
UP-1
Short name:
UP1
Short name:
Urine protein 1
Gene namesi
Name:SCGB1A1
Synonyms:CC10, CCSP, UGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:12523. SCGB1A1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: UniProtKB
  3. nuclear envelope Source: Ensembl
  4. rough endoplasmic reticulum Source: Ensembl
  5. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21213 PublicationsAdd
BLAST
Chaini22 – 9170UteroglobinPRO_0000036365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 – 24Interchain (with C-90)
Disulfide bondi90 – 90Interchain (with C-24)

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP11684.
PaxDbiP11684.
PeptideAtlasiP11684.
PRIDEiP11684.

PTM databases

PhosphoSiteiP11684.

Expressioni

Tissue specificityi

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Gene expression databases

BgeeiP11684.
CleanExiHS_SCGB1A1.
ExpressionAtlasiP11684. baseline and differential.
GenevestigatoriP11684.

Organism-specific databases

HPAiCAB025686.
HPA031828.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Binary interactionsi

WithEntry#Exp.IntActNotes
FN1P027513EBI-7797649,EBI-1220319

Protein-protein interaction databases

BioGridi113203. 3 interactions.
IntActiP11684. 2 interactions.
STRINGi9606.ENSP00000278282.

Structurei

3D structure databases

ProteinModelPortaliP11684.
SMRiP11684. Positions 23-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39130.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiP11684.
OMAiASAEICP.
PhylomeDBiP11684.
TreeFamiTF338407.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11684-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS
60 70 80 90
PDQDMREAGA QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N
Length:91
Mass (Da):9,994
Last modified:October 1, 1989 - v1
Checksum:iFE65ACA678F12ABD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241C → E AA sequence (PubMed:11788998)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561R → G.
Corresponds to variant rs1802634 [ dbSNP | Ensembl ].
VAR_012045
Natural varianti68 – 681T → A.
Corresponds to variant rs1802632 [ dbSNP | Ensembl ].
VAR_012046

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13197 mRNA. Translation: CAA31584.1.
U01101 mRNA. Translation: AAA81885.1.
U01102 Genomic DNA. Translation: AAA18297.1.
CR541780 mRNA. Translation: CAG46579.1.
AK312165 mRNA. Translation: BAG35099.1.
CH471076 Genomic DNA. Translation: EAW74018.1.
BC004481 mRNA. Translation: AAH04481.1.
X59875 Genomic DNA. Translation: CAA42532.1.
CCDSiCCDS8020.1.
PIRiJS0036.
S26651.
RefSeqiNP_003348.1. NM_003357.4.
UniGeneiHs.523732.

Genome annotation databases

EnsembliENST00000278282; ENSP00000278282; ENSG00000149021.
GeneIDi7356.
KEGGihsa:7356.
UCSCiuc001ntj.3. human.

Polymorphism databases

DMDMi112672.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13197 mRNA. Translation: CAA31584.1.
U01101 mRNA. Translation: AAA81885.1.
U01102 Genomic DNA. Translation: AAA18297.1.
CR541780 mRNA. Translation: CAG46579.1.
AK312165 mRNA. Translation: BAG35099.1.
CH471076 Genomic DNA. Translation: EAW74018.1.
BC004481 mRNA. Translation: AAH04481.1.
X59875 Genomic DNA. Translation: CAA42532.1.
CCDSiCCDS8020.1.
PIRiJS0036.
S26651.
RefSeqiNP_003348.1. NM_003357.4.
UniGeneiHs.523732.

3D structure databases

ProteinModelPortaliP11684.
SMRiP11684. Positions 23-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113203. 3 interactions.
IntActiP11684. 2 interactions.
STRINGi9606.ENSP00000278282.

PTM databases

PhosphoSiteiP11684.

Polymorphism databases

DMDMi112672.

Proteomic databases

MaxQBiP11684.
PaxDbiP11684.
PeptideAtlasiP11684.
PRIDEiP11684.

Protocols and materials databases

DNASUi7356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278282; ENSP00000278282; ENSG00000149021.
GeneIDi7356.
KEGGihsa:7356.
UCSCiuc001ntj.3. human.

Organism-specific databases

CTDi7356.
GeneCardsiGC11P062188.
HGNCiHGNC:12523. SCGB1A1.
HPAiCAB025686.
HPA031828.
MIMi192020. gene.
neXtProtiNX_P11684.
PharmGKBiPA34989.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39130.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiP11684.
OMAiASAEICP.
PhylomeDBiP11684.
TreeFamiTF338407.

Miscellaneous databases

ChiTaRSiSCGB1A1. human.
GeneWikiiUteroglobin.
GenomeRNAii7356.
NextBioi28804.
PROiP11684.
SOURCEiSearch...

Gene expression databases

BgeeiP11684.
CleanExiHS_SCGB1A1.
ExpressionAtlasiP11684. baseline and differential.
GenevestigatoriP11684.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein."
    Singh G., Katyal S.L., Brown W.E., Phillips S., Kennedy A.L., Anthony J., Squeglia N.
    Biochim. Biophys. Acta 950:329-337(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease."
    Hay J.G., Danel C., Chu C., Crystal R.G.
    Am. J. Physiol. 268:L565-L575(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Lung.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  7. "Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines."
    Wolf M., Klug J., Hackenberg R., Gessler M., Grzeschik K.-H., Beato M., Suske G.
    Hum. Mol. Genet. 1:371-378(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
  8. "Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein."
    Okutani R., Itoh Y., Hirata H., Kasahara T., Mukaida N., Kawai T.
    J. Chromatogr. A 577:25-35(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-74.
    Tissue: Urine.
  9. "Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions."
    Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A., van Damme J., de Ley M.
    Clin. Chim. Acta 207:239-249(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-45.
    Tissue: Urine.
  10. "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting."
    Ghafouri B., Stahlbom B., Tagesson C., Lindahl M.
    Proteomics 2:112-120(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-33.
  11. "Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9-A resolution."
    Umland T.C., Swaminathan S., Singh G., Warty V., Furey W., Pletcher J., Sax M.
    Nat. Struct. Biol. 1:538-545(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

Entry informationi

Entry nameiUTER_HUMAN
AccessioniPrimary (citable) accession number: P11684
Secondary accession number(s): B2R5F2
, Q6FHH3, Q9UCM2, Q9UCM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 4, 2015
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.