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Protein

Uteroglobin

Gene

SCGB1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPhospholipase A2 inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Clara cell phospholipid-binding protein
Short name:
CCPBP
Clara cells 10 kDa secretory protein
Short name:
CC10
Secretoglobin family 1A member 1
Urinary protein 1
Short name:
UP-1
Short name:
UP1
Short name:
Urine protein 1
Gene namesi
Name:SCGB1A1
Synonyms:CC10, CCSP, UGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149021.6
HGNCiHGNC:12523 SCGB1A1
MIMi192020 gene
neXtProtiNX_P11684

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7356
OpenTargetsiENSG00000149021
PharmGKBiPA34989

Polymorphism and mutation databases

BioMutaiSCGB1A1
DMDMi112672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 213 PublicationsAdd BLAST21
ChainiPRO_000003636522 – 91UteroglobinAdd BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24Interchain (with C-90)
Disulfide bondi90Interchain (with C-24)

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP11684
PaxDbiP11684
PeptideAtlasiP11684
PRIDEiP11684
ProteomicsDBi52798

PTM databases

iPTMnetiP11684
PhosphoSitePlusiP11684

Expressioni

Tissue specificityi

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Gene expression databases

BgeeiENSG00000149021
CleanExiHS_SCGB1A1
ExpressionAtlasiP11684 baseline and differential
GenevisibleiP11684 HS

Organism-specific databases

HPAiCAB025686
HPA031828

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113203, 6 interactors
IntActiP11684, 2 interactors
MINTiP11684
STRINGi9606.ENSP00000278282

Structurei

3D structure databases

ProteinModelPortaliP11684
SMRiP11684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J459 Eukaryota
ENOG4111966 LUCA
GeneTreeiENSGT00530000064300
HOGENOMiHOG000220914
HOVERGENiHBG018062
InParanoidiP11684
OMAiASAEICP
OrthoDBiEOG091G15B2
PhylomeDBiP11684
TreeFamiTF338407

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
IPR000329 Uteroglobin
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
PRINTSiPR00486 UTEROGLOBIN
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS
60 70 80 90
PDQDMREAGA QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N
Length:91
Mass (Da):9,994
Last modified:October 1, 1989 - v1
Checksum:iFE65ACA678F12ABD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24C → E AA sequence (PubMed:11788998).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01204556R → G. Corresponds to variant dbSNP:rs1802634Ensembl.1
Natural variantiVAR_01204668T → A. Corresponds to variant dbSNP:rs1802632Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13197 mRNA Translation: CAA31584.1
U01101 mRNA Translation: AAA81885.1
U01102 Genomic DNA Translation: AAA18297.1
CR541780 mRNA Translation: CAG46579.1
AK312165 mRNA Translation: BAG35099.1
CH471076 Genomic DNA Translation: EAW74018.1
BC004481 mRNA Translation: AAH04481.1
X59875 Genomic DNA Translation: CAA42532.1
CCDSiCCDS8020.1
PIRiJS0036
S26651
RefSeqiNP_003348.1, NM_003357.4
UniGeneiHs.523732

Genome annotation databases

EnsembliENST00000278282; ENSP00000278282; ENSG00000149021
GeneIDi7356
KEGGihsa:7356
UCSCiuc001ntj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUTER_HUMAN
AccessioniPrimary (citable) accession number: P11684
Secondary accession number(s): B2R5F2
, Q6FHH3, Q9UCM2, Q9UCM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 20, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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