P11684 (UTER_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uteroglobin

Alternative name(s):
Clara cell phospholipid-binding protein
Short name=CCPBP
Clara cells 10 kDa secretory protein
Short name=CC10
Secretoglobin family 1A member 1
Urinary protein 1
Short name=UP-1
Short name=UP1
Short name=Urine protein 1

Gene names

Name:	SCGB1A1
Synonyms:	CC10, CCSP, UGB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Subunit structure	Homodimer; antiparallel disulfide-linked.
Subcellular location	Secreted.
Tissue specificity	Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Sequence similarities	Belongs to the secretoglobin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Phospholipase A2 inhibitor
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	embryo implantation Traceable author statement PubMed 10587371. Source: ProtInc negative regulation of T cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-13 production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-4 production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-5 production Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of inflammatory response Inferred from electronic annotation. Source: Compara regulation of mRNA stability Inferred from electronic annotation. Source: Compara response to cytokine stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to ozone Inferred from electronic annotation. Source: Compara response to silicon dioxide Inferred from electronic annotation. Source: Compara response to xenobiotic stimulus Inferred from electronic annotation. Source: Compara signal transduction Non-traceable author statement PubMed 10587371. Source: ProtInc
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara nuclear envelope Inferred from electronic annotation. Source: Compara rough endoplasmic reticulum Inferred from electronic annotation. Source: Compara secretory granule Inferred from electronic annotation. Source: Compara
Molecular_function	phospholipase A2 inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.8 Ref.9 Ref.10
	Chain	22 – 91	70	Uteroglobin		PRO_0000036365
Amino acid modifications
	Disulfide bond	24		Interchain (with C-90)
	Disulfide bond	90		Interchain (with C-24)
Natural variations
	Natural variant	56	1	R → G. Corresponds to variant rs1802634 [ dbSNP | Ensembl ].		VAR_012045
	Natural variant	68	1	T → A. Corresponds to variant rs1802632 [ dbSNP | Ensembl ].		VAR_012046
Experimental info
	Sequence conflict	24	1	C → E AA sequence Ref.10

Sequences

	Sequence		Length	Mass (Da)
	P11684 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: FE65ACA678F12ABD	FASTA	91	9,994
	10 20 30 40 50 60 MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA 70 80 90 QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein." Singh G., Katyal S.L., Brown W.E., Phillips S., Kennedy A.L., Anthony J., Squeglia N. Biochim. Biophys. Acta 950:329-337(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease." Hay J.G., Danel C., Chu C., Crystal R.G. Am. J. Physiol. 268:L565-L575(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Lung.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[7]	"Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines." Wolf M., Klug J., Hackenberg R., Gessler M., Grzeschik K.-H., Beato M., Suske G. Hum. Mol. Genet. 1:371-378(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
[8]	"Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein." Okutani R., Itoh Y., Hirata H., Kasahara T., Mukaida N., Kawai T. J. Chromatogr. A 577:25-35(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-74. Tissue: Urine.
[9]	"Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions." Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A., van Damme J., de Ley M. Clin. Chim. Acta 207:239-249(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-45. Tissue: Urine.
[10]	"Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting." Ghafouri B., Stahlbom B., Tagesson C., Lindahl M. Proteomics 2:112-120(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-33.
[11]	"Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9-A resolution." Umland T.C., Swaminathan S., Singh G., Warty V., Furey W., Pletcher J., Sax M. Nat. Struct. Biol. 1:538-545(1994) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13197 mRNA. Translation: CAA31584.1. U01101 mRNA. Translation: AAA81885.1. U01102 Genomic DNA. Translation: AAA18297.1. CR541780 mRNA. Translation: CAG46579.1. AK312165 mRNA. Translation: BAG35099.1. CH471076 Genomic DNA. Translation: EAW74018.1. BC004481 mRNA. Translation: AAH04481.1. X59875 Genomic DNA. Translation: CAA42532.1.
IPI	IPI00006705.
PIR	JS0036. S26651.
RefSeq	NP_003348.1. NM_003357.4.
UniGene	Hs.523732.
3D structure databases
ProteinModelPortal	P11684.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000278282.
PTM databases
PhosphoSite	P11684.
Polymorphism databases
DMDM	112672.
Proteomic databases
PaxDb	P11684.
PeptideAtlas	P11684.
PRIDE	P11684.
Protocols and materials databases
DNASU	7356.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278282; ENSP00000278282; ENSG00000149021.
GeneID	7356.
KEGG	hsa:7356.
UCSC	uc001ntj.3. human.
Organism-specific databases
CTD	7356.
GeneCards	GC11P062188.
HGNC	HGNC:12523. SCGB1A1.
HPA	CAB025686.
MIM	192020. gene.
neXtProt	NX_P11684.
PharmGKB	PA34989.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39130.
HOGENOM	HOG000220914.
HOVERGEN	HBG018062.
InParanoid	P11684.
OMA	ASAEICP.
OrthoDB	EOG4XKV8P.
PhylomeDB	P11684.
Enzyme and pathway databases
Pathway_Interaction_DB	hnf3apathway. FOXA1 transcription factor network.
Gene expression databases
ArrayExpress	P11684.
Bgee	P11684.
CleanEx	HS_SCGB1A1.
Genevestigator	P11684.
GermOnline	ENSG00000149021. Homo sapiens.
Family and domain databases
InterPro	IPR016126. Secretoglobin. IPR000329. Uteroglobin-like. IPR006039. Uteroglobin-like_fam. IPR006038. Uteroglobin-like_superfam. [Graphical view]
PANTHER	PTHR10136. PTHR10136. 1 hit.
Pfam	PF01099. Uteroglobin. 1 hit. [Graphical view]
PRINTS	PR00486. UTEROGLOBIN.
SMART	SM00096. UTG. 1 hit. [Graphical view]
SUPFAM	SSF48201. Secretoglobin. 1 hit.
PROSITE	PS51311. SCGB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SCGB1A1. human.
GenomeRNAi	7356.
NextBio	28804.
SOURCE	Search...

Entry information

Entry name

UTER_HUMAN

Accession

Primary (citable) accession number: P11684
Secondary accession number(s): B2R5F2 , Q6FHH3, Q9UCM2, Q9UCM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.