Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P11684 (UTER_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uteroglobin
Alternative name(s):
Clara cell phospholipid-binding protein
Short name=CCPBP
Clara cells 10 kDa secretory protein
Short name=CC10
Secretoglobin family 1A member 1
Urinary protein 1
Short name=UP-1
Short name=UP1
Short name=Urine protein 1
Gene names
Name:SCGB1A1
Synonyms:CC10, CCSP, UGB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Subunit structure

Homodimer; antiparallel disulfide-linked.

Subcellular location

Secreted.

Tissue specificity

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Sequence similarities

Belongs to the secretoglobin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionPhospholipase A2 inhibitor
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processembryo implantation

Traceable author statement PubMed 10587371. Source: ProtInc

female pregnancy

Non-traceable author statement PubMed 10587371. Source: ProtInc

negative regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-13 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-4 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-5 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

regulation of mRNA stability

Inferred from electronic annotation. Source: Ensembl

response to cytokine

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to fibroblast growth factor

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to ozone

Inferred from electronic annotation. Source: Ensembl

response to silicon dioxide

Inferred from electronic annotation. Source: Ensembl

response to xenobiotic stimulus

Inferred from electronic annotation. Source: Ensembl

signal transduction

Non-traceable author statement PubMed 10587371. Source: ProtInc

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

nuclear envelope

Inferred from electronic annotation. Source: Ensembl

rough endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

secretory granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionphospholipase A2 inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 18243143. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FN1P027513EBI-7797649,EBI-1220319

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.8 Ref.9 Ref.10
Chain22 – 9170Uteroglobin
PRO_0000036365

Amino acid modifications

Disulfide bond24Interchain (with C-90)
Disulfide bond90Interchain (with C-24)

Natural variations

Natural variant561R → G.
Corresponds to variant rs1802634 [ dbSNP | Ensembl ].
VAR_012045
Natural variant681T → A.
Corresponds to variant rs1802632 [ dbSNP | Ensembl ].
VAR_012046

Experimental info

Sequence conflict241C → E AA sequence Ref.10

Sequences

Sequence LengthMass (Da)Tools
P11684 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: FE65ACA678F12ABD

FASTA919,994
        10         20         30         40         50         60 
MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA 

        70         80         90 
QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N 

« Hide

References

« Hide 'large scale' references
[1]"Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein."
Singh G., Katyal S.L., Brown W.E., Phillips S., Kennedy A.L., Anthony J., Squeglia N.
Biochim. Biophys. Acta 950:329-337(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease."
Hay J.G., Danel C., Chu C., Crystal R.G.
Am. J. Physiol. 268:L565-L575(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Lung.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[7]"Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines."
Wolf M., Klug J., Hackenberg R., Gessler M., Grzeschik K.-H., Beato M., Suske G.
Hum. Mol. Genet. 1:371-378(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
[8]"Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein."
Okutani R., Itoh Y., Hirata H., Kasahara T., Mukaida N., Kawai T.
J. Chromatogr. A 577:25-35(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-74.
Tissue: Urine.
[9]"Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions."
Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A., van Damme J., de Ley M.
Clin. Chim. Acta 207:239-249(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-45.
Tissue: Urine.
[10]"Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting."
Ghafouri B., Stahlbom B., Tagesson C., Lindahl M.
Proteomics 2:112-120(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-33.
[11]"Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9-A resolution."
Umland T.C., Swaminathan S., Singh G., Warty V., Furey W., Pletcher J., Sax M.
Nat. Struct. Biol. 1:538-545(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13197 mRNA. Translation: CAA31584.1.
U01101 mRNA. Translation: AAA81885.1.
U01102 Genomic DNA. Translation: AAA18297.1.
CR541780 mRNA. Translation: CAG46579.1.
AK312165 mRNA. Translation: BAG35099.1.
CH471076 Genomic DNA. Translation: EAW74018.1.
BC004481 mRNA. Translation: AAH04481.1.
X59875 Genomic DNA. Translation: CAA42532.1.
CCDSCCDS8020.1.
PIRJS0036.
S26651.
RefSeqNP_003348.1. NM_003357.4.
UniGeneHs.523732.

3D structure databases

ProteinModelPortalP11684.
SMRP11684. Positions 23-90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113203. 2 interactions.
IntActP11684. 2 interactions.
STRING9606.ENSP00000278282.

PTM databases

PhosphoSiteP11684.

Polymorphism databases

DMDM112672.

Proteomic databases

MaxQBP11684.
PaxDbP11684.
PeptideAtlasP11684.
PRIDEP11684.

Protocols and materials databases

DNASU7356.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278282; ENSP00000278282; ENSG00000149021.
GeneID7356.
KEGGhsa:7356.
UCSCuc001ntj.3. human.

Organism-specific databases

CTD7356.
GeneCardsGC11P062188.
HGNCHGNC:12523. SCGB1A1.
HPACAB025686.
HPA031828.
MIM192020. gene.
neXtProtNX_P11684.
PharmGKBPA34989.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39130.
HOGENOMHOG000220914.
HOVERGENHBG018062.
InParanoidP11684.
OMAFSPDQDM.
PhylomeDBP11684.
TreeFamTF338407.

Gene expression databases

ArrayExpressP11684.
BgeeP11684.
CleanExHS_SCGB1A1.
GenevestigatorP11684.

Family and domain databases

InterProIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSPR00486. UTEROGLOBIN.
SMARTSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMSSF48201. SSF48201. 1 hit.
PROSITEPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSCGB1A1. human.
GeneWikiUteroglobin.
GenomeRNAi7356.
NextBio28804.
PROP11684.
SOURCESearch...

Entry information

Entry nameUTER_HUMAN
AccessionPrimary (citable) accession number: P11684
Secondary accession number(s): B2R5F2 expand/collapse secondary AC list , Q6FHH3, Q9UCM2, Q9UCM4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM