Reviewed, UniProtKB/Swiss-Prot P11681 (ABL_CALVI)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein kinase ABL
    EC=2.7.10.2

Gene names

Name:

ABL

Organism

Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)

Taxonomic identifier

7373 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Oestroidea › Calliphoridae › Calliphorinae › Calliphora

Protein attributes

Sequence length	74 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Gene Ontology (GO)
Biological process	peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›74	›74	Tyrosine-protein kinase ABL		PRO_0000088053
Regions
	Domain	‹1 – ›74	›74	Protein kinase
	Motif	50 – 74	25	Kinase activation loop By similarity
Sites
	Active site	32	1	Proton acceptor By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	74	1

Sequences

	Sequence		Length	Mass (Da)
	P11681-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: DBF86E8D35001CCA	FASTA	74	8,303
	10 20 30 40 50 60 RETLDAVALL YMATQIASGM SYLEARNYIH RDLAARNCLV GDNKLVKVAD FGLARLMRDD 70 TYTAHAGAKF PIKW

References

[1]	"Isolation and characterization of abl gene sequences in Calliphora erythrocephala." Durica D.S., Restrepo M.A., Thomas T.L., Beckingham K. Gene 59:63-76(1987) [PubMed: 3125084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18427 Genomic DNA. Translation: AAA28232.1.
PIR	A29597.
3D structure databases
SMR	P11681. Positions 1-74.
ModBase	Search...
Proteomic databases
PRIDE	P11681.
Enzyme and pathway databases
BRENDA	2.7.10.2. 2654.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR020700. Tyr_kinase_non-rcpt_Abl. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. [Graphical view]
PANTHER	PTHR23256:SF144. Tyr_kinase_non-rcpt_Abl. 1 hit. PTHR23256. Tyr_prot_kinase. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABL_CALVI

Accession

Primary (citable) accession number: P11681

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	February 9, 2010
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)