P11681 (ABL_CALVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase ABL
EC=2.7.10.2

Gene names

Name:

ABL

Organism

Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)

Taxonomic identifier

7373 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Calyptratae › Oestroidea › Calliphoridae › Calliphorinae › Calliphora

Protein attributes

Sequence length	74 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›74	›74	Tyrosine-protein kinase ABL		PRO_0000088053
Regions
	Domain	‹1 – ›74	›74	Protein kinase
	Motif	50 – 74	25	Kinase activation loop By similarity
Sites
	Active site	32	1	Proton acceptor By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	74	1

Sequences

	Sequence		Length	Mass (Da)
	P11681 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: DBF86E8D35001CCA	FASTA	74	8,303
	10 20 30 40 50 60 RETLDAVALL YMATQIASGM SYLEARNYIH RDLAARNCLV GDNKLVKVAD FGLARLMRDD 70 TYTAHAGAKF PIKW

References

[1]	"Isolation and characterization of abl gene sequences in Calliphora erythrocephala." Durica D.S., Restrepo M.A., Thomas T.L., Beckingham K. Gene 59:63-76(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18427 Genomic DNA. Translation: AAA28232.1.
PIR	A29597.
3D structure databases
ProteinModelPortal	P11681.
SMR	P11681. Positions 1-74.
ModBase	Search...
Proteomic databases
PRIDE	P11681.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABL_CALVI

Accession

Primary (citable) accession number: P11681

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)