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P11681 (ABL_CALVI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase ABL

EC=2.7.10.2
Gene names
Name:ABL
OrganismCalliphora vicina (Blue blowfly) (Calliphora erythrocephala)
Taxonomic identifier7373 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeCalliphorinaeCalliphora

Protein attributes

Sequence length74 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Tyrosine-protein kinase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

non-membrane spanning protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›74›74Tyrosine-protein kinase ABL
PRO_0000088053

Regions

Domain‹1 – ›74›74Protein kinase
Motif50 – 7425Kinase activation loop By similarity

Sites

Active site321Proton acceptor By similarity

Experimental info

Non-terminal residue11
Non-terminal residue741

Sequences

Sequence LengthMass (Da)Tools
P11681 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: DBF86E8D35001CCA

FASTA748,303
        10         20         30         40         50         60 
RETLDAVALL YMATQIASGM SYLEARNYIH RDLAARNCLV GDNKLVKVAD FGLARLMRDD 

        70 
TYTAHAGAKF PIKW 

« Hide

References

[1]"Isolation and characterization of abl gene sequences in Calliphora erythrocephala."
Durica D.S., Restrepo M.A., Thomas T.L., Beckingham K.
Gene 59:63-76(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M18427 Genomic DNA. Translation: AAA28232.1.
PIRA29597.

3D structure databases

ProteinModelPortalP11681.
SMRP11681. Positions 1-74.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP11681.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameABL_CALVI
AccessionPrimary (citable) accession number: P11681
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families