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Protein

Properdin

Gene

Cfp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-173736. Alternative complement activation.
R-MMU-174577. Activation of C3 and C5.
R-MMU-5173214. O-glycosylation of TSR domain-containing proteins.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Properdin
Alternative name(s):
Complement factor P
Gene namesi
Name:Cfp
Synonyms:Pfc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:97545. Cfp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 464442ProperdinPRO_0000043369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 68PROSITE-ProRule annotation
Disulfide bondi39 ↔ 71PROSITE-ProRule annotation
Disulfide bondi85 ↔ 123PROSITE-ProRule annotation
Disulfide bondi89 ↔ 129PROSITE-ProRule annotation
Disulfide bondi100 ↔ 107PROSITE-ProRule annotation
Disulfide bondi144 ↔ 180PROSITE-ProRule annotation
Disulfide bondi148 ↔ 186PROSITE-ProRule annotation
Disulfide bondi159 ↔ 170PROSITE-ProRule annotation
Disulfide bondi201 ↔ 244PROSITE-ProRule annotation
Disulfide bondi205 ↔ 250PROSITE-ProRule annotation
Disulfide bondi220 ↔ 234PROSITE-ProRule annotation
Disulfide bondi265 ↔ 302PROSITE-ProRule annotation
Disulfide bondi269 ↔ 308PROSITE-ProRule annotation
Disulfide bondi280 ↔ 292PROSITE-ProRule annotation
Disulfide bondi323 ↔ 365PROSITE-ProRule annotation
Disulfide bondi332 ↔ 371PROSITE-ProRule annotation
Disulfide bondi345 ↔ 355PROSITE-ProRule annotation
Disulfide bondi386 ↔ 450PROSITE-ProRule annotation
Disulfide bondi390 ↔ 456PROSITE-ProRule annotation
Disulfide bondi402 ↔ 434PROSITE-ProRule annotation
Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP11680.
PaxDbiP11680.
PeptideAtlasiP11680.
PRIDEiP11680.

PTM databases

iPTMnetiP11680.
PhosphoSiteiP11680.
SwissPalmiP11680.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001128.
CleanExiMM_CFP.
ExpressionAtlasiP11680. baseline and differential.
GenevisibleiP11680. MM.

Interactioni

Subunit structurei

In plasma, properdin exists as dimers, trimers or tetramers in the relative proportions of 26:54:20.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001156.

Structurei

3D structure databases

ProteinModelPortaliP11680.
SMRiP11680. Positions 76-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 7249TSP type-1 0PROSITE-ProRule annotationAdd
BLAST
Domaini73 – 13058TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini132 – 18756TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini189 – 25163TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini253 – 30957TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini311 – 37262TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 45784TSP type-1 6PROSITE-ProRule annotationAdd
BLAST

Domaini

TSP type-1 domains 0 and 6 bind to each other and mediate multimerization.By similarity

Sequence similaritiesi

Contains 7 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IUGK. Eukaryota.
ENOG410ZHSM. LUCA.
GeneTreeiENSGT00840000129679.
HOGENOMiHOG000231326.
HOVERGENiHBG008263.
InParanoidiP11680.
KOiK15412.
OMAiQVCPTHG.
OrthoDBiEOG091G07MO.
PhylomeDBiP11680.
TreeFamiTF315491.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS50092. TSP1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAEMQAPQW LLLLLVILPA TGSDPVLCFT QYEESSGRCK GLLGRDIRVE
60 70 80 90 100
DCCLNAAYAF QEHDGGLCQA CRSPQWSAWS LWGPCSVTCS EGSQLRHRRC
110 120 130 140 150
VGRGGQCSEN VAPGTLEWQL QACEDQPCCP EMGGWSEWGP WGPCSVTCSK
160 170 180 190 200
GTQIRQRVCD NPAPKCGGHC PGEAQQSQAC DTQKTCPTHG AWASWGPWSP
210 220 230 240 250
CSGSCLGGAQ EPKETRSRSC SAPAPSHQPP GKPCSGPAYE HKACSGLPPC
260 270 280 290 300
PVAGGWGPWS PLSPCSVTCG LGQTLEQRTC DHPAPRHGGP FCAGDATRNQ
310 320 330 340 350
MCNKAVPCPV NGEWEAWGKW SDCSRLRMSI NCEGTPGQQS RSRSCGGRKF
360 370 380 390 400
NGKPCAGKLQ DIRHCYNIHN CIMKGSWSQW STWSLCTPPC SPNATRVRQR
410 420 430 440 450
LCTPLLPKYP PTVSMVEGQG EKNVTFWGTP RPLCEALQGQ KLVVEEKRSC
460
LHVPVCKDPE EKKP
Length:464
Mass (Da):50,327
Last modified:December 6, 2005 - v2
Checksum:iC787F5493042379A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581Y → N in BAE42416 (PubMed:16141072).Curated
Sequence conflicti201 – 2011C → R in CAA31389 (PubMed:3045564).Curated
Sequence conflicti347 – 3471G → D in CAA31389 (PubMed:3045564).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150212 mRNA. Translation: BAE29382.1.
AK152782 mRNA. Translation: BAE31492.1.
AK159291 mRNA. Translation: BAE34967.1.
AK171374 mRNA. Translation: BAE42416.1.
X12905 mRNA. Translation: CAA31389.1.
CCDSiCCDS30047.1.
PIRiS05478.
RefSeqiNP_032849.2. NM_008823.4.
UniGeneiMm.3064.

Genome annotation databases

EnsembliENSMUST00000001156; ENSMUSP00000001156; ENSMUSG00000001128.
GeneIDi18636.
KEGGimmu:18636.
UCSCiuc009sub.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150212 mRNA. Translation: BAE29382.1.
AK152782 mRNA. Translation: BAE31492.1.
AK159291 mRNA. Translation: BAE34967.1.
AK171374 mRNA. Translation: BAE42416.1.
X12905 mRNA. Translation: CAA31389.1.
CCDSiCCDS30047.1.
PIRiS05478.
RefSeqiNP_032849.2. NM_008823.4.
UniGeneiMm.3064.

3D structure databases

ProteinModelPortaliP11680.
SMRiP11680. Positions 76-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001156.

PTM databases

iPTMnetiP11680.
PhosphoSiteiP11680.
SwissPalmiP11680.

Proteomic databases

MaxQBiP11680.
PaxDbiP11680.
PeptideAtlasiP11680.
PRIDEiP11680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001156; ENSMUSP00000001156; ENSMUSG00000001128.
GeneIDi18636.
KEGGimmu:18636.
UCSCiuc009sub.1. mouse.

Organism-specific databases

CTDi5199.
MGIiMGI:97545. Cfp.

Phylogenomic databases

eggNOGiENOG410IUGK. Eukaryota.
ENOG410ZHSM. LUCA.
GeneTreeiENSGT00840000129679.
HOGENOMiHOG000231326.
HOVERGENiHBG008263.
InParanoidiP11680.
KOiK15412.
OMAiQVCPTHG.
OrthoDBiEOG091G07MO.
PhylomeDBiP11680.
TreeFamiTF315491.

Enzyme and pathway databases

ReactomeiR-MMU-173736. Alternative complement activation.
R-MMU-174577. Activation of C3 and C5.
R-MMU-5173214. O-glycosylation of TSR domain-containing proteins.
R-MMU-977606. Regulation of Complement cascade.

Miscellaneous databases

PROiP11680.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001128.
CleanExiMM_CFP.
ExpressionAtlasiP11680. baseline and differential.
GenevisibleiP11680. MM.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS50092. TSP1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROP_MOUSE
AccessioniPrimary (citable) accession number: P11680
Secondary accession number(s): Q3TB98, Q3U779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.