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Protein

Arginine exporter protein ArgO

Gene

argO

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine. May also be involved in the export of canavanine (a plant-derived antimetabolite).1 Publication

GO - Molecular functioni

  • arginine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • arginine transmembrane transport Source: GOC
  • L-arginine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YGGA-MONOMER.
ECOL316407:JW2890-MONOMER.

Protein family/group databases

TCDBi2.A.75.1.2. the l-lysine exporter (lyse) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine exporter protein ArgO
Gene namesi
Name:argO
Synonyms:yggA
Ordered Locus Names:b2923, JW2890
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11159. argO.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Topological domaini22 – 3615CytoplasmicSequence analysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST
Topological domaini58 – 6710PeriplasmicSequence analysis
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 11022CytoplasmicSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Topological domaini132 – 14615PeriplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Topological domaini168 – 17811CytoplasmicSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 21112PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Arginine exporter protein ArgOPRO_0000204158Add
BLAST

Proteomic databases

PaxDbiP11667.
PRIDEiP11667.

Expressioni

Inductioni

Transcriptionally regulated by ArgP in response to the accumulation of intracellular arginine or canavanine. Lysine has a negative effect on the expression of argO.

Interactioni

Protein-protein interaction databases

BioGridi4263380. 11 interactions.
STRINGi511145.b2923.

Structurei

3D structure databases

ProteinModelPortaliP11667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZUB. Bacteria.
COG1279. LUCA.
HOGENOMiHOG000122948.
InParanoidiP11667.
KOiK06895.
OMAiEHVFAVC.
OrthoDBiEOG6CS048.
PhylomeDBiP11667.

Family and domain databases

HAMAPiMF_01901. ArgO.
InterProiIPR023445. Arg_export_ArgO_enterobac.
IPR004777. Lys/arg_exporter.
IPR001123. LysE-type.
[Graphical view]
PANTHERiPTHR30086. PTHR30086. 1 hit.
PfamiPF01810. LysE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00948. 2a75. 1 hit.

Sequencei

Sequence statusi: Complete.

P11667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSYYFQGLA LGAAMILPLG PQNAFVMNQG IRRQYHIMIA LLCAISDLVL
60 70 80 90 100
ICAGIFGGSA LLMQSPWLLA LVTWGGVAFL LWYGFGAFKT AMSSNIELAS
110 120 130 140 150
AEVMKQGRWK IIATMLAVTW LNPHVYLDTF VVLGSLGGQL DVEPKRWFAL
160 170 180 190 200
GTISASFLWF FGLALLAAWL APRLRTAKAQ RIINLVVGCV MWFIALQLAR
210
DGIAHAQALF S
Length:211
Mass (Da):23,176
Last modified:October 1, 1996 - v2
Checksum:i2DAFE27B6A9BE822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69090.1.
U00096 Genomic DNA. Translation: AAC75960.1.
AP009048 Genomic DNA. Translation: BAE76987.1.
X14436 Genomic DNA. Translation: CAA32607.1.
PIRiB65077. QQEC5A.
RefSeqiNP_417398.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC75960; AAC75960; b2923.
BAE76987; BAE76987; BAE76987.
GeneIDi947418.
KEGGiecj:JW2890.
eco:b2923.
PATRICi32121260. VBIEscCol129921_3018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69090.1.
U00096 Genomic DNA. Translation: AAC75960.1.
AP009048 Genomic DNA. Translation: BAE76987.1.
X14436 Genomic DNA. Translation: CAA32607.1.
PIRiB65077. QQEC5A.
RefSeqiNP_417398.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP11667.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263380. 11 interactions.
STRINGi511145.b2923.

Protein family/group databases

TCDBi2.A.75.1.2. the l-lysine exporter (lyse) family.

Proteomic databases

PaxDbiP11667.
PRIDEiP11667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75960; AAC75960; b2923.
BAE76987; BAE76987; BAE76987.
GeneIDi947418.
KEGGiecj:JW2890.
eco:b2923.
PATRICi32121260. VBIEscCol129921_3018.

Organism-specific databases

EchoBASEiEB1148.
EcoGeneiEG11159. argO.

Phylogenomic databases

eggNOGiENOG4108ZUB. Bacteria.
COG1279. LUCA.
HOGENOMiHOG000122948.
InParanoidiP11667.
KOiK06895.
OMAiEHVFAVC.
OrthoDBiEOG6CS048.
PhylomeDBiP11667.

Enzyme and pathway databases

BioCyciEcoCyc:YGGA-MONOMER.
ECOL316407:JW2890-MONOMER.

Miscellaneous databases

PROiP11667.

Family and domain databases

HAMAPiMF_01901. ArgO.
InterProiIPR023445. Arg_export_ArgO_enterobac.
IPR004777. Lys/arg_exporter.
IPR001123. LysE-type.
[Graphical view]
PANTHERiPTHR30086. PTHR30086. 1 hit.
PfamiPF01810. LysE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00948. 2a75. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Identification, molecular cloning and sequence analysis of a gene cluster encoding the class II fructose 1,6-bisphosphate aldolase, 3-phosphoglycerate kinase and a putative second glyceraldehyde 3-phosphate dehydrogenase of Escherichia coli."
    Alefounder P.R., Perham R.N.
    Mol. Microbiol. 3:723-732(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-211.
    Strain: K12 / CS520.
  4. "Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli."
    Nandineni M.R., Gowrishankar J.
    J. Bacteriol. 186:3539-3546(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiARGO_ECOLI
AccessioniPrimary (citable) accession number: P11667
Secondary accession number(s): Q2M9R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1996
Last modified: January 20, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.