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Protein

Fumarase E

Gene

fumE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate.1 Publication

Catalytic activityi

(S)-malate = fumarate + H2O.1 Publication

GO - Molecular functioni

  • fumarate hydratase activity Source: EcoCyc

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciEcoCyc:EG11162-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarase E1 Publication (EC:4.2.1.21 Publication)
Gene namesi
Name:fumE1 Publication
Synonyms:yggDImported
Ordered Locus Names:b2929, JW2896
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11162. yggD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001693631 – 169Fumarase EAdd BLAST169

Proteomic databases

PaxDbiP11663.
PRIDEiP11663.

Interactioni

Protein-protein interaction databases

BioGridi4262333. 86 interactors.
IntActiP11663. 5 interactors.
STRINGi316385.ECDH10B_3104.

Structurei

3D structure databases

ProteinModelPortaliP11663.
SMRiP11663.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11663.

Family & Domainsi

Sequence similaritiesi

Belongs to the MtlR/FumE family.Curated

Phylogenomic databases

eggNOGiENOG4108R4K. Bacteria.
COG3722. LUCA.
HOGENOMiHOG000124415.

Family and domain databases

InterProiView protein in InterPro
IPR007761. MtlR-like.
PANTHERiPTHR37941. PTHR37941. 1 hit.
PfamiView protein in Pfam
PF05068. MtlR. 1 hit.

Sequencei

Sequence statusi: Complete.

P11663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLTEDDVL EQLDAQDNLF SFMKTAHTIL LQGIRQFLPS LFVDNDEEIV
60 70 80 90 100
EYAVKPLLAQ SGPLDDIDVA LRLIYALGKM DKWLYADITH FSQFWHYLNE
110 120 130 140 150
QDETPGFADD MTWDFISNVN SITRNAMLYD ALKAMKFADF SVWSEARFSG
160
MVKTALTLAV TTTLKELTP
Length:169
Mass (Da):19,272
Last modified:October 1, 1996 - v3
Checksum:i427302F600960D31
GO

Sequence cautioni

The sequence CAA32601 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69096.1.
U00096 Genomic DNA. Translation: AAC75966.1.
AP009048 Genomic DNA. Translation: BAE76993.1.
X14436 Genomic DNA. Translation: CAA32601.1. Different initiation.
PIRiH65077. QQEC2B.
RefSeqiNP_417404.1. NC_000913.3.
WP_000224147.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75966; AAC75966; b2929.
BAE76993; BAE76993; BAE76993.
GeneIDi946861.
KEGGiecj:JW2896.
eco:b2929.
PATRICifig|1411691.4.peg.3803.

Similar proteinsi

Entry informationi

Entry nameiFUME_ECOLI
AccessioniPrimary (citable) accession number: P11663
Secondary accession number(s): Q2M9R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families