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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

Mtnd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled electron transport Source: InterPro
  • response to hydrogen peroxide Source: RGD
  • response to hypoxia Source: RGD
  • response to organonitrogen compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.
R-RNO-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:Mtnd5
Synonyms:mt-Nd5, Nd5
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Mitochondrion

Organism-specific databases

RGDi620560. mt-Nd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Transmembranei116 – 13823HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Transmembranei300 – 31920HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence analysisAdd
BLAST
Transmembranei409 – 42921HelicalSequence analysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence analysisAdd
BLAST
Transmembranei481 – 50121HelicalSequence analysisAdd
BLAST
Transmembranei581 – 60121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609NADH-ubiquinone oxidoreductase chain 5PRO_0000118141Add
BLAST

Proteomic databases

PaxDbiP11661.
PRIDEiP11661.

Expressioni

Gene expression databases

ExpressionAtlasiP11661. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044573.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4668. Eukaryota.
COG1009. LUCA.
HOGENOMiHOG000100570.
HOVERGENiHBG108343.
InParanoidiP11661.
KOiK03883.
OMAiEFSMWYM.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

P11661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMMTSSILM ILILLTTPII ISMTNLPKLI DFPSYATSSI KFSFLLSLLP
60 70 80 90 100
LLLFFHHNTE YMITNWHWLT INSIKLTMSF KIDYFSILFL SVALFVTWSI
110 120 130 140 150
MQFSSWYMHS DPHINRFIKY LMMFLITMLI LTSANNLFQL FIGWEGVGIM
160 170 180 190 200
SFLLIGWWYG RADANTAALQ AILYNRVGDI GFILAMTWFC LNMNSWELQQ
210 220 230 240 250
IFLTNTNNLV PLTGLLIAAT GKSAQFGLHP WLPSAMEGPT PVSALLHSST
260 270 280 290 300
MVVAGIFLMI RFHPLTSNNS TIMTAMLCLG AITTLFTAIC ALTQNDIKKI
310 320 330 340 350
VAFSTSSQLG LMMVTLGINQ PYLAFLHICT HAFFKAMLFM CSGSIIHSLN
360 370 380 390 400
DEQDIRKMGN MMKAMPFTSS CLIIGSLALT GMPFLTGFYS KDLIIEAINT
410 420 430 440 450
CNTNAWALMI TLIATSMTAV YSMRIIYFVT MTKPRYSPLI TINENNPNLI
460 470 480 490 500
NPIKRLALGS ILAGFLISLN IPPTNIQILT MPWHLKMTAL LITILGFAIA
510 520 530 540 550
LELNNLTLNL SMSKPTKLSS FSTSLGYYPP IMHRIIPQKT LNSSYKLSLN
560 570 580 590 600
LLDLIWLEKT IPKSTSITQT QLSKMMSNQK GLIKLYFLSF LITISLIFIL

HTLNPEWFQ
Length:609
Mass (Da):68,618
Last modified:April 1, 2015 - v3
Checksum:i1C876639DC556967
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 72SS → IL in CAA32964 (PubMed:2504926).Curated
Sequence conflicti13 – 131I → D in CAA32964 (PubMed:2504926).Curated
Sequence conflicti20 – 3819IISMT…SYATS → TFSMTILTKLMYFRHMLIT in CAA32964 (PubMed:2504926).CuratedAdd
BLAST
Sequence conflicti93 – 931A → S in CAA32964 (PubMed:2504926).Curated
Sequence conflicti126 – 1272IT → NN in CAA32964 (PubMed:2504926).Curated
Sequence conflicti161 – 1611R → L in CAA32964 (PubMed:2504926).Curated
Sequence conflicti206 – 2061T → TN in CAA32964 (PubMed:2504926).Curated
Sequence conflicti348 – 3481S → I in CAA32964 (PubMed:2504926).Curated
Sequence conflicti533 – 5331H → P in CAA32964 (PubMed:2504926).Curated
Sequence conflicti557 – 5571L → S in CAA32964 (PubMed:2504926).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14848 Genomic DNA. Translation: CAA32964.1.
AY172581 Genomic DNA. Translation: AAN77604.1.
PIRiS04757.
RefSeqiAP_004902.1. AC_000022.2.
YP_665639.1. NC_001665.2.

Genome annotation databases

EnsembliENSRNOT00000048767; ENSRNOP00000044573; ENSRNOG00000029971.
GeneIDi26202.
KEGGirno:26202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14848 Genomic DNA. Translation: CAA32964.1.
AY172581 Genomic DNA. Translation: AAN77604.1.
PIRiS04757.
RefSeqiAP_004902.1. AC_000022.2.
YP_665639.1. NC_001665.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044573.

Proteomic databases

PaxDbiP11661.
PRIDEiP11661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048767; ENSRNOP00000044573; ENSRNOG00000029971.
GeneIDi26202.
KEGGirno:26202.

Organism-specific databases

CTDi4540.
RGDi620560. mt-Nd5.

Phylogenomic databases

eggNOGiKOG4668. Eukaryota.
COG1009. LUCA.
HOGENOMiHOG000100570.
HOVERGENiHBG108343.
InParanoidiP11661.
KOiK03883.
OMAiEFSMWYM.

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.
R-RNO-6799198. Complex I biogenesis.

Miscellaneous databases

PROiP11661.

Gene expression databases

ExpressionAtlasiP11661. baseline and differential.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates."
    Gadaleta G., Pepe G., de Candia G., Quagliariello C., Sbisa E., Saccone C.
    J. Mol. Evol. 28:497-516(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
  2. Saccone C.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiNU5M_RAT
AccessioniPrimary (citable) accession number: P11661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 1, 2015
Last modified: June 8, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.