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Protein

Major cell-surface adhesin PAc

Gene

pac

Organism
Streptococcus mutans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Surface protein antigen implicated in dental caries.

Names & Taxonomyi

Protein namesi
Recommended name:
Major cell-surface adhesin PAc
Alternative name(s):
Antigen I/II
Gene namesi
Name:pac
OrganismiStreptococcus mutans
Taxonomic identifieri1309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 381 PublicationAdd BLAST38
ChainiPRO_000000564539 – 1535Major cell-surface adhesin PAcAdd BLAST1497
PropeptideiPRO_00000056461536 – 1565Removed by sortasePROSITE-ProRule annotationAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1535Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_610.

Structurei

Secondary structure

11565
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi465 – 490Combined sources26
Turni491 – 495Combined sources5
Beta strandi499 – 502Combined sources4
Beta strandi517 – 527Combined sources11
Helixi529 – 537Combined sources9
Helixi539 – 541Combined sources3
Helixi542 – 546Combined sources5
Helixi552 – 554Combined sources3
Helixi557 – 560Combined sources4
Helixi563 – 565Combined sources3
Beta strandi566 – 569Combined sources4
Beta strandi572 – 574Combined sources3
Turni585 – 587Combined sources3
Beta strandi593 – 599Combined sources7
Beta strandi604 – 610Combined sources7
Beta strandi620 – 631Combined sources12
Beta strandi638 – 640Combined sources3
Beta strandi642 – 649Combined sources8
Helixi650 – 652Combined sources3
Beta strandi654 – 657Combined sources4
Beta strandi664 – 666Combined sources3
Beta strandi668 – 679Combined sources12
Beta strandi687 – 694Combined sources8
Beta strandi701 – 709Combined sources9
Beta strandi711 – 715Combined sources5
Beta strandi721 – 725Combined sources5
Beta strandi728 – 731Combined sources4
Beta strandi760 – 762Combined sources3
Helixi766 – 769Combined sources4
Beta strandi771 – 778Combined sources8
Beta strandi780 – 788Combined sources9
Helixi789 – 791Combined sources3
Beta strandi812 – 816Combined sources5
Beta strandi824 – 826Combined sources3
Beta strandi1003 – 1009Combined sources7
Beta strandi1025 – 1032Combined sources8
Beta strandi1045 – 1050Combined sources6
Beta strandi1055 – 1057Combined sources3
Helixi1059 – 1064Combined sources6
Beta strandi1069 – 1074Combined sources6
Helixi1075 – 1077Combined sources3
Beta strandi1079 – 1084Combined sources6
Helixi1086 – 1093Combined sources8
Turni1094 – 1097Combined sources4
Beta strandi1106 – 1111Combined sources6
Beta strandi1117 – 1120Combined sources4
Beta strandi1123 – 1126Combined sources4
Turni1127 – 1129Combined sources3
Beta strandi1130 – 1133Combined sources4
Beta strandi1137 – 1140Combined sources4
Beta strandi1159 – 1161Combined sources3
Beta strandi1180 – 1187Combined sources8
Helixi1190 – 1192Combined sources3
Helixi1199 – 1202Combined sources4
Beta strandi1206 – 1211Combined sources6
Turni1214 – 1216Combined sources3
Beta strandi1217 – 1219Combined sources3
Helixi1221 – 1223Combined sources3
Beta strandi1225 – 1228Combined sources4
Beta strandi1236 – 1244Combined sources9
Turni1245 – 1247Combined sources3
Helixi1250 – 1258Combined sources9
Beta strandi1267 – 1273Combined sources7
Helixi1275 – 1282Combined sources8
Turni1283 – 1286Combined sources4
Beta strandi1289 – 1297Combined sources9
Helixi1299 – 1304Combined sources6
Beta strandi1306 – 1316Combined sources11
Beta strandi1319 – 1330Combined sources12
Beta strandi1336 – 1342Combined sources7
Beta strandi1361 – 1367Combined sources7
Beta strandi1373 – 1377Combined sources5
Beta strandi1382 – 1387Combined sources6
Turni1390 – 1392Combined sources3
Beta strandi1393 – 1405Combined sources13
Beta strandi1407 – 1409Combined sources3
Helixi1422 – 1424Combined sources3
Beta strandi1425 – 1430Combined sources6
Turni1431 – 1434Combined sources4
Beta strandi1435 – 1440Combined sources6
Helixi1442 – 1447Combined sources6
Beta strandi1456 – 1464Combined sources9
Beta strandi1466 – 1472Combined sources7
Beta strandi1474 – 1478Combined sources5
Beta strandi1481 – 1484Combined sources4
Beta strandi1488 – 1492Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JMMX-ray2.40A463-839[»]
3OPUX-ray2.18A/B/C/D/E/F1154-1492[»]
3QE5X-ray2.50A/B991-1485[»]
ProteinModelPortaliP11657.
SMRiP11657.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11657.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati203 – 285A1Add BLAST83
Repeati286 – 367A2Add BLAST82
Repeati368 – 448A3Add BLAST81
Repeati848 – 887P1Add BLAST40
Repeati888 – 926P2Add BLAST39
Repeati927 – 964P3Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 448Heptad repeats of Y-[EQ]-X-X-L-A-XAdd BLAST246
Regioni461 – 834V-region (lectin-like)Add BLAST374

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1532 – 1536LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 201Ala-richAdd BLAST45
Compositional biasi835 – 988Pro-richAdd BLAST154

Sequence similaritiesi

Belongs to the SpaP/Ssp5/SpaA family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR026345. Adh_isopep-form_adh_dom.
IPR032300. Antigen_C.
IPR021197. Cross-wall-target_lipo_motif.
IPR013574. Glucan-bd_C/Surface_Ag-I/II_V.
IPR019948. Gram-positive_anchor.
IPR009578. Surface_Ag_rpt.
[Graphical view]
PfamiPF16364. Antigen_C. 1 hit.
PF08363. GbpC. 1 hit.
PF00746. Gram_pos_anchor. 1 hit.
PF06696. Strep_SA_rep. 7 hits.
[Graphical view]
SUPFAMiSSF74914. SSF74914. 1 hit.
TIGRFAMsiTIGR04228. isopep_sspB_C2. 1 hit.
TIGR03726. strep_RK_lipo. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKKTYGFR KSKISKTLCG AVLGTVAAVS VAGQKVFADE TTTTSDVDTK
60 70 80 90 100
VVGTQTGNPA TNLPEAQGSA SKEAEQSQTK LERQMVHTIE VPKTDLDQAA
110 120 130 140 150
KDAKSAGVNV VQDADVNKGT VKTPEEAVQK ETEIKEDYTK QAEDIKKTTD
160 170 180 190 200
QYKSDVAAHE AEVAKIKAKN QATKEQYEKD MAAHKAEVER INAANAASKT
210 220 230 240 250
AYEAKLAQYQ ADLAAVQKTN AANQAAYQKA LAAYQAELKR VQEANAAAKA
260 270 280 290 300
AYDTAVAANN AKNTEIAAAN EEIRKRNATA KAEYETKLAQ YQAELKRVQE
310 320 330 340 350
ANAANEADYQ AKLTAYQTEL ARVQKANADA KATYEAAVAA NNAKNAALTA
360 370 380 390 400
ENTAIKQRNE NAKATYEAAL KQYEADLAAV KKANAANEAD YQAKLTAYQT
410 420 430 440 450
ELARVQKANA DAKAAYEAAV AANNAANAAL TAENTAIKKR NADAKADYEA
460 470 480 490 500
KLAKYQADLA KYQKDLADYP VKLKAYEDEQ TSIKAALAEL EKHKNEDGNL
510 520 530 540 550
TEPSAQNLVY DLEPNANLSL TTDGKFLKAS AVDDAFSKST SKAKYDQKIL
560 570 580 590 600
QLDDLDITNL EQSNDVASSM ELYGNFGDKA GWSTTVSNNS QVKWGSVLLE
610 620 630 640 650
RGQSATATYT NLQNSYYNGK KISKIVYKYT VDPKSKFQGQ KVWLGIFTDP
660 670 680 690 700
TLGVFASAYT GQVEKNTSIF IKNEFTFYHE DEKPINFDNA LLSVTSLNRE
710 720 730 740 750
HNSIEMAKDY SGKFVKISGS SIGEKNGMIY ATDTLNFKQG EGGSRWTMYK
760 770 780 790 800
NSQAGSGWDS SDAPNSWYGA GAIKMSGPNN HVTVGATSAT NVMPVSDMPV
810 820 830 840 850
VPGKDNTDGK KPNIWYSLNG KIRAVNVPKV TKEKPTPPVK PTAPTKPTYE
860 870 880 890 900
TEKPLKPAPV APNYEKEPTP PTRTPDQAEP NKPTPPTYET EKPLEPAPVE
910 920 930 940 950
PSYEAEPTPP TRTPDQAEPN KPTPPTYETE KPLEPAPVEP SYEAEPTPPT
960 970 980 990 1000
PTPDQPEPNK PVEPTYEVIP TPPTDPVYQD LPTPPSDPTV HFHYFKLAVQ
1010 1020 1030 1040 1050
PQVNKEIRNN NDINIDRTLV AKQSVVKFQL KTADLPAGRD ETTSFVLVDP
1060 1070 1080 1090 1100
LPSGYQFNPE ATKAASPGFD VTYDNATNTV TFKATAATLA TFNADLTKSV
1110 1120 1130 1140 1150
ATIYPTVVGQ VLNDGATYKN NFTLTVNDAY GIKSNVVRVT TPGKPNDPDN
1160 1170 1180 1190 1200
PNNNYIKPTK VNKNENGVVI DGKTVLAGST NYYELTWDLD QYKNDRSSAD
1210 1220 1230 1240 1250
TIQKGFYYVD DYPEEALELR QDLVKITDAN GNEVTGVSVD NYTNLEAAPQ
1260 1270 1280 1290 1300
EIRDVLSKAG IRPKGAFQIF RADNPREFYD TYVKTGIDLK IVSPMVVKKQ
1310 1320 1330 1340 1350
MGQTGGSYEN QAYQIDFGNG YASNIVINNV PKINPKKDVT LTLDPADTNN
1360 1370 1380 1390 1400
VDGQTIPLNT VFNYRLIGGI IPANHSEELF EYNFYDDYDQ TGDHYTGQYK
1410 1420 1430 1440 1450
VFAKVDITLK NGVIIKSGTE LTQYTTAEVD TTKGAITIKF KEAFLRSVSI
1460 1470 1480 1490 1500
DSAFQAESYI QMKRIAVGTF ENTYINTVNG VTYSSNTVKT TTPEDPADPT
1510 1520 1530 1540 1550
DPQDPSSPRT STVIIYKPQS TAYQPSSVQE TLPNTGVTNN AYMPLLGIIG
1560
LVTSFSLLGL KAKKD
Length:1,565
Mass (Da):170,782
Last modified:October 1, 1989 - v1
Checksum:i4C3B05C809D0C32A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14490 Genomic DNA. Translation: CAA32652.1.
AB040534 Genomic DNA. Translation: BAC54564.1.
PIRiS04729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14490 Genomic DNA. Translation: CAA32652.1.
AB040534 Genomic DNA. Translation: BAC54564.1.
PIRiS04729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JMMX-ray2.40A463-839[»]
3OPUX-ray2.18A/B/C/D/E/F1154-1492[»]
3QE5X-ray2.50A/B991-1485[»]
ProteinModelPortaliP11657.
SMRiP11657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP11657.

Family and domain databases

InterProiIPR026345. Adh_isopep-form_adh_dom.
IPR032300. Antigen_C.
IPR021197. Cross-wall-target_lipo_motif.
IPR013574. Glucan-bd_C/Surface_Ag-I/II_V.
IPR019948. Gram-positive_anchor.
IPR009578. Surface_Ag_rpt.
[Graphical view]
PfamiPF16364. Antigen_C. 1 hit.
PF08363. GbpC. 1 hit.
PF00746. Gram_pos_anchor. 1 hit.
PF06696. Strep_SA_rep. 7 hits.
[Graphical view]
SUPFAMiSSF74914. SSF74914. 1 hit.
TIGRFAMsiTIGR04228. isopep_sspB_C2. 1 hit.
TIGR03726. strep_RK_lipo. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAC_STRMG
AccessioniPrimary (citable) accession number: P11657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.