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Protein

Major cell-surface adhesin PAc

Gene

pac

Organism
Streptococcus mutans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Surface protein antigen implicated in dental caries.

Names & Taxonomyi

Protein namesi
Recommended name:
Major cell-surface adhesin PAc
Alternative name(s):
Antigen I/II
Gene namesi
Name:pac
OrganismiStreptococcus mutans
Taxonomic identifieri1309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 38381 PublicationAdd
BLAST
Chaini39 – 15351497Major cell-surface adhesin PAcPRO_0000005645Add
BLAST
Propeptidei1536 – 156530Removed by sortasePROSITE-ProRule annotationPRO_0000005646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1535 – 15351Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_610.

Structurei

Secondary structure

1
1565
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi465 – 49026Combined sources
Turni491 – 4955Combined sources
Beta strandi499 – 5024Combined sources
Beta strandi517 – 52711Combined sources
Helixi529 – 5379Combined sources
Helixi539 – 5413Combined sources
Helixi542 – 5465Combined sources
Helixi552 – 5543Combined sources
Helixi557 – 5604Combined sources
Helixi563 – 5653Combined sources
Beta strandi566 – 5694Combined sources
Beta strandi572 – 5743Combined sources
Turni585 – 5873Combined sources
Beta strandi593 – 5997Combined sources
Beta strandi604 – 6107Combined sources
Beta strandi620 – 63112Combined sources
Beta strandi638 – 6403Combined sources
Beta strandi642 – 6498Combined sources
Helixi650 – 6523Combined sources
Beta strandi654 – 6574Combined sources
Beta strandi664 – 6663Combined sources
Beta strandi668 – 67912Combined sources
Beta strandi687 – 6948Combined sources
Beta strandi701 – 7099Combined sources
Beta strandi711 – 7155Combined sources
Beta strandi721 – 7255Combined sources
Beta strandi728 – 7314Combined sources
Beta strandi760 – 7623Combined sources
Helixi766 – 7694Combined sources
Beta strandi771 – 7788Combined sources
Beta strandi780 – 7889Combined sources
Helixi789 – 7913Combined sources
Beta strandi812 – 8165Combined sources
Beta strandi824 – 8263Combined sources
Beta strandi1003 – 10097Combined sources
Beta strandi1025 – 10328Combined sources
Beta strandi1045 – 10506Combined sources
Beta strandi1055 – 10573Combined sources
Helixi1059 – 10646Combined sources
Beta strandi1069 – 10746Combined sources
Helixi1075 – 10773Combined sources
Beta strandi1079 – 10846Combined sources
Helixi1086 – 10938Combined sources
Turni1094 – 10974Combined sources
Beta strandi1106 – 11116Combined sources
Beta strandi1117 – 11204Combined sources
Beta strandi1123 – 11264Combined sources
Turni1127 – 11293Combined sources
Beta strandi1130 – 11334Combined sources
Beta strandi1137 – 11404Combined sources
Beta strandi1159 – 11613Combined sources
Beta strandi1180 – 11878Combined sources
Helixi1190 – 11923Combined sources
Helixi1199 – 12024Combined sources
Beta strandi1206 – 12116Combined sources
Turni1214 – 12163Combined sources
Beta strandi1217 – 12193Combined sources
Helixi1221 – 12233Combined sources
Beta strandi1225 – 12284Combined sources
Beta strandi1236 – 12449Combined sources
Turni1245 – 12473Combined sources
Helixi1250 – 12589Combined sources
Beta strandi1267 – 12737Combined sources
Helixi1275 – 12828Combined sources
Turni1283 – 12864Combined sources
Beta strandi1289 – 12979Combined sources
Helixi1299 – 13046Combined sources
Beta strandi1306 – 131611Combined sources
Beta strandi1319 – 133012Combined sources
Beta strandi1336 – 13427Combined sources
Beta strandi1361 – 13677Combined sources
Beta strandi1373 – 13775Combined sources
Beta strandi1382 – 13876Combined sources
Turni1390 – 13923Combined sources
Beta strandi1393 – 140513Combined sources
Beta strandi1407 – 14093Combined sources
Helixi1422 – 14243Combined sources
Beta strandi1425 – 14306Combined sources
Turni1431 – 14344Combined sources
Beta strandi1435 – 14406Combined sources
Helixi1442 – 14476Combined sources
Beta strandi1456 – 14649Combined sources
Beta strandi1466 – 14727Combined sources
Beta strandi1474 – 14785Combined sources
Beta strandi1481 – 14844Combined sources
Beta strandi1488 – 14925Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JMMX-ray2.40A463-839[»]
3OPUX-ray2.18A/B/C/D/E/F1154-1492[»]
3QE5X-ray2.50A/B991-1485[»]
ProteinModelPortaliP11657.
SMRiP11657. Positions 463-839.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11657.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati203 – 28583A1Add
BLAST
Repeati286 – 36782A2Add
BLAST
Repeati368 – 44881A3Add
BLAST
Repeati848 – 88740P1Add
BLAST
Repeati888 – 92639P2Add
BLAST
Repeati927 – 96438P3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni203 – 448246Heptad repeats of Y-[EQ]-X-X-L-A-XAdd
BLAST
Regioni461 – 834374V-region (lectin-like)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1532 – 15365LPXTG sorting signalPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 20145Ala-richAdd
BLAST
Compositional biasi835 – 988154Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SpaP/Ssp5/SpaA family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR026345. Adh_isopep-form_adh_dom.
IPR032300. Antigen_C.
IPR021197. Cross-wall-target_lipo_motif.
IPR013574. Glucan-bd_C/Surface_Ag-I/II_V.
IPR019948. Gram-positive_anchor.
IPR009578. Surface_Ag_rpt.
[Graphical view]
PfamiPF16364. Antigen_C. 1 hit.
PF08363. GbpC. 1 hit.
PF00746. Gram_pos_anchor. 1 hit.
PF06696. Strep_SA_rep. 7 hits.
[Graphical view]
SUPFAMiSSF74914. SSF74914. 1 hit.
TIGRFAMsiTIGR04228. isopep_sspB_C2. 1 hit.
TIGR03726. strep_RK_lipo. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKKTYGFR KSKISKTLCG AVLGTVAAVS VAGQKVFADE TTTTSDVDTK
60 70 80 90 100
VVGTQTGNPA TNLPEAQGSA SKEAEQSQTK LERQMVHTIE VPKTDLDQAA
110 120 130 140 150
KDAKSAGVNV VQDADVNKGT VKTPEEAVQK ETEIKEDYTK QAEDIKKTTD
160 170 180 190 200
QYKSDVAAHE AEVAKIKAKN QATKEQYEKD MAAHKAEVER INAANAASKT
210 220 230 240 250
AYEAKLAQYQ ADLAAVQKTN AANQAAYQKA LAAYQAELKR VQEANAAAKA
260 270 280 290 300
AYDTAVAANN AKNTEIAAAN EEIRKRNATA KAEYETKLAQ YQAELKRVQE
310 320 330 340 350
ANAANEADYQ AKLTAYQTEL ARVQKANADA KATYEAAVAA NNAKNAALTA
360 370 380 390 400
ENTAIKQRNE NAKATYEAAL KQYEADLAAV KKANAANEAD YQAKLTAYQT
410 420 430 440 450
ELARVQKANA DAKAAYEAAV AANNAANAAL TAENTAIKKR NADAKADYEA
460 470 480 490 500
KLAKYQADLA KYQKDLADYP VKLKAYEDEQ TSIKAALAEL EKHKNEDGNL
510 520 530 540 550
TEPSAQNLVY DLEPNANLSL TTDGKFLKAS AVDDAFSKST SKAKYDQKIL
560 570 580 590 600
QLDDLDITNL EQSNDVASSM ELYGNFGDKA GWSTTVSNNS QVKWGSVLLE
610 620 630 640 650
RGQSATATYT NLQNSYYNGK KISKIVYKYT VDPKSKFQGQ KVWLGIFTDP
660 670 680 690 700
TLGVFASAYT GQVEKNTSIF IKNEFTFYHE DEKPINFDNA LLSVTSLNRE
710 720 730 740 750
HNSIEMAKDY SGKFVKISGS SIGEKNGMIY ATDTLNFKQG EGGSRWTMYK
760 770 780 790 800
NSQAGSGWDS SDAPNSWYGA GAIKMSGPNN HVTVGATSAT NVMPVSDMPV
810 820 830 840 850
VPGKDNTDGK KPNIWYSLNG KIRAVNVPKV TKEKPTPPVK PTAPTKPTYE
860 870 880 890 900
TEKPLKPAPV APNYEKEPTP PTRTPDQAEP NKPTPPTYET EKPLEPAPVE
910 920 930 940 950
PSYEAEPTPP TRTPDQAEPN KPTPPTYETE KPLEPAPVEP SYEAEPTPPT
960 970 980 990 1000
PTPDQPEPNK PVEPTYEVIP TPPTDPVYQD LPTPPSDPTV HFHYFKLAVQ
1010 1020 1030 1040 1050
PQVNKEIRNN NDINIDRTLV AKQSVVKFQL KTADLPAGRD ETTSFVLVDP
1060 1070 1080 1090 1100
LPSGYQFNPE ATKAASPGFD VTYDNATNTV TFKATAATLA TFNADLTKSV
1110 1120 1130 1140 1150
ATIYPTVVGQ VLNDGATYKN NFTLTVNDAY GIKSNVVRVT TPGKPNDPDN
1160 1170 1180 1190 1200
PNNNYIKPTK VNKNENGVVI DGKTVLAGST NYYELTWDLD QYKNDRSSAD
1210 1220 1230 1240 1250
TIQKGFYYVD DYPEEALELR QDLVKITDAN GNEVTGVSVD NYTNLEAAPQ
1260 1270 1280 1290 1300
EIRDVLSKAG IRPKGAFQIF RADNPREFYD TYVKTGIDLK IVSPMVVKKQ
1310 1320 1330 1340 1350
MGQTGGSYEN QAYQIDFGNG YASNIVINNV PKINPKKDVT LTLDPADTNN
1360 1370 1380 1390 1400
VDGQTIPLNT VFNYRLIGGI IPANHSEELF EYNFYDDYDQ TGDHYTGQYK
1410 1420 1430 1440 1450
VFAKVDITLK NGVIIKSGTE LTQYTTAEVD TTKGAITIKF KEAFLRSVSI
1460 1470 1480 1490 1500
DSAFQAESYI QMKRIAVGTF ENTYINTVNG VTYSSNTVKT TTPEDPADPT
1510 1520 1530 1540 1550
DPQDPSSPRT STVIIYKPQS TAYQPSSVQE TLPNTGVTNN AYMPLLGIIG
1560
LVTSFSLLGL KAKKD
Length:1,565
Mass (Da):170,782
Last modified:October 1, 1989 - v1
Checksum:i4C3B05C809D0C32A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14490 Genomic DNA. Translation: CAA32652.1.
AB040534 Genomic DNA. Translation: BAC54564.1.
PIRiS04729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14490 Genomic DNA. Translation: CAA32652.1.
AB040534 Genomic DNA. Translation: BAC54564.1.
PIRiS04729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JMMX-ray2.40A463-839[»]
3OPUX-ray2.18A/B/C/D/E/F1154-1492[»]
3QE5X-ray2.50A/B991-1485[»]
ProteinModelPortaliP11657.
SMRiP11657. Positions 463-839.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP11657.

Family and domain databases

InterProiIPR026345. Adh_isopep-form_adh_dom.
IPR032300. Antigen_C.
IPR021197. Cross-wall-target_lipo_motif.
IPR013574. Glucan-bd_C/Surface_Ag-I/II_V.
IPR019948. Gram-positive_anchor.
IPR009578. Surface_Ag_rpt.
[Graphical view]
PfamiPF16364. Antigen_C. 1 hit.
PF08363. GbpC. 1 hit.
PF00746. Gram_pos_anchor. 1 hit.
PF06696. Strep_SA_rep. 7 hits.
[Graphical view]
SUPFAMiSSF74914. SSF74914. 1 hit.
TIGRFAMsiTIGR04228. isopep_sspB_C2. 1 hit.
TIGR03726. strep_RK_lipo. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAC_STRMG
AccessioniPrimary (citable) accession number: P11657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.