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Protein

Nuclear pore membrane glycoprotein 210

Gene

Nup210

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.By similarity

GO - Molecular functioni

  • protein dimerization activity Source: RGD
  • structural constituent of nuclear pore Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore membrane glycoprotein 210
Short name:
Nuclear pore protein gp210
Alternative name(s):
Nuclear envelope pore membrane protein POM 210
Short name:
POM210
Nucleoporin Nup210
Pore membrane protein of 210 kDa
Gene namesi
Name:Nup210
Synonyms:Gp210, Pom210
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi69339. Nup210.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 18051780Lumenal1 PublicationAdd
BLAST
Transmembranei1806 – 182823HelicalCuratedAdd
BLAST
Topological domaini1829 – 188658Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • nuclear membrane Source: UniProtKB-SubCell
  • nuclear pore Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 18861861Nuclear pore membrane glycoprotein 210PRO_0000019926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi681 – 6811N-linked (GlcNAc...)Sequence analysis
Glycosylationi1039 – 10391N-linked (GlcNAc...)Sequence analysis
Modified residuei1839 – 18391PhosphoserineBy similarity
Modified residuei1844 – 18441PhosphothreonineBy similarity
Modified residuei1873 – 18731PhosphoserineBy similarity
Modified residuei1876 – 18761PhosphoserineBy similarity
Modified residuei1880 – 18801Phosphoserine1 Publication
Modified residuei1885 – 18851PhosphoserineBy similarity

Post-translational modificationi

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides.1 Publication
Phosphorylated at Ser-1880 in mitosis specifically; not phosphorylated in interphase.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP11654.
PRIDEiP11654.

PTM databases

iPTMnetiP11654.
PhosphoSiteiP11654.
SwissPalmiP11654.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005390.
GenevisibleiP11654. RN.

Interactioni

Subunit structurei

Forms dimers and possibly higher-order oligomers.1 Publication

GO - Molecular functioni

  • protein dimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008888.

Family & Domainsi

Sequence similaritiesi

Belongs to the NUP210 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1833. Eukaryota.
ENOG410XNNU. LUCA.
GeneTreeiENSGT00390000009491.
HOGENOMiHOG000115312.
HOVERGENiHBG082098.
InParanoidiP11654.
KOiK14314.
OMAiAHTTVKV.
OrthoDBiEOG091G006N.
PhylomeDBiP11654.
TreeFamiTF313331.

Family and domain databases

InterProiIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF02368. Big_2. 1 hit.
[Graphical view]
SMARTiSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARASLIQPG LWALLLLQAV GPAVAAKLNI PKVLLPFTRA TRVNFTLEAS
60 70 80 90 100
EGCYRWSSTR PEVASIEPLG SSEQQCSQKA VVQARLTQPA RLTSIIFAED
110 120 130 140 150
ITTGQVLRCD AIVDLIHGIQ IVSTTRELYL EDSPLELKIQ ALDSEGNTFS
160 170 180 190 200
TLAGLVFDWT IVKDTEANGF SDSHNALRIL TFLESTYIPP SYISEMEKAA
210 220 230 240 250
KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL ENILLNPAYD
260 270 280 290 300
VYLLVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP DPQGDPARPV
310 320 330 340 350
AVLTQDTSRV TAMQMGQSNL VLGHRSIRMQ GASRLPNSTI YVVEAGYLGF
360 370 380 390 400
TVHPGDRWVL ETGHLYAVTI EVFDRSSNKV YPSDNIRIEA VFPAEFFEVL
410 420 430 440 450
SSSQNGSYHH VRAIQSGQTT ISASLTSVVD QDGGVHVLQV PVWNQQEVDI
460 470 480 490 500
HIPITLYPSI LTFPWQPKTG AYQYTIKAHG GSGNFTWSSS SYMVATVTVK
510 520 530 540 550
GVMTTGGDTG LSVIRAHDVQ NPLHFGEMKV YVIEPSSMEF APCQVEARVG
560 570 580 590 600
HTLELPLTIS GLMPGGSSEV VTLSDCSHFD LVVEVENQGV FQPLPGRLPP
610 620 630 640 650
GPEHCSGVKV RADAQGSTTL LVSYTHGHVH LGAKITLAAY LPLKAVDPSS
660 670 680 690 700
VAVVTLGSSK EMLFEGGPRP WVLEPSKFFR NVTSEDTGSI SLSLLGPPAS
710 720 730 740 750
RNYQQHRVLV TCQALGEQVI ALSVGNRPSL SNPFPAVEPT VVKSVCAPPS
760 770 780 790 800
RLTLMPVYAL PQLDLSCPLL QQNKQVVPVS SHRNPLLDLG AYDQQGRRFD
810 820 830 840 850
NFSSLSIQWE SFRPLLASIE VDQPMQLVSQ DDGNGQKKLH GLQTVSVHEA
860 870 880 890 900
SGTTAISATA TGYQQSHLSA AGVKQLRDPL VPVSASIELI LVEDVRVSPE
910 920 930 940 950
EVTIYNHPGV QVELHITEGS GYFFLNTSTQ DIINVAYQDT RGVAMVHPLF
960 970 980 990 1000
PGSSTVMVHD LCLTFPAPAK ATIHVSDIQE LYVRVVDKVE IGKAVKAYVR
1010 1020 1030 1040 1050
VLDFYKKPFL AKYFTFMDLK LRAASQIITL VTLDEALDNY TATFLVHGVA
1060 1070 1080 1090 1100
IGQTSLSASV TDKSGQRVSS TAQQIEVFPP FRLIPRKVTL IIGAMIQITS
1110 1120 1130 1140 1150
EGGPQPQSNI LFSINNESVA AVSSAGLVRG LMVGNGSVLG VVQAVDAETG
1160 1170 1180 1190 1200
KVIIVSQDHV EVEVLQLQAV RIRAPITRMR TGTQMPVYVT GITSNQSPFS
1210 1220 1230 1240 1250
FGNAVPGLTF HWSVTKRDVL DLRGRHHEVS IRLSPQYNFA MNVHGRVKGR
1260 1270 1280 1290 1300
TGLRVVVKAL DPTAGQLHGL GKELSDEIQI QVFEKLRLLN PEVEAEQILM
1310 1320 1330 1340 1350
SPNSFIKLQT NRDGAAILSY RVLDGPEKAP IVHIDEKGFL VSGSGIGVST
1360 1370 1380 1390 1400
LEVIAQEPFG TNQTVLVAVK VSPISYLRIS MSPVLHTQHK EVLTALPLGM
1410 1420 1430 1440 1450
TVTFTVHFHD SSGDIFHAHN SDLNFATNRD DFVQIGKGAT NNTCIIRTVS
1460 1470 1480 1490 1500
VGLTLLHVWD VEHLGLSDFV PLPVLQAITP ELSGAVVVGD ILCLASVLIS
1510 1520 1530 1540 1550
LGGVSGTWSS SAGNVLYVDP KTGVAIARDA GPVTVYYEIA GHLKTFKEIV
1560 1570 1580 1590 1600
VVTPQKIVAR RLHATQTSIQ EATASKVTVS VGDRSSNLLG ECSSAQREAI
1610 1620 1630 1640 1650
EALHPESLIS CQLQFKQDVF DFPARDIFSV EPGFDTALGQ YLCSVTMHRL
1660 1670 1680 1690 1700
TDKQLKHLNM KKTSLAVTAS MPSSRTSVEK VGAEVPFSPG LYANQAEILL
1710 1720 1730 1740 1750
SNHYPSSEVK IFGAVEILEN LEVRSGSPAV LASVKEKSFG LPSFITYTVG
1760 1770 1780 1790 1800
VLDPTAGSQG PLSTALTFSS PATNQAITIP VTVAFVLDRR GPGPYGASLL
1810 1820 1830 1840 1850
SHFLDSYQVM FFTFFALLAG TAVTIIAYHT VCAPRELASP LALTPHASPQ
1860 1870 1880
HSPHYLASSP TAFNTLPSDR KASPPSGLWS PAYASH
Length:1,886
Mass (Da):204,159
Last modified:October 1, 1989 - v1
Checksum:i6920B93C20A6C5D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00826 mRNA. Translation: CAA68759.1.
PIRiS04921.
RefSeqiNP_445774.1. NM_053322.2.
UniGeneiRn.3189.

Genome annotation databases

EnsembliENSRNOT00000008888; ENSRNOP00000008888; ENSRNOG00000005390.
GeneIDi58958.
KEGGirno:58958.
UCSCiRGD:69339. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00826 mRNA. Translation: CAA68759.1.
PIRiS04921.
RefSeqiNP_445774.1. NM_053322.2.
UniGeneiRn.3189.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008888.

PTM databases

iPTMnetiP11654.
PhosphoSiteiP11654.
SwissPalmiP11654.

Proteomic databases

PaxDbiP11654.
PRIDEiP11654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008888; ENSRNOP00000008888; ENSRNOG00000005390.
GeneIDi58958.
KEGGirno:58958.
UCSCiRGD:69339. rat.

Organism-specific databases

CTDi23225.
RGDi69339. Nup210.

Phylogenomic databases

eggNOGiKOG1833. Eukaryota.
ENOG410XNNU. LUCA.
GeneTreeiENSGT00390000009491.
HOGENOMiHOG000115312.
HOVERGENiHBG082098.
InParanoidiP11654.
KOiK14314.
OMAiAHTTVKV.
OrthoDBiEOG091G006N.
PhylomeDBiP11654.
TreeFamiTF313331.

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiP11654.

Gene expression databases

BgeeiENSRNOG00000005390.
GenevisibleiP11654. RN.

Family and domain databases

InterProiIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF02368. Big_2. 1 hit.
[Graphical view]
SMARTiSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPO210_RAT
AccessioniPrimary (citable) accession number: P11654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.