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Protein

Nuclear pore membrane glycoprotein 210

Gene

Nup210

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.By similarity

GO - Molecular functioni

  • protein dimerization activity Source: RGD
  • structural constituent of nuclear pore Source: RGD

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859 snRNP Assembly
R-RNO-3108214 SUMOylation of DNA damage response and repair proteins
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-4551638 SUMOylation of chromatin organization proteins
R-RNO-4570464 SUMOylation of RNA binding proteins
R-RNO-4615885 SUMOylation of DNA replication proteins
R-RNO-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore membrane glycoprotein 210
Short name:
Nuclear pore protein gp210
Alternative name(s):
Nuclear envelope pore membrane protein POM 210
Short name:
POM210
Nucleoporin Nup210
Pore membrane protein of 210 kDa
Gene namesi
Name:Nup210
Synonyms:Gp210, Pom210
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi69339 Nup210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 1805Lumenal1 PublicationAdd BLAST1780
Transmembranei1806 – 1828HelicalCuratedAdd BLAST23
Topological domaini1829 – 1886Cytoplasmic1 PublicationAdd BLAST58

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001992626 – 1886Nuclear pore membrane glycoprotein 210Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1039N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1839PhosphoserineBy similarity1
Modified residuei1844PhosphothreonineBy similarity1
Modified residuei1873PhosphoserineBy similarity1
Modified residuei1876PhosphoserineBy similarity1
Modified residuei1880Phosphoserine1 Publication1
Modified residuei1885PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides.1 Publication
Phosphorylated at Ser-1880 in mitosis specifically; not phosphorylated in interphase.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP11654
PRIDEiP11654

PTM databases

iPTMnetiP11654
PhosphoSitePlusiP11654
SwissPalmiP11654

Expressioni

Gene expression databases

BgeeiENSRNOG00000005390
GenevisibleiP11654 RN

Interactioni

Subunit structurei

Forms dimers and possibly higher-order oligomers.1 Publication

GO - Molecular functioni

  • protein dimerization activity Source: RGD

Protein-protein interaction databases

CORUMiP11654
STRINGi10116.ENSRNOP00000008888

Structurei

3D structure databases

SMRiP11654
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NUP210 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1833 Eukaryota
ENOG410XNNU LUCA
GeneTreeiENSGT00390000009491
HOGENOMiHOG000115312
HOVERGENiHBG082098
InParanoidiP11654
KOiK14314
OMAiHFGEMKV
OrthoDBiEOG091G006N
PhylomeDBiP11654
TreeFamiTF313331

Family and domain databases

InterProiView protein in InterPro
IPR003343 Big_2
IPR008964 Invasin/intimin_cell_adhesion
PfamiView protein in Pfam
PF02368 Big_2, 1 hit
SMARTiView protein in SMART
SM00635 BID_2, 1 hit
SUPFAMiSSF49373 SSF49373, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARASLIQPG LWALLLLQAV GPAVAAKLNI PKVLLPFTRA TRVNFTLEAS
60 70 80 90 100
EGCYRWSSTR PEVASIEPLG SSEQQCSQKA VVQARLTQPA RLTSIIFAED
110 120 130 140 150
ITTGQVLRCD AIVDLIHGIQ IVSTTRELYL EDSPLELKIQ ALDSEGNTFS
160 170 180 190 200
TLAGLVFDWT IVKDTEANGF SDSHNALRIL TFLESTYIPP SYISEMEKAA
210 220 230 240 250
KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL ENILLNPAYD
260 270 280 290 300
VYLLVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP DPQGDPARPV
310 320 330 340 350
AVLTQDTSRV TAMQMGQSNL VLGHRSIRMQ GASRLPNSTI YVVEAGYLGF
360 370 380 390 400
TVHPGDRWVL ETGHLYAVTI EVFDRSSNKV YPSDNIRIEA VFPAEFFEVL
410 420 430 440 450
SSSQNGSYHH VRAIQSGQTT ISASLTSVVD QDGGVHVLQV PVWNQQEVDI
460 470 480 490 500
HIPITLYPSI LTFPWQPKTG AYQYTIKAHG GSGNFTWSSS SYMVATVTVK
510 520 530 540 550
GVMTTGGDTG LSVIRAHDVQ NPLHFGEMKV YVIEPSSMEF APCQVEARVG
560 570 580 590 600
HTLELPLTIS GLMPGGSSEV VTLSDCSHFD LVVEVENQGV FQPLPGRLPP
610 620 630 640 650
GPEHCSGVKV RADAQGSTTL LVSYTHGHVH LGAKITLAAY LPLKAVDPSS
660 670 680 690 700
VAVVTLGSSK EMLFEGGPRP WVLEPSKFFR NVTSEDTGSI SLSLLGPPAS
710 720 730 740 750
RNYQQHRVLV TCQALGEQVI ALSVGNRPSL SNPFPAVEPT VVKSVCAPPS
760 770 780 790 800
RLTLMPVYAL PQLDLSCPLL QQNKQVVPVS SHRNPLLDLG AYDQQGRRFD
810 820 830 840 850
NFSSLSIQWE SFRPLLASIE VDQPMQLVSQ DDGNGQKKLH GLQTVSVHEA
860 870 880 890 900
SGTTAISATA TGYQQSHLSA AGVKQLRDPL VPVSASIELI LVEDVRVSPE
910 920 930 940 950
EVTIYNHPGV QVELHITEGS GYFFLNTSTQ DIINVAYQDT RGVAMVHPLF
960 970 980 990 1000
PGSSTVMVHD LCLTFPAPAK ATIHVSDIQE LYVRVVDKVE IGKAVKAYVR
1010 1020 1030 1040 1050
VLDFYKKPFL AKYFTFMDLK LRAASQIITL VTLDEALDNY TATFLVHGVA
1060 1070 1080 1090 1100
IGQTSLSASV TDKSGQRVSS TAQQIEVFPP FRLIPRKVTL IIGAMIQITS
1110 1120 1130 1140 1150
EGGPQPQSNI LFSINNESVA AVSSAGLVRG LMVGNGSVLG VVQAVDAETG
1160 1170 1180 1190 1200
KVIIVSQDHV EVEVLQLQAV RIRAPITRMR TGTQMPVYVT GITSNQSPFS
1210 1220 1230 1240 1250
FGNAVPGLTF HWSVTKRDVL DLRGRHHEVS IRLSPQYNFA MNVHGRVKGR
1260 1270 1280 1290 1300
TGLRVVVKAL DPTAGQLHGL GKELSDEIQI QVFEKLRLLN PEVEAEQILM
1310 1320 1330 1340 1350
SPNSFIKLQT NRDGAAILSY RVLDGPEKAP IVHIDEKGFL VSGSGIGVST
1360 1370 1380 1390 1400
LEVIAQEPFG TNQTVLVAVK VSPISYLRIS MSPVLHTQHK EVLTALPLGM
1410 1420 1430 1440 1450
TVTFTVHFHD SSGDIFHAHN SDLNFATNRD DFVQIGKGAT NNTCIIRTVS
1460 1470 1480 1490 1500
VGLTLLHVWD VEHLGLSDFV PLPVLQAITP ELSGAVVVGD ILCLASVLIS
1510 1520 1530 1540 1550
LGGVSGTWSS SAGNVLYVDP KTGVAIARDA GPVTVYYEIA GHLKTFKEIV
1560 1570 1580 1590 1600
VVTPQKIVAR RLHATQTSIQ EATASKVTVS VGDRSSNLLG ECSSAQREAI
1610 1620 1630 1640 1650
EALHPESLIS CQLQFKQDVF DFPARDIFSV EPGFDTALGQ YLCSVTMHRL
1660 1670 1680 1690 1700
TDKQLKHLNM KKTSLAVTAS MPSSRTSVEK VGAEVPFSPG LYANQAEILL
1710 1720 1730 1740 1750
SNHYPSSEVK IFGAVEILEN LEVRSGSPAV LASVKEKSFG LPSFITYTVG
1760 1770 1780 1790 1800
VLDPTAGSQG PLSTALTFSS PATNQAITIP VTVAFVLDRR GPGPYGASLL
1810 1820 1830 1840 1850
SHFLDSYQVM FFTFFALLAG TAVTIIAYHT VCAPRELASP LALTPHASPQ
1860 1870 1880
HSPHYLASSP TAFNTLPSDR KASPPSGLWS PAYASH
Length:1,886
Mass (Da):204,159
Last modified:October 1, 1989 - v1
Checksum:i6920B93C20A6C5D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00826 mRNA Translation: CAA68759.1
PIRiS04921
RefSeqiNP_445774.1, NM_053322.2
UniGeneiRn.3189

Genome annotation databases

EnsembliENSRNOT00000008888; ENSRNOP00000008888; ENSRNOG00000005390
GeneIDi58958
KEGGirno:58958
UCSCiRGD:69339 rat

Similar proteinsi

Entry informationi

Entry nameiPO210_RAT
AccessioniPrimary (citable) accession number: P11654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health