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P11640

- RDRP_MCMVK

UniProt

P11640 - RDRP_MCMVK

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Protein

RNA-directed RNA polymerase

Gene
ORF2
Organism
Maize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication Inferred.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
111 kDa protein
Protein p111
Cleaved into the following chain:
Gene namesi
ORF Names:ORF2
OrganismiMaize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV)
Taxonomic identifieri882210 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeMachlomovirus
Virus hostiZea mays (Maize) [TaxID: 4577]
ProteomesiUP000007071: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965RNA-directed RNA polymerasePRO_0000040211Add
BLAST
Chaini1 – 438438Protein p50PRO_0000040212Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP11640.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini662 – 778117RdRp catalyticAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11640-1 [UniParc]FASTAAdd to Basket

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MATLPSIHAF WKLWWPTFSE ERKMTVVQAL RNGLTRKLFQ ITQIAQQILR    50
WPPYIRERMT SSLGQSLVKT FQTLLGIRKA LSRLCLTRNM NVDIFTMLLI 100
PFKFLSQLCS QIVASANFVI QTFRHGLSRG LCLARCRNPE TMRSGWSKHT 150
LQMQNCSSTS PLMTPFQPQI ARDLSNPHGL WMSTRNKLTR TGGSAIQQTS 200
RYVRLAVRFS LLAAGAYISC VLARKALKEY VYRWELKSDQ ELPTREQSQI 250
SQVEQAMEQN GAMMVMKLNG PTAPILSLQD CLTKHVLVPE IVDEEGTVTQ 300
KEQSTFLIRE FGPAVRNLVT LAKLEFGGIP KKTTANELTV WRFLVRKCEH 350
ANMNPTDSRT AISMALPYVF MPCRTDVGRA SIPLRDESIE ICRQYRAQFV 400
EETPLRRVFN NPLSGKAWRN WVRHLGGLDD PALFQELKXG CLEEWLGVQS 450
RRTRARHPKL RSHFKDTRHK TRRVFRIAGL GNLYEFGVHN NSAVNLERGL 500
MERVFYVKDD KGELVSCPEP ISGIFWKNLK GFRNSIVHHV GHRHPVSRET 550
FLAYYTGPKR TMYEKAVNSL YEMPVSYDDA KLKTFVKAEK INLTKKADPV 600
PRVIQPRAPR YNVELGRYLR PVEHPIYHAI DKIWGGPTIM KGYSVEQIGR 650
HIENAFRSFT DPVAIGFDAS RFDQHVSVEA LRWEHSVYSR IYGYPELLTQ 700
LLRWQIHNRG TAYASDGAFN YQVDGKRMSG DMNISLGNCI LATAITHDFV 750
TKLGIPARLI NNGDDNVLIC PAVEVGRVRQ ELYRHWLNYG FEVISEEPVY 800
ILEQVEFCQM RPVFDGTQYT MMRDPRTTMS KDAYAVTPFN TPTAARRWMR 850
AVGECGLSLT GGLPVKQEYY TALVKHGLDP KNIKQGKDFD SGLYYLSKLS 900
NRKWQEVQES ARYSFWLAFG YTPDEQRALE EYFKSWTPTF EWSTTGILAE 950
IPECLLLKHN PLPPT 965
Length:965
Mass (Da):110,880
Last modified:October 5, 2010 - v3
Checksum:i8507E5D2DF86C612
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14736 Genomic RNA. Translation: CAA32862.1.
X14736 Genomic RNA. Translation: CAB55589.1.
PIRiJQ0058.
RefSeqiNP_619718.1. NC_003627.1.
NP_619719.1. NC_003627.1.

Genome annotation databases

GeneIDi2652939.
2652940.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14736 Genomic RNA. Translation: CAA32862.1 .
X14736 Genomic RNA. Translation: CAB55589.1 .
PIRi JQ0058.
RefSeqi NP_619718.1. NC_003627.1.
NP_619719.1. NC_003627.1.

3D structure databases

ProteinModelPortali P11640.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2652939.
2652940.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the maize chlorotic mottle virus genome."
    Nutter R.C., Scheets K., Panganiban L.C., Lommel S.A.
    Nucleic Acids Res. 17:3163-3177(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_MCMVK
AccessioniPrimary (citable) accession number: P11640
Secondary accession number(s): Q9IBM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 439.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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