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P11640

- RDRP_MCMVK

UniProt

P11640 - RDRP_MCMVK

Protein

RNA-directed RNA polymerase

Gene

ORF2

Organism
Maize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    111 kDa protein
    Protein p111
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF2
    OrganismiMaize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV)
    Taxonomic identifieri882210 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeMachlomovirus
    Virus hostiZea mays (Maize) [TaxID: 4577]
    ProteomesiUP000007071: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 965965RNA-directed RNA polymerasePRO_0000040211Add
    BLAST
    Chaini1 – 438438Protein p50PRO_0000040212Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP11640.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini662 – 778117RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11640-1 [UniParc]FASTAAdd to Basket

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    MATLPSIHAF WKLWWPTFSE ERKMTVVQAL RNGLTRKLFQ ITQIAQQILR    50
    WPPYIRERMT SSLGQSLVKT FQTLLGIRKA LSRLCLTRNM NVDIFTMLLI 100
    PFKFLSQLCS QIVASANFVI QTFRHGLSRG LCLARCRNPE TMRSGWSKHT 150
    LQMQNCSSTS PLMTPFQPQI ARDLSNPHGL WMSTRNKLTR TGGSAIQQTS 200
    RYVRLAVRFS LLAAGAYISC VLARKALKEY VYRWELKSDQ ELPTREQSQI 250
    SQVEQAMEQN GAMMVMKLNG PTAPILSLQD CLTKHVLVPE IVDEEGTVTQ 300
    KEQSTFLIRE FGPAVRNLVT LAKLEFGGIP KKTTANELTV WRFLVRKCEH 350
    ANMNPTDSRT AISMALPYVF MPCRTDVGRA SIPLRDESIE ICRQYRAQFV 400
    EETPLRRVFN NPLSGKAWRN WVRHLGGLDD PALFQELKXG CLEEWLGVQS 450
    RRTRARHPKL RSHFKDTRHK TRRVFRIAGL GNLYEFGVHN NSAVNLERGL 500
    MERVFYVKDD KGELVSCPEP ISGIFWKNLK GFRNSIVHHV GHRHPVSRET 550
    FLAYYTGPKR TMYEKAVNSL YEMPVSYDDA KLKTFVKAEK INLTKKADPV 600
    PRVIQPRAPR YNVELGRYLR PVEHPIYHAI DKIWGGPTIM KGYSVEQIGR 650
    HIENAFRSFT DPVAIGFDAS RFDQHVSVEA LRWEHSVYSR IYGYPELLTQ 700
    LLRWQIHNRG TAYASDGAFN YQVDGKRMSG DMNISLGNCI LATAITHDFV 750
    TKLGIPARLI NNGDDNVLIC PAVEVGRVRQ ELYRHWLNYG FEVISEEPVY 800
    ILEQVEFCQM RPVFDGTQYT MMRDPRTTMS KDAYAVTPFN TPTAARRWMR 850
    AVGECGLSLT GGLPVKQEYY TALVKHGLDP KNIKQGKDFD SGLYYLSKLS 900
    NRKWQEVQES ARYSFWLAFG YTPDEQRALE EYFKSWTPTF EWSTTGILAE 950
    IPECLLLKHN PLPPT 965
    Length:965
    Mass (Da):110,880
    Last modified:October 5, 2010 - v3
    Checksum:i8507E5D2DF86C612
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14736 Genomic RNA. Translation: CAA32862.1.
    X14736 Genomic RNA. Translation: CAB55589.1.
    PIRiJQ0058.
    RefSeqiNP_619718.1. NC_003627.1.
    NP_619719.1. NC_003627.1.

    Genome annotation databases

    GeneIDi2652939.
    2652940.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14736 Genomic RNA. Translation: CAA32862.1 .
    X14736 Genomic RNA. Translation: CAB55589.1 .
    PIRi JQ0058.
    RefSeqi NP_619718.1. NC_003627.1.
    NP_619719.1. NC_003627.1.

    3D structure databases

    ProteinModelPortali P11640.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2652939.
    2652940.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete nucleotide sequence of the maize chlorotic mottle virus genome."
      Nutter R.C., Scheets K., Panganiban L.C., Lommel S.A.
      Nucleic Acids Res. 17:3163-3177(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_MCMVK
    AccessioniPrimary (citable) accession number: P11640
    Secondary accession number(s): Q9IBM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 70 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 439.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3