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P11640 (RDRP_MCMVK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

EC=2.7.7.48
Alternative name(s):
111 kDa protein
Protein p111

Cleaved into the following chain:

  1. Protein p50
Gene names
ORF Names:ORF2
OrganismMaize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV) [Reference proteome]
Taxonomic identifier882210 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeMachlomovirus
Virus hostZea mays (Maize) [TaxID: 4577]

Protein attributes

Sequence length965 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase that plays an essential role in the virus replication Probable.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Miscellaneous

Readthrough of the terminator UAG occurs at position 439.

Sequence similarities

Belongs to the tombusviridae RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 965965RNA-directed RNA polymerase
PRO_0000040211
Chain1 – 438438Protein p50
PRO_0000040212

Regions

Domain662 – 778117RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P11640 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 8507E5D2DF86C612

FASTA965110,880
        10         20         30         40         50         60 
MATLPSIHAF WKLWWPTFSE ERKMTVVQAL RNGLTRKLFQ ITQIAQQILR WPPYIRERMT 

        70         80         90        100        110        120 
SSLGQSLVKT FQTLLGIRKA LSRLCLTRNM NVDIFTMLLI PFKFLSQLCS QIVASANFVI 

       130        140        150        160        170        180 
QTFRHGLSRG LCLARCRNPE TMRSGWSKHT LQMQNCSSTS PLMTPFQPQI ARDLSNPHGL 

       190        200        210        220        230        240 
WMSTRNKLTR TGGSAIQQTS RYVRLAVRFS LLAAGAYISC VLARKALKEY VYRWELKSDQ 

       250        260        270        280        290        300 
ELPTREQSQI SQVEQAMEQN GAMMVMKLNG PTAPILSLQD CLTKHVLVPE IVDEEGTVTQ 

       310        320        330        340        350        360 
KEQSTFLIRE FGPAVRNLVT LAKLEFGGIP KKTTANELTV WRFLVRKCEH ANMNPTDSRT 

       370        380        390        400        410        420 
AISMALPYVF MPCRTDVGRA SIPLRDESIE ICRQYRAQFV EETPLRRVFN NPLSGKAWRN 

       430        440        450        460        470        480 
WVRHLGGLDD PALFQELKXG CLEEWLGVQS RRTRARHPKL RSHFKDTRHK TRRVFRIAGL 

       490        500        510        520        530        540 
GNLYEFGVHN NSAVNLERGL MERVFYVKDD KGELVSCPEP ISGIFWKNLK GFRNSIVHHV 

       550        560        570        580        590        600 
GHRHPVSRET FLAYYTGPKR TMYEKAVNSL YEMPVSYDDA KLKTFVKAEK INLTKKADPV 

       610        620        630        640        650        660 
PRVIQPRAPR YNVELGRYLR PVEHPIYHAI DKIWGGPTIM KGYSVEQIGR HIENAFRSFT 

       670        680        690        700        710        720 
DPVAIGFDAS RFDQHVSVEA LRWEHSVYSR IYGYPELLTQ LLRWQIHNRG TAYASDGAFN 

       730        740        750        760        770        780 
YQVDGKRMSG DMNISLGNCI LATAITHDFV TKLGIPARLI NNGDDNVLIC PAVEVGRVRQ 

       790        800        810        820        830        840 
ELYRHWLNYG FEVISEEPVY ILEQVEFCQM RPVFDGTQYT MMRDPRTTMS KDAYAVTPFN 

       850        860        870        880        890        900 
TPTAARRWMR AVGECGLSLT GGLPVKQEYY TALVKHGLDP KNIKQGKDFD SGLYYLSKLS 

       910        920        930        940        950        960 
NRKWQEVQES ARYSFWLAFG YTPDEQRALE EYFKSWTPTF EWSTTGILAE IPECLLLKHN 


PLPPT 

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References

[1]"The complete nucleotide sequence of the maize chlorotic mottle virus genome."
Nutter R.C., Scheets K., Panganiban L.C., Lommel S.A.
Nucleic Acids Res. 17:3163-3177(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14736 Genomic RNA. Translation: CAA32862.1.
X14736 Genomic RNA. Translation: CAB55589.1.
PIRJQ0058.
RefSeqNP_619718.1. NC_003627.1.
NP_619719.1. NC_003627.1.

3D structure databases

ProteinModelPortalP11640.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2652939.
2652940.

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_MCMVK
AccessionPrimary (citable) accession number: P11640
Secondary accession number(s): Q9IBM2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families