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Protein

RNA-directed RNA polymerase

Gene

ORF2

Organism
Maize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Miscellaneous

Readthrough of the terminator UAG occurs at position 439.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
111 kDa protein
Protein p111
Cleaved into the following chain:
Gene namesi
ORF Names:ORF2
OrganismiMaize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV)
Taxonomic identifieri882210 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTombusviridaeMachlomovirus
Virus hostiZea mays (Maize) [TaxID: 4577]
Proteomesi
  • UP000007071 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000402111 – 965RNA-directed RNA polymeraseAdd BLAST965
ChainiPRO_00000402121 – 438Protein p50Add BLAST438

Structurei

3D structure databases

ProteinModelPortaliP11640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini662 – 778RdRp catalyticPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG09000032.

Family and domain databases

InterProiView protein in InterPro
IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
PfamiView protein in Pfam
PF00998. RdRP_3. 1 hit.
PROSITEiView protein in PROSITE
PS50507. RDRP_SSRNA_POS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLPSIHAF WKLWWPTFSE ERKMTVVQAL RNGLTRKLFQ ITQIAQQILR
60 70 80 90 100
WPPYIRERMT SSLGQSLVKT FQTLLGIRKA LSRLCLTRNM NVDIFTMLLI
110 120 130 140 150
PFKFLSQLCS QIVASANFVI QTFRHGLSRG LCLARCRNPE TMRSGWSKHT
160 170 180 190 200
LQMQNCSSTS PLMTPFQPQI ARDLSNPHGL WMSTRNKLTR TGGSAIQQTS
210 220 230 240 250
RYVRLAVRFS LLAAGAYISC VLARKALKEY VYRWELKSDQ ELPTREQSQI
260 270 280 290 300
SQVEQAMEQN GAMMVMKLNG PTAPILSLQD CLTKHVLVPE IVDEEGTVTQ
310 320 330 340 350
KEQSTFLIRE FGPAVRNLVT LAKLEFGGIP KKTTANELTV WRFLVRKCEH
360 370 380 390 400
ANMNPTDSRT AISMALPYVF MPCRTDVGRA SIPLRDESIE ICRQYRAQFV
410 420 430 440 450
EETPLRRVFN NPLSGKAWRN WVRHLGGLDD PALFQELKXG CLEEWLGVQS
460 470 480 490 500
RRTRARHPKL RSHFKDTRHK TRRVFRIAGL GNLYEFGVHN NSAVNLERGL
510 520 530 540 550
MERVFYVKDD KGELVSCPEP ISGIFWKNLK GFRNSIVHHV GHRHPVSRET
560 570 580 590 600
FLAYYTGPKR TMYEKAVNSL YEMPVSYDDA KLKTFVKAEK INLTKKADPV
610 620 630 640 650
PRVIQPRAPR YNVELGRYLR PVEHPIYHAI DKIWGGPTIM KGYSVEQIGR
660 670 680 690 700
HIENAFRSFT DPVAIGFDAS RFDQHVSVEA LRWEHSVYSR IYGYPELLTQ
710 720 730 740 750
LLRWQIHNRG TAYASDGAFN YQVDGKRMSG DMNISLGNCI LATAITHDFV
760 770 780 790 800
TKLGIPARLI NNGDDNVLIC PAVEVGRVRQ ELYRHWLNYG FEVISEEPVY
810 820 830 840 850
ILEQVEFCQM RPVFDGTQYT MMRDPRTTMS KDAYAVTPFN TPTAARRWMR
860 870 880 890 900
AVGECGLSLT GGLPVKQEYY TALVKHGLDP KNIKQGKDFD SGLYYLSKLS
910 920 930 940 950
NRKWQEVQES ARYSFWLAFG YTPDEQRALE EYFKSWTPTF EWSTTGILAE
960
IPECLLLKHN PLPPT
Length:965
Mass (Da):110,880
Last modified:October 5, 2010 - v3
Checksum:i8507E5D2DF86C612
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14736 Genomic RNA. Translation: CAA32862.1.
X14736 Genomic RNA. Translation: CAB55589.1.
PIRiJQ0058.
RefSeqiNP_619718.1. NC_003627.1.
NP_619719.1. NC_003627.1.

Genome annotation databases

GeneIDi2652939.
2652940.
KEGGivg:2652939.
vg:2652940.

Keywords - Coding sequence diversityi

RNA suppression of termination

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRDRP_MCMVK
AccessioniPrimary (citable) accession number: P11640
Secondary accession number(s): Q9IBM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 5, 2010
Last modified: March 15, 2017
This is version 75 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families