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Protein

RNA-directed RNA polymerase

Gene

ORF2

Organism
Maize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
111 kDa protein
Protein p111
Cleaved into the following chain:
Gene namesi
ORF Names:ORF2
OrganismiMaize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV)
Taxonomic identifieri882210 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeMachlomovirus
Virus hostiZea mays (Maize) [TaxID: 4577]
ProteomesiUP000007071: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965RNA-directed RNA polymerasePRO_0000040211Add
BLAST
Chaini1 – 438438Protein p50PRO_0000040212Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP11640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini662 – 778117RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11640-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLPSIHAF WKLWWPTFSE ERKMTVVQAL RNGLTRKLFQ ITQIAQQILR
60 70 80 90 100
WPPYIRERMT SSLGQSLVKT FQTLLGIRKA LSRLCLTRNM NVDIFTMLLI
110 120 130 140 150
PFKFLSQLCS QIVASANFVI QTFRHGLSRG LCLARCRNPE TMRSGWSKHT
160 170 180 190 200
LQMQNCSSTS PLMTPFQPQI ARDLSNPHGL WMSTRNKLTR TGGSAIQQTS
210 220 230 240 250
RYVRLAVRFS LLAAGAYISC VLARKALKEY VYRWELKSDQ ELPTREQSQI
260 270 280 290 300
SQVEQAMEQN GAMMVMKLNG PTAPILSLQD CLTKHVLVPE IVDEEGTVTQ
310 320 330 340 350
KEQSTFLIRE FGPAVRNLVT LAKLEFGGIP KKTTANELTV WRFLVRKCEH
360 370 380 390 400
ANMNPTDSRT AISMALPYVF MPCRTDVGRA SIPLRDESIE ICRQYRAQFV
410 420 430 440 450
EETPLRRVFN NPLSGKAWRN WVRHLGGLDD PALFQELKXG CLEEWLGVQS
460 470 480 490 500
RRTRARHPKL RSHFKDTRHK TRRVFRIAGL GNLYEFGVHN NSAVNLERGL
510 520 530 540 550
MERVFYVKDD KGELVSCPEP ISGIFWKNLK GFRNSIVHHV GHRHPVSRET
560 570 580 590 600
FLAYYTGPKR TMYEKAVNSL YEMPVSYDDA KLKTFVKAEK INLTKKADPV
610 620 630 640 650
PRVIQPRAPR YNVELGRYLR PVEHPIYHAI DKIWGGPTIM KGYSVEQIGR
660 670 680 690 700
HIENAFRSFT DPVAIGFDAS RFDQHVSVEA LRWEHSVYSR IYGYPELLTQ
710 720 730 740 750
LLRWQIHNRG TAYASDGAFN YQVDGKRMSG DMNISLGNCI LATAITHDFV
760 770 780 790 800
TKLGIPARLI NNGDDNVLIC PAVEVGRVRQ ELYRHWLNYG FEVISEEPVY
810 820 830 840 850
ILEQVEFCQM RPVFDGTQYT MMRDPRTTMS KDAYAVTPFN TPTAARRWMR
860 870 880 890 900
AVGECGLSLT GGLPVKQEYY TALVKHGLDP KNIKQGKDFD SGLYYLSKLS
910 920 930 940 950
NRKWQEVQES ARYSFWLAFG YTPDEQRALE EYFKSWTPTF EWSTTGILAE
960
IPECLLLKHN PLPPT
Length:965
Mass (Da):110,880
Last modified:October 5, 2010 - v3
Checksum:i8507E5D2DF86C612
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14736 Genomic RNA. Translation: CAA32862.1.
X14736 Genomic RNA. Translation: CAB55589.1.
PIRiJQ0058.
RefSeqiNP_619718.1. NC_003627.1.
NP_619719.1. NC_003627.1.

Genome annotation databases

GeneIDi2652939.
2652940.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14736 Genomic RNA. Translation: CAA32862.1.
X14736 Genomic RNA. Translation: CAB55589.1.
PIRiJQ0058.
RefSeqiNP_619718.1. NC_003627.1.
NP_619719.1. NC_003627.1.

3D structure databases

ProteinModelPortaliP11640.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2652939.
2652940.

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete nucleotide sequence of the maize chlorotic mottle virus genome."
    Nutter R.C., Scheets K., Panganiban L.C., Lommel S.A.
    Nucleic Acids Res. 17:3163-3177(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_MCMVK
AccessioniPrimary (citable) accession number: P11640
Secondary accession number(s): Q9IBM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 5, 2010
Last modified: January 7, 2015
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 439.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.