Reviewed, UniProtKB/Swiss-Prot P11635 (DHQA_NEUCR)

Names and origin

Protein names

Recommended name:
    Quinate dehydrogenase
    EC=1.1.1.24

Gene names

Name:	qa-3
ORF Names:	NCU06025

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Quinate + NAD+ = 3-dehydroquinate + NADH.
Pathway	Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1.
Induction	By quinic acid and the positive regulator qa-1f.
Miscellaneous	N.crassa can utilize quinic acid as sole carbon source, oxidizing it to protocatechuic acid and ultimately to succinic acid and acetic acid. The conversion of quinic acid to protocatechuic acid is catalyzed by enzymes which are encoded by three coordinately regulated genes comprising the qa gene cluster.
Caution	It is uncertain whether Met-1 or Met-14 is the initiator.
Sequence caution	The sequence CAA32751.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Quinate metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW quinate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro quinate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Quinate dehydrogenase		PRO_0000079893

Sequences

	Sequence		Length	Mass (Da)
	P11635-1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 8A951802A06C03D4	FASTA	339	37,271
	10 20 30 40 50 60 MSTATTTTSA TTTMSVVQPR QQELLHLTST PDITPYTRHG YLFGQKLAAS MSPLLHSIVY 70 80 90 100 110 120 SHLSLNWAQL RLDSPSIPLF LQLAQHPDFY GASVTMPHKV AIIPHLDHLT PECRDVGACN 130 140 150 160 170 180 TLFLKTDPAT GRRLYCGANT DVIGVRESFV QNVSDPARVY ESRPALVIGG GGAARSAVYA 190 200 210 220 230 240 LHKWLGATDI YLVNRDKSEV DAVIAECTER GYGDRLVHVA SVEQAEGLEG PGAIVACIPD 250 260 270 280 290 300 FPPKTEKEML VRRIVETFLM KEEKGAMLEM CYNPSPFTEL GALAEHEGWQ VILGTEALIW 310 320 330 QGIEQDKYWT GRTNEELPIQ QIKEVIAAKL AEASKSHTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa." Geever R.F., Huiet L., Baum J.A., Tyler B.M., Patel V.B., Rutledge B.J., Case M.E., Giles N.H. J. Mol. Biol. 207:15-34(1989) [PubMed: 2525625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X14603 Genomic DNA. Translation: CAA32751.1. Sequence problems. AABX02000021 Genomic DNA. Translation: EAA30379.2. Different initiation.
PIR	S04253.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P11635.
Enzyme and pathway databases
BioCyc	NCRA-XX3-01:NCRA-XX3-01-009773-MON.
BRENDA	1.1.1.24. 266.
Family and domain databases
InterPro	IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHQA_NEUCR

Accession

Primary (citable) accession number: P11635
Secondary accession number(s): Q7RVA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	December 4, 2007
Last modified:	September 22, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)