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Protein

Adenosine receptor A2a

Gene

ADORA2A

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-417973. Adenosine P1 receptors.
R-CFA-418555. G alpha (s) signalling events.
R-CFA-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2a
Gene namesi
Name:ADORA2A
Synonyms:RDC8
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 26

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularBy similarity
Transmembranei8 – 3225Helical; Name=1By similarityAdd
BLAST
Topological domaini33 – 4210CytoplasmicBy similarity
Transmembranei43 – 6624Helical; Name=2By similarityAdd
BLAST
Topological domaini67 – 7711ExtracellularBy similarityAdd
BLAST
Transmembranei78 – 10023Helical; Name=3By similarityAdd
BLAST
Topological domaini101 – 12020CytoplasmicBy similarityAdd
BLAST
Transmembranei121 – 14323Helical; Name=4By similarityAdd
BLAST
Topological domaini144 – 17330ExtracellularBy similarityAdd
BLAST
Transmembranei174 – 19825Helical; Name=5By similarityAdd
BLAST
Topological domaini199 – 23436CytoplasmicBy similarityAdd
BLAST
Transmembranei235 – 25824Helical; Name=6By similarityAdd
BLAST
Topological domaini259 – 2668ExtracellularBy similarity
Transmembranei267 – 29024Helical; Name=7By similarityAdd
BLAST
Topological domaini291 – 412122CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Adenosine receptor A2aPRO_0000068996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 159PROSITE-ProRule annotation
Disulfide bondi74 ↔ 146PROSITE-ProRule annotation
Disulfide bondi77 ↔ 166PROSITE-ProRule annotation
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi259 ↔ 262PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP11617.

Interactioni

Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020374.

Structurei

3D structure databases

ProteinModelPortaliP11617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 17710Agonist bindingBy similarity
Regioni246 – 2538Agonist bindingBy similarity
Regioni264 – 27411Agonist bindingBy similarityAdd
BLAST

Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP11617.
KOiK04266.
OMAiPGVWANG.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24246:SF28. PTHR24246:SF28. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTMGSWVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA
60 70 80 90 100
ADIAVGVLAI PFAITISTGF CAACHNCLFF ACFVLVLTQS SIFSLLAIAI
110 120 130 140 150
DRYIAIRIPL RYNGLVTGTR AKGIIAVCWV LSFAIGLTPM LGWNNCSQPK
160 170 180 190 200
EGRNYSQGCG EGQVACLFED VVPMNYMVYY NFFAFVLVPL LLMLGVYLRI
210 220 230 240 250
FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH
260 270 280 290 300
IINCFTFFCP ECSHAPLWLM YLTIVLSHTN SVVNPFIYAY RIREFRQTFR
310 320 330 340 350
KIIRSHVLRR REPFKAGGTS ARALAAHGSD GEQISLRLNG HPPGVWANGS
360 370 380 390 400
APHPERRPNG YTLGLVSGGI APESHGDMGL PDVELLSHEL KGACPESPGL
410
EGPLAQDGAG VS
Length:412
Mass (Da):45,061
Last modified:October 1, 1989 - v1
Checksum:iEB1B094AD581C6A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14052 mRNA. Translation: CAA32210.1.
PIRiD30341.
RefSeqiNP_001003278.1. NM_001003278.1.
UniGeneiCfa.3818.

Genome annotation databases

EnsembliENSCAFT00000021939; ENSCAFP00000020374; ENSCAFG00000013828.
GeneIDi403960.
KEGGicfa:403960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14052 mRNA. Translation: CAA32210.1.
PIRiD30341.
RefSeqiNP_001003278.1. NM_001003278.1.
UniGeneiCfa.3818.

3D structure databases

ProteinModelPortaliP11617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020374.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP11617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000021939; ENSCAFP00000020374; ENSCAFG00000013828.
GeneIDi403960.
KEGGicfa:403960.

Organism-specific databases

CTDi135.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP11617.
KOiK04266.
OMAiPGVWANG.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Enzyme and pathway databases

ReactomeiR-CFA-417973. Adenosine P1 receptors.
R-CFA-418555. G alpha (s) signalling events.
R-CFA-5683826. Surfactant metabolism.

Miscellaneous databases

NextBioi20817450.

Family and domain databases

InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24246:SF28. PTHR24246:SF28. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Selective amplification and cloning of four new members of the G protein-coupled receptor family."
    Libert F., Parmentier M., Lefort A., Dinsart C., van Sande J., Maenhaut C., Simons M.-J., Dumont J.E., Vassart G.
    Science 244:569-572(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.
  2. "Complete nucleotide sequence of a putative G protein coupled receptor: RDC8."
    Libert F., Parmentier M., Lefort A., Dumont J.E., Vassart G.
    Nucleic Acids Res. 18:1914-1914(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.
  3. Cited for: FUNCTION.

Entry informationi

Entry nameiAA2AR_CANLF
AccessioniPrimary (citable) accession number: P11617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.