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Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-417973 Adenosine P1 receptors
R-CFA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
Synonyms:RDC7
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:37665 ADORA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 326CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689891 – 326Adenosine receptor A1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP11616
PRIDEiP11616

Expressioni

Gene expression databases

BgeeiENSCAFG00000010298

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000015121

Structurei

3D structure databases

ProteinModelPortaliP11616
SMRiP11616
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP11616
KOiK04265
OMAiVWAVRIN
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P11616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPRTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT PRRAAVAIAG CWILSFVVGL TPLFGWNRLG
160 170 180 190 200
EAQRAWAANG SGGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRRQ LGKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PSCRKPSILM YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL
310 320
KIWNDHFRCQ PTPPVDEDPP EEAPHD
Length:326
Mass (Da):36,400
Last modified:October 1, 1989 - v1
Checksum:iD55FCE6914AEA50E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14051 mRNA Translation: CAA32209.1
PIRiC30341
RefSeqiNP_001003279.1, NM_001003279.1
XP_005622211.1, XM_005622154.2
XP_005622212.1, XM_005622155.2
UniGeneiCfa.3819

Genome annotation databases

EnsembliENSCAFT00000016346; ENSCAFP00000015121; ENSCAFG00000010298
GeneIDi403961
KEGGicfa:403961

Similar proteinsi

Entry informationi

Entry nameiAA1R_CANLF
AccessioniPrimary (citable) accession number: P11616
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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