Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-417973. Adenosine P1 receptors.
R-CFA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
Synonyms:RDC7
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 326CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689891 – 326Adenosine receptor A1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP11616.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000015121.

Structurei

3D structure databases

ProteinModelPortaliP11616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP11616.
KOiK04265.
OMAiVYAFRIH.
OrthoDBiEOG091G0I3U.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPRTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT PRRAAVAIAG CWILSFVVGL TPLFGWNRLG
160 170 180 190 200
EAQRAWAANG SGGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRRQ LGKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PSCRKPSILM YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL
310 320
KIWNDHFRCQ PTPPVDEDPP EEAPHD
Length:326
Mass (Da):36,400
Last modified:October 1, 1989 - v1
Checksum:iD55FCE6914AEA50E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14051 mRNA. Translation: CAA32209.1.
PIRiC30341.
RefSeqiNP_001003279.1. NM_001003279.1.
XP_005622211.1. XM_005622154.2.
XP_005622212.1. XM_005622155.2.
UniGeneiCfa.3819.

Genome annotation databases

EnsembliENSCAFT00000016346; ENSCAFP00000015121; ENSCAFG00000010298.
GeneIDi403961.
KEGGicfa:403961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14051 mRNA. Translation: CAA32209.1.
PIRiC30341.
RefSeqiNP_001003279.1. NM_001003279.1.
XP_005622211.1. XM_005622154.2.
XP_005622212.1. XM_005622155.2.
UniGeneiCfa.3819.

3D structure databases

ProteinModelPortaliP11616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000015121.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP11616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000016346; ENSCAFP00000015121; ENSCAFG00000010298.
GeneIDi403961.
KEGGicfa:403961.

Organism-specific databases

CTDi134.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP11616.
KOiK04265.
OMAiVYAFRIH.
OrthoDBiEOG091G0I3U.
TreeFamiTF325296.

Enzyme and pathway databases

ReactomeiR-CFA-417973. Adenosine P1 receptors.
R-CFA-418594. G alpha (i) signalling events.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAA1R_CANLF
AccessioniPrimary (citable) accession number: P11616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.