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Protein

Alpha-1B adrenergic receptor

Gene

ADRA1B

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:ADRA1B
Synonyms:RDC5
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei‹1 – 8›8Helical; Name=2By similarity
Topological domaini9 – 2012ExtracellularBy similarityAdd
BLAST
Transmembranei21 – 4424Helical; Name=3By similarityAdd
BLAST
Topological domaini45 – 6420CytoplasmicBy similarityAdd
BLAST
Transmembranei65 – 8723Helical; Name=4By similarityAdd
BLAST
Topological domaini88 – 10417ExtracellularBy similarityAdd
BLAST
Transmembranei105 – 12723Helical; Name=5By similarityAdd
BLAST
Topological domaini128 – 19871CytoplasmicBy similarityAdd
BLAST
Transmembranei199 – 22224Helical; Name=6By similarityAdd
BLAST
Topological domaini223 – 2297ExtracellularBy similarity
Transmembranei230 – 25425Helical; Name=7By similarityAdd
BLAST
Topological domaini255 – 417163CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 417›417Alpha-1B adrenergic receptorPRO_0000069068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 98PROSITE-ProRule annotation
Modified residuei167 – 1671PhosphothreonineBy similarity
Lipidationi268 – 2681S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP11615.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000043083.

Structurei

3D structure databases

ProteinModelPortaliP11615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi371 – 38111Nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi271 – 28111Poly-ArgAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP11615.
KOiK04136.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P11615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLPFSAALEV LGYWVLGRIF CDIWAAVDVL CCTASILSLC AISIDRYIGV
60 70 80 90 100
RYSLQYPTLV TRRKAILALL GVWVLSTVIS IGPLLGWKEP APNDDKECGV
110 120 130 140 150
TEEPFYALFS SLGSFYIPLA VILVMYCRVY IVAKRTTKNL EAGVMKEMSN
160 170 180 190 200
SKELTLRIHS KNFHEDTLSS TKAKGHNPRS SIAVKLFKFS REKKAAKTLG
210 220 230 240 250
IVVGMFILCW LPFFIALPLG SLFSTLKPPD AVFKVVFWLG YFNSCLNPII
260 270 280 290 300
YPCSSKEFKR AFVRILGCQC RGRRRRRRRR RLGGCAYTYR PWTRGGSLER
310 320 330 340 350
SQSRKDSLDD SGSCLSGSQR TLPSASPSPG YLGRAAPPPV ELCAVPEWKA
360 370 380 390 400
PGALLSLPAP QPPGRRGRRD SGPLFTFRLL AERGSPAAGD GACRPAPDAA
410
NGQPGFKTNM PLAPGQF
Length:417
Mass (Da):45,892
Last modified:October 1, 1989 - v1
Checksum:iD523397626E12F64
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14050 mRNA. Translation: CAA32208.1.
PIRiE30341.
RefSeqiNP_001183964.2. NM_001197035.2.
UniGeneiCfa.3820.

Genome annotation databases

GeneIDi403962.
KEGGicfa:403962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14050 mRNA. Translation: CAA32208.1.
PIRiE30341.
RefSeqiNP_001183964.2. NM_001197035.2.
UniGeneiCfa.3820.

3D structure databases

ProteinModelPortaliP11615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000043083.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP11615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403962.
KEGGicfa:403962.

Organism-specific databases

CTDi147.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP11615.
KOiK04136.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Selective amplification and cloning of four new members of the G protein-coupled receptor family."
    Libert F., Parmentier M., Lefort A., Dinsart C., van Sande J., Maenhaut C., Simons M.-J., Dumont J.E., Vassart G.
    Science 244:569-572(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiADA1B_CANLF
AccessioniPrimary (citable) accession number: P11615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.