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Protein

Alpha-1B adrenergic receptor

Gene

ADRA1B

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:ADRA1B
Synonyms:RDC5
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei‹1 – 8Helical; Name=2By similarity›8
Topological domaini9 – 20ExtracellularBy similarityAdd BLAST12
Transmembranei21 – 44Helical; Name=3By similarityAdd BLAST24
Topological domaini45 – 64CytoplasmicBy similarityAdd BLAST20
Transmembranei65 – 87Helical; Name=4By similarityAdd BLAST23
Topological domaini88 – 104ExtracellularBy similarityAdd BLAST17
Transmembranei105 – 127Helical; Name=5By similarityAdd BLAST23
Topological domaini128 – 198CytoplasmicBy similarityAdd BLAST71
Transmembranei199 – 222Helical; Name=6By similarityAdd BLAST24
Topological domaini223 – 229ExtracellularBy similarity7
Transmembranei230 – 254Helical; Name=7By similarityAdd BLAST25
Topological domaini255 – 417CytoplasmicBy similarityAdd BLAST163

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000069068‹1 – 417Alpha-1B adrenergic receptorAdd BLAST›417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 98PROSITE-ProRule annotation
Modified residuei167PhosphothreonineBy similarity1
Lipidationi268S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP11615.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000043083.

Structurei

3D structure databases

ProteinModelPortaliP11615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi371 – 381Nuclear localization signalBy similarityAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi271 – 281Poly-ArgAdd BLAST11

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP11615.
KOiK04136.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P11615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLPFSAALEV LGYWVLGRIF CDIWAAVDVL CCTASILSLC AISIDRYIGV
60 70 80 90 100
RYSLQYPTLV TRRKAILALL GVWVLSTVIS IGPLLGWKEP APNDDKECGV
110 120 130 140 150
TEEPFYALFS SLGSFYIPLA VILVMYCRVY IVAKRTTKNL EAGVMKEMSN
160 170 180 190 200
SKELTLRIHS KNFHEDTLSS TKAKGHNPRS SIAVKLFKFS REKKAAKTLG
210 220 230 240 250
IVVGMFILCW LPFFIALPLG SLFSTLKPPD AVFKVVFWLG YFNSCLNPII
260 270 280 290 300
YPCSSKEFKR AFVRILGCQC RGRRRRRRRR RLGGCAYTYR PWTRGGSLER
310 320 330 340 350
SQSRKDSLDD SGSCLSGSQR TLPSASPSPG YLGRAAPPPV ELCAVPEWKA
360 370 380 390 400
PGALLSLPAP QPPGRRGRRD SGPLFTFRLL AERGSPAAGD GACRPAPDAA
410
NGQPGFKTNM PLAPGQF
Length:417
Mass (Da):45,892
Last modified:October 1, 1989 - v1
Checksum:iD523397626E12F64
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14050 mRNA. Translation: CAA32208.1.
PIRiE30341.
RefSeqiNP_001183964.2. NM_001197035.2.
UniGeneiCfa.3820.

Genome annotation databases

GeneIDi403962.
KEGGicfa:403962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14050 mRNA. Translation: CAA32208.1.
PIRiE30341.
RefSeqiNP_001183964.2. NM_001197035.2.
UniGeneiCfa.3820.

3D structure databases

ProteinModelPortaliP11615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000043083.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP11615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403962.
KEGGicfa:403962.

Organism-specific databases

CTDi147.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP11615.
KOiK04136.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA1B_CANLF
AccessioniPrimary (citable) accession number: P11615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.