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Protein

Serine/threonine-protein phosphatase PP-Y

Gene

PpY-55A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi62Manganese 1By similarity1
Metal bindingi88Manganese 1By similarity1
Metal bindingi88Manganese 2By similarity1
Metal bindingi120Manganese 2By similarity1
Active sitei121Proton donorBy similarity1
Metal bindingi169Manganese 2By similarity1
Metal bindingi244Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • protein dephosphorylation Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

SignaLinkiP11612.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-Y (EC:3.1.3.16)
Gene namesi
Name:PpY-55A
Synonyms:PpD19, PPY
ORF Names:CG10930
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003140. PpY-55A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588891 – 314Serine/threonine-protein phosphatase PP-YAdd BLAST314

Proteomic databases

PaxDbiP11612.
PRIDEiP11612.

Expressioni

Gene expression databases

BgeeiFBgn0003140.
ExpressionAtlasiP11612. differential.
GenevisibleiP11612. DM.

Interactioni

Protein-protein interaction databases

BioGridi71474. 1 interactor.
STRINGi7227.FBpp0085996.

Structurei

3D structure databases

ProteinModelPortaliP11612.
SMRiP11612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-Y subfamily.Curated

Phylogenomic databases

eggNOGiKOG0374. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00900000141228.
InParanoidiP11612.
KOiK01090.
OMAiWADLNHT.
OrthoDBiEOG091G0EKF.
PhylomeDBiP11612.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P11612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLTTHEID CIIKELTSLN GSECTLKEEL IERLIQQTRE VIKWQPMLLE
60 70 80 90 100
LQAPVNICGD IHGQFTDLLR IFKACGFPPK ANYLFLGDYV DRGKQSLETI
110 120 130 140 150
CLLFAYKVKY PLNFFLLRGN HESASINKIY GFYDEIKRRH TVRLWHSFTD
160 170 180 190 200
CFNWLPVAAL VGERIFCCHG GLSPSLRNLQ QINHIQRPTD IPDEGIMCDL
210 220 230 240 250
LWADLNHTTK GWGHNDRGVS FTFDKVIVRD FLKAFDLQLM VRAHEVVEDG
260 270 280 290 300
YEFFANRQLV TVFSAPNYCG MMNNAGGVMS VSTDLICSFV IILPCHKYKM
310
IATDANQMPT NEEE
Length:314
Mass (Da):35,980
Last modified:August 30, 2005 - v2
Checksum:i6078CB66571261F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66T → K in AAB22467 (PubMed:1321058).Curated1
Sequence conflicti123S → C (PubMed:2541022).Curated1
Sequence conflicti123S → C (PubMed:2166691).Curated1
Sequence conflicti147S → N (PubMed:2541022).Curated1
Sequence conflicti147S → N (PubMed:2166691).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07510 mRNA. Translation: CAA68808.1.
AE013599 Genomic DNA. Translation: AAF57771.1.
AY075165 mRNA. Translation: AAL68035.1.
S40001 Genomic DNA. Translation: AAB22467.1.
PIRiS03963. PAFFY.
RefSeqiNP_001286554.1. NM_001299625.1.
NP_476689.1. NM_057341.4.
UniGeneiDm.3593.

Genome annotation databases

EnsemblMetazoaiFBtr0086817; FBpp0085996; FBgn0003140.
FBtr0344898; FBpp0311209; FBgn0003140.
GeneIDi48532.
KEGGidme:Dmel_CG10930.

Similar proteinsi

Entry informationi

Entry nameiPPY_DROME
AccessioniPrimary (citable) accession number: P11612
Secondary accession number(s): Q26247, Q9V8A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 30, 2005
Last modified: October 25, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families