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P11612

- PPY_DROME

UniProt

P11612 - PPY_DROME

Protein

Serine/threonine-protein phosphatase PP-Y

Gene

PpY-55A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Manganese 1By similarity
    Metal bindingi62 – 621Manganese 1By similarity
    Metal bindingi88 – 881Manganese 1By similarity
    Metal bindingi88 – 881Manganese 2By similarity
    Metal bindingi120 – 1201Manganese 2By similarity
    Active sitei121 – 1211Proton donorBy similarity
    Metal bindingi169 – 1691Manganese 2By similarity
    Metal bindingi244 – 2441Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: FlyBase

    GO - Biological processi

    1. protein dephosphorylation Source: FlyBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    SignaLinkiP11612.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP-Y (EC:3.1.3.16)
    Gene namesi
    Name:PpY-55A
    Synonyms:PpD19, PPY
    ORF Names:CG10930
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0003140. PpY-55A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. nucleus Source: FlyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Serine/threonine-protein phosphatase PP-YPRO_0000058889Add
    BLAST

    Proteomic databases

    PaxDbiP11612.

    Expressioni

    Gene expression databases

    BgeeiP11612.

    Structurei

    3D structure databases

    ProteinModelPortaliP11612.
    SMRiP11612. Positions 9-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-Y subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    GeneTreeiENSGT00530000062911.
    InParanoidiP11612.
    KOiK01090.
    OMAiDVICRAH.
    OrthoDBiEOG7CK377.
    PhylomeDBiP11612.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11612-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLTTHEID CIIKELTSLN GSECTLKEEL IERLIQQTRE VIKWQPMLLE    50
    LQAPVNICGD IHGQFTDLLR IFKACGFPPK ANYLFLGDYV DRGKQSLETI 100
    CLLFAYKVKY PLNFFLLRGN HESASINKIY GFYDEIKRRH TVRLWHSFTD 150
    CFNWLPVAAL VGERIFCCHG GLSPSLRNLQ QINHIQRPTD IPDEGIMCDL 200
    LWADLNHTTK GWGHNDRGVS FTFDKVIVRD FLKAFDLQLM VRAHEVVEDG 250
    YEFFANRQLV TVFSAPNYCG MMNNAGGVMS VSTDLICSFV IILPCHKYKM 300
    IATDANQMPT NEEE 314
    Length:314
    Mass (Da):35,980
    Last modified:August 30, 2005 - v2
    Checksum:i6078CB66571261F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661T → K in AAB22467. (PubMed:1321058)Curated
    Sequence conflicti123 – 1231S → C(PubMed:2541022)Curated
    Sequence conflicti123 – 1231S → C(PubMed:2166691)Curated
    Sequence conflicti147 – 1471S → N(PubMed:2541022)Curated
    Sequence conflicti147 – 1471S → N(PubMed:2166691)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07510 mRNA. Translation: CAA68808.1.
    AE013599 Genomic DNA. Translation: AAF57771.1.
    AY075165 mRNA. Translation: AAL68035.1.
    S40001 Genomic DNA. Translation: AAB22467.1.
    PIRiS03963. PAFFY.
    RefSeqiNP_476689.1. NM_057341.3.
    UniGeneiDm.3593.

    Genome annotation databases

    EnsemblMetazoaiFBtr0086817; FBpp0085996; FBgn0003140.
    GeneIDi48532.
    KEGGidme:Dmel_CG10930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07510 mRNA. Translation: CAA68808.1 .
    AE013599 Genomic DNA. Translation: AAF57771.1 .
    AY075165 mRNA. Translation: AAL68035.1 .
    S40001 Genomic DNA. Translation: AAB22467.1 .
    PIRi S03963. PAFFY.
    RefSeqi NP_476689.1. NM_057341.3.
    UniGenei Dm.3593.

    3D structure databases

    ProteinModelPortali P11612.
    SMRi P11612. Positions 9-294.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P11612.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0086817 ; FBpp0085996 ; FBgn0003140 .
    GeneIDi 48532.
    KEGGi dme:Dmel_CG10930.

    Organism-specific databases

    CTDi 48532.
    FlyBasei FBgn0003140. PpY-55A.

    Phylogenomic databases

    eggNOGi COG0639.
    GeneTreei ENSGT00530000062911.
    InParanoidi P11612.
    KOi K01090.
    OMAi DVICRAH.
    OrthoDBi EOG7CK377.
    PhylomeDBi P11612.

    Enzyme and pathway databases

    SignaLinki P11612.

    Miscellaneous databases

    GenomeRNAii 48532.
    NextBioi 839446.

    Gene expression databases

    Bgeei P11612.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal localization of a novel Drosophila protein phosphatase."
      Dombradi V., Axton J.M., Glover D.M., Cohen P.T.W.
      FEBS Lett. 247:391-395(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Head.
    2. "Protein serine/threonine phosphatases; an expanding family."
      Cohen P.T.W., Brewis N.D., Hughes V., Mann D.J.
      FEBS Lett. 268:355-359(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Testis.
    6. "Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases."
      Chen M.X., Chen Y.H., Cohen P.T.W.
      FEBS Lett. 306:54-58(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-87.

    Entry informationi

    Entry nameiPPY_DROME
    AccessioniPrimary (citable) accession number: P11612
    Secondary accession number(s): Q26247, Q9V8A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3