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P11612 (PPY_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP-Y

EC=3.1.3.16
Gene names
Name:PpY-55A
Synonyms:PpD19, PPY
ORF Names:CG10930
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-Y subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Serine/threonine-protein phosphatase PP-Y
PRO_0000058889

Sites

Active site1211Proton donor By similarity
Metal binding601Manganese 1 By similarity
Metal binding621Manganese 1 By similarity
Metal binding881Manganese 1 By similarity
Metal binding881Manganese 2 By similarity
Metal binding1201Manganese 2 By similarity
Metal binding1691Manganese 2 By similarity
Metal binding2441Manganese 2 By similarity

Experimental info

Sequence conflict661T → K in AAB22467. Ref.6
Sequence conflict1231S → C Ref.1
Sequence conflict1231S → C Ref.2
Sequence conflict1471S → N Ref.1
Sequence conflict1471S → N Ref.2

Sequences

Sequence LengthMass (Da)Tools
P11612 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 6078CB66571261F0

FASTA31435,980
        10         20         30         40         50         60 
MAVLTTHEID CIIKELTSLN GSECTLKEEL IERLIQQTRE VIKWQPMLLE LQAPVNICGD 

        70         80         90        100        110        120 
IHGQFTDLLR IFKACGFPPK ANYLFLGDYV DRGKQSLETI CLLFAYKVKY PLNFFLLRGN 

       130        140        150        160        170        180 
HESASINKIY GFYDEIKRRH TVRLWHSFTD CFNWLPVAAL VGERIFCCHG GLSPSLRNLQ 

       190        200        210        220        230        240 
QINHIQRPTD IPDEGIMCDL LWADLNHTTK GWGHNDRGVS FTFDKVIVRD FLKAFDLQLM 

       250        260        270        280        290        300 
VRAHEVVEDG YEFFANRQLV TVFSAPNYCG MMNNAGGVMS VSTDLICSFV IILPCHKYKM 

       310 
IATDANQMPT NEEE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and chromosomal localization of a novel Drosophila protein phosphatase."
Dombradi V., Axton J.M., Glover D.M., Cohen P.T.W.
FEBS Lett. 247:391-395(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Head.
[2]"Protein serine/threonine phosphatases; an expanding family."
Cohen P.T.W., Brewis N.D., Hughes V., Mann D.J.
FEBS Lett. 268:355-359(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[5]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Testis.
[6]"Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases."
Chen M.X., Chen Y.H., Cohen P.T.W.
FEBS Lett. 306:54-58(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-87.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y07510 mRNA. Translation: CAA68808.1.
AE013599 Genomic DNA. Translation: AAF57771.1.
AY075165 mRNA. Translation: AAL68035.1.
S40001 Genomic DNA. Translation: AAB22467.1.
PIRPAFFY. S03963.
RefSeqNP_476689.1. NM_057341.3.
UniGeneDm.3593.

3D structure databases

ProteinModelPortalP11612.
SMRP11612. Positions 9-294.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP11612.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0086817; FBpp0085996; FBgn0003140.
GeneID48532.
KEGGdme:Dmel_CG10930.

Organism-specific databases

CTD48532.
FlyBaseFBgn0003140. PpY-55A.

Phylogenomic databases

eggNOGCOG0639.
GeneTreeENSGT00530000062911.
InParanoidP11612.
KOK01090.
OMADVICRAH.
OrthoDBEOG7CK377.
PhylomeDBP11612.

Enzyme and pathway databases

SignaLinkP11612.

Gene expression databases

BgeeP11612.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi48532.
NextBio839446.

Entry information

Entry namePPY_DROME
AccessionPrimary (citable) accession number: P11612
Secondary accession number(s): Q26247, Q9V8A0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase