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P11612

- PPY_DROME

UniProt

P11612 - PPY_DROME

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Protein

Serine/threonine-protein phosphatase PP-Y

Gene
PpY-55A, PpD19, PPY, CG10930
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Manganese 1 By similarity
Metal bindingi62 – 621Manganese 1 By similarity
Metal bindingi88 – 881Manganese 1 By similarity
Metal bindingi88 – 881Manganese 2 By similarity
Metal bindingi120 – 1201Manganese 2 By similarity
Active sitei121 – 1211Proton donor By similarity
Metal bindingi169 – 1691Manganese 2 By similarity
Metal bindingi244 – 2441Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  1. protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

SignaLinkiP11612.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-Y (EC:3.1.3.16)
Gene namesi
Name:PpY-55A
Synonyms:PpD19, PPY
ORF Names:CG10930
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003140. PpY-55A.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. nucleus Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Serine/threonine-protein phosphatase PP-YPRO_0000058889Add
BLAST

Proteomic databases

PaxDbiP11612.

Expressioni

Gene expression databases

BgeeiP11612.

Structurei

3D structure databases

ProteinModelPortaliP11612.
SMRiP11612. Positions 9-294.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
InParanoidiP11612.
KOiK01090.
OMAiDVICRAH.
OrthoDBiEOG7CK377.
PhylomeDBiP11612.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11612-1 [UniParc]FASTAAdd to Basket

« Hide

MAVLTTHEID CIIKELTSLN GSECTLKEEL IERLIQQTRE VIKWQPMLLE    50
LQAPVNICGD IHGQFTDLLR IFKACGFPPK ANYLFLGDYV DRGKQSLETI 100
CLLFAYKVKY PLNFFLLRGN HESASINKIY GFYDEIKRRH TVRLWHSFTD 150
CFNWLPVAAL VGERIFCCHG GLSPSLRNLQ QINHIQRPTD IPDEGIMCDL 200
LWADLNHTTK GWGHNDRGVS FTFDKVIVRD FLKAFDLQLM VRAHEVVEDG 250
YEFFANRQLV TVFSAPNYCG MMNNAGGVMS VSTDLICSFV IILPCHKYKM 300
IATDANQMPT NEEE 314
Length:314
Mass (Da):35,980
Last modified:August 30, 2005 - v2
Checksum:i6078CB66571261F0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661T → K in AAB22467. 1 Publication
Sequence conflicti123 – 1231S → C1 Publication
Sequence conflicti123 – 1231S → C1 Publication
Sequence conflicti147 – 1471S → N1 Publication
Sequence conflicti147 – 1471S → N1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07510 mRNA. Translation: CAA68808.1.
AE013599 Genomic DNA. Translation: AAF57771.1.
AY075165 mRNA. Translation: AAL68035.1.
S40001 Genomic DNA. Translation: AAB22467.1.
PIRiS03963. PAFFY.
RefSeqiNP_476689.1. NM_057341.3.
UniGeneiDm.3593.

Genome annotation databases

EnsemblMetazoaiFBtr0086817; FBpp0085996; FBgn0003140.
GeneIDi48532.
KEGGidme:Dmel_CG10930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07510 mRNA. Translation: CAA68808.1 .
AE013599 Genomic DNA. Translation: AAF57771.1 .
AY075165 mRNA. Translation: AAL68035.1 .
S40001 Genomic DNA. Translation: AAB22467.1 .
PIRi S03963. PAFFY.
RefSeqi NP_476689.1. NM_057341.3.
UniGenei Dm.3593.

3D structure databases

ProteinModelPortali P11612.
SMRi P11612. Positions 9-294.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P11612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0086817 ; FBpp0085996 ; FBgn0003140 .
GeneIDi 48532.
KEGGi dme:Dmel_CG10930.

Organism-specific databases

CTDi 48532.
FlyBasei FBgn0003140. PpY-55A.

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00530000062911.
InParanoidi P11612.
KOi K01090.
OMAi DVICRAH.
OrthoDBi EOG7CK377.
PhylomeDBi P11612.

Enzyme and pathway databases

SignaLinki P11612.

Miscellaneous databases

GenomeRNAii 48532.
NextBioi 839446.

Gene expression databases

Bgeei P11612.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal localization of a novel Drosophila protein phosphatase."
    Dombradi V., Axton J.M., Glover D.M., Cohen P.T.W.
    FEBS Lett. 247:391-395(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Head.
  2. "Protein serine/threonine phosphatases; an expanding family."
    Cohen P.T.W., Brewis N.D., Hughes V., Mann D.J.
    FEBS Lett. 268:355-359(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Testis.
  6. "Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases."
    Chen M.X., Chen Y.H., Cohen P.T.W.
    FEBS Lett. 306:54-58(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-87.

Entry informationi

Entry nameiPPY_DROME
AccessioniPrimary (citable) accession number: P11612
Secondary accession number(s): Q26247, Q9V8A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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